EKS-MUM-00432

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00432

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	549.2	3.7E-165	504	769	266

Status

Reviewed

Ensembl Protein

ENSMUSP00000106410

UniProt Accession

P55144; O09070; O09080; P70285; Q60752; Q62482; Q62483; Q62484; Q6NZM6; Q78E85; Q78E87;

Protein Name

Tyrosine-protein kinase receptor TYRO3

Protein Synonyms/Alias

Etk2/tyro3; TK19-2; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE;

Gene Name

Tyro3

Gene Synonyms/Alias

Tyro3; Dtk, Rse;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000027298	ENSMUSP00000106410	ENSMUST00000110783
ENSMUSG00000027298	ENSMUSP00000028763	ENSMUST00000028763

Organism

Mus musculus

Functional Description

Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to several ligands including TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Protein Length

876

Protein Sequence
(FASTA)

MDDKLENTLG RWAGENGLSI GEYLAIKGLK LMGAPVKMTV SQGQPVKLNC SVEGMEDPDI 60

HWMKDGTVVQ NASQVSISIS EHSWIGLLSL KSVERSDAGL YWCQVKDGEE TKISQSVWLT 120

VEGVPFFTVE PKDLAVPPNA PFQLSCEAVG PPEPVTIYWW RGLTKVGGPA PSPSVLNVTG 180

VTQRTEFSCE ARNIKGLATS RPAIVRLQAP PAAPFNTTVT TISSYNASVA WVPGADGLAL 240

LHSCTVQVAH APGEWEALAV VVPVPPFTCL LRNLAPATNY SLRVRCANAL GPSPYGDWVP 300

FQTKGLAPAR APQNFHAIRT DSGLILEWEE VIPEDPGEGP LGPYKLSWVQ ENGTQDELMV 360

EGTRANLTDW DPQKDLILRV CASNAIGDGP WSQPLVVSSH DHAGRQGPPH SRTSWVPVVL 420

GVLTALITAA ALALILLRKR RKETRFGQAF DSVMARGEPA VHFRAARSFN RERPERIEAT 480

LDSLGISDEL KEKLEDVLIP EQQFTLGRML GKGEFGSVRE AQLKQEDGSF VKVAVKMLKA 540

DIIASSDIEE FLREAACMKE FDHPHVAKLV GVSLRSRAKG RLPIPMVILP FMKHGDLHAF 600

LLASRIGENP FNLPLQTLVR FMVDIACGME YLSSRNFIHR DLAARNCMLA EDMTVCVADF 660

GLSRKIYSGD YYRQGCASKL PVKWLALESL ADNLYTVHSD VWAFGVTMWE IMTRGQTPYA 720

GIENAEIYNY LIGGNRLKQP PECMEEVYDL MYQCWSADPK QRPSFTCLRM ELENILGHLS 780

VLSTSQDPLY INIERAEQPT ESGSPEVHCG ERSSSEAGDG SGVGAVGGIP SDSRYIFSPG 840

GLSESPGQLE QQPESPLNEN QRLLLLQQGL LPHSSC 876

Nucleotide Sequence
(FASTA)

ATGGACGACA AACTGGAAAA CACTCTGGGA AGATGGGCTG GGGAGAATGG TCTTTCGATA 60

GGAGAATACT TGGCGATTAA AGGCCTGAAG CTCATGGGCG CCCCAGTGAA GATGACCGTG 120

TCTCAGGGGC AGCCAGTGAA GCTCAACTGC AGCGTGGAGG GGATGGAGGA CCCTGACATC 180

CACTGGATGA AGGATGGCAC CGTGGTCCAG AATGCAAGCC AGGTGTCCAT CTCCATCAGC 240

GAGCACAGCT GGATTGGCTT ACTCAGCCTA AAGTCAGTGG AACGGTCTGA TGCTGGCCTG 300

TACTGGTGCC AGGTGAAGGA TGGGGAGGAA ACCAAGATTT CTCAGTCAGT ATGGCTCACT 360

GTCGAAGGTG TGCCATTCTT CACAGTGGAA CCAAAAGATC TGGCGGTGCC ACCCAATGCC 420

CCTTTTCAGC TGTCTTGTGA GGCTGTGGGT CCTCCAGAAC CCGTAACCAT TTACTGGTGG 480

AGAGGACTCA CTAAGGTTGG GGGACCTGCT CCCTCTCCCT CTGTTTTAAA TGTGACAGGA 540

GTGACCCAGC GCACAGAGTT TTCTTGTGAA GCCCGCAACA TAAAAGGCCT GGCCACTTCC 600

CGACCAGCCA TTGTTCGCCT TCAAGCACCG CCTGCAGCTC CTTTCAACAC CACAGTAACA 660

ACGATCTCCA GCTACAACGC TAGCGTGGCC TGGGTGCCAG GTGCTGACGG CCTAGCTCTG 720

CTGCATTCCT GTACTGTACA GGTGGCACAC GCCCCAGGAG AATGGGAGGC CCTTGCTGTT 780

GTGGTTCCTG TGCCACCTTT TACCTGCCTG CTTCGGAACT TGGCCCCTGC CACCAACTAC 840

AGCCTTAGGG TGCGCTGTGC CAATGCCTTG GGCCCTTCTC CCTACGGCGA CTGGGTGCCC 900

TTTCAGACAA AGGGCCTAGC GCCAGCCAGA GCTCCTCAGA ATTTCCATGC CATTCGTACC 960

GACTCAGGCC TTATCCTGGA ATGGGAAGAA GTGATTCCTG AGGACCCTGG GGAAGGCCCC 1020

CTAGGACCTT ATAAGCTGTC CTGGGTCCAA GAAAATGGAA CCCAGGATGA GCTGATGGTG 1080

GAAGGGACCA GGGCCAATCT GACCGACTGG GATCCCCAGA AGGACCTGAT TTTGCGTGTG 1140

TGTGCCTCCA ATGCAATTGG TGATGGGCCC TGGAGTCAGC CACTGGTGGT GTCTTCTCAT 1200

GACCATGCAG GGAGGCAGGG CCCTCCCCAC AGCCGCACAT CCTGGGTGCC TGTGGTCCTG 1260

GGCGTGCTCA CCGCCCTGAT CACAGCTGCT GCCTTGGCCC TCATCCTGCT TCGGAAGAGA 1320

CGCAAGGAGA CGCGTTTCGG GCAAGCCTTT GACAGTGTCA TGGCCCGAGG GGAGCCAGCT 1380

GTACACTTCC GGGCAGCCCG ATCTTTCAAT CGAGAAAGGC CTGAACGCAT TGAGGCCACA 1440

TTGGATAGCC TGGGCATCAG CGATGAATTG AAGGAAAAGC TGGAGGATGT CCTCATTCCA 1500

GAGCAGCAGT TCACCCTCGG TCGGATGTTG GGCAAAGGAG AGTTTGGATC AGTGCGGGAA 1560

GCCCAGCTAA AGCAGGAAGA TGGCTCCTTC GTGAAAGTGG CAGTGAAGAT GCTGAAAGCT 1620

GACATCATTG CCTCAAGCGA CATAGAAGAG TTCCTCCGGG AAGCAGCTTG CATGAAGGAG 1680

TTTGACCATC CACACGTGGC CAAGCTTGTT GGGGTGAGCC TCCGGAGCAG GGCTAAAGGT 1740

CGTCTCCCCA TTCCCATGGT CATCCTGCCC TTCATGAAAC ATGGAGACTT GCACGCCTTT 1800

CTGCTCGCCT CCCGAATCGG GGAGAACCCT TTTAACCTGC CCCTCCAGAC CCTGGTCCGG 1860

TTCATGGTGG ACATTGCCTG TGGCATGGAG TACCTGAGCT CCCGGAACTT CATCCACCGA 1920

GACCTAGCAG CTCGGAATTG CATGCTGGCC GAGGACATGA CAGTGTGTGT GGCTGATTTT 1980

GGACTCTCTC GGAAAATCTA TAGCGGGGAC TATTATCGTC AGGGCTGTGC CTCCAAATTG 2040

CCCGTCAAGT GGCTGGCCCT GGAGAGCTTG GCTGACAACT TGTATACTGT ACACAGTGAT 2100

GTGTGGGCCT TCGGGGTGAC CATGTGGGAG ATCATGACTC GTGGGCAGAC GCCATATGCT 2160

GGCATTGAAA ATGCCGAGAT TTACAACTAC CTCATCGGCG GGAACCGCCT GAAGCAGCCT 2220

CCGGAGTGCA TGGAGGAAGT GTATGATCTC ATGTACCAGT GCTGGAGCGC CGACCCCAAG 2280

CAGCGCCCAA GCTTCACGTG TCTGCGAATG GAACTGGAGA ACATTCTGGG CCACCTGTCT 2340

GTGCTGTCCA CCAGCCAGGA CCCCTTGTAC ATCAACATTG AGAGAGCTGA GCAGCCTACT 2400

GAGAGTGGCA GCCCTGAGGT CCACTGTGGA GAGCGATCCA GCAGCGAGGC AGGGGACGGC 2460

AGTGGCGTGG GGGCAGTAGG TGGCATCCCC AGTGACTCTC GGTACATCTT CAGCCCCGGA 2520

GGGCTATCCG AGTCACCAGG GCAGCTGGAG CAGCAGCCAG AAAGCCCCCT CAATGAGAAC 2580

CAGAGGCTGT TGTTGCTGCA GCAAGGGCTA CTGCCTCACA GTAGCTGTTA A 2631

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         ++lg++lg+gefgsv+e+qlkqedgs++kvavk+lk+diia+s+ieefl+eaacmkefdh

Q: 504   FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDH  563

         68**********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         p+v++lvgvsl+s++kgrlp+p+vilpfmk+gdlhafll+sr+genp++lplqtlv+fmv

Q: 564   PHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMV  623

         ************************************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         dia+gmeylssrnfihrdlaarncmlaedmtvcvadfgls+kiysgdyyrqg+++klpvk

Q: 624   DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK  683

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl++gnrlkqp++c

Q: 684   WLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPEC  743

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvlr  266

         ++e+ydlmy+cw+adpk+rpsf+ lr

Q: 744   MEEVYDLMYQCWSADPKQRPSFTCLR  769

         ***********************998

Domain Sequence
(FASTA)

FTLGRMLGKG EFGSVREAQL KQEDGSFVKV AVKMLKADII ASSDIEEFLR EAACMKEFDH 60

PHVAKLVGVS LRSRAKGRLP IPMVILPFMK HGDLHAFLLA SRIGENPFNL PLQTLVRFMV 120

DIACGMEYLS SRNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 180

WLALESLADN LYTVHSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIG GNRLKQPPEC 240

MEEVYDLMYQ CWSADPKQRP SFTCLR 266

Keyword

3D-structure; Alternative splicing; ATP-binding; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005789	; C:endoplasmic reticulum membrane
GO:0016021	; C:integral to membrane
GO:0005635	; C:nuclear envelope
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0043548	; F:phosphatidylinositol 3-kinase binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0043277	; P:apoptotic cell clearance
GO:0021885	; P:forebrain cell migration
GO:0001779	; P:natural killer cell differentiation
GO:0050728	; P:negative regulation of inflammatory response
GO:0045824	; P:negative regulation of innate immune response
GO:0051250	; P:negative regulation of lymphocyte activation
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:0034122	; P:negative regulation of toll-like receptor signaling pathway
GO:0070050	; P:neuron homeostasis
GO:0042698	; P:ovulation cycle
GO:0070527	; P:platelet aggregation
GO:0046777	; P:protein autophosphorylation
GO:0043491	; P:protein kinase B signaling cascade
GO:0032940	; P:secretion by cell
GO:0007283	; P:spermatogenesis
GO:0034446	; P:substrate adhesion-dependent cell spreading
GO:0060068	; P:vagina development

KEGG

mmu:22174

;

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 1.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013