EKS-MUM-00310
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00310
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR451.23.7E-135208495288
StatusReviewed
Ensembl ProteinENSMUSP00000056784
UniProt AccessionP37172; Q3UDH5; Q91VF1;
Protein NameActivin receptor type-1
Protein Synonyms/Alias Activin receptor type I; ACTR-I; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I; TSK-7L;
Gene NameAcvr1
Gene Synonyms/Alias Acvr1; Acvrlk2, Tgfb1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000026836ENSMUSP00000088453ENSMUST00000090935
ENSMUSG00000026836ENSMUSP00000056784ENSMUST00000056376
ENSMUSG00000026836ENSMUSP00000108218ENSMUST00000112599
ENSMUSG00000026836ENSMUSP00000120755ENSMUST00000126407
ENSMUSG00000026836ENSMUSP00000108220ENSMUST00000112601
OrganismMus musculus
Functional DescriptionOn ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved in left-right pattern formation during embryogenesis.
Protein Length509
Protein Sequence
(FASTA)
MVDGVMILPV LMMMAFPSPS VEDEKPKVNQ KLYMCVCEGL SCGNEDHCEG QQCFSSLSIN 60
DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF 120
HLEVGLIILS VVFAVCLLAC ILGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 180
AELLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 240
DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 300
DTVSCLRIVL SIASGLAHLH IEIFGTQGKS AIAHRDLKSK NILVKKNGQC CIADLGLAVM 360
HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 420
NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 480
NPSARLTALR IKKTLTKIDN SLDKLKTDC 509
Nucleotide Sequence
(FASTA)
ATGGTCGATG GAGTAATGAT CCTTCCTGTG CTAATGATGA TGGCTTTCCC TTCCCCGAGT 60
GTGGAAGATG AGAAGCCCAA GGTCAACCAG AAACTTTACA TGTGTGTGTG TGAGGGCCTC 120
TCCTGCGGGA ACGAGGACCA CTGTGAAGGC CAGCAGTGTT TTTCTTCTCT GAGCATCAAC 180
GATGGCTTCC ACGTCTACCA GAAGGGCTGC TTTCAGGTTT ATGAGCAGGG GAAGATGACG 240
TGTAAGACCC CGCCGTCACC TGGCCAGGCT GTGGAGTGCT GCCAAGGGGA CTGGTGTAAC 300
AGGAACATCA CGGCCCAGCT GCCCACTAAA GGGAAGTCCT TCCCCGGAAC ACAGAATTTC 360
CACCTGGAAG TTGGCCTTAT CATCCTCTCG GTGGTGTTTG CAGTATGTCT TTTAGCTTGC 420
ATCCTTGGAG TTGCTCTCAG GAAGTTTAAG AGACGCAATC AAGAGCGCCT GAACCCCAGA 480
GACGTGGAGT ATGGTACCAT TGAAGGGCTC ATCACCACCA ATGTGGGAGA CAGCACTCTA 540
GCGGAACTAC TAGATCACTC GTGTACATCA GGAAGTGGCT CCGGTCTTCC TTTCCTGGTA 600
CAGAGAACGG TGGCTCGCCA GATAACCCTG TTGGAGTGTG TCGGGAAGGG CCGGTATGGA 660
GAAGTATGGA GGGGCAGCTG GCAAGGCGAA AATGTCGCTG TGAAGATCTT CTCCTCCCGA 720
GACGAGAAGT CATGGTTCAG GGAGACGGAA TTGTACAACA CTGTGATGTT GAGGCATGAA 780
AATATCTTAG GTTTCATCGC TTCAGACATG ACCTCCAGAC ACTCCAGTAC CCAGCTGTGG 840
CTCATCACAC ATTACCATGA AATGGGATCG TTGTATGACT ACCTTCAGCT CACTACTCTG 900
GATACGGTTA GCTGCCTTCG GATTGTACTG TCCATAGCCA GCGGCCTTGC CCATTTGCAC 960
ATAGAGATAT TTGGGACCCA AGGGAAGTCC GCCATTGCCC ATCGAGATCT GAAGAGCAAA 1020
AACATCCTGG TGAAGAAGAA TGGACAGTGC TGCATAGCAG ATTTGGGCCT GGCAGTCATG 1080
CATTCCCAGA GCACAAACCA GCTTGATGTG GGAAACAACC CCCGTGTGGG GACCAAGCGC 1140
TACATGGCTC CGGAAGTGCT CGATGAAACC ATCCAAGTGG ATTGCTTTGA TTCTTATAAG 1200
AGGGTCGATA TTTGGGCCTT TGGCCTTGTT CTGTGGGAAG TGGCCAGGCG AATGGTGAGC 1260
AATGGTATAG TGGAAGATTA CAAGCCACCA TTCTATGATG TGGTTCCCAA TGACCCAAGT 1320
TTTGAAGATA TGAGGAAAGT TGTCTGTGTG GATCAACAGA GGCCAAACAT ACCTAACAGA 1380
TGGTTCTCAG ACCCGACATT AACTTCTCTG GCGAAGCTGA TGAAAGAGTG CTGGTATCAG 1440
AACCCATCCG CAAGACTCAC AGCTCTACGT ATCAAAAAGA CTTTGACCAA AATCGATAAT 1500
TCCCTAGACA AATTAAAAAC TGACTGTTGA 1530
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         ++lle++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tv+lrhenil+fia
Q: 208   ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA  267
         789*********************************************************
S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120
         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+
Q: 268   SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  327
         ************************************************************
S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180
         g  K aiaHRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE
Q: 328   G--KSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  385
         *..*********************************************************
S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240
         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m
Q: 386   VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  444
         **********************************9.************************
S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l
Q: 445   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  495
         *************************************************97
Domain Sequence
(FASTA)
ITLLECVGKG RYGEVWRGSW QGENVAVKIF SSRDEKSWFR ETELYNTVML RHENILGFIA 60
SDMTSRHSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120
GKSAIAHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180
DETIQVDCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240
VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNPSARLT ALRIKKTL 288
KeywordATP-binding; Complete proteome; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00259
EKS-ANC-00266
EKS-BOT-00277
EKS-CAJ-00284
EKS-CAF-00283
EKS-CAP-00312
EKS-CIS-00045
EKS-DAR-00618
EKS-DRM-00143
EKS-EQC-00269
EKS-FEC-00264
EKS-GAM-00173
EKS-GAG-00231
EKS-GAA-00339
EKS-GOG-00276
EKS-HOS-00284
EKS-LAC-00291
EKS-LOA-00287
EKS-MAM-00279
EKS-MEG-00221
EKS-MIM-00019
EKS-MOD-00275
EKS-MUP-00272
EKS-MYL-00280
EKS-NOL-00254
EKS-ORN-00357
EKS-ORA-00242
EKS-ORC-00261
EKS-ORL-00334
EKS-OTG-00283
EKS-PAT-00261
EKS-PES-00246
EKS-PEM-00150
EKS-POA-00269
EKS-RAN-00294
EKS-SAH-00261
EKS-SUS-00244
EKS-TAG-00290
EKS-TAR-00359
EKS-TEN-00356
EKS-XET-00351
EKS-XIM-00350
Gene Ontology
GO:0048179; C:activin receptor complex
GO:0045177; C:apical part of cell
GO:0005887; C:integral to plasma membrane
GO:0016361; F:activin receptor activity, type I
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0050431; F:transforming growth factor beta binding
GO:0005025; F:transforming growth factor beta receptor activity, type I
GO:0002526; P:acute inflammatory response
GO:0003289; P:atrial septum primum morphogenesis
GO:0030509; P:BMP signaling pathway
GO:0060923; P:cardiac muscle cell fate commitment
GO:0071385; P:cellular response to glucocorticoid stimulus
GO:0007368; P:determination of left/right symmetry
GO:0003143; P:embryonic heart tube morphogenesis
GO:0003197; P:endocardial cushion development
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0001702; P:gastrulation with mouth forming second
GO:0007281; P:germ cell development
GO:0007507; P:heart development
GO:0001701; P:in utero embryonic development
GO:0001707; P:mesoderm formation
GO:0003183; P:mitral valve morphogenesis
GO:0032926; P:negative regulation of activin receptor signaling pathway
GO:0043066; P:negative regulation of apoptotic process
GO:0001755; P:neural crest cell migration
GO:0060389; P:pathway-restricted SMAD protein phosphorylation
GO:0001569; P:patterning of blood vessels
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0060037; P:pharyngeal system development
GO:0030501; P:positive regulation of bone mineralization
GO:2000017; P:positive regulation of determination of dorsal identity
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0048641; P:regulation of skeletal muscle tissue development
GO:0023014; P:signal transduction by phosphorylation
GO:0051145; P:smooth muscle cell differentiation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0001655; P:urogenital system development
KEGG
mmu:11477;
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013