Tag | Content |
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EKPD ID | EKS-MUM-00402 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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TK/Src | 433.9 | 4.3E-130 | 252 | 500 | 249 |
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Status | Reviewed |
Ensembl Protein | ENSMUSP00000030693 |
UniProt Accession | P14234; Q61404; Q8BGM0; |
Protein Name | Tyrosine-protein kinase Fgr |
Protein Synonyms/Alias | Proto-oncogene c-Fgr; p55-Fgr; |
Gene Name | Fgr |
Gene Synonyms/Alias | Fgr; |
Ensembl Information | |
Organism | Mus musculus |
Functional Description | Non-receptor tyrosine-protein kinase that transmitssignals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCER1G and FCGR2. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes (PubMed:11672534). Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages (PubMed:8666673 and PubMed:9687507). Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation (PubMed:15561106). Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling (PubMed:21746961). Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. |
Protein Length | 517 |
Protein Sequence (FASTA) | MGCVFCKKLE PASKEDVGLE GDFRSQTAEE RYFPDPTQGR TSSVFPQPTS PAFLNTGNMR 60 | SISGTGVTIF VALYDYEART GDDLTFTKGE KFHILNNTEY DWWEARSLSS GHRGYVPSNY 120 | VAPVDSIQAE EWYFGKISRK DAERQLLSSG NPQGAFLIRE SETTKGAYSL SIRDWDQNRG 180 | DHIKHYKIRK LDTGGYYITT RAQFDSIQDL VRHYMEVNDG LCYLLTAPCT TTKPQTLGLA 240 | KDAWEIDRNS IALERRLGTG CFGDVWLGTW NCSTKVAVKT LKPGTMSPKA FLEEAQIMKL 300 | LRHDKLVQLY AVVSEEPIYI VTEFMCYGSL LDFLKDREGQ NLMLPHLVDM AAQVAEGMAY 360 | MERMNYIHRD LRAANILVGE YLICKIADFG LARLIEDNEY NPQQGTKFPI KWTAPEAALF 420 | GRFTVKSDVW SFGILLTELI TKGRVPYPGM NNREVLEQVE HGYHMPCPPG CPASLYEVME 480 | QAWRLDPEER PTFEYLQSFL EDYFTSTEPQ YQPGDQT 517 |
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Nucleotide Sequence (FASTA) | ATGGGCTGTG TGTTCTGCAA GAAGTTGGAG CCTGCATCCA AGGAGGATGT GGGCCTGGAA 60 | GGGGACTTCC GGAGCCAAAC GGCTGAAGAA CGCTATTTCC CTGACCCCAC TCAAGGCCGG 120 | ACTTCGTCCG TCTTTCCTCA GCCCACCAGC CCTGCTTTCC TCAACACTGG CAACATGAGA 180 | AGCATCTCAG GGACCGGAGT GACCATATTC GTCGCCCTGT ACGACTATGA GGCCAGGACA 240 | GGGGATGACC TCACCTTCAC CAAAGGCGAG AAGTTCCACA TCCTGAACAA TACGGAGTAT 300 | GACTGGTGGG AGGCTCGCTC CCTGAGCTCC GGACACAGAG GCTATGTTCC CAGCAACTAT 360 | GTTGCTCCTG TGGATTCCAT CCAGGCTGAA GAGTGGTACT TCGGAAAGAT CAGTAGAAAG 420 | GATGCAGAGA GGCAGCTTCT GTCCTCTGGT AACCCCCAGG GGGCCTTTCT CATTCGGGAA 480 | AGCGAGACCA CCAAAGGGGC CTACTCCCTG TCCATCCGTG ACTGGGACCA GAACAGAGGC 540 | GATCACATAA AGCATTATAA GATCCGAAAG CTGGACACGG GCGGCTACTA CATCACCACA 600 | CGGGCCCAGT TTGACTCCAT ACAGGACCTA GTGCGGCACT ACATGGAAGT GAATGATGGT 660 | CTGTGCTACT TGCTTACGGC GCCTTGTACC ACCACTAAGC CCCAGACTCT AGGCCTGGCC 720 | AAGGATGCCT GGGAGATCGA CCGGAACTCC ATAGCACTGG AACGCAGGCT GGGCACCGGC 780 | TGCTTTGGAG ATGTGTGGCT GGGCACATGG AACTGCAGCA CAAAGGTGGC AGTGAAGACG 840 | CTGAAGCCGG GCACCATGTC CCCGAAGGCA TTCCTGGAGG AGGCACAGAT CATGAAGCTG 900 | CTGAGGCACG ACAAGCTGGT GCAGCTGTAT GCGGTGGTGT CGGAGGAACC CATTTATATT 960 | GTGACAGAGT TCATGTGCTA TGGTAGCTTG CTGGATTTCC TAAAGGATCG AGAAGGTCAG 1020 | AACTTGATGC TGCCCCATCT AGTGGACATG GCTGCCCAGG TAGCCGAGGG CATGGCCTAC 1080 | ATGGAACGCA TGAACTATAT CCACCGAGAC TTGAGGGCAG CCAACATCCT GGTGGGGGAA 1140 | TACCTAATAT GCAAGATCGC TGACTTCGGG CTGGCACGCC TCATAGAGGA CAATGAGTAT 1200 | AACCCCCAAC AAGGAACCAA GTTCCCCATC AAGTGGACAG CCCCAGAGGC CGCCCTCTTT 1260 | GGCAGATTCA CTGTCAAATC AGACGTGTGG TCCTTTGGGA TTCTGCTCAC TGAACTGATC 1320 | ACCAAGGGCA GAGTTCCCTA CCCAGGTATG AACAACCGGG AAGTGTTGGA ACAGGTGGAG 1380 | CATGGCTACC ACATGCCGTG CCCTCCAGGA TGTCCTGCAT CCCTGTATGA GGTCATGGAG 1440 | CAGGCGTGGC GCCTGGATCC AGAGGAGAGG CCCACCTTTG AGTACCTGCA GTCTTTCCTG 1500 | GAAGACTATT TCACCTCCAC AGAACCACAG TACCAGCCTG GAGACCAGAC ATAG 1554 |
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Domain Profile | S: 2 klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya 61 | l+++lG+G+fG+vwlg+w+ s+kvavktlk+gt+sp+afleeaqi+k lrh+klv+lya | Q: 252 ALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYA 311 | 789********************************************************* |
| S: 62 vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd 121 | vvse ePiyivte+m Gslldflk++eg++l lp+lvd+aaqvaeGmay+e++n+ihrd | Q: 312 VVSE-EPIYIVTEFMCYGSLLDFLKDREGQNLMLPHLVDMAAQVAEGMAYMERMNYIHRD 370 | ***9.******************************************************* |
| S: 122 laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW 181 | l+a+n+lvge l++k+adfGlarlied+ey++++g+k+PikWtaPea+ +g+ft+ksdvW | Q: 371 LRAANILVGEYLICKIADFGLARLIEDNEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVW 430 | ************************************************************ |
| S: 182 sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer 241 | sfGillte++tkG+vPypGm+n+evleqve+gy++p+p cp++lye+++++w+ dpeer | Q: 431 SFGILLTELITKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPASLYEVMEQAWRLDPEER 490 | ************************************************************ |
| S: 242 Ptfetlqevl 251 | Ptfe+lq++l | Q: 491 PTFEYLQSFL 500 | *******986 |
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Domain Sequence (FASTA) | ALERRLGTGC FGDVWLGTWN CSTKVAVKTL KPGTMSPKAF LEEAQIMKLL RHDKLVQLYA 60 | VVSEEPIYIV TEFMCYGSLL DFLKDREGQN LMLPHLVDMA AQVAEGMAYM ERMNYIHRDL 120 | RAANILVGEY LICKIADFGL ARLIEDNEYN PQQGTKFPIK WTAPEAALFG RFTVKSDVWS 180 | FGILLTELIT KGRVPYPGMN NREVLEQVEH GYHMPCPPGC PASLYEVMEQ AWRLDPEERP 240 | TFEYLQSFL 249 |
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Keyword | ATP-binding; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Immunity; Innate immunity; Kinase; Lipoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Proto-oncogene; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase; Ubl conjugation. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |