EKS-MUM-00339

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00339

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	520.8	1.7E-156	194	463	270

Status

Reviewed

Ensembl Protein

ENSMUSP00000123020

UniProt Accession

P08923; A2AQ22;

Protein Name

Leukocyte tyrosine kinase receptor

Protein Synonyms/Alias

Gene Name

Ltk

Gene Synonyms/Alias

Ltk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000027297	ENSMUSP00000123020	ENSMUST00000140224
ENSMUSG00000027297	ENSMUSP00000080774	ENSMUST00000082130
ENSMUSG00000027297	ENSMUSP00000028759	ENSMUST00000028759

Organism

Mus musculus

Functional Description

Orphan receptor with a tyrosine-protein kinase activity.The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (By similarity).

Protein Length

576

Protein Sequence
(FASTA)

LETRAAAPGS GGRGGAAGGD TSESDLLWAD GEDGTSFVHP SGELYLQPLA VTEGHGEVEI 60

RKHPNCSHCP FKDCQWQAEL WTAECTCPEG TELAVDNVTC MDLPTTASPL ILMGAVVAAL 120

ALSLLMMCAV LILVNQKCQG LWGTRLPGPE LELSKLRSSA IRTAPNPYYC QVGLSPAQPW 180

PLPPGLTEVS PANVTLLRAL GHGAFGEVYE GLVTGLPGDS SPLPVAIKTL PELCSHQDEL 240

DFLMEALIIS KFSHQNIVRC VGLSFRSAPR LILLELMSGG DMKSFLRHSR PHPGQLAPLT 300

MQDLLQLAQD IAQGCHYLEE NHFIHRDIAA RNCLLSCSGA SRVAKIGDFG MARDIYQASY 360

YRKGGRTLLP VKWMPPEALL EGLFTSKTDS WSFGVLLWEI FSLGYMPYPG HTNQEVLDFI 420

ATGNRMDPPR NCPGPVYRIM TQCWQHQPEL RPDFGSILER IQYCTQDPDV LNSPLPVEPG 480

PILEEEEASR LGNRSLEGLR SPKPLELSSQ NLKSWGGGLL GSWLPSGLKT LKPRCLQPQN 540

IWNPTYGSWT PRGPQGEDTG IEHCNGSSSS SIPGIQ 576

Nucleotide Sequence
(FASTA)

CTGGAGACCC GCGCGGCGGC GCCGGGCAGC GGCGGGAGAG GAGGCGCGGC AGGCGGTGAT 60

ACTTCTGAGT CTGACCTCCT CTGGGCTGAT GGGGAAGATG GCACATCCTT TGTCCACCCC 120

AGTGGTGAGC TCTACCTACA GCCTCTGGCA GTCACAGAGG GCCATGGGGA GGTGGAGATC 180

CGAAAGCATC CCAACTGCAG TCACTGCCCT TTCAAAGACT GCCAGTGGCA GGCAGAGCTC 240

TGGACGGCCG AATGCACGTG CCCAGAGGGC ACGGAGCTAG CTGTGGATAA TGTCACTTGC 300

ATGGACCTGC CAACCACCGC AAGCCCTCTG ATCCTGATGG GAGCTGTAGT GGCAGCCTTG 360

GCACTGAGTC TCCTAATGAT GTGTGCAGTC CTGATTCTAG TGAACCAGAA GTGTCAGGGC 420

CTGTGGGGGA CCAGGCTGCC AGGCCCTGAG CTTGAGCTAA GCAAGCTTCG ATCCTCTGCC 480

ATCAGGACAG CACCCAACCC TTACTATTGT CAGGTGGGAC TCAGTCCTGC CCAGCCCTGG 540

CCTTTGCCCC CAGGGCTCAC TGAGGTTTCA CCAGCCAATG TCACTCTACT CAGAGCCCTT 600

GGCCATGGTG CCTTTGGGGA AGTGTACGAG GGACTAGTGA CTGGTCTTCC TGGGGACTCC 660

AGTCCTCTTC CAGTGGCTAT TAAGACTCTG CCAGAGCTCT GCTCCCATCA GGATGAGCTG 720

GATTTTCTCA TGGAGGCTCT GATCATCAGC AAGTTCAGCC ATCAGAACAT TGTACGCTGT 780

GTGGGGCTCA GCTTTCGGTC TGCCCCGCGC CTCATTCTGC TGGAGCTGAT GTCTGGTGGG 840

GACATGAAGA GCTTTTTGAG GCACAGCAGA CCACACCCAG GACAACTGGC ACCTCTGACC 900

ATGCAGGACC TATTGCAGCT GGCCCAGGAT ATAGCCCAGG GCTGCCACTA CCTGGAGGAA 960

AATCACTTCA TTCACAGAGA CATTGCTGCC CGTAACTGTC TGCTTAGCTG CAGTGGAGCC 1020

AGCCGAGTGG CCAAGATTGG AGATTTTGGA ATGGCAAGAG ATATCTACCA GGCCAGTTAT 1080

TATCGCAAGG GTGGCCGGAC CTTGCTCCCA GTCAAGTGGA TGCCGCCAGA AGCTCTCCTG 1140

GAGGGCCTTT TCACATCCAA GACAGACTCC TGGTCTTTTG GGGTCCTGCT CTGGGAGATC 1200

TTCTCACTGG GGTATATGCC CTACCCTGGA CATACCAACC AGGAGGTTCT AGACTTCATT 1260

GCCACAGGGA ACAGGATGGA CCCTCCTAGG AACTGTCCTG GGCCAGTGTA CCGAATCATG 1320

ACCCAGTGTT GGCAGCATCA GCCGGAGCTC CGCCCTGACT TTGGCAGCAT CTTGGAACGG 1380

ATTCAGTACT GCACTCAGGA CCCTGATGTG CTGAACTCAC CCCTGCCCGT GGAACCTGGG 1440

CCCATTCTAG AGGAGGAAGA GGCCTCCAGG CTGGGAAACA GGTCACTGGA GGGTCTTAGA 1500

TCCCCAAAGC CCCTAGAGCT GAGTTCTCAG AACTTGAAGA GCTGGGGAGG AGGCCTTCTT 1560

GGCTCTTGGC TGCCCTCTGG CCTCAAGACC CTCAAACCCA GGTGCCTCCA ACCTCAGAAC 1620

ATTTGGAACC CCACCTATGG CTCCTGGACC CCAAGGGGCC CCCAGGGTGA AGATACAGGC 1680

ATTGAACACT GCAATGGCTC CTCCTCAAGT TCCATTCCAG GCATCCAGTA G 1731

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         ++l+ralG+GafGevyeglv+glpgd+s+l va+ktlpe +s+qdeldfl+ealiiskf+

Q: 194   VTLLRALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKFS  253

         689*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr++G+s++++prlillel++GGd+ksflr+srp+p ql++l+m+dll++a+d+a+

Q: 254   HQNIVRCVGLSFRSAPRLILLELMSGGDMKSFLRHSRPHPGQLAPLTMQDLLQLAQDIAQ  313

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+lls++G+srvaki+dfGmardiy+a+yyrkggr+llpvkw

Q: 314   GCHYLEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARDIYQASYYRKGGRTLLPVKW  373

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppea+leG+ftsktd+wsfGvllwe+fslG++pypg++nqevl+++++G+r+d+p+++p

Q: 374   MPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCP  433

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h+pe rp+f siler+q+

Q: 434   GPVYRIMTQCWQHQPELRPDFGSILERIQY  463

         ****************************97

Domain Sequence
(FASTA)

VTLLRALGHG AFGEVYEGLV TGLPGDSSPL PVAIKTLPEL CSHQDELDFL MEALIISKFS 60

HQNIVRCVGL SFRSAPRLIL LELMSGGDMK SFLRHSRPHP GQLAPLTMQD LLQLAQDIAQ 120

GCHYLEENHF IHRDIAARNC LLSCSGASRV AKIGDFGMAR DIYQASYYRK GGRTLLPVKW 180

MPPEALLEGL FTSKTDSWSF GVLLWEIFSL GYMPYPGHTN QEVLDFIATG NRMDPPRNCP 240

GPVYRIMTQC WQHQPELRPD FGSILERIQY 270

Keyword

Alternative promoter usage; Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Endoplasmic reticulum; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>

Gene Ontology

GO:0005783	; C:endoplasmic reticulum
GO:0016021	; C:integral to membrane
GO:0016020	; C:membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915	; P:apoptotic process
GO:0008283	; P:cell proliferation
GO:0071300	; P:cellular response to retinoic acid
GO:0014065	; P:phosphatidylinositol 3-kinase cascade
GO:0010976	; P:positive regulation of neuron projection development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

mmu:17005

;

InterPros

IPR011009	; Kinase-like_dom.
IPR026984	; LTK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013