| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00370 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/DCAMKL | 456.4 | 6.9E-137 | 83 | 340 | 258 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000070292 |
| UniProt Accession | Q9JLM8; Q6P207; |
| Protein Name | Serine/threonine-protein kinase DCLK1 |
| Protein Synonyms/Alias | Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1; |
| Gene Name | Dclk1 |
| Gene Synonyms/Alias | Dclk1; Dcamkl1, Dclk; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity). |
| Protein Length | 422 |
Protein Sequence
(FASTA) | | MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRIS QHGGSSTSLS STKVCSSMDE 60 | | NDGPGEEESE EGFQIPATIT ERYKVGRTIG DGNFAVVKEC IERSTAREYA LKIIKKSKCR 120 | | GKEHMIQNEV SILRRVKHPN IVLLIEEMDV PTELYLVMEL VKGGDLFDAI TSTSKYTERD 180 | | ASGMLYNLAS AIKYLHSLNI VHRDIKPENL LVYEHQDGSK SLKLGDFGLA TIVDGPLYTV 240 | | CGTPTYVAPE IIAETGYGLK VDIWAAGVIT YILLCGFPPF RGSGDDQEVL FDQILMGQVD 300 | | FPSPYWDNVS DSAKELINMM LLVNVDQRFS AVQVLEHPWV NDDGLPENEH QLSVAGKIKK 360 | | HFNTGPKPSS TAAGVSVIAL DHGFTIKRSG SLDYYQQPGM YWIRPPLLIR RGRFSDEDAT 420 | | RM 422 |
|
Nucleotide Sequence
(FASTA) | | ATGTTAGAGC TCATAGAAGT TAATGGAACC CCTGGTAGTC AGCTCTCTAC TCCACGCTCG 60 | | GGCAAGTCAC CAAGTCCATC ACCCACCAGC CCAGGAAGCC TGCGGAAGCA GAGGATCTCT 120 | | CAGCATGGCG GCTCCTCGAC TTCACTTTCA TCCACTAAAG TTTGCAGCTC AATGGATGAG 180 | | AATGATGGCC CTGGGGAAGA AGAGTCTGAG GAAGGCTTCC AGATTCCTGC CACAATAACA 240 | | GAGAGATACA AAGTCGGGAG AACAATAGGA GACGGAAATT TTGCTGTTGT CAAGGAATGT 300 | | ATAGAGAGGT CGACTGCTCG GGAGTATGCC CTGAAAATCA TCAAGAAAAG CAAATGCCGA 360 | | GGCAAAGAGC ACATGATCCA GAACGAGGTC TCCATCCTAC GGAGGGTGAA GCACCCCAAC 420 | | ATTGTCCTCC TGATTGAAGA GATGGATGTG CCGACTGAAC TGTATCTTGT AATGGAATTA 480 | | GTGAAGGGTG GAGACCTTTT CGATGCCATC ACCTCCACTA GCAAATACAC AGAGAGAGAT 540 | | GCCAGCGGGA TGCTGTACAA CCTGGCCAGC GCCATCAAAT ACCTGCACAG CCTGAACATC 600 | | GTCCACCGTG ACATCAAGCC AGAGAATCTG CTGGTGTATG AGCACCAGGA TGGCAGTAAG 660 | | TCACTCAAGT TGGGTGACTT TGGCCTGGCC ACAATTGTCG ACGGCCCCCT GTACACAGTC 720 | | TGTGGCACCC CAACATATGT GGCTCCAGAA ATCATTGCAG AGACTGGATA TGGCCTCAAG 780 | | GTGGACATCT GGGCAGCTGG CGTGATCACT TATATCCTGC TGTGTGGCTT CCCTCCGTTC 840 | | CGTGGAAGTG GGGATGACCA GGAGGTGCTT TTTGACCAGA TCTTGATGGG CCAAGTGGAC 900 | | TTTCCATCTC CGTATTGGGA CAATGTGTCA GATTCTGCTA AGGAGCTCAT CAACATGATG 960 | | CTGTTGGTTA ACGTGGACCA GAGATTTTCA GCCGTGCAGG TCCTTGAGCA TCCCTGGGTT 1020 | | AATGATGATG GTCTCCCAGA AAATGAGCAT CAGCTGTCAG TAGCTGGCAA AATCAAGAAG 1080 | | CATTTCAACA CAGGCCCCAA GCCGAGCAGC ACTGCAGCAG GAGTTTCTGT AATAGCACTG 1140 | | GACCACGGGT TTACCATCAA GAGATCAGGG TCTTTGGACT ACTACCAACA ACCAGGAATG 1200 | | TATTGGATAA GACCACCGCT CTTGATAAGG AGAGGCAGGT TTTCCGACGA AGACGCAACC 1260 | | AGGATGTGA 1269 |
|
| Domain Profile | S: 1 yeigrviGdGnfavvkevreretgkeyalkiidksklkGkehlidneveilkkvkhpniv 60 | y++gr+iGdGnfavvke++er+t++eyalkii+ksk++Gkeh+i+nev+il++vkhpniv | Q: 83 YKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIV 142 | 99********************************************************** |
| S: 61 klieeletetelylvlelvkgGdlfdaitkstkleerdaaimilelakalkylhelnivh 120 | liee+++ telylv+elvkgGdlfdait+++k++erda+ m+++la+a+kylh+lnivh | Q: 143 LLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVH 202 | ************************************************************ |
| S: 121 rdvkpenllvvekedgskslkladfGlaaevegplytvcGtPtyvaPeilaetGyglkvd 180 | rd+kpenllv+e++dgskslkl+dfGla++v+gplytvcGtPtyvaPei+aetGyglkvd | Q: 203 RDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVD 262 | ************************************************************ |
| S: 181 iWaaGvilyillvGfpPfrssdedqeelfdlilsgklefpsPyWdnisdkakdlvsrlle 240 | iWaaGvi+yill+GfpPfr+s++dqe lfd+il+g+++fpsPyWdn+sd+ak+l++++l | Q: 263 IWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLL 322 | ************************************************************ |
| S: 241 vdeekrltaeqilehpwv 258 | v++++r++a q+lehpwv | Q: 323 VNVDQRFSAVQVLEHPWV 340 | *****************8 |
|
Domain Sequence
(FASTA) | | YKVGRTIGDG NFAVVKECIE RSTAREYALK IIKKSKCRGK EHMIQNEVSI LRRVKHPNIV 60 | | LLIEEMDVPT ELYLVMELVK GGDLFDAITS TSKYTERDAS GMLYNLASAI KYLHSLNIVH 120 | | RDIKPENLLV YEHQDGSKSL KLGDFGLATI VDGPLYTVCG TPTYVAPEII AETGYGLKVD 180 | | IWAAGVITYI LLCGFPPFRG SGDDQEVLFD QILMGQVDFP SPYWDNVSDS AKELINMMLL 240 | | VNVDQRFSAV QVLEHPWV 258 |
|
| Keyword | Alternative splicing; ATP-binding; Complete proteome; Developmental protein; Differentiation; Kinase; Neurogenesis; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |