EKS-MUM-00031

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00031

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	349.1	4.6E-104	874	1146	273

Status

Unreviewed

Ensembl Protein

ENSMUSP00000099842

UniProt Accession

B1ASP2;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

Jak1

Gene Synonyms/Alias

Jak1; mCG_21706, RP23-336G7.2-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000028530	ENSMUSP00000122957	ENSMUST00000149297
ENSMUSG00000028530	ENSMUSP00000099842	ENSMUST00000102781

Organism

Mus musculus

Functional Description

Protein Length

1153

Protein Sequence
(FASTA)

MQYLNIKEDC NAMAFCAKMR SFKKTEVKQV VPEPGVEVTF YLLDREPLRL GSGEYTAEEL 60

CIRAAQECSI SPLCHNLFAL YDESTKLWYA PNRIITVDDK TSLRLHYRMR FYFTNWHGTN 120

DNEQSVWRHS PKKQKNGYEK KRVPEATPLL DASSLEYLFA QGQYDLIKCL APIRDPKTEQ 180

DGHDIENECL GMAVLAISHY AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 240

NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENELS 300

RCHSNDSGNV LYEVMVTGNL GIQWRQKPNV VPVEKEKNKL KRKKLEYNKH KKDDERNKLR 360

EEWNNFSYFP EITHIVIKES VVSINKQDNK NMELKLSSRE EALSFVSLVD GYFRLTADAH 420

HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT 480

CFEKSEVLGG QKQFKNFQIE VQKGRYSLHG SMDHFPSLRD LMNHLKKQIL RTDNISFVLK 540

RCCQPKPREI SNLLVATKKA QEWQPVYSMS QLSFDRILKK DIIQGEHLGR GTRTHIYSGT 600

LLDYKDEEGI AEEKKIKVIL KVLDPSHRDI SLAFFEAASM MRQVSHKHIV YLYGVCVRDV 660

ENIMVEEFVE GGPLDLFMHR KSDALTTPWK FKVAKQLASA LSYLEDKDLV HGNVCTKNLL 720

LAREGIDSDI GPFIKLSDPG IPVSVLTRQE CIERIPWIAP ECVEDSKNLS VAADKWSFGT 780

TLWEICYNGE IPLKDKTLIE KERFYESRCR PVTPSCKELA DLMTRCMNYD PNQRPFFRAI 840

MRDINKLEEQ NPDIVSEKQP TTEVDPTHFE KRFLKRIRDL GEGHFGKVEL CRYDPEGDNT 900

GEQVAVKSLK PESGGNHIAD LKKEIEILRN LYHENIVKYK GICMEDGGNG IKLIMEFLPS 960

GSLKEYLPKN KNKINLKQQL KYAIQICKGM DYLGSRQYVH RDLAARNVLV ESEHQVKIGD 1020

FGLTKAIETD KEYYTVKDDR DSPVFWYAPE CLIQCKFYIA SDVWSFGVTL HELLTYCDSD 1080

FSPMALFLKM IGPTHGQMTV TRLVNTLKEG KRLPCPPNCP DEVYQLMRKC WEFQPSNRTT 1140

FQNLIEGFEA LLK 1153

Nucleotide Sequence
(FASTA)

ATGCAGTATC TAAATATAAA AGAGGACTGC AATGCCATGG CGTTCTGTGC TAAAATGAGG 60

AGCTTCAAGA AGACTGAGGT GAAGCAGGTG GTCCCTGAGC CTGGAGTGGA GGTGACTTTC 120

TATCTGTTGG ACAGGGAGCC CCTCCGCCTG GGCAGCGGAG AGTATACAGC CGAGGAGCTG 180

TGCATCAGGG CCGCCCAGGA GTGCAGTATC TCTCCTCTCT GTCACAACCT CTTCGCCCTG 240

TACGATGAGA GCACCAAGCT CTGGTACGCT CCGAACCGAA TCATCACTGT GGATGACAAA 300

ACGTCTCTCC GGCTCCACTA CCGCATGAGG TTCTACTTTA CCAACTGGCA CGGAACCAAT 360

GACAACGAAC AGTCTGTATG GCGACATTCT CCAAAGAAGC AGAAAAACGG CTATGAGAAG 420

AAAAGGGTTC CAGAAGCAAC CCCACTCCTT GATGCCAGTT CACTGGAGTA TCTGTTTGCA 480

CAGGGACAGT ATGATTTGAT CAAATGCCTG GCTCCCATTC GGGACCCCAA GACGGAGCAA 540

GACGGACATG ATATTGAAAA TGAGTGCCTG GGCATGGCGG TCCTGGCCAT CTCCCACTAT 600

GCCATGATGA AGAAGATGCA GTTGCCGGAA CTTCCCAAAG ACATCAGCTA CAAGCGATAT 660

ATTCCAGAAA CATTGAATAA ATCCATCAGA CAGAGGAACC TTCTTACCAG GATGCGAATA 720

AATAATGTTT TCAAGGATTT CTTGAAGGAA TTTAACAACA AGACCATCTG TGACAGCAGT 780

GTGTCTACAC ATGACCTGAA GGTGAAATAC CTGGCTACCT TGGAAACTTT GACAAAACAT 840

TATGGAGCTG AAATATTTGA GACTTCTATG CTACTGATTT CATCAGAAAA TGAATTGAGT 900

CGATGCCATT CGAATGACAG TGGCAATGTT CTCTATGAGG TCATGGTGAC TGGAAATCTC 960

GGGATCCAGT GGCGGCAGAA ACCAAATGTT GTTCCTGTTG AAAAGGAAAA AAATAAACTG 1020

AAGCGGAAAA AACTGGAATA TAATAAACAC AAGAAGGATG ATGAGAGAAA CAAACTCCGG 1080

GAAGAGTGGA ACAATTTTTC CTATTTCCCT GAAATCACCC ACATTGTAAT AAAGGAGTCT 1140

GTGGTCAGCA TTAACAAACA GGACAACAAA AACATGGAAC TCAAGCTCTC TTCTCGAGAG 1200

GAAGCCTTGT CCTTTGTGTC CCTGGTGGAT GGCTACTTCC GGCTCACTGC AGATGCCCAC 1260

CATTACCTCT GTACTGATGT GGCTCCCCCA CTGATTGTCC ACAATATACA GAACGGCTGC 1320

CACGGTCCAA TCTGCACAGA ATATGCCATC AATAAGCTGC GGCAGGAAGG GAGTGAAGAG 1380

GGGATGTACG TGCTGAGGTG GAGCTGCACC GACTTTGACA ACATTCTTAT GACTGTCACC 1440

TGCTTTGAAA AGTCTGAGGT ATTGGGTGGC CAGAAGCAGT TCAAGAACTT TCAGATTGAG 1500

GTACAGAAGG GCCGCTACAG CCTGCATGGC TCTATGGACC ACTTTCCCAG CCTGCGAGAC 1560

CTCATGAACC ACCTCAAGAA GCAGATCCTG CGCACGGACA ACATAAGCTT TGTGCTGAAA 1620

CGATGCTGTC AGCCTAAGCC TCGAGAAATC TCCAATCTGC TCGTAGCCAC TAAGAAAGCC 1680

CAGGAGTGGC AGCCTGTCTA CTCCATGAGC CAGCTGAGCT TTGATCGGAT CCTTAAGAAA 1740

GATATTATAC AAGGTGAGCA CCTTGGCAGA GGCACAAGAA CACATATCTA TTCTGGGACC 1800

CTGCTGGACT ACAAGGATGA GGAAGGAATT GCTGAAGAGA AGAAGATAAA AGTGATCCTC 1860

AAAGTCCTAG ACCCCAGCCA CCGGGACATC TCTCTGGCCT TCTTTGAGGC TGCTAGCATG 1920

ATGAGACAGG TTTCCCACAA ACATATAGTG TACCTCTACG GCGTGTGTGT CCGAGATGTG 1980

GAAAATATCA TGGTGGAAGA GTTTGTGGAG GGGGGGCCGT TGGATCTCTT CATGCACCGG 2040

AAAAGTGATG CGCTTACTAC CCCCTGGAAG TTCAAGGTTG CCAAACAGCT GGCCAGTGCC 2100

CTGAGTTACT TGGAAGATAA AGACCTGGTT CATGGAAATG TGTGCACTAA AAACCTCCTT 2160

CTGGCCCGTG AGGGCATTGA CAGTGACATT GGCCCGTTCA TCAAGCTTAG TGACCCTGGC 2220

ATCCCAGTCT CTGTGCTGAC CAGGCAAGAG TGCATAGAGC GAATCCCCTG GATCGCTCCT 2280

GAGTGTGTTG AAGACTCCAA GAACCTGAGT GTGGCTGCTG ACAAGTGGAG CTTTGGAACC 2340

ACGCTCTGGG AAATCTGCTA CAACGGAGAG ATTCCTCTCA AAGACAAGAC CCTCATTGAG 2400

AAAGAGAGGT TTTATGAAAG CCGCTGCAGG CCTGTGACTC CATCTTGCAA GGAGCTAGCT 2460

GACCTCATGA CTCGCTGCAT GAACTATGAC CCCAACCAGA GACCCTTCTT CCGAGCCATC 2520

ATGAGGGACA TTAACAAGCT GGAGGAGCAG AATCCAGACA TTGTTTCAGA AAAGCAGCCA 2580

ACAACAGAGG TGGACCCCAC TCACTTTGAA AAGCGGTTCC TGAAGAGGAT TCGTGACTTG 2640

GGAGAGGGTC ACTTTGGGAA GGTTGAGCTC TGCAGATATG ATCCTGAGGG AGACAACACA 2700

GGGGAGCAGG TAGCTGTCAA GTCCCTGAAG CCTGAGAGTG GAGGTAACCA CATAGCTGAT 2760

CTGAAGAAGG AGATAGAGAT CTTACGGAAC CTCTACCATG AGAACATTGT GAAGTACAAA 2820

GGAATCTGCA TGGAAGACGG AGGCAATGGT ATCAAGCTCA TCATGGAGTT TCTGCCTTCG 2880

GGAAGCCTAA AGGAGTATCT GCCAAAGAAT AAGAACAAAA TCAACCTCAA ACAGCAGCTA 2940

AAATATGCCA TCCAGATTTG TAAGGGGATG GACTACTTGG GTTCTCGGCA ATACGTTCAC 3000

CGGGACTTAG CAGCAAGAAA TGTCCTTGTT GAGAGTGAGC ATCAAGTGAA GATCGGAGAC 3060

TTTGGTTTAA CCAAAGCAAT TGAAACCGAT AAGGAGTACT ACACAGTCAA GGACGACCGG 3120

GACAGCCCAG TGTTCTGGTA CGCTCCGGAA TGTTTAATCC AGTGTAAATT TTATATCGCC 3180

TCTGATGTCT GGTCTTTTGG AGTGACACTG CACGAGCTGC TCACTTACTG TGACTCAGAT 3240

TTTAGTCCCA TGGCCTTGTT CCTGAAAATG ATAGGCCCAA CTCATGGCCA GATGACAGTG 3300

ACACGGCTTG TGAATACTCT GAAAGAAGGA AAGCGTCTGC CATGTCCACC CAACTGTCCT 3360

GATGAGGTTT ATCAGCTTAT GAGAAAATGC TGGGAATTCC AACCATCTAA CCGGACAACT 3420

TTTCAGAACC TTATTGAAGG ATTTGAAGCA CTTTTAAAAT AA 3462

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h

Q: 874   LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNLYH  933

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c+++g n  +l+me+++sGsL++yL+k+k++++l+++l++a q++k+m+YL

Q: 934   ENIVKYKGICMEDGGNgiKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYL  993

         ************************************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         +++++vhrd+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++rds+++w+

Q: 994   GSRQYVHRDLAARNVLVESEHQ------VKIGDFGLTKAIETDkEYYTVKDDRDSPVFWY  1047

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+++k +++asdvWsFgvtl+ellt c+++ sp    l++++++       r++++

Q: 1048  APECLIQCK-FYIASDVWSFGVTLHELLTyCDSDFSPmalfLKMIGPThgqmtvtRLVNT  1106

         *********.*******************************9****999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         l+e++rlp+p+ cp+e+++lm++c++ +ps+r++F++++e

Q: 1107  LKEGKRLPCPPnCPDEVYQLMRKCWEFQPSNRTTFQNLIE  1146

         *************************************987

Domain Sequence
(FASTA)

LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPES GGNHIADLKK EIEILRNLYH 60

ENIVKYKGIC MEDGGNGIKL IMEFLPSGSL KEYLPKNKNK INLKQQLKYA IQICKGMDYL 120

GSRQYVHRDL AARNVLVESE HQVKIGDFGL TKAIETDKEY YTVKDDRDSP VFWYAPECLI 180

QCKFYIASDV WSFGVTLHEL LTYCDSDFSP MALFLKMIGP THGQMTVTRL VNTLKEGKRL 240

PCPPNCPDEV YQLMRKCWEF QPSNRTTFQN LIE 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway
GO:0007167	; P:enzyme linked receptor protein signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046677	; P:response to antibiotic

KEGG

mmu:16451

;

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013