EKS-MUM-00116
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00116
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/MLCK402.02.5E-120303557255
StatusReviewed
Ensembl ProteinENSMUSP00000028970
UniProt AccessionQ8VCR8; A2APB9;
Protein NameMyosin light chain kinase 2, skeletal/cardiac muscle
Protein Synonyms/Alias MLCK2;
Gene NameMylk2
Gene Synonyms/Alias Mylk2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000027470ENSMUSP00000028970ENSMUST00000028970
OrganismMus musculus
Functional DescriptionImplicated in the level of global muscle contraction andcardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain (By similarity).
Protein Length613
Protein Sequence
(FASTA)
MTTENGAVEL GSQSLSTEQT PKAAAGDGPS ASEKEPSAPA TEKDLSPPNA KKDPGAPDPK 60
NNPDPPSLKK DPAKAPGPEK KGDPVPASAS SQGPSGEGDG GGGPAEGSEG PPAALPLPTA 120
TAEASIQKLD PTQAPSGNQG SGEAKAGKKA AECREAGRRG SPAFLHSPSC PAIISCSEKT 180
LAVKPLSETT DLVFTGVSVT PDPQDPGPVK AGGTNALAEK KKEEAEKASG QAGQAKVQGD 240
TPQRIGFQAV PSERVEVGQA LCLTAREEDC FQILDDCPPP PAPFPHRIVE LRTGNVNSEF 300
SMNSKEALGG GKFGAVCTCT ERATGLKLAA KVIKKQTPKD KEMVLLEIEV MNQLNHRNLI 360
QLYAAIETSH EIILFMEYIE GGELFERIVD EDYHLTEVDT MVFVRQICDG ILFMHKMRVL 420
HLDLKPENIL CVNTTGHLVK IIDFGLARRY NPNEKLKVNF GTPEFLSPEV VNYDQISDKT 480
DMWSLGVITY MLLSGLSPFL GDDDTETLNN VLSANWYFDE ETFEAVSDEA KDFVSNLLTK 540
DQSARMSAEQ CLAHPWLNNL AEKAKRCNRR LKSQILLKKY LMKRRWKKNF IAVSAANRFK 600
KISSSGALMA LGV 613
Nucleotide Sequence
(FASTA)
ATGACTACAG AAAACGGAGC AGTTGAGCTG GGAAGCCAGA GCCTGTCAAC AGAACAGACA 60
CCTAAAGCCG CTGCAGGTGA TGGACCTTCA GCTTCAGAAA AAGAACCCAG CGCCCCAGCC 120
ACAGAGAAAG ACCTGAGCCC CCCTAACGCG AAGAAAGACC CGGGCGCGCC AGATCCAAAG 180
AACAATCCAG ATCCACCCTC CCTGAAGAAA GATCCCGCCA AAGCCCCTGG CCCAGAGAAA 240
AAGGGTGACC CGGTCCCAGC TTCAGCCAGC AGCCAGGGCC CTTCAGGAGA GGGAGATGGA 300
GGTGGGGGAC CTGCTGAAGG CAGTGAGGGG CCTCCTGCAG CCTTGCCCCT GCCCACTGCT 360
ACAGCCGAGG CCAGCATCCA GAAGCTGGAC CCCACGCAAG CACCCTCAGG CAACCAGGGA 420
TCCGGAGAAG CCAAGGCAGG CAAGAAGGCA GCAGAATGCC GCGAAGCAGG AAGAAGGGGC 480
TCACCTGCCT TTCTCCACAG CCCTAGCTGC CCGGCTATCA TCTCCTGCTC TGAGAAGACA 540
CTGGCTGTGA AGCCCCTAAG CGAGACAACA GACCTCGTCT TTACAGGGGT GTCTGTGACC 600
CCTGACCCCC AAGATCCTGG TCCAGTCAAA GCAGGAGGGA CAAACGCCCT GGCAGAGAAG 660
AAGAAGGAAG AGGCAGAGAA AGCCTCAGGC CAGGCCGGGC AGGCTAAGGT GCAAGGGGAC 720
ACCCCCCAGA GGATCGGGTT CCAGGCTGTT CCCTCAGAGA GAGTGGAGGT GGGGCAGGCC 780
CTCTGTCTCA CTGCCAGGGA GGAAGACTGC TTCCAAATCC TGGATGATTG TCCACCGCCC 840
CCAGCCCCCT TCCCACACAG GATCGTGGAG CTGAGGACCG GAAATGTCAA CAGTGAATTC 900
AGCATGAACT CAAAGGAGGC ACTGGGAGGT GGCAAATTTG GAGCTGTGTG CACCTGCACG 960
GAGAGAGCCA CAGGCCTCAA GCTGGCAGCC AAGGTCATCA AGAAACAGAC ACCCAAGGAC 1020
AAGGAAATGG TGTTGCTGGA GATCGAGGTC ATGAACCAGC TGAACCATCG CAACCTGATC 1080
CAGCTGTACG CAGCCATTGA GACCTCTCAC GAGATCATCC TGTTCATGGA ATACATCGAG 1140
GGCGGCGAGC TCTTTGAGAG GATTGTGGAT GAAGACTACC ATCTGACGGA GGTGGACACC 1200
ATGGTGTTCG TCAGGCAGAT CTGCGACGGG ATCCTCTTCA TGCACAAGAT GAGGGTCCTG 1260
CATCTGGACC TCAAGCCAGA GAACATCCTG TGTGTGAATA CCACTGGGCA CTTGGTGAAG 1320
ATAATTGACT TTGGCTTGGC GAGGAGGTAT AACCCCAATG AGAAACTGAA GGTGAATTTT 1380
GGGACCCCGG AGTTCCTGTC ACCGGAGGTG GTGAACTACG ACCAAATCTC TGACAAGACA 1440
GACATGTGGA GCCTTGGGGT GATCACCTAC ATGCTACTGA GTGGCCTCTC TCCCTTCCTG 1500
GGAGACGATG ACACGGAGAC CTTAAACAAT GTCCTGTCTG CCAACTGGTA CTTTGATGAG 1560
GAGACCTTTG AAGCTGTGTC AGATGAGGCC AAAGACTTTG TCTCCAATCT TCTCACGAAG 1620
GACCAGAGTG CCAGAATGAG TGCTGAGCAG TGCCTCGCCC ACCCCTGGCT CAACAACCTG 1680
GCAGAAAAAG CCAAACGCTG CAACCGTCGC CTCAAGTCCC AGATCCTGCT TAAGAAATAC 1740
CTCATGAAGA GGCGTTGGAA GAAAAACTTC ATTGCTGTCA GCGCAGCCAA TCGCTTCAAG 1800
AAGATCAGTA GCTCGGGGGC ACTGATGGCT CTGGGGGTCT GA 1842
Domain Profile
S: 2     sikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliql  61
         + ke+lg Gkfg+v++++e++tg klaak++k +++kdke+v  Eie++nql+H++liql
Q: 303   NSKEALGGGKFGAVCTCTERATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQL  362
         67899*******************************************************
S: 62    ydafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivHl  121
         y+a+e+++ei+l++E++eggelferiv+edy+ltE ++++fvrq+++++ ++Hk++++Hl
Q: 363   YAAIETSHEIILFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHL  422
         ************************************************************
S: 122   dlkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslatDm  181
         dlkpenil+++++++ +K+idFGlar+++++eklkv+fgtpef++PEvvn++++s +tDm
Q: 423   DLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDM  482
         ************************************************************
S: 182   WsvGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvkek  241
         Ws+Gvity+LlsGlsPFlgd+d+etl+nv sa++ fdee+f++vs+eakdF+s+ll+k++
Q: 483   WSLGVITYMLLSGLSPFLGDDDTETLNNVLSANWYFDEETFEAVSDEAKDFVSNLLTKDQ  542
         ************************************************************
S: 242   kkRmsaeeaLkhkwl  256
         ++Rmsae++L+h+wl
Q: 543   SARMSAEQCLAHPWL  557
         **************8
Domain Sequence
(FASTA)
NSKEALGGGK FGAVCTCTER ATGLKLAAKV IKKQTPKDKE MVLLEIEVMN QLNHRNLIQL 60
YAAIETSHEI ILFMEYIEGG ELFERIVDED YHLTEVDTMV FVRQICDGIL FMHKMRVLHL 120
DLKPENILCV NTTGHLVKII DFGLARRYNP NEKLKVNFGT PEFLSPEVVN YDQISDKTDM 180
WSLGVITYML LSGLSPFLGD DDTETLNNVL SANWYFDEET FEAVSDEAKD FVSNLLTKDQ 240
SARMSAEQCL AHPWL 255
KeywordATP-binding; Calmodulin-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00105
EKS-BOT-00115
EKS-CAJ-00117
EKS-CAF-00118
EKS-CAP-00112
EKS-DAR-00368
EKS-EQC-00111
EKS-FEC-00107
EKS-GAG-00095
EKS-GOG-00114
EKS-HOS-00117
EKS-ICT-00109
EKS-LOA-00111
EKS-MAM-00113
EKS-MIM-00051
EKS-MOD-00113
EKS-MUP-00117
EKS-NOL-00106
EKS-ORC-00108
EKS-OTG-00118
EKS-RAN-00113
EKS-SAH-00107
EKS-SUS-00101
Gene Ontology
GO:0043025; C:neuronal cell body
GO:0005634; C:nucleus
GO:0014069; C:postsynaptic density
GO:0008021; C:synaptic vesicle
GO:0043195; C:terminal button
GO:0005524; F:ATP binding
GO:0004687; F:myosin light chain kinase activity
GO:0055007; P:cardiac muscle cell differentiation
GO:0055008; P:cardiac muscle tissue morphogenesis
GO:0007274; P:neuromuscular synaptic transmission
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0051272; P:positive regulation of cellular component movement
GO:0031448; P:positive regulation of fast-twitch skeletal muscle fiber contraction
GO:0010628; P:positive regulation of gene expression
GO:0046777; P:protein autophosphorylation
GO:0051726; P:regulation of cell cycle
GO:0043408; P:regulation of MAPK cascade
GO:0032971; P:regulation of muscle filament sliding
GO:0048168; P:regulation of neuronal synaptic plasticity
GO:0014816; P:satellite cell differentiation
GO:0035914; P:skeletal muscle cell differentiation
GO:0006941; P:striated muscle contraction
GO:0048489; P:synaptic vesicle transport
GO:0006833; P:water transport
KEGG
mmu:228785;
InterPros
IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013