EKS-MUM-00402
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00402
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src433.94.3E-130252500249
StatusReviewed
Ensembl ProteinENSMUSP00000030693
UniProt AccessionP14234; Q61404; Q8BGM0;
Protein NameTyrosine-protein kinase Fgr
Protein Synonyms/Alias Proto-oncogene c-Fgr; p55-Fgr;
Gene NameFgr
Gene Synonyms/Alias Fgr;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000028874ENSMUSP00000128411ENSMUST00000171223
ENSMUSG00000028874ENSMUSP00000030693ENSMUST00000030693
OrganismMus musculus
Functional DescriptionNon-receptor tyrosine-protein kinase that transmitssignals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCER1G and FCGR2. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes (PubMed:11672534). Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages (PubMed:8666673 and PubMed:9687507). Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation (PubMed:15561106). Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling (PubMed:21746961). Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
Protein Length517
Protein Sequence
(FASTA)
MGCVFCKKLE PASKEDVGLE GDFRSQTAEE RYFPDPTQGR TSSVFPQPTS PAFLNTGNMR 60
SISGTGVTIF VALYDYEART GDDLTFTKGE KFHILNNTEY DWWEARSLSS GHRGYVPSNY 120
VAPVDSIQAE EWYFGKISRK DAERQLLSSG NPQGAFLIRE SETTKGAYSL SIRDWDQNRG 180
DHIKHYKIRK LDTGGYYITT RAQFDSIQDL VRHYMEVNDG LCYLLTAPCT TTKPQTLGLA 240
KDAWEIDRNS IALERRLGTG CFGDVWLGTW NCSTKVAVKT LKPGTMSPKA FLEEAQIMKL 300
LRHDKLVQLY AVVSEEPIYI VTEFMCYGSL LDFLKDREGQ NLMLPHLVDM AAQVAEGMAY 360
MERMNYIHRD LRAANILVGE YLICKIADFG LARLIEDNEY NPQQGTKFPI KWTAPEAALF 420
GRFTVKSDVW SFGILLTELI TKGRVPYPGM NNREVLEQVE HGYHMPCPPG CPASLYEVME 480
QAWRLDPEER PTFEYLQSFL EDYFTSTEPQ YQPGDQT 517
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGTTCTGCAA GAAGTTGGAG CCTGCATCCA AGGAGGATGT GGGCCTGGAA 60
GGGGACTTCC GGAGCCAAAC GGCTGAAGAA CGCTATTTCC CTGACCCCAC TCAAGGCCGG 120
ACTTCGTCCG TCTTTCCTCA GCCCACCAGC CCTGCTTTCC TCAACACTGG CAACATGAGA 180
AGCATCTCAG GGACCGGAGT GACCATATTC GTCGCCCTGT ACGACTATGA GGCCAGGACA 240
GGGGATGACC TCACCTTCAC CAAAGGCGAG AAGTTCCACA TCCTGAACAA TACGGAGTAT 300
GACTGGTGGG AGGCTCGCTC CCTGAGCTCC GGACACAGAG GCTATGTTCC CAGCAACTAT 360
GTTGCTCCTG TGGATTCCAT CCAGGCTGAA GAGTGGTACT TCGGAAAGAT CAGTAGAAAG 420
GATGCAGAGA GGCAGCTTCT GTCCTCTGGT AACCCCCAGG GGGCCTTTCT CATTCGGGAA 480
AGCGAGACCA CCAAAGGGGC CTACTCCCTG TCCATCCGTG ACTGGGACCA GAACAGAGGC 540
GATCACATAA AGCATTATAA GATCCGAAAG CTGGACACGG GCGGCTACTA CATCACCACA 600
CGGGCCCAGT TTGACTCCAT ACAGGACCTA GTGCGGCACT ACATGGAAGT GAATGATGGT 660
CTGTGCTACT TGCTTACGGC GCCTTGTACC ACCACTAAGC CCCAGACTCT AGGCCTGGCC 720
AAGGATGCCT GGGAGATCGA CCGGAACTCC ATAGCACTGG AACGCAGGCT GGGCACCGGC 780
TGCTTTGGAG ATGTGTGGCT GGGCACATGG AACTGCAGCA CAAAGGTGGC AGTGAAGACG 840
CTGAAGCCGG GCACCATGTC CCCGAAGGCA TTCCTGGAGG AGGCACAGAT CATGAAGCTG 900
CTGAGGCACG ACAAGCTGGT GCAGCTGTAT GCGGTGGTGT CGGAGGAACC CATTTATATT 960
GTGACAGAGT TCATGTGCTA TGGTAGCTTG CTGGATTTCC TAAAGGATCG AGAAGGTCAG 1020
AACTTGATGC TGCCCCATCT AGTGGACATG GCTGCCCAGG TAGCCGAGGG CATGGCCTAC 1080
ATGGAACGCA TGAACTATAT CCACCGAGAC TTGAGGGCAG CCAACATCCT GGTGGGGGAA 1140
TACCTAATAT GCAAGATCGC TGACTTCGGG CTGGCACGCC TCATAGAGGA CAATGAGTAT 1200
AACCCCCAAC AAGGAACCAA GTTCCCCATC AAGTGGACAG CCCCAGAGGC CGCCCTCTTT 1260
GGCAGATTCA CTGTCAAATC AGACGTGTGG TCCTTTGGGA TTCTGCTCAC TGAACTGATC 1320
ACCAAGGGCA GAGTTCCCTA CCCAGGTATG AACAACCGGG AAGTGTTGGA ACAGGTGGAG 1380
CATGGCTACC ACATGCCGTG CCCTCCAGGA TGTCCTGCAT CCCTGTATGA GGTCATGGAG 1440
CAGGCGTGGC GCCTGGATCC AGAGGAGAGG CCCACCTTTG AGTACCTGCA GTCTTTCCTG 1500
GAAGACTATT TCACCTCCAC AGAACCACAG TACCAGCCTG GAGACCAGAC ATAG 1554
Domain Profile
S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61
          l+++lG+G+fG+vwlg+w+ s+kvavktlk+gt+sp+afleeaqi+k lrh+klv+lya
Q: 252   ALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYA  311
         789*********************************************************
S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121
         vvse ePiyivte+m  Gslldflk++eg++l lp+lvd+aaqvaeGmay+e++n+ihrd
Q: 312   VVSE-EPIYIVTEFMCYGSLLDFLKDREGQNLMLPHLVDMAAQVAEGMAYMERMNYIHRD  370
         ***9.*******************************************************
S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181
         l+a+n+lvge l++k+adfGlarlied+ey++++g+k+PikWtaPea+ +g+ft+ksdvW
Q: 371   LRAANILVGEYLICKIADFGLARLIEDNEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVW  430
         ************************************************************
S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241
         sfGillte++tkG+vPypGm+n+evleqve+gy++p+p  cp++lye+++++w+ dpeer
Q: 431   SFGILLTELITKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPASLYEVMEQAWRLDPEER  490
         ************************************************************
S: 242   Ptfetlqevl  251
         Ptfe+lq++l
Q: 491   PTFEYLQSFL  500
         *******986
Domain Sequence
(FASTA)
ALERRLGTGC FGDVWLGTWN CSTKVAVKTL KPGTMSPKAF LEEAQIMKLL RHDKLVQLYA 60
VVSEEPIYIV TEFMCYGSLL DFLKDREGQN LMLPHLVDMA AQVAEGMAYM ERMNYIHRDL 120
RAANILVGEY LICKIADFGL ARLIEDNEYN PQQGTKFPIK WTAPEAALFG RFTVKSDVWS 180
FGILLTELIT KGRVPYPGMN NREVLEQVEH GYHMPCPPGC PASLYEVMEQ AWRLDPEERP 240
TFEYLQSFL 249
KeywordATP-binding; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Immunity; Innate immunity; Kinase; Lipoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Proto-oncogene; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase; Ubl conjugation.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>
EKS-AIM-00344
EKS-BOT-00371
EKS-CAJ-00374
EKS-CAF-00373
EKS-CAP-00403
EKS-EQC-00362
EKS-FEC-00357
EKS-GOG-00361
EKS-ICT-00349
EKS-LOA-00379
EKS-MAM-00370
EKS-MUP-00364
EKS-NOL-00341
EKS-ORA-00323
EKS-ORC-00348
EKS-OTG-00373
EKS-PAT-00350
EKS-POA-00360
EKS-RAN-00385
EKS-SAH-00341
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0005829; C:cytosol
GO:0005743; C:mitochondrial inner membrane
GO:0005758; C:mitochondrial intermembrane space
GO:0005886; C:plasma membrane
GO:0032587; C:ruffle membrane
GO:0005524; F:ATP binding
GO:0034987; F:immunoglobulin receptor binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0001784; F:phosphotyrosine binding
GO:0019901; F:protein kinase binding
GO:0050830; P:defense response to Gram-positive bacterium
GO:0045087; P:innate immune response
GO:0007229; P:integrin-mediated signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0030335; P:positive regulation of cell migration
GO:0050715; P:positive regulation of cytokine secretion
GO:0043306; P:positive regulation of mast cell degranulation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0046777; P:protein autophosphorylation
GO:0032956; P:regulation of actin cytoskeleton organization
GO:0008360; P:regulation of cell shape
GO:0045088; P:regulation of innate immune response
GO:0050764; P:regulation of phagocytosis
GO:0045859; P:regulation of protein kinase activity
KEGG
mmu:14191;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013