EKS-MUM-00171

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00171

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	496.2	4.4E-149	453	711	259

Status

Unreviewed

Ensembl Protein

ENSMUSP00000124963

UniProt Accession

Q8CAH8;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

Prkg2

Gene Synonyms/Alias

Prkg2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000029334	ENSMUSP00000124963	ENSMUST00000161490
ENSMUSG00000029334	ENSMUSP00000031277	ENSMUST00000031277

Organism

Mus musculus

Functional Description

Protein Length

762

Protein Sequence
(FASTA)

MGNGSVKPKH AKHPDGHSGN LSNEALRSKV LELERELRRK DAELQEREYH LKELREQLAK 60

QTVAIAELTE ELQSKCIQLN KLQDVIHVQG GSPLQASPDK VPLDVHRKTS GLVSLHSRRG 120

AKAGVSAEPT TRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM 180

VECMYGRNYQ QGSYVIKQGE PGNHIFVLAE GRLEVFQGEK LLSSIPMWTT FGELAILYNC 240

TRTASVKAIT NVKTWALDRE VFQNIMRRTA QARDEEYRNF LRSVSLLKNL PEDKLTKIID 300

CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ KGEYFGEKAL 360

ISDDVRSANI IAEENDVACL VIDRETFNQT VGTFDELQKY LEGYVATLNR DDEKRHAKRS 420

MSSWKLSKAL SLEMIQLKEK VARFSSTSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA 480

MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS 540

ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDADGYL KLVDFGFAKK 600

IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGIDQMMTYN 660

LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN GINDIKKHRW LNGFNWEGLK 720

ARSLPSPLRR ELSGPIDHSY FDKYPPEKGV PPDEMSGWDK DF 762

Nucleotide Sequence
(FASTA)

ATGGGAAATG GTTCAGTGAA GCCCAAGCAT GCTAAGCACC CAGATGGCCA TTCAGGGAAC 60

CTCAGCAATG AAGCCCTGCG GAGCAAGGTG TTGGAGCTGG AGCGGGAGCT GAGGAGGAAG 120

GACGCGGAAC TTCAGGAACG GGAGTACCAC CTGAAGGAGC TTCGGGAGCA GCTGGCCAAG 180

CAGACCGTGG CCATCGCAGA GCTCACAGAA GAACTGCAGA GCAAGTGCAT CCAGCTGAAC 240

AAGCTGCAGG ATGTGATCCA CGTGCAGGGA GGAAGCCCAC TGCAGGCCTC TCCCGACAAA 300

GTGCCTCTGG ATGTTCACCG CAAGACCTCA GGCTTGGTCT CGCTCCACAG CAGGAGGGGG 360

GCGAAGGCTG GAGTGTCTGC AGAGCCAACC ACCCGAACCT ATGACCTCAA CAAACCCCCC 420

GAGTTTTCCT TTGAGAAAGC GAGAGTCAGG AAGGATTCCA GTGAGAAAAA GCTCATCACA 480

GATGCCCTGA ATAAGAACCA GTTTCTGAAG AGATTGGATC CCCAGCAGAT CAAGGACATG 540

GTGGAATGCA TGTACGGGAG AAACTATCAA CAGGGCAGCT ACGTCATTAA GCAGGGGGAA 600

CCAGGCAACC ATATCTTTGT GCTGGCCGAG GGTAGACTTG AGGTGTTCCA GGGAGAGAAG 660

TTGCTATCAT CCATCCCAAT GTGGACCACG TTTGGGGAAC TGGCTATTTT GTACAACTGT 720

ACTCGGACTG CCTCAGTGAA AGCGATTACC AATGTTAAAA CTTGGGCCCT CGATAGAGAG 780

GTTTTCCAGA ACATTATGAG GAGAACAGCC CAAGCCCGGG ATGAGGAGTA CAGAAACTTC 840

CTCAGAAGTG TCTCCTTGTT GAAGAATTTA CCTGAAGACA AACTAACCAA GATCATTGAC 900

TGCTTGGAAG TGGAATACTA TGACAAAGGA GATTACATCA TCAGAGAAGG AGAAGAAGGG 960

AGCACCTTTT TCATTTTGGC AAAAGGCAAG GTGAAAGTCA CACAGAGCAC AGAGGGCCAT 1020

GATCAGCCAC AGTTGATCAA GACACTGCAG AAAGGAGAGT ACTTTGGAGA AAAGGCTCTG 1080

ATCAGTGATG ACGTCAGATC AGCCAATATA ATTGCGGAAG AAAATGATGT CGCATGCCTC 1140

GTGATAGATC GAGAAACATT CAACCAAACT GTCGGGACAT TTGATGAACT CCAAAAATAT 1200

CTTGAGGGGT ATGTGGCCAC CCTGAACCGT GACGATGAAA AAAGACACGC AAAGCGCTCC 1260

ATGTCTAGCT GGAAGCTGTC CAAAGCCCTT TCTCTGGAGA TGATTCAGCT GAAAGAGAAG 1320

GTGGCCCGAT TCTCCTCAAC CTCCCCATTC CAGAACCTCG AGATTATCGC AACACTGGGC 1380

GTTGGTGGGT TCGGAAGAGT GGAGCTTGTT AAAGTGAAAA ATGAGAATGT TGCTTTTGCC 1440

ATGAAGTGTA TAAGGAAGAA GCACATTGTT GATACAAAGC AGCAAGAACA TGTCTACTCA 1500

GAAAAGAGGA TCCTGGAAGA GCTGTGTTCT CCCTTCATCG TGAAGTTGTA TCGTACTTTC 1560

AAGGACAATA AATATGTATA CATGCTTCTG GAGGCCTGCT TAGGTGGGGA GCTGTGGAGT 1620

ATACTGAGGG ACAGAGGCAG CTTCGATGAA CCCACCTCCA AATTCTGTGT CGCTTGTGTG 1680

ACAGAAGCAT TTGATTATCT GCACCGACTA GGCATCATCT ACAGAGACCT GAAGCCAGAG 1740

AACTTAATTC TGGATGCCGA TGGCTACCTT AAGTTGGTTG ACTTTGGATT CGCTAAGAAG 1800

ATTGGCTCTG GACAGAAAAC GTGGACATTC TGTGGGACTC CAGAGTATGT GGCCCCCGAG 1860

GTCATTCTTA ACAAAGGACA TGACTTCAGT GTGGATTTCT GGTCCCTGGG GATTCTGGTC 1920

TATGAGCTCC TAACGGGCAA CCCTCCCTTT TCTGGGATAG ACCAAATGAT GACCTACAAT 1980

TTGATTCTCA AGGGAATCGA GAAAATGGAT TTCCCCAGAA AGATAACAAG GCGCCCTGAG 2040

GATTTGATCC GGAGGCTTTG CAGGCAAAAC CCAACAGAAA GGCTGGGAAA TCTGAAGAAC 2100

GGGATCAACG ACATTAAGAA ACACAGGTGG TTAAATGGTT TTAATTGGGA AGGGCTGAAA 2160

GCACGGAGCC TTCCGTCACC TTTACGGAGA GAGCTCAGTG GCCCCATAGA TCACAGCTAC 2220

TTTGACAAGT ATCCTCCTGA AAAGGGGGTG CCTCCGGATG AAATGTCAGG CTGGGATAAA 2280

GACTTCTGA 2289

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l++iatlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqehv+sekrilee++s+

Q: 453   LEIIATLGVGGFGRVELVKVKN-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSP  511

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivklyrtfkd+kyvy+lleaclggelw+ilrdrgsfd+ t+kf+vacv+ea++ylh+ +

Q: 512   FIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLG  571

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld++gylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv

Q: 572   IIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  631

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+k+++prkit+++edli++lcr+np

Q: 632   DFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNP  691

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dikkh+w+

Q: 692   TERLGNLKNGINDIKKHRWL  711

         *******************7

Domain Sequence
(FASTA)

LEIIATLGVG GFGRVELVKV KNENVAFAMK CIRKKHIVDT KQQEHVYSEK RILEELCSPF 60

IVKLYRTFKD NKYVYMLLEA CLGGELWSIL RDRGSFDEPT SKFCVACVTE AFDYLHRLGI 120

IYRDLKPENL ILDADGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180

FWSLGILVYE LLTGNPPFSG IDQMMTYNLI LKGIEKMDFP RKITRRPEDL IRRLCRQNPT 240

ERLGNLKNGI NDIKKHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

mmu:19092

;

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013