EPS-MUM-00023

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUM-00023

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	229.2	1.7E-67	93	349	257

Status

Reviewed

Ensembl Protein

ENSMUSP00000029355

UniProt Accession

Q8BHN0; Q3UGL2; Q810H0; Q8C021; Q8C1D5; Q9Z0T1;

Protein Name

Protein phosphatase 1L

Protein Synonyms/Alias

Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon; PP2C-epsilon;

Gene Name

Ppm1l

Gene Synonyms/Alias

Ppm1l; Kiaa4175;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000027784	ENSMUSP00000120467	ENSMUST00000134037
ENSMUSG00000027784	ENSMUSP00000029355	ENSMUST00000029355

Organism

Mus musculus

Functional Description

Acts as a suppressor of the SAPK signaling pathways byassociating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.

Protein Length

360

Protein Sequence
(FASTA)

MIEDTMTLLS LLGRIMRYFL LRPETLFLLC ISLALWSYFF HTDEVKTIVK SSRDAVKMVK 60

GKVAEIMQND RLGGLDVLEA EFSKTWEFKS HNVAVYSIQG RRDHMEDRFE VLTDLANKTH 120

PSIFGIFDGH GGETAAEYVK SRLPEALKQH LQDYEKDKEN SVLTYQTILE QQILSIDREM 180

LEKLTVSYDE AGTTCLIALL SDKDLTVANV GDSRGVLCDK DGNAIPLSHD HKPYQLKERK 240

RIKRAGGFIS FNGSWRVQGI LAMSRSLGDY PLKNLNVVIP DPDILTFDLD KLQPEFMILA 300

SDGLWDAFSN EEAVRFIKER LDEPHFGAKS IVLQSFYRGC PDNITVMVVK FRNSSKTEEH 360

Nucleotide Sequence
(FASTA)

ATGATAGAGG ATACAATGAC TTTGCTGTCT CTGCTGGGTC GCATCATGCG CTACTTCTTA 60

CTGAGACCCG AGACGCTTTT CCTGCTGTGC ATCAGCTTGG CTCTCTGGAG TTACTTCTTC 120

CACACGGACG AAGTGAAGAC CATCGTTAAG TCTAGCCGGG ACGCGGTGAA GATGGTGAAG 180

GGCAAGGTGG CCGAGATTAT GCAGAACGAT CGTCTTGGAG GACTTGATGT GCTGGAGGCC 240

GAGTTTTCCA AGACCTGGGA ATTCAAGAGC CATAATGTGG CGGTGTACTC CATCCAGGGC 300

CGGAGAGACC ACATGGAAGA TCGCTTCGAA GTTCTCACCG ATCTAGCCAA CAAGACGCAC 360

CCGTCCATCT TCGGAATCTT TGATGGGCAC GGCGGCGAGA CTGCAGCGGA ATATGTAAAA 420

TCTCGACTCC CAGAGGCTCT TAAGCAGCAC CTTCAGGATT ATGAGAAGGA CAAAGAAAAC 480

AGTGTTCTGA CCTACCAGAC CATCCTCGAG CAGCAGATCT TGTCAATTGA CCGGGAAATG 540

CTGGAAAAGT TGACAGTCTC CTATGATGAA GCAGGCACAA CGTGTTTGAT CGCTCTACTC 600

TCAGATAAAG ACCTCACCGT GGCCAACGTT GGTGACTCTC GGGGAGTCTT GTGTGACAAA 660

GATGGCAATG CCATCCCCTT GTCTCACGAT CACAAGCCTT ACCAGCTGAA GGAAAGGAAG 720

AGGATAAAGA GAGCTGGTGG GTTCATCAGC TTTAATGGCT CCTGGAGGGT CCAGGGAATC 780

CTAGCCATGT CTCGATCCCT GGGAGACTAT CCACTGAAAA ATCTCAACGT GGTCATCCCA 840

GACCCAGACA TCTTGACCTT TGACCTGGAC AAGCTGCAGC CGGAGTTCAT GATCTTGGCC 900

TCAGATGGCC TGTGGGATGC TTTCAGCAAT GAAGAAGCGG TTCGATTCAT CAAGGAGCGC 960

TTGGATGAGC CCCACTTTGG GGCCAAAAGC ATCGTCCTGC AGTCCTTTTA CAGAGGCTGC 1020

CCTGACAACA TCACTGTCAT GGTGGTGAAG TTCAGGAATA GTAGCAAAAC AGAAGAGCAC 1080

TGA 1083

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         v v+s++grr++med++++ +++++++      ++fg++DGhgg+++a++++++l e+l+

Q: 93    VAVYSIQGRRDHMEDRFEVLTDLANKTHP----SIFGIFDGHGGETAAEYVKSRLPEALK  148

         6789***************9999998665....69*************************

S: 63    eele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskly  118

         + l+    ++e++    +++l++  ls+d+e+  le+ + + d+ G+t+++al++d++l+

Q: 149   QHLQdyekDKENSVLTYQTILEQQILSIDREM--LEKLTVSYDEAGTTCLIALLSDKDLT  206

         ****654433344444459*************..999999********************

S: 119   vanvGdSravLcr.ngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsR  176

         vanvGdSr vLc+ +g+a++ls dHkp + +E++Ri++agg +  + g  Rv+G La+sR

Q: 207   VANVGDSRGVLCDkDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN-GSwRVQGILAMSR  265

         *************566************************999977.667**********

S: 177   alGdlylk..pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekke  233

         +lGd+ lk   +v+p+P++  ++l++ +  f+iLasDGlwd +sneeav++++++l+

Q: 266   SLGDYPLKnlNVVIPDPDILTFDLDKLQPeFMILASDGLWDAFSNEEAVRFIKERLD---  322

         ********8889************765544***************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

         ++   ak++v ++  rg+ dn++++vv

Q: 323   EPHFGAKSIVLQSFYRGCPDNITVMVV  349

         999********************9997

Domain Sequence
(FASTA)

VAVYSIQGRR DHMEDRFEVL TDLANKTHPS IFGIFDGHGG ETAAEYVKSR LPEALKQHLQ 60

DYEKDKENSV LTYQTILEQQ ILSIDREMLE KLTVSYDEAG TTCLIALLSD KDLTVANVGD 120

SRGVLCDKDG NAIPLSHDHK PYQLKERKRI KRAGGFISFN GSWRVQGILA MSRSLGDYPL 180

KNLNVVIPDP DILTFDLDKL QPEFMILASD GLWDAFSNEE AVRFIKERLD EPHFGAKSIV 240

LQSFYRGCPD NITVMVV 257

Keyword

Alternative splicing; Complete proteome; Hydrolase; Magnesium; Manganese; Membrane; Metal-binding; Protein phosphatase; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000165	; P:MAPK cascade
GO:0006470	; P:protein dephosphorylation
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

mmu:242083

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013