EPS-MUM-00029

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUM-00029

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	169.4	3.0E-49	306	499	194

Status

Reviewed

Ensembl Protein

ENSMUSP00000031032

UniProt Accession

Q61074;

Protein Name

Protein phosphatase 1G

Protein Synonyms/Alias

Fibroblast growth factor-inducible protein 13; FIN13; Protein phosphatase 1C; Protein phosphatase 2C isoform gamma; PP2C-gamma; Protein phosphatase magnesium-dependent 1 gamma;

Gene Name

Ppm1g

Gene Synonyms/Alias

Ppm1g; Fin13, Ppm1c;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000029147	ENSMUSP00000031032	ENSMUST00000031032

Organism

Mus musculus

Functional Description

May be involved in regulation of cell cycle.

Protein Length

542

Protein Sequence
(FASTA)

MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD NETAMFSVYD 60

GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALQDAFLA IDAKLTTEEV IKELAQIAGR 120

PTEDEDDKDK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCQKVPPH TKSGIGTGDE 180

PGPQGLNGEA GPEDPSRETP SQENGPTAKG HTGFSSNSEH GTEAGQISEP GTATGEAGPS 240

CSSASDKLPR VAKSKFFEDS EDESDEVEEE EDDSEECSED EDGYSSEEAE NEEDEDDTEE 300

AEEDDDEEMM VPGMEGKEEP GSDSGTTAVV ALIRGKQLIV ANAGDSRCVV SEAGKALDMS 360

YDHKPEDEVE LARIKNAGGK VTMDGRVNGG LNLSRAIGDH FYKRNKNLPP QEQMISALPD 420

IKVLTLTDDH EFMVIACDGI WNVMSSQEVV DFIQSKISQR DENGELRLLS SIVEELLDQC 480

LAPDTSGDGT GCDNMTCIII CFKPRNTVEL QAESGKRKLE EALSTEGAED TGNSDKKKAK 540

RD 542

Nucleotide Sequence
(FASTA)

ATGGGTGCCT ACCTCTCTCA GCCCAACACG GTGAAGTGCT CCGGGGACGG GGTTGGCGCC 60

CCGCGGCTCC CGCTGCCCTA CGGCTTCTCC GCCATGCAAG GCTGGCGCGT CTCCATGGAG 120

GATGCTCACA ACTGTATTCC TGAGCTGGAC AATGAGACAG CCATGTTTTC TGTCTACGAT 180

GGACATGGAG GGGAAGAGGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATTATCAAA 240

GATCAGAAGG CCTACAAGGA AGGCAAGCTT CAGAAGGCTT TACAAGATGC CTTCTTGGCT 300

ATTGATGCCA AGCTGACCAC AGAGGAAGTC ATTAAGGAAC TGGCCCAGAT TGCAGGGAGA 360

CCCACTGAAG ATGAGGATGA TAAAGACAAA GTAGCAGATG AGGATGATGT GGACAATGAG 420

GAGGCTGCAT TGTTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACGCGATAT 480

GGGCAGAACT GTCAGAAGGT CCCTCCCCAC ACCAAATCTG GAATTGGGAC AGGCGATGAA 540

CCAGGGCCCC AGGGCCTCAA TGGGGAGGCT GGACCTGAGG ACCCATCTAG GGAAACTCCT 600

TCCCAGGAAA ATGGCCCCAC AGCCAAAGGC CACACAGGCT TTTCCTCCAA CTCGGAACAT 660

GGGACTGAGG CAGGCCAAAT TAGTGAGCCC GGTACTGCTA CCGGTGAGGC TGGACCTTCC 720

TGCTCTTCAG CCTCTGACAA GCTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT 780

GAAGATGAAT CAGATGAGGT GGAGGAAGAG GAGGATGACA GTGAGGAATG TAGTGAGGAC 840

GAGGACGGCT ACAGCAGTGA GGAGGCAGAG AACGAGGAAG ACGAGGATGA CACGGAGGAG 900

GCTGAAGAGG ATGATGATGA AGAGATGATG GTCCCTGGAA TGGAAGGCAA AGAAGAGCCT 960

GGTTCTGACA GTGGCACAAC AGCGGTGGTG GCTCTGATCA GAGGGAAGCA GTTGATTGTG 1020

GCCAATGCAG GAGACTCTCG CTGTGTGGTG TCCGAGGCTG GCAAAGCTTT AGATATGTCC 1080

TATGACCACA AACCAGAGGA TGAAGTGGAG CTGGCACGCA TCAAGAATGC TGGTGGCAAG 1140

GTCACCATGG ATGGACGAGT CAATGGAGGC CTCAACCTCT CCAGGGCCAT TGGAGACCAC 1200

TTCTACAAGA GAAACAAAAA CTTGCCACCC CAGGAACAGA TGATTTCTGC CCTTCCTGAC 1260

ATCAAGGTGC TGACTCTCAC TGATGACCAT GAATTCATGG TCATTGCTTG TGACGGCATC 1320

TGGAATGTGA TGAGCAGCCA GGAGGTTGTA GACTTTATTC AATCAAAGAT CAGTCAACGT 1380

GATGAAAACG GGGAGCTTCG GTTATTGTCA TCCATTGTGG AAGAGCTGCT GGATCAGTGC 1440

CTGGCGCCAG ACACTTCTGG GGATGGTACA GGGTGTGACA ACATGACGTG CATCATCATT 1500

TGCTTCAAGC CCCGAAACAC AGTAGAGCTT CAGGCAGAGA GTGGCAAGAG GAAACTGGAG 1560

GAGGCACTGT CCACGGAGGG GGCTGAAGAC ACCGGCAACA GTGACAAAAA GAAGGCCAAG 1620

AGGGACTAG 1629

Domain Profile

S: 87    deel..kvleeksldidksGstavvalikdsklyvanvGdSravLcrngkavelssdHkp  144

         dee+    +e k++  + sG+tavvali++++l+van+GdSr+v +  gka+ +s dHkp

Q: 306   DEEMmvPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKP  365

         666622224444445566******************************************

S: 145   sredEleRieeaggsvilkdgaRvlGvLavsRalGdlylk.........pyvtpePevts  195

         + e El+Ri++agg+v+ +   Rv+G L++sRa+Gd ++k         +++++ P++ +

Q: 366   EDEVELARIKNAGGKVTMDG--RVNGGLNLSRAIGDHFYKrnknlppqeQMISALPDIKV  423

         *******************9..**************************************

S: 196   hrltsedefliLasDGlwdvvsneeavslvrdvle......kkeaeqeaakkLvklalar  249

          +lt ++ef+++a+DG+w+v+s++e+v+++++ ++      + + ++++ ++L++++la

Q: 424   LTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISqrdengELRLLSSIVEELLDQCLAP  483

         ********************************9998877666667788999999999999

S: 250   gsk......dnvsaiv  259

          ++      dn++ i+

Q: 484   DTSgdgtgcDNMTCII  499

         9987777777777766

Domain Sequence
(FASTA)

DEEMMVPGME GKEEPGSDSG TTAVVALIRG KQLIVANAGD SRCVVSEAGK ALDMSYDHKP 60

EDEVELARIK NAGGKVTMDG RVNGGLNLSR AIGDHFYKRN KNLPPQEQMI SALPDIKVLT 120

LTDDHEFMVI ACDGIWNVMS SQEVVDFIQS KISQRDENGE LRLLSSIVEE LLDQCLAPDT 180

SGDGTGCDNM TCII 194

Keyword

Acetylation; Cell cycle; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0007050	; P:cell cycle arrest
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0006470	; P:protein dephosphorylation

KEGG

mmu:14208

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 2.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013