EKS-MUM-00340
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00340
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20365.05.4E-10925289265
StatusReviewed
Ensembl ProteinENSMUSP00000125411
UniProt AccessionP83510;
Protein NameTraf2 and NCK-interacting protein kinase
Protein Synonyms/Alias
Gene NameTnik
Gene Synonyms/Alias Tnik; Kiaa0551;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000027692ENSMUSP00000125466ENSMUST00000159308
ENSMUSG00000027692ENSMUSP00000124876ENSMUST00000159680
ENSMUSG00000027692ENSMUSP00000124681ENSMUST00000159236
ENSMUSG00000027692ENSMUSP00000125081ENSMUST00000160307
ENSMUSG00000027692ENSMUSP00000125411ENSMUST00000161964
ENSMUSG00000027692ENSMUSP00000123859ENSMUST00000160934
ENSMUSG00000027692ENSMUSP00000124387ENSMUST00000162485
ENSMUSG00000027692ENSMUSP00000124011ENSMUST00000160518
ENSMUSG00000027692ENSMUSP00000124726ENSMUST00000162777
OrganismMus musculus
Functional DescriptionSerine/threonine kinase that acts as an essentialactivator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading (By similarity).
Protein Length1268
Protein Sequence
(FASTA)
MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 60
DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 120
KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180
TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 240
ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 300
QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 360
NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 420
REQRRHYEEQ MRREEERRRA EHEQEYKRKQ LEEQRQAERL QRQLKQERDY LVSLQHQRQE 480
QRPLEKKPLY HYKEGMSPSE KPAWAKEIPQ LVAVKSQGPA LTASQSVHEQ PTKGLSGFQE 540
ALNVTSHRVE MPRQNSDPTS ENPPLPTRIE KFDRSSWLRQ EEDIPPKVPQ RTTSISPALA 600
RKNSPGNGSA LGPRLGSQPI RASNPDLRRT EPVLESSLQR TSSGSSSSSS TPSSQPSSQG 660
GSQPGSQAGS SERSRVRANS KSEGSPVLPH EPSKVKPEES RDITRPSRPA DLTALAKELR 720
ELRIEETNRP LKKVTDYSSS SEESESSEEE EEDGESETHD GTVAVSDIPR LIPTGAPGNN 780
EQYNMGMVGT HGLETSHADT FGGSISREGT LMIRETAEEK KRSGHSDSNG FAGHINLPDL 840
VQQSHSPAGT PTEGLGRVST HSQEMDSGAE YGIGSSTKAS FTPFVDPRVY QTSPTDEDEE 900
DDESSAAALF TSELLRQEQA KLNEARKISV VNVNPTNIRP HSDTPEIRKY KKRFNSEILC 960
AALWGVNLLV GTENGLMLLD RSGQGKVYNL INRRRFQQMD VLEGLNVLVT ISGKKNKLRV 1020
YYLSWLRNRI LHNDPEVEKK QGWITVGDLE GCIHYKVVKY ERIKFLVIAL KNAVEIYAWA 1080
PKPYHKFMAF KSFADLQHKP LLVDLTVEEG QRLKVIFGSH TGFHVIDVDS GNSYDIYIPS 1140
HIQGNITPHA IVILPKTDGM EMLVCYEDEG VYVNTYGRIT KDVVLQWGEM PTSVAYIHSN 1200
QIMGWGEKAI EIRSVETGHL DGVFMHKRAQ RLKFLCERND KVFFASVRSG GSSQVFFMTL 1260
NRNSMMNW 1268
Nucleotide Sequence
(FASTA)
ATGGCGAGCG ACTCCCCAGC TCGCAGCCTG GATGAAATCG ATCTCTCCGC CCTGAGGGAC 60
CCTGCAGGGA TCTTTGAGTT GGTGGAACTT GTCGGAAATG GCACGTATGG TCAAGTTTAT 120
AAGGGTCGTC ATGTCAAAAC GGGCCAGCTT GCTGCCATTA AGGTTATGGA TGTCACAGGG 180
GATGAAGAGG AAGAAATCAA ACAAGAAATT AACATGTTGA AGAAATATTC TCATCACAGG 240
AACATTGCTA CATACTACGG TGCTTTTATC AAAAAGAACC CTCCTGGCAT GGATGACCAA 300
CTCTGGTTGG TTATGGAGTT CTGTGGTGCT GGCTCTGTCA CTGACCTGAT CAAGAACACG 360
AAAGGCAACA CATTGAAAGA GGAGTGGATT GCATACATCT GCAGGGAGAT CTTACGGGGC 420
CTGAGTCACC TGCACCAGCA CAAAGTGATT CATCGAGATA TCAAAGGGCA GAACGTCTTG 480
TTGACTGAAA ATGCAGAGGT TAAGCTAGTG GATTTTGGAG TGAGTGCCCA GCTTGACCGA 540
ACTGTGGGCA GGAGGAACAC GTTCATCGGG ACTCCCTACT GGATGGCACC AGAAGTCATT 600
GCCTGTGATG AGAACCCGGA TGCCACATAT GATTTCAAGA GTGACTTGTG GTCTTTGGGA 660
ATCACCGCCA TTGAGATGGC AGAAGGTGCC CCCCCCCTCT GTGACATGCA TCCCATGAGA 720
GCCCTCTTCC TCATCCCACG GAACCCTGCA CCTCGGCTCA AGTCTAAGAA GTGGTCAAAA 780
AAATTCCAGT CATTTATCGA GAGCTGCTTG GTAAAGAATC ACAGCCAGCG GCCAGCCACG 840
GAGCAGTTGA TGAAGCACCC ATTCATACGA GACCAACCTA ATGAGAGGCA GGTCCGCATC 900
CAGCTGAAGG ACCACATTGA TCGAACAAAG AAGAAGCGAG GAGAAAAAGA TGAGACTGAG 960
TATGAATACA GCGGAAGTGA GGAAGAAGAG GAAGAGAATG ACTCTGGGGA ACCCAGCTCC 1020
ATTCTGAACC TACCAGGGGA GTCAACACTG CGAAGGGACT TCCTGAGACT GCAGCTGGCC 1080
AACAAGGAGC GCTCAGAGGC CCTGCGGCGC CAACAGCTGG AGCAGCAGCA GCGGGAGAAT 1140
GAAGAACACA AGCGGCAGCT ACTGGCTGAG CGCCAGAAGC GCATCGAAGA GCAGAAGGAG 1200
CAAAGGCGGA GGCTGGAGGA GCAACAAAGG CGAGAAAAAG AGCTTCGGAA ACAGCAGGAG 1260
CGGGAACAGC GCCGGCACTA CGAAGAACAG ATGCGTCGGG AGGAGGAGAG GAGGCGTGCC 1320
GAACATGAGC AGGAATATAA GCGCAAACAA TTGGAAGAAC AGAGACAAGC AGAAAGACTG 1380
CAGAGGCAGC TAAAGCAAGA GCGGGACTAT CTGGTTTCCC TCCAGCATCA GCGGCAGGAG 1440
CAGAGGCCCC TGGAGAAGAA GCCACTGTAC CATTACAAGG AGGGCATGAG TCCTAGTGAG 1500
AAGCCGGCCT GGGCCAAGGA GATCCCGCAG CTGGTAGCTG TCAAATCCCA GGGACCTGCC 1560
TTGACGGCCT CCCAGTCAGT ACATGAGCAA CCCACAAAGG GCCTGTCTGG GTTCCAGGAG 1620
GCTCTGAATG TGACCTCTCA CCGGGTCGAG ATGCCACGCC AGAACTCGGA TCCCACCTCA 1680
GAAAACCCTC CTCTCCCCAC GAGAATTGAG AAGTTTGACA GAAGCTCTTG GTTACGACAG 1740
GAAGAAGACA TTCCACCAAA GGTGCCTCAA AGAACAACTT CTATATCCCC AGCACTAGCC 1800
AGAAAGAATT CCCCTGGCAA TGGCAGTGCT CTGGGCCCCA GACTTGGATC TCAGCCCATC 1860
AGAGCAAGCA ACCCTGATCT GCGCAGGACA GAGCCAGTCC TGGAGAGTTC CCTGCAGCGG 1920
ACAAGCAGTG GCAGTTCCTC CAGCTCCAGC ACTCCCAGCT CCCAGCCCAG CTCCCAAGGA 1980
GGCTCTCAAC CTGGCTCCCA AGCAGGATCT AGTGAGCGGT CCAGAGTGCG GGCCAACAGT 2040
AAGTCCGAAG GATCACCCGT GCTCCCCCAT GAGCCTTCCA AGGTGAAACC AGAAGAATCC 2100
AGAGACATCA CACGGCCCAG TCGGCCAGCT GATCTGACGG CATTAGCCAA AGAATTACGA 2160
GAACTCCGCA TTGAAGAAAC AAACCGCCCC CTGAAGAAAG TGACTGATTA CTCTTCCTCC 2220
AGCGAGGAGT CGGAGAGCAG TGAGGAAGAA GAGGAAGATG GAGAGAGTGA GACACATGAC 2280
GGGACGGTGG CTGTCAGTGA CATACCCAGA CTAATACCCA CCGGAGCTCC AGGGAACAAT 2340
GAGCAGTACA ACATGGGGAT GGTCGGGACA CATGGGCTGG AAACTTCGCA TGCGGACACC 2400
TTTGGCGGCA GCATTTCAAG AGAAGGAACC TTGATGATCA GAGAGACGGC TGAAGAGAAG 2460
AAGCGATCTG GCCACAGTGA CAGTAATGGA TTCGCCGGTC ACATCAATCT CCCAGACCTT 2520
GTACAGCAGA GCCATTCGCC AGCTGGAACT CCCACTGAGG GGCTGGGCCG CGTCTCCACT 2580
CATTCCCAGG AGATGGACTC TGGGGCTGAA TATGGTATAG GGAGCAGCAC CAAAGCCTCT 2640
TTCACCCCCT TCGTGGACCC TCGAGTGTAC CAGACATCGC CCACTGATGA AGATGAAGAG 2700
GATGATGAGT CTTCAGCTGC TGCCCTGTTT ACTAGCGAAC TTCTTAGGCA AGAACAGGCC 2760
AAACTCAATG AAGCGAGGAA GATTTCAGTG GTAAATGTGA ACCCAACAAA CATTCGCCCT 2820
CATAGTGACA CACCGGAAAT CAGAAAATAC AAGAAACGCT TCAATTCAGA AATACTTTGT 2880
GCAGCTCTAT GGGGTGTGAA CCTTCTGGTG GGGACTGAAA ATGGCCTGAT GCTTTTGGAC 2940
AGAAGTGGCC AAGGCAAAGT CTACAACCTA ATCAACCGGA GGCGGTTTCA GCAGATGGAT 3000
GTGCTAGAAG GACTAAATGT TCTTGTCACG ATATCAGGAA AGAAGAACAA GCTCCGTGTG 3060
TACTATCTCT CATGGTTAAG AAACAGAATC CTGCACAATG ACCCAGAAGT GGAAAAGAAG 3120
CAGGGCTGGA TCACTGTCGG TGACTTGGAA GGCTGCATCC ATTACAAAGT CGTTAAATAT 3180
GAAAGAATCA AGTTCCTGGT GATTGCCTTA AAGAATGCAG TAGAGATATA TGCGTGGGCC 3240
CCTAAACCTT ACCATAAGTT CATGGCATTT AAGTCTTTTG CAGATCTTCA GCATAAGCCT 3300
CTGCTCGTTG ACCTCACAGT AGAAGAAGGT CAAAGGTTAA AGGTCATATT TGGCTCACAC 3360
ACTGGTTTCC ATGTAATTGA TGTTGATTCT GGAAACTCCT ACGATATCTA TATACCATCC 3420
CATATTCAGG GCAATATCAC TCCTCATGCT ATCGTCATCT TGCCTAAAAC AGATGGAATG 3480
GAGATGCTTG TCTGCTATGA GGATGAAGGG GTGTACGTGA ACACCTACGG CCGGATCACT 3540
AAGGATGTGG TGCTCCAATG GGGAGAAATG CCCACATCTG TGGCCTACAT TCATTCCAAT 3600
CAGATAATGG GCTGGGGCGA GAAAGCTATT GAGATCCGGT CAGTGGAAAC AGGACATTTG 3660
GATGGAGTGT TTATGCATAA ACGAGCTCAA AGGTTAAAGT TTCTATGTGA AAGAAATGAT 3720
AAGGTATTTT TTGCATCCGT GCGATCTGGA GGAAGTAGCC AAGTGTTTTT CATGACCCTC 3780
AACAGAAATT CCATGATGAA CTGGTAA 3807
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59
         +el+e +g+G++g+vy++r++ktg+l+aik+++++  +++ee+++ei++lkk++h +ni 
Q: 25    FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG-DEEEEIKQEINMLKKYSHhRNIA  83
         899********************************8.999*************998****
S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113
         +y+++f+k      +++lwlvme++ +Gs++dl+k+++ ++lkEe+iayi+re+l++L++
Q: 84    TYYGAFIKknppgmDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSH  143
         ************************************************************
S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173
         lH++kviHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++
Q: 144   LHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  203
         ************************************************************
S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230
            + +Yd k+D+wslGItaie+aeg+pP++d++p++al++i++n++p+lksk k+sk+f
Q: 204   enpDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSK-KWSKKF  262
         999999********************************************888.******
S: 231   kefvekclqknpekRpsasellkhkFl  257
         ++f+e+cl kn ++Rp++++l+kh+F+
Q: 263   QSFIESCLVKNHSQRPATEQLMKHPFI  289
         **************************7
Domain Sequence
(FASTA)
FELVELVGNG TYGQVYKGRH VKTGQLAAIK VMDVTGDEEE EIKQEINMLK KYSHHRNIAT 60
YYGAFIKKNP PGMDDQLWLV MEFCGAGSVT DLIKNTKGNT LKEEWIAYIC REILRGLSHL 120
HQHKVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180
NPDATYDFKS DLWSLGITAI EMAEGAPPLC DMHPMRALFL IPRNPAPRLK SKKWSKKFQS 240
FIESCLVKNH SQRPATEQLM KHPFI 265
KeywordAlternative splicing; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Endosome; Kinase; Neurogenesis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00288
EKS-ANC-00307
EKS-BOT-00325
EKS-CAJ-00314
EKS-CAF-00329
EKS-CAP-00343
EKS-EQC-00300
EKS-FEC-00295
EKS-GAG-00270
EKS-GAA-00382
EKS-GOG-00305
EKS-HOS-00315
EKS-ICT-00307
EKS-LAC-00328
EKS-LOA-00329
EKS-MAM-00312
EKS-MOD-00303
EKS-MUP-00305
EKS-MYL-00320
EKS-NOL-00284
EKS-ORN-00400
EKS-ORA-00286
EKS-ORC-00291
EKS-ORL-00382
EKS-OTG-00324
EKS-PAT-00292
EKS-PES-00274
EKS-PEM-00170
EKS-POA-00300
EKS-RAN-00324
EKS-SUS-00290
EKS-TAG-00323
EKS-TAR-00403
EKS-TEN-00419
EKS-XET-00385
EKS-XIM-00416
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0005634; C:nucleus
GO:0048471; C:perinuclear region of cytoplasm
GO:0055037; C:recycling endosome
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0007256; P:activation of JNKK activity
GO:0046777; P:protein autophosphorylation
GO:0048814; P:regulation of dendrite morphogenesis
GO:0016055; P:Wnt receptor signaling pathway
KEGG
mmu:665113;
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013