EKS-MUM-00293

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00293

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	415.2	2.5E-124	63	315	253

Status

Unreviewed

Ensembl Protein

ENSMUSP00000076130

UniProt Accession

Q6P571;

Protein Name

Protein Synonyms/Alias

Polo-like kinase 3 (Drosophila); Polo-like kinase 3 (Drosophila), isoform CRA_c; Serine/threonine-protein kinase PLK3;

Gene Name

Plk3

Gene Synonyms/Alias

Plk3; mCG_14437, RP23-59L24.6-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000028680	ENSMUSP00000076130	ENSMUST00000076859
ENSMUSG00000028680	ENSMUSP00000120476	ENSMUST00000147730

Organism

Mus musculus

Functional Description

Protein Length

648

Protein Sequence
(FASTA)

MEPAAGFLSP RPFPRAAAPS APPAGPGPPA NASPRSEPEV LAGPRAPDPP GRLITDPLSG 60

RTYTKGRLLG KGGFARCYEA TDTESGIAYA VKVIPQSRVA KPHQREKILN EIELHRDLQH 120

RHIVRFSHHF EDADNIYIFL ELCSRKSLAH IWKARHTLLE PEVRYYLRQI LSGLKYLHQR 180

GILHRDLKLG NFFITDNMEL KVGDFGLAAR LEPPEQRKKT ICGTPNYVAP EVLLRQGHGP 240

EADVWSLGCV MYTLLCGSPP FETADLKETY RCIKQVHYTL PASLSLPARQ LLAAILRASP 300

RDRPSIEQIL RHDFFTKGYT PDRLPVSSCV TVPDLTPPNP ARSLFAKVTK SLFGRKKNKN 360

KNHSEDQDNV SCLVSGLMRT SIGHPDVRPE APVVSGQAPA SLVETAAEDS SPRGTLASSG 420

DGFEEGLTVA TVVESALCAL RNCVAFMPPA EQNPAPLAQP EPLVWVSKWV DYSNKFGFGY 480

QLSSRRVAVL FNDGTHMALS ANRKTVHYNP TSTKHFSFSM GSVPRALQPQ LGILRYFASY 540

MEQHLMKGGD LPSVEEAEVP APPLLLQWVK TDQALLMLFS DGTVQVNFYG DHTKLILSGW 600

EPLLVTFVAR NRSACTYLAS HLRQLGCSPD LRQRLRYALR LLRDQSPA 648

Nucleotide Sequence
(FASTA)

ATGGAGCCCG CCGCCGGCTT CTTGTCTCCG CGCCCCTTCC CGCGCGCGGC TGCCCCGTCC 60

GCGCCCCCCG CCGGCCCGGG GCCGCCTGCC AATGCCTCCC CGCGATCGGA ACCTGAGGTG 120

CTGGCCGGGC CACGGGCGCC GGATCCTCCT GGTCGCCTCA TCACCGACCC TCTCAGCGGC 180

CGTACCTACA CCAAGGGTCG CTTGTTGGGC AAGGGGGGCT TCGCACGCTG CTATGAAGCC 240

ACTGACACCG AGTCTGGTAT AGCCTACGCG GTCAAAGTCA TCCCACAGAG TCGCGTCGCC 300

AAGCCGCATC AGCGCGAGAA GATCCTAAAT GAGATAGAGT TGCACCGAGA CCTACAGCAC 360

CGCCATATCG TTCGCTTTTC ACATCATTTC GAGGATGCTG ACAACATATA CATTTTCCTG 420

GAGCTCTGTA GCCGAAAGTC CCTGGCCCAC ATCTGGAAGG CCCGACACAC CCTGTTGGAA 480

CCAGAGGTTC GCTACTACCT GCGCCAGATC CTTTCTGGCC TCAAGTACTT GCACCAGAGG 540

GGTATCTTAC ACAGAGATCT CAAGCTGGGA AATTTTTTCA TCACGGATAA CATGGAACTG 600

AAGGTGGGGG ATTTTGGGCT GGCAGCTCGA TTAGAGCCCC CAGAGCAGAG GAAAAAGACC 660

ATCTGTGGCA CTCCCAACTA CGTGGCTCCA GAAGTGCTGC TGAGACAGGG CCATGGCCCC 720

GAGGCAGATG TGTGGTCGCT TGGTTGTGTC ATGTACACGC TCCTGTGTGG GAGCCCCCCA 780

TTTGAGACTG CTGACCTGAA GGAGACATAC CGCTGCATCA AGCAGGTTCA TTACACGCTA 840

CCTGCCAGCC TCTCCCTGCC TGCCCGGCAG CTCCTGGCTG CCATCCTCCG AGCTTCACCC 900

AGAGACCGCC CTTCCATTGA ACAGATTTTA CGCCATGACT TCTTTACGAA GGGCTACACC 960

CCTGATCGGC TCCCGGTCAG CAGCTGTGTG ACAGTCCCAG ATCTGACACC CCCCAACCCT 1020

GCGAGGAGTC TGTTTGCCAA AGTTACCAAG AGCCTGTTTG GCAGGAAAAA GAACAAGAAT 1080

AAGAACCATT CTGAGGACCA GGATAATGTC TCCTGCTTGG TGAGTGGCCT CATGCGCACA 1140

TCCATCGGTC ATCCAGATGT CAGGCCGGAG GCTCCTGTAG TTTCAGGCCA GGCCCCTGCC 1200

AGCTTGGTAG AGACAGCTGC CGAGGACAGC TCGCCCCGTG GGACACTGGC CAGCAGTGGA 1260

GATGGGTTTG AAGAAGGTTT GACTGTGGCC ACAGTGGTAG AGTCTGCCCT CTGTGCACTG 1320

AGAAACTGTG TGGCCTTCAT GCCCCCAGCC GAACAGAACC CAGCCCCGCT GGCACAGCCA 1380

GAGCCTCTGG TGTGGGTCAG CAAGTGGGTT GACTACTCCA ACAAGTTTGG CTTTGGCTAT 1440

CAGCTGTCCA GCCGCCGTGT AGCCGTGCTC TTCAATGATG GCACACACAT GGCCCTGTCA 1500

GCCAATAGGA AGACGGTGCA CTACAACCCC ACCAGCACGA AGCACTTCTC CTTCTCCATG 1560

GGTTCTGTGC CCCGAGCTCT GCAGCCTCAG CTGGGCATCC TGCGGTATTT TGCGTCCTAC 1620

ATGGAACAGC ACCTCATGAA GGGTGGAGAT CTGCCCAGTG TGGAAGAGGC GGAGGTGCCT 1680

GCCCCACCCT TGCTGCTGCA GTGGGTCAAG ACTGACCAGG CCCTCCTCAT GCTGTTCAGT 1740

GATGGCACTG TCCAGGTGAA CTTCTACGGG GACCACACGA AGCTGATCCT CAGTGGCTGG 1800

GAGCCTCTCC TTGTGACCTT CGTGGCCCGC AATCGCAGTG CTTGTACTTA CCTCGCTTCC 1860

CACCTCCGGC AGCTGGGCTG CTCCCCAGAC TTGCGGCAGC GACTGCGCTA CGCTCTGCGC 1920

CTGCTCAGGG ACCAAAGCCC TGCTTAG 1947

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y++g+llGkGgfa+cye++d+e++ ++avkv+p+s++ak++qrek+ +eie+hr+l+h++

Q: 63    YTKGRLLGKGGFARCYEATDTESGIAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH  122

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv+++++fed++n+y++lelcsr+sla+++k+r++l epevryylrqi+sglkylh++ i

Q: 123   IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI  182

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+++++e+k+gdfGla+rle++e+rkkt+cGtPny+aPevl ++gh+ e+

Q: 183   LHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEA  242

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc++ytll+G+PPfet++lkety++ik+ +y+lP+sls +a++l+a++l+++P++

Q: 243   DVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRD  302

         ************************************************************

S: 241   rpsleevlkdefl  253

         rps+e++l+++f+

Q: 303   RPSIEQILRHDFF  315

         ************8

Domain Sequence
(FASTA)

YTKGRLLGKG GFARCYEATD TESGIAYAVK VIPQSRVAKP HQREKILNEI ELHRDLQHRH 60

IVRFSHHFED ADNIYIFLEL CSRKSLAHIW KARHTLLEPE VRYYLRQILS GLKYLHQRGI 120

LHRDLKLGNF FITDNMELKV GDFGLAARLE PPEQRKKTIC GTPNYVAPEV LLRQGHGPEA 180

DVWSLGCVMY TLLCGSPPFE TADLKETYRC IKQVHYTLPA SLSLPARQLL AAILRASPRD 240

RPSIEQILRH DFF 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0030425	; C:dendrite
GO:0005795	; C:Golgi stack
GO:0043025	; C:neuronal cell body
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0090166	; P:Golgi disassembly
GO:0043066	; P:negative regulation of apoptotic process
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:2000777	; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
GO:0006974	; P:response to DNA damage stimulus
GO:0006970	; P:response to osmotic stress
GO:0009314	; P:response to radiation
GO:0000302	; P:response to reactive oxygen species
GO:0000084	; P:S phase of mitotic cell cycle

KEGG

mmu:12795

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR020658	; Ser/Thr_kinase_Plk3.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013