EKS-MUM-00148

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00148

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/CDC7	562.2	7.4E-169	52	527	476

Status

Reviewed

Ensembl Protein

ENSMUSP00000112392

UniProt Accession

Q9Z0H0; Q9WUV1; Q9Z2Y7;

Protein Name

Cell division cycle 7-related protein kinase

Protein Synonyms/Alias

CDC7-related kinase; muCdc7;

Gene Name

Cdc7

Gene Synonyms/Alias

Cdc7; Cdc7l1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000029283	ENSMUSP00000031221	ENSMUST00000031221
ENSMUSG00000029283	ENSMUSP00000113385	ENSMUST00000118261
ENSMUSG00000029283	ENSMUSP00000112392	ENSMUST00000117196
ENSMUSG00000029283	ENSMUSP00000119612	ENSMUST00000129938
ENSMUSG00000029283	ENSMUSP00000075792	ENSMUST00000076467

Organism

Mus musculus

Functional Description

Seems to phosphorylate critical substrates that regulatethe G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

Protein Length

532

Protein Sequence
(FASTA)

MEEPMAFSSL RGSDRCPADD SLKKYEQSVK LSGIKRDIEE LCEAVPQLVN VFKIKDKIGE 60

GTFSSVYLAT AQLQEGHEEK IALKHLIPTS HPMRIAAELQ CLTVAGGQDN VMGLKYCFRK 120

NDHVVIAMPY LEHESFLDIL NSLSFQEVRE YMYNLFVALK RIHQFGIVHR DVKPSNFLYN 180

RRLKKYALVD FGLAQGTRDT KIELLKFVQS EAQQEDCSRN KYHGVVGHKG LLSRPAPKTV 240

DQQCTPKTSV KRSYTQVHIK QGKDGKLIKQ SKTVDIISRK LATKKTAIST KAMNSVMRET 300

ARSCPAVLTC DCYGSDRVCS VCLSRRQQVA PRAGTPGFRA PEVLTKCPDQ TTAIDMWSAG 360

VIFLSLLSGR YPFYKASDDL TALAQIMTIR GSRETIQAAK AFGKSVLCSK EVPAQDLRAL 420

CERLRGLDST TPRSASGPPG NASYDPAASK NTDHKASRVQ AAQAQHSEDS LYKRDNDGYW 480

SHPKDCTSNS EGWDSVPDEA YDLLDKLLDL NPASRITAEA ALLHAFFKDM CS 532

Nucleotide Sequence
(FASTA)

ATGGAGGAGC CAATGGCGTT TTCTTCCCTT CGTGGCAGTG ACAGGTGTCC GGCTGATGAC 60

TCTTTAAAAA AATATGAGCA GAGTGTTAAA CTTTCAGGTA TTAAAAGAGA TATTGAGGAG 120

CTTTGTGAAG CTGTACCACA ACTAGTCAAT GTGTTCAAAA TTAAGGACAA AATTGGAGAA 180

GGCACCTTCA GCTCTGTTTA TTTGGCCACA GCACAGTTGC AAGAAGGACA TGAAGAGAAA 240

ATTGCGCTGA AACACTTAAT TCCCACAAGT CATCCTATGA GGATTGCAGC AGAGCTTCAG 300

TGTCTGACAG TTGCAGGGGG GCAAGACAAT GTCATGGGAC TTAAGTACTG CTTCAGAAAA 360

AATGATCATG TGGTTATTGC TATGCCGTAT CTGGAACATG AGTCCTTTTT GGACATTTTG 420

AATTCTCTTT CCTTCCAAGA AGTTCGGGAA TATATGTATA ATCTTTTTGT AGCTTTGAAA 480

CGGATTCATC AGTTTGGTAT TGTTCACCGT GATGTGAAGC CCAGCAATTT TTTATACAAT 540

AGACGTCTGA AAAAGTATGC CTTGGTGGAC TTCGGTTTGG CCCAGGGAAC CCGTGACACA 600

AAAATAGAGC TGCTCAAGTT TGTCCAGTCT GAGGCTCAGC AGGAAGATTG TTCACGAAAC 660

AAGTATCATG GAGTCGTTGG ACACAAGGGC CTGCTGAGTC GCCCGGCACC TAAAACTGTG 720

GATCAGCAGT GTACCCCAAA AACTTCTGTC AAAAGATCCT ACACACAAGT TCACATTAAG 780

CAAGGAAAAG ACGGAAAGCT CATCAAGCAA TCAAAGACTG TGGACATAAT ATCACGAAAG 840

CTAGCGACAA AAAAGACGGC CATTTCTACA AAAGCTATGA ACAGCGTGAT GAGGGAAACT 900

GCCAGGTCCT GCCCTGCTGT CCTCACCTGC GACTGCTATG GATCAGATAG AGTCTGCAGC 960

GTTTGCCTGT CGAGGCGGCA GCAGGTTGCC CCTAGGGCAG GCACACCAGG ATTCAGAGCG 1020

CCAGAGGTCC TGACAAAGTG TCCTGACCAG ACCACAGCGA TTGACATGTG GTCTGCAGGT 1080

GTCATATTCC TGTCCTTGCT CAGTGGGCGG TACCCATTTT ACAAGGCCAG TGATGACTTA 1140

ACTGCTTTGG CTCAGATCAT GACAATTCGA GGATCCAGGG AAACTATCCA GGCTGCTAAA 1200

GCTTTTGGCA AATCAGTTCT GTGTAGCAAA GAAGTCCCAG CACAAGACTT GAGAGCTCTC 1260

TGTGAGAGAC TGCGGGGTCT AGACTCTACC ACTCCCAGGT CAGCCAGTGG TCCTCCAGGG 1320

AATGCTTCCT ATGACCCTGC TGCTTCCAAG AACACTGACC ACAAAGCATC CCGTGTACAG 1380

GCTGCTCAGG CACAGCACTC AGAGGACTCC TTGTATAAAA GGGACAACGA TGGCTATTGG 1440

AGTCATCCCA AAGACTGCAC TTCCAACTCA GAAGGCTGGG ACTCAGTACC TGATGAAGCC 1500

TATGACCTGC TCGACAAGCT TCTGGACCTA AACCCAGCTT CAAGGATAAC AGCAGAAGCA 1560

GCCTTATTAC ATGCGTTCTT TAAAGATATG TGCTCCTGA 1599

Domain Profile

S: 1     fkikdkiGeGtfssvylataqleegleekialkhliptshPeriaaeLelltvlgGqenv  60

         fkikdkiGeGtfssvylataql+eg+eekialkhliptshP+riaaeL++ltv+gGq+nv

Q: 52    FKIKDKIGEGTFSSVYLATAQLQEGHEEKIALKHLIPTSHPMRIAAELQCLTVAGGQDNV  111

         9***********************************************************

S: 61    vglkecfrkndsvvivlpylehesfldllrslsfqevreYlrnLlvalkrvhkfgivhrD  120

         +glk+cfrknd+vvi++pylehesfld+l+slsfqevreY++nL+valkr+h+fgivhrD

Q: 112   MGLKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMYNLFVALKRIHQFGIVHRD  171

         ************************************************************

S: 121   vkpsnfLynrrlkkfaLvDfGLaq..............seaqkeecsrn..........l  156

         vkpsnfLynrrlkk+aLvDfGLaq              seaq+e+csrn          l

Q: 172   VKPSNFLYNRRLKKYALVDFGLAQgtrdtkiellkfvqSEAQQEDCSRNkyhgvvghkgL  231

         **********************************************************99

S: 157   lsaavekevd..................................................  166

         ls++++k+vd

Q: 232   LSRPAPKTVDqqctpktsvkrsytqvhikqgkdgklikqsktvdiisrklatkktaistk  291

         ************************************************************

S: 167   .................tcdcygtdkvcsvclsrrqqvanraGtpGfraPevLlkipdqt  209

                          tcdcyg+d+vcsvclsrrqqva+raGtpGfraPevL+k+pdqt

Q: 292   amnsvmretarscpavlTCDCYGSDRVCSVCLSRRQQVAPRAGTPGFRAPEVLTKCPDQT  351

         ************************************************************

S: 210   taiDiwsaGvilLsllsgryPffkasddlealaeivtilGsreiikaakafgksvllske  269

         taiD+wsaGvi+LsllsgryPf+kasddl+ala+i+ti+Gsre+i+aakafgksvl+ske

Q: 352   TAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKAFGKSVLCSKE  411

         ************************************************************

S: 270   vp..........................................................  271

vp

Q: 412   VPaqdlralcerlrgldsttprsasgppgnasydpaaskntdhkasrvqaaqaqhsedsl  471

         ************************************************************

S: 272   ...dsdsye................PdeaydlldkllelnPakritaeealkhpff  308

            d+d+y+                Pdeaydlldkll+lnPa+ritae+al+h+ff

Q: 472   ykrDNDGYWshpkdctsnsegwdsvPDEAYDLLDKLLDLNPASRITAEAALLHAFF  527

         ***9999999999999***************************************8

Domain Sequence
(FASTA)

FKIKDKIGEG TFSSVYLATA QLQEGHEEKI ALKHLIPTSH PMRIAAELQC LTVAGGQDNV 60

MGLKYCFRKN DHVVIAMPYL EHESFLDILN SLSFQEVREY MYNLFVALKR IHQFGIVHRD 120

VKPSNFLYNR RLKKYALVDF GLAQGTRDTK IELLKFVQSE AQQEDCSRNK YHGVVGHKGL 180

LSRPAPKTVD QQCTPKTSVK RSYTQVHIKQ GKDGKLIKQS KTVDIISRKL ATKKTAISTK 240

AMNSVMRETA RSCPAVLTCD CYGSDRVCSV CLSRRQQVAP RAGTPGFRAP EVLTKCPDQT 300

TAIDMWSAGV IFLSLLSGRY PFYKASDDLT ALAQIMTIRG SRETIQAAKA FGKSVLCSKE 360

VPAQDLRALC ERLRGLDSTT PRSASGPPGN ASYDPAASKN TDHKASRVQA AQAQHSEDSL 420

YKRDNDGYWS HPKDCTSNSE GWDSVPDEAY DLLDKLLDLN PASRITAEAA LLHAFF 476

Keyword

Alternative splicing; ATP-binding; Cell cycle; Cell division; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007049	; P:cell cycle
GO:0051301	; P:cell division
GO:0008284	; P:positive regulation of cell proliferation
GO:0033261	; P:regulation of S phase

KEGG

mmu:12545

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013