| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00462 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Other/Aur | 466.8 | 3.3E-140 | 124 | 374 | 251 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000104767 |
| UniProt Accession | P97477; O35624; Q8C3H8; Q91YU4; |
| Protein Name | Aurora kinase A |
| Protein Synonyms/Alias | Aurora 2; Aurora family kinase 1; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; Ipl1- and aurora-related kinase 1; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase Ayk1; Serine/threonine-protein kinase aurora-A; |
| Gene Name | Aurka |
| Gene Synonyms/Alias | Aurka; Aik, Airk, Ark1, Aura, Ayk1, Btak, Iak1, Stk15, Stk6; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Mitotic serine/threonine kinases that contributes to theregulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizating p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. |
| Protein Length | 395 |
Protein Sequence
(FASTA) | | MDRCKENCVS RPVKTTVPFG PKRVLVTEQI PSQNLGSASS GQAQRVLCPS NSQRVPSQAQ 60 | | KLGAGQKPAP KQLPAASVPR PVSRLNNPQK NEQPAASGND SEKEQASLQK TEDTKKRQWT 120 | | LEDFDIGRPL GKGKFGNVYL ARERQSKFIL ALKVLFKTQL EKANVEHQLR REVEIQSHLR 180 | | HPNILRLYGY FHDATRVYLI LEYAPLGTVY RELQKLSKFD EQRTATYITE LANALSYCHS 240 | | KRVIHRDIKP ENLLLGSNGE LKIADFGWSV HAPSSRRTTM CGTLDYLPPE MIEGRMHDEK 300 | | VDLWSLGVLC YEFLVGMPPF EAHTYQETYR RISRVEFTFP DFVTEGARDL ISRLLKHNAS 360 | | QRLTLAEVLE HPWIKANSSK PPTGHTSKEP TSKSS 395 |
|
Nucleotide Sequence
(FASTA) | | ATGGACAGAT GTAAAGAAAA CTGTGTCTCC AGGCCTGTTA AGACCACTGT TCCCTTCGGT 60 | | CCGAAACGCG TCTTGGTGAC TGAGCAGATT CCGTCTCAGA ACCTAGGATC TGCTAGCAGT 120 | | GGCCAGGCCC AGCGGGTCCT GTGTCCTTCT AACTCCCAGC GTGTCCCTTC ACAAGCCCAG 180 | | AAACTTGGAG CAGGTCAGAA GCCGGCACCA AAGCAGTTGC CAGCTGCCAG TGTTCCTAGG 240 | | CCTGTGTCCC GGCTCAATAA CCCCCAGAAG AATGAGCAGC CTGCAGCCTC CGGAAATGAT 300 | | TCTGAAAAGG AGCAGGCATC CTTGCAGAAG ACCGAAGACA CAAAAAAAAG GCAGTGGACT 360 | | TTGGAAGATT TTGACATTGG CCGCCCACTA GGAAAAGGGA AGTTTGGAAA TGTCTACTTG 420 | | GCGCGGGAGA GACAAAGCAA GTTCATCCTG GCTCTGAAGG TGCTGTTTAA AACACAGCTG 480 | | GAGAAGGCGA ACGTGGAGCA CCAGCTTCGG AGAGAGGTGG AGATCCAGTC GCACCTGCGG 540 | | CACCCCAACA TCCTCAGGCT GTATGGCTAT TTCCATGACG CCACCCGAGT TTATCTGATT 600 | | CTAGAATATG CGCCCCTTGG AACAGTCTAT AGAGAGCTCC AAAAACTCTC CAAGTTTGAC 660 | | GAGCAGAGAA CAGCTACTTA CATCACTGAG TTGGCAAACG CTCTGTCTTA CTGTCATTCA 720 | | AAGAGAGTGA TCCACAGAGA CATTAAGCCA GAGAACTTAC TGCTTGGCTC AAACGGAGAG 780 | | TTGAAGATTG CAGACTTCGG GTGGTCGGTG CATGCTCCAT CTTCCAGGAG AACCACAATG 840 | | TGTGGCACCC TGGACTACCT GCCCCCAGAG ATGATTGAAG GCCGGATGCA TGACGAGAAG 900 | | GTGGACCTCT GGAGCCTCGG CGTTCTCTGC TATGAGTTCC TAGTGGGGAT GCCTCCTTTC 960 | | GAGGCACACA CGTACCAGGA GACTTACAGA AGGATATCTC GGGTTGAATT CACTTTCCCT 1020 | | GACTTTGTGA CAGAGGGAGC CAGGGACCTC ATTTCAAGAC TGTTAAAACA CAACGCAAGC 1080 | | CAAAGGCTAA CACTAGCGGA AGTCCTTGAG CACCCTTGGA TCAAAGCTAA TTCTTCCAAA 1140 | | CCTCCAACTG GCCACACTAG CAAAGAGCCA ACCAGCAAAT CATCTTAG 1188 |
|
| Domain Profile | S: 1 feiGrklGkGkfGnvylarekkskfivalkvlfkeqlekegvekqlrreieiqshlkhpn 60 | f+iGr+lGkGkfGnvylare++skfi+alkvlfk+qlek++ve+qlrre+eiqshl+hpn | Q: 124 FDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRHPN 183 | 9*********************************************************** |
| S: 61 ilrlygyfhdekrvylileyaprGelykelqkskkldeqraakyieeladalsylhkkkv 120 | ilrlygyfhd++rvylileyap G++y+elqk +k+deqr+a+yi+ela+alsy+h+k+v | Q: 184 ILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRV 243 | ************************************************************ |
| S: 121 ihrdikpenlllgskgelkladfGwsvhapsskrktlcGtldylppemvegreydekvdl 180 | ihrdikpenlllgs+gelk+adfGwsvhapss+r+t+cGtldylppem+egr++dekvdl | Q: 244 IHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTMCGTLDYLPPEMIEGRMHDEKVDL 303 | ************************************************************ |
| S: 181 walGvlcyellvGkppfeseskdetykrikkvdlklpssvskgakdliskllkkepkerl 240 | w+lGvlcye+lvG+ppfe+++++ety+ri++v++++p++v++ga+dlis+llk+++++rl | Q: 304 WSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNASQRL 363 | ************************************************************ |
| S: 241 tladvlahpwi 251 | tla+vl+hpwi | Q: 364 TLAEVLEHPWI 374 | **********8 |
|
Domain Sequence
(FASTA) | | FDIGRPLGKG KFGNVYLARE RQSKFILALK VLFKTQLEKA NVEHQLRREV EIQSHLRHPN 60 | | ILRLYGYFHD ATRVYLILEY APLGTVYREL QKLSKFDEQR TATYITELAN ALSYCHSKRV 120 | | IHRDIKPENL LLGSNGELKI ADFGWSVHAP SSRRTTMCGT LDYLPPEMIE GRMHDEKVDL 180 | | WSLGVLCYEF LVGMPPFEAH TYQETYRRIS RVEFTFPDFV TEGARDLISR LLKHNASQRL 240 | | TLAEVLEHPW I 251 |
|
| Keyword | 3D-structure; Alternative splicing; ATP-binding; Cell cycle; Cell division; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Microtubule; Mitosis; Nucleotide-binding; Phosphoprotein; Proto-oncogene; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
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| Prints | |
| Created Date | 20-Feb-2013 |