EKS-MUM-00406

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00406

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	391.4	4.0E-117	247	495	249

Status

Reviewed

Ensembl Protein

ENSMUSP00000016498

UniProt Accession

Q62270; Q62360; Q923M5;

Protein Name

Tyrosine-protein kinase Srms

Protein Synonyms/Alias

PTK70;

Gene Name

Srms

Gene Synonyms/Alias

Srms; Srm;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000027579	ENSMUSP00000016498	ENSMUST00000016498

Organism

Mus musculus

Functional Description

May be involved in proliferation or differentiation ofkeratinocytes in the skin.

Protein Length

507

Protein Sequence
(FASTA)

MRFRPQPGPL GMEPFLRKRL TFLSFFWDKI WPADESEEDI PRIQGHDDNP VPEQAAAVEP 60

CSFPAPRARL FRALYDFTAR CAEELSVSRG DRLYALKEEG DYIFAQRLSG PPSTGLVPVT 120

YLAKATPEPP SDQPWYFSGI SRAQAQQLLL SPANAPGAFL IRPSESSIGG YSLSVRAQAK 180

VCHYRICMAP SGSLYLQEGQ LFPSLDALLA YYKTNWKLIQ NPLLQPCIPQ IPLVQDEWER 240

PRSEFVLRRK LGEGFFGEVW EGLWLGSIPV AVKVIKSADM KLADLTKEIE ALKSLRHERL 300

IRLHAICSLG EPVYIVTELM GKGNLQVYLG SSEGKALSLP HLLGFACQVA EGMSYLEERR 360

VVHRDLAARN VLVGDDLTCK VADFGLARLL KDDVYSPSSG SKIPVKWTAP EAANYRVFSQ 420

KSDVWSFGIL LYEVFTYGQC PYEGMTNHET LQQISRGYRL PRPAVCPAEV YVLMVECWKG 480

SPEERPTFAI LREKLNAINR RLHLGLT 507

Nucleotide Sequence
(FASTA)

ATGCGCTTTC GTCCGCAACC AGGCCCCCTA GGCATGGAGC CCTTCCTCAG GAAGCGGCTC 60

ACTTTCTTGT CCTTTTTCTG GGATAAGATA TGGCCAGCGG ATGAATCGGA GGAAGACATC 120

CCCAGGATCC AGGGACACGA CGACAACCCA GTGCCGGAGC AAGCCGCTGC CGTTGAACCT 180

TGTAGCTTCC CAGCCCCACG CGCCCGACTC TTCCGCGCGC TCTACGACTT CACTGCTCGA 240

TGTGCAGAGG AACTGAGCGT CAGCCGTGGG GACAGACTCT ACGCCCTCAA GGAGGAGGGG 300

GACTACATCT TTGCCCAAAG GCTCTCTGGT CCACCCAGCA CCGGACTAGT TCCTGTCACC 360

TACCTTGCCA AGGCTACCCC GGAGCCGCCC TCAGACCAAC CTTGGTACTT CAGTGGGATC 420

AGCAGGGCTC AGGCCCAGCA GTTGCTCTTG TCTCCTGCCA ATGCACCAGG GGCCTTCCTC 480

ATCCGGCCCA GCGAAAGCAG CATCGGGGGC TATTCTCTAT CAGTCAGGGC CCAGGCCAAA 540

GTCTGCCACT ACCGCATCTG CATGGCACCC AGTGGCAGCC TCTATCTGCA GGAGGGCCAA 600

CTCTTCCCCA GCCTGGATGC ACTGCTGGCT TACTACAAGA CCAACTGGAA GCTGATCCAG 660

AACCCTCTGC TGCAGCCCTG CATACCCCAG ATACCCTTGG TTCAGGACGA GTGGGAACGA 720

CCACGTTCAG AATTTGTCCT TCGGAGAAAG CTGGGTGAAG GTTTCTTCGG GGAGGTGTGG 780

GAAGGCCTGT GGCTGGGCTC TATCCCTGTG GCAGTGAAGG TTATCAAATC AGCTGACATG 840

AAGCTGGCAG ACCTCACCAA GGAGATTGAG GCACTGAAGA GCTTGAGGCA TGAGAGGCTG 900

ATCCGGCTGC ACGCTATATG TTCCCTCGGT GAACCTGTGT ACATCGTTAC TGAACTCATG 960

GGCAAGGGCA ACTTGCAAGT CTACCTGGGC AGCTCTGAGG GAAAGGCCCT GAGCCTGCCC 1020

CATCTACTGG GATTTGCCTG CCAGGTAGCT GAGGGCATGA GCTACCTGGA GGAGCGGCGT 1080

GTCGTCCACC GGGACTTGGC TGCCAGGAAC GTGCTGGTGG GTGATGACCT CACCTGCAAG 1140

GTAGCTGATT TTGGCCTGGC CAGACTGCTC AAGGATGATG TCTACTCCCC AAGCAGTGGC 1200

TCCAAGATCC CTGTCAAGTG GACGGCACCT GAGGCTGCTA ATTACCGTGT CTTTTCCCAA 1260

AAGTCAGATG TCTGGTCCTT TGGCATCCTG CTGTATGAGG TCTTCACTTA TGGCCAGTGT 1320

CCCTATGAAG GAATGACCAA CCATGAGACG CTACAGCAGA TTAGTCGTGG ATACCGGCTG 1380

CCACGCCCAG CTGTCTGCCC AGCAGAGGTC TATGTGCTCA TGGTAGAGTG CTGGAAGGGC 1440

AGCCCTGAGG AGCGTCCCAC CTTTGCCATA CTGAGGGAGA AGCTGAATGC CATAAACAGA 1500

CGCCTCCATC TGGGCCTCAC GTGA 1524

Domain Profile

S: 3     lvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklyav  62

         l +klGeG fGevw+g+w gs++vavk++k+++++ +++++e+++lk+lrhe+l++l+a+

Q: 247   LRRKLGEGFFGEVWEGLWLGSIPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHAI  306

         789*********************************************************

S: 63    vseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrdl  122

         +s +eP+yivtelm kG+l+ +l ++egk+l+lp+l+ +a+qvaeGm+ylee++++hrdl

Q: 307   CSLGEPVYIVTELMGKGNLQVYLGSSEGKALSLPHLLGFACQVAEGMSYLEERRVVHRDL  366

         ************************************************************

S: 123   aarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvWs  182

         aarnvlvg++l++kvadfGlarl++dd y++++g+k+P+kWtaPea+++++f++ksdvWs

Q: 367   AARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWS  426

         ************************************************************

S: 183   fGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeerP  242

         fGill+e++t+G++Py+Gmtn+e+l+q++rgyrlprp+ cp+e+y l++ecwk +peerP

Q: 427   FGILLYEVFTYGQCPYEGMTNHETLQQISRGYRLPRPAVCPAEVYVLMVECWKGSPEERP  486

         ************************************************************

S: 243   tfetlqevl  251

         tf +l+e+l

Q: 487   TFAILREKL  495

         *****9876

Domain Sequence
(FASTA)

LRRKLGEGFF GEVWEGLWLG SIPVAVKVIK SADMKLADLT KEIEALKSLR HERLIRLHAI 60

CSLGEPVYIV TELMGKGNLQ VYLGSSEGKA LSLPHLLGFA CQVAEGMSYL EERRVVHRDL 120

AARNVLVGDD LTCKVADFGL ARLLKDDVYS PSSGSKIPVK WTAPEAANYR VFSQKSDVWS 180

FGILLYEVFT YGQCPYEGMT NHETLQQISR GYRLPRPAVC PAEVYVLMVE CWKGSPEERP 240

TFAILREKL 249

Keyword

Acetylation; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013