EKS-MUM-00519

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00519

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	439.0	1.0E-131	18	273	256

Status

Reviewed

Ensembl Protein

ENSMUSP00000029664

UniProt Accession

Q8BM85; Q8BWD3; Q8BY53;

Protein Name

TBC domain-containing protein kinase-like protein

Protein Synonyms/Alias

Gene Name

Tbck

Gene Synonyms/Alias

Tbck;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000028030	ENSMUSP00000029664	ENSMUST00000029664
ENSMUSG00000028030	ENSMUSP00000129205	ENSMUST00000169172

Organism

Mus musculus

Functional Description

Protein Length

762

Protein Sequence
(FASTA)

MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 60

RGKHERLVVV AEHCERSLED LLRERKPVSH STVLCIAYEV LEGLHYLNKH GIVHRALSPH 120

NILLDRKGHI KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGIPKTT DHVPSEKPLP 180

SGPKSDVWSL GIILFELCVG RKLFQSLDVS ERVKFLLTLG CVDDTIIVLA EEHGCLDIIK 240

ELPENVINIL KKCLTFHPSK RPTPDELMKD QVFSEVSPLY TPFIKPASLF SSSLRCADLT 300

LPEDISDLCK DIDNDYLAER SIEEVYYLWC LAGGDLEKEL INKEIIRSKP PVCTLPNFLF 360

EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSNNEL 420

SAAATLPLII RERDTEYQLN RIILFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL 480

GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESVNL FCWTPKSATY RQHAQPPKPA 720

SESSVVRSSA PYFSAECTDP PKTDLGNKAS PVWKMHCAAP RA 762

Nucleotide Sequence
(FASTA)

ATGTTTCCTC TGAAGGATGC TGAGATGGGC GCCTTTACCT TCTTTGCCTC TGCTCTCCCA 60

CATGATGTTT GTGGAAGCAA CGGACTTCCT CTCACACCAA ATTCCATCAA AATCTTAGGT 120

CGCTTTCAAA TCCTTAAGAC CATCACCCAC CCCAGACTGT GCCAATATGT GGATATTTCT 180

AGGGGAAAGC ATGAAAGACT GGTGGTGGTG GCGGAGCACT GTGAGCGCAG TTTGGAAGAC 240

CTTCTACGAG AAAGGAAGCC TGTGAGTCAT TCAACAGTTC TGTGCATAGC ATATGAGGTA 300

CTTGAGGGCT TACATTACTT GAACAAGCAT GGCATAGTAC ACCGGGCCTT GTCTCCCCAT 360

AATATCCTGT TGGATCGGAA GGGCCATATT AAACTGGCTA AATTTGGACT TTATCACATG 420

ACAGCCCATG GTGATGATGT TGATTTCCCA ATAGGGTATC CCTCATACCT GGCACCTGAG 480

GTAATTGCAC AAGGAATTCC CAAAACTACT GATCATGTGC CAAGTGAAAA ACCATTGCCT 540

TCTGGCCCCA AATCAGATGT ATGGTCTCTT GGGATAATTT TATTTGAGCT TTGTGTGGGG 600

AGAAAATTGT TTCAGAGCTT GGATGTTTCT GAAAGAGTAA AATTTTTGCT TACTTTGGGC 660

TGTGTAGATG ATACTATAAT AGTTCTCGCT GAGGAGCATG GGTGTCTGGA CATTATCAAG 720

GAGCTTCCTG AAAATGTGAT AAATATTTTG AAGAAGTGCC TCACCTTCCA TCCTTCTAAG 780

AGGCCAACCC CAGATGAGTT AATGAAGGAC CAGGTGTTCA GTGAAGTGTC ACCTTTATAC 840

ACCCCCTTTA TCAAACCTGC CAGTCTGTTT TCATCTTCTC TGAGATGCGC TGATCTAACT 900

CTGCCTGAGG ATATCAGTGA CTTGTGTAAA GATATAGACA ATGATTACCT GGCAGAGAGA 960

TCTATTGAGG AAGTTTACTA CCTTTGGTGT TTGGCTGGAG GGGACCTGGA AAAGGAGCTT 1020

ATAAACAAGG AAATTATTCG CTCCAAGCCA CCTGTCTGCA CACTCCCGAA TTTTCTCTTT 1080

GAAGATGGAG AAAGTTTTGG ACAAGGTCGA GATAGAAGCT CACTCTTAGA TGACACCACA 1140

GTCACGTTGT CTTTGTGCCA GCTAAGAAAC AGATTAAAAG ATGTTGGTGG AGAAGCGTTT 1200

TACCCATTGC TGGAGGATGA CCAGTCAAAT TTGCCACATT CAAACAGCAA TAATGAGTTG 1260

TCTGCAGCTG CTACCCTGCC TTTAATCATC AGAGAGAGGG ATACAGAATA TCAGCTCAAC 1320

AGGATTATTC TCTTTGACAG GCTGTTGAAG GCTTACCCAT ACAAAAAAAA TCAAATCTGG 1380

AAAGAAGCAA GAGTTGACAT CCCTCCACTT ATGAGAGGTT TAACCTGGGC TGCTCTTCTG 1440

GGAGTTGAGG GAGCTATTCA TGCCAAGTAT GACGCCATTG ACAAAGACAC TCCGATTCCT 1500

ACAGATAGAC AAATTGAGGT AGACATCCCT CGCTGTCATC AGTATGACGA GCTGTTGTCA 1560

TCACCAGAAG GCCATGCAAA GTTCCGGCGT GTACTGAAAG CCTGGGTGGT TTCTCATCCT 1620

GATCTTGTGT ACTGGCAAGG TCTTGACTCA CTCTGTGCTC CATTCCTGTA TCTAAATTTC 1680

AACAATGAAG CCTTGGCATA TGCGTGCATG TCTGCTTTTA TTCCCAAATA CCTGTATAAC 1740

TTCTTCTTGA AGGACAACTC TCATGTAATA CAAGAGTACC TGACCGTGTT CTCCCAGATG 1800

ATCGCCTTCC ATGATCCAGA GCTGAGTAAT CACCTCAACG AGATTGGCTT CATTCCCGAT 1860

CTCTACGCCA TCCCTTGGTT TCTCACCATG TTTACTCATG TATTTCCACT GCACAAAATT 1920

TTCCACCTCT GGGATACATT ACTGCTCGGA AATTCCTCTT TCCCATTCTG CATTGGAGTA 1980

GCCATCCTCC AGCAGCTGCG GGACCGTCTT TTGGCCAATG GCTTCAATGA ATGCATCCTT 2040

CTCTTCTCTG ACTTACCAGA AATTGACATT GAACGCTGCG TACGTGAGTC GGTCAATCTG 2100

TTTTGCTGGA CTCCTAAAAG TGCTACATAC AGACAGCATG CTCAGCCTCC AAAGCCAGCC 2160

TCGGAGAGCA GTGTAGTGCG AAGCTCAGCG CCTTACTTCT CTGCTGAGTG TACAGATCCT 2220

CCAAAGACAG ACCTGGGGAA CAAAGCCTCT CCGGTGTGGA AAATGCATTG TGCAGCCCCC 2280

AGAGCATAG 2289

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+disrgkher++vvaeh+e+s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+erkpvs+s+vl+iayevl+gl+ylnkh+ivhral+p++illdrkg+ +kLak+G

Q: 78    LEDLLRERKPVSHSTVLCIAYEVLEGLHYLNKHGIVHRALSPHNILLDRKGH-IKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G+dvdfpigy+sylaPe+i+q+         ++k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAHGDDVDFPIGYPSYLAPEVIAQGipkttdhvpSEKPLPSGPKSDVWSLGIILFE  196

         ************************************************************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld+ser+k+ll+l++vd+t+i+laee++cldiik+l+e+++++lkkCLt+

Q: 197   LCVGRKLFQSLDVSERVKFLLTLGCVDDTIIVLAEEHGCLDIIKELPENVINILKKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +pskRp+pdel+k++vf

Q: 257   HPSKRPTPDELMKDQVF  273

         ***************98

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT ITHPRLCQYV DISRGKHERL VVVAEHCERS 60

LEDLLRERKP VSHSTVLCIA YEVLEGLHYL NKHGIVHRAL SPHNILLDRK GHIKLAKFGL 120

YHMTAHGDDV DFPIGYPSYL APEVIAQGIP KTTDHVPSEK PLPSGPKSDV WSLGIILFEL 180

CVGRKLFQSL DVSERVKFLL TLGCVDDTII VLAEEHGCLD IIKELPENVI NILKKCLTFH 240

PSKRPTPDEL MKDQVF 256

Keyword

Alternative splicing; Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005097	; F:Rab GTPase activator activity
GO:0016772	; F:transferase activity, transferring phosphorus-containing groups
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

mmu:271981

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.

SMARTs

SM00164

; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013