EKS-MUM-00188

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00188

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NRBP	540.1	2.4E-162	65	328	264

Status

Reviewed

Ensembl Protein

ENSMUSP00000031034

UniProt Accession

Q99J45; Q8BL77;

Protein Name

Nuclear receptor-binding protein

Protein Synonyms/Alias

HLS7-interacting protein kinase; MLF1 adapter molecule;

Gene Name

Nrbp1

Gene Synonyms/Alias

Nrbp1; Madm, Nrbp;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000029148	ENSMUSP00000031034	ENSMUST00000031034
ENSMUSG00000029148	ENSMUSP00000116421	ENSMUST00000139602
ENSMUSG00000029148	ENSMUSP00000077426	ENSMUST00000078312
ENSMUSG00000029148	ENSMUSP00000122115	ENSMUST00000155934
ENSMUSG00000029148	ENSMUSP00000122174	ENSMUST00000152534

Organism

Mus musculus

Functional Description

May play a role in subcellular trafficking between theendoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (By similarity).

Protein Length

535

Protein Sequence
(FASTA)

MSEGESQTVV SSGSDPKVES SSLAPGLTSV SPPVTSTTSA ASPEEEEESE DESEILEESP 60

CGRWQKRREE VNQRNVPGID SAYLAMDTEE GVEVVWNEVQ FSERKNYKLQ EEKVRAVFDN 120

LIQLEHLNIV KFHKYWADVK ENKARVIFIT EYMSSGSLKQ FLKKTKKNHK TMNEKAWKRW 180

CTQILSALSY LHSCDPPIIH GNLTCDTIFI QHNGLIKIGS VAPDTINNHV KTCREEQKNL 240

HFFAPEYGEV TNVTTAVDIY SFGMCALEMA VLEIQGNGES SYVPQEAISS AIQLLEDSLQ 300

REFIQKCLQS EPARRPTARE LLFHPALFEV PSLKLLAAHC IVGHQHMIPE NALEEITKNM 360

DTSAVLAEIP AGPGREPVQT LYSQSPALEL DKFLEDVRNG IYPLTAFGLP RPQQPQQEEV 420

TSPVVPPSVK TPTPEPAEVE TRKVVLMQCN IESVEEGVKH HLTLLLKLED KLNRHLSCDL 480

MPNESIPDLA AELVQLGFIS EADQSRLTSL LEETLNKFNF TRNSTLNTAT VTVSS 535

Nucleotide Sequence
(FASTA)

ATGTCGGAAG GGGAGTCCCA AACAGTAGTC AGCAGTGGCT CAGACCCAAA GGTAGAATCC 60

TCATCTTTAG CTCCTGGCCT GACTTCTGTG TCACCTCCTG TGACCTCTAC AACTTCAGCT 120

GCTTCTCCCG AGGAAGAAGA AGAAAGTGAA GATGAGTCTG AGATCTTGGA AGAGTCACCC 180

TGTGGGCGCT GGCAGAAGAG GCGAGAAGAG GTGAATCAGC GTAATGTACC AGGCATTGAC 240

AGTGCATACC TGGCCATGGA TACAGAGGAA GGTGTGGAGG TTGTGTGGAA TGAGGTACAG 300

TTCTCTGAAC GCAAGAACTA CAAACTGCAG GAGGAAAAGG TCCGTGCAGT GTTTGATAAT 360

CTGATTCAGC TGGAACATCT TAACATTGTT AAGTTTCACA AATATTGGGC TGATGTTAAA 420

GAGAACAAGG CTAGGGTGAT TTTCATCACA GAATACATGT CCTCTGGGAG TCTTAAGCAG 480

TTTCTGAAGA AGACCAAAAA GAACCACAAG ACTATGAATG AAAAGGCTTG GAAACGCTGG 540

TGTACACAGA TCCTCTCTGC CCTAAGCTAC CTGCACTCCT GTGACCCTCC CATCATCCAT 600

GGGAACCTGA CCTGTGACAC CATCTTCATC CAGCACAACG GACTCATCAA GATTGGCTCT 660

GTGGCTCCTG ACACTATCAA CAATCACGTG AAGACTTGCC GGGAAGAACA GAAGAACCTA 720

CACTTTTTTG CACCAGAGTA TGGAGAAGTC ACAAACGTGA CAACAGCAGT GGACATCTAC 780

TCCTTTGGCA TGTGTGCACT GGAGATGGCA GTGCTGGAGA TTCAGGGCAA TGGCGAGTCC 840

TCATATGTGC CACAGGAAGC CATCAGCAGT GCCATCCAGC TACTAGAAGA CTCATTACAG 900

AGGGAGTTTA TTCAAAAGTG CCTGCAGTCT GAGCCTGCTC GGAGACCAAC AGCCAGAGAA 960

CTTCTGTTCC ACCCAGCACT GTTTGAAGTG CCCTCACTCA AGCTTCTTGC TGCTCACTGT 1020

ATCGTGGGGC ACCAACACAT GATCCCAGAG AACGCTCTAG AGGAGATCAC CAAGAACATG 1080

GATACCAGTG CTGTACTAGC TGAAATTCCC GCAGGGCCAG GACGAGAACC AGTTCAGACT 1140

TTGTACTCTC AGTCACCAGC CCTAGAATTA GACAAATTCC TTGAAGATGT CAGGAATGGG 1200

ATCTACCCTC TGACAGCCTT TGGGCTACCT CGGCCTCAGC AGCCACAGCA GGAGGAGGTG 1260

ACATCACCTG TTGTGCCCCC CTCTGTCAAG ACTCCAACTC CTGAGCCAGC TGAAGTGGAG 1320

ACACGAAAGG TGGTGCTGAT GCAGTGCAAC ATCGAATCTG TGGAGGAGGG AGTCAAACAC 1380

CATCTAACAC TTCTGCTGAA GCTGGAGGAC AAATTGAACC GGCACCTGAG CTGTGACCTG 1440

ATGCCAAATG AGAGCATCCC GGACTTGGCA GCTGAGCTGG TGCAGCTGGG CTTCATTAGT 1500

GAGGCTGATC AGAGCCGCCT GACTTCTCTG CTGGAGGAGA CGCTCAACAA GTTCAACTTC 1560

ACCAGGAACA GTACACTCAA CACAGCCACT GTCACCGTCT CCTCGTAG 1608

Domain Profile

S: 1     qkrreevnqrdvpgidsaylamdteegvevvwnevqfserkefkaqeekiravfdnlvql  60

         qkrreevnqr+vpgidsaylamdteegvevvwnevqfserk++k+qeek+ravfdnl+ql

Q: 65    QKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQL  124

         89**********************************************************

S: 61    dhlnivklhkywldtkeakarvifiteyvssgslkqflkktkknakalnakawkrwctqi  120

         +hlnivk+hkyw+d+ke+karvifitey+ssgslkqflkktkkn+k++n+kawkrwctqi

Q: 125   EHLNIVKFHKYWADVKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQI  184

         ************************************************************

S: 121   lsalsylhscdppiihgnltcdtifiqhnglikigsvlpdairssvkaereelrnlhffa  180

         lsalsylhscdppiihgnltcdtifiqhnglikigsv+pd+i+++vk++ree++nlhffa

Q: 185   LSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFA  244

         ************************************************************

S: 181   peygevtelttavdiysfglcalelavleiqgngess.vteeaieraiksledplqrefi  239

         peygevt++ttavdiysfg+cale+avleiqgngess v++eai++ai++led+lqrefi

Q: 245   PEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSyVPQEAISSAIQLLEDSLQREFI  304

         ************************************99**********************

S: 240   rkclakdparrpsarellfhrvlf  263

         +kcl+++parrp+arellfh++lf

Q: 305   QKCLQSEPARRPTARELLFHPALF  328

         **********************98

Domain Sequence
(FASTA)

QKRREEVNQR NVPGIDSAYL AMDTEEGVEV VWNEVQFSER KNYKLQEEKV RAVFDNLIQL 60

EHLNIVKFHK YWADVKENKA RVIFITEYMS SGSLKQFLKK TKKNHKTMNE KAWKRWCTQI 120

LSALSYLHSC DPPIIHGNLT CDTIFIQHNG LIKIGSVAPD TINNHVKTCR EEQKNLHFFA 180

PEYGEVTNVT TAVDIYSFGM CALEMAVLEI QGNGESSYVP QEAISSAIQL LEDSLQREFI 240

QKCLQSEPAR RPTARELLFH PALF 264

Keyword

Acetylation; Cell projection; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005938	; C:cell cortex
GO:0012505	; C:endomembrane system
GO:0030027	; C:lamellipodium
GO:0016020	; C:membrane
GO:0048471	; C:perinuclear region of cytoplasm
GO:0042803	; F:protein homodimerization activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006888	; P:ER to Golgi vesicle-mediated transport

KEGG

mmu:192292

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013