EKS-MUM-00211

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00211

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	511.7	9.9E-154	4	289	286

Status

Reviewed

Ensembl Protein

ENSMUSP00000063617

UniProt Accession

Q9QUK0; Q3UL60; Q3V3X7; Q9QYI1; Q9QYI2;

Protein Name

Cyclin-dependent kinase-like 2

Protein Synonyms/Alias

Serine/threonine-protein kinase KKIAMRE;

Gene Name

Cdkl2

Gene Synonyms/Alias

Cdkl2; Kkiamre, Kkm;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000029403	ENSMUSP00000084199	ENSMUST00000086978
ENSMUSG00000029403	ENSMUSP00000108765	ENSMUST00000113140
ENSMUSG00000029403	ENSMUSP00000063617	ENSMUST00000069937
ENSMUSG00000029403	ENSMUSP00000108768	ENSMUST00000113143

Organism

Mus musculus

Functional Description

Protein Length

564

Protein Sequence
(FASTA)

MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 60

ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LKLFPNGLDY QVVQKYLFQI INGIGFCHSH 120

NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 180

KAVDIWAIGC LVIEMLMGQP LFPGESDIDQ LHHIMTCLGN LIPRHQELFY KNPVFAGVRL 240

PEVKDAEAEP LESRYPKLPE AVISLAKKCL HIDPDKRPFC ADLLRHDFFQ MDGFAERFSQ 300

ELQLKIEKDA RNNSLPKKSQ NRKKEKDDAL GEERKTLVVQ DTNADPKIKD SKVFKVKGSK 360

IDVEKMEKGS RASNANCLHD NGTNHKGLAS TSLRDCSNVN IDHSRNPGTA IPPLTHNLSA 420

VAPGINAGMG TIPGVQNYRV DEKTKKYCNP FVKPNQPPPA GIYNMNVSTS VSGEKYLLQA 480

NKKRKEYPKA DVRLPELNYN HLPELRALEG IARNSRLIKK ENKCLSESRI PSLAAIDLHV 540

SSVASHQMLP ALEMTSSCTR ALIP 564

Nucleotide Sequence
(FASTA)

ATGGAGAAGT ACGAGAACCT AGGATTGGTT GGAGAGGGGA GTTACGGAAT GGTGATGAAG 60

TGTAGGAACA AAGACAGTGG AAGAATTGTG GCCATTAAGA AGTTCCTAGA AAGTGACGAT 120

GATAAAATGG TTAAGAAGAT CGCAATGCGA GAGATCAAGT TACTAAAGCA ACTGCGGCAT 180

GAAAATTTGG TGAATCTGTT GGAAGTATGT AAGAAAAAAA AACGTTGGTA CCTAGTCTTT 240

GAATTTGTTG ACCACACGAT TCTTGATGAC TTGAAACTCT TTCCAAATGG ACTAGACTAT 300

CAAGTAGTTC AAAAATATTT GTTTCAGATT ATTAATGGAA TTGGATTTTG CCACAGTCAC 360

AATATCATAC ACAGAGATAT AAAGCCTGAG AATATATTAG TCTCCCAGTC TGGCGTTGTA 420

AAATTATGTG ACTTTGGATT TGCACGGACC CTGGCGGCTC CAGGGGAGGT TTACACTGAC 480

TATGTGGCCA CCCGGTGGTA CAGAGCTCCA GAACTGCTGG TCGGTGACGT CAAGTATGGC 540

AAGGCTGTGG ATATCTGGGC CATTGGTTGT CTGGTCATTG AAATGCTTAT GGGGCAGCCA 600

CTGTTTCCAG GAGAATCTGA TATTGATCAG CTACATCATA TTATGACATG TTTAGGTAAT 660

TTAATTCCAA GACACCAGGA GCTATTTTAT AAAAATCCTG TGTTTGCTGG AGTAAGGTTG 720

CCTGAGGTCA AAGATGCAGA AGCAGAGCCT CTTGAGAGCC GCTATCCTAA GCTCCCTGAA 780

GCTGTGATCA GTTTAGCAAA GAAATGCTTG CACATTGACC CAGACAAAAG GCCCTTCTGT 840

GCTGACCTTC TGCGCCATGA CTTCTTTCAA ATGGATGGAT TTGCTGAGAG GTTTTCTCAA 900

GAATTGCAGT TAAAAATAGA GAAAGATGCC AGGAATAATT CTTTACCTAA AAAGTCTCAA 960

AACAGAAAGA AAGAAAAAGA CGATGCCTTA GGTGAAGAAA GAAAAACCCT TGTGGTACAG 1020

GATACCAATG CTGACCCCAA AATTAAGGAT TCAAAAGTAT TTAAAGTAAA GGGGTCAAAA 1080

ATTGATGTTG AGAAAATGGA AAAAGGAAGT AGAGCTTCAA ATGCCAACTG TCTCCATGAC 1140

AATGGGACAA ACCACAAAGG CTTGGCTTCC ACCAGCCTCA GAGATTGCAG CAATGTCAAC 1200

ATTGATCACT CAAGGAACCC AGGCACAGCG ATTCCTCCCC TCACACACAA TCTTTCTGCA 1260

GTTGCTCCTG GCATTAATGC TGGAATGGGG ACTATTCCTG GCGTTCAGAA TTACAGAGTG 1320

GATGAGAAAA CAAAGAAATA CTGTAATCCA TTTGTTAAAC CAAATCAGCC TCCTCCAGCA 1380

GGGATTTATA ATATGAATGT GAGCACATCC GTCTCAGGTG AAAAGTACCT CCTTCAGGCA 1440

AACAAGAAAA GGAAGGAATA TCCCAAAGCA GACGTGCGGT TGCCTGAACT AAACTATAAC 1500

CATCTTCCTG AACTGAGAGC TTTAGAAGGC ATAGCTCGAA ATTCTAGGCT AATAAAGAAA 1560

GAGAACAAAT GCCTTTCAGA ATCTCGAATT CCCTCTCTGG CTGCCATTGA TCTGCACGTG 1620

TCCAGTGTTG CATCACACCA GATGCTGCCA GCCCTGGAGA TGACGTCCTC TTGCACGAGA 1680

GCACTGATAC CCTAG 1695

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lg vGeGsyG+v+kcrnkd+g+ivaikkfles+ddk+vkkia+reikllkql+henl

Q: 4     YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnllev+++kk++ylvfe+vd+t+ld+l+ +pnG+++++v+k+l+qi+++i fch++nii

Q: 64    VNLLEVCKKKKRWYLVFEFVDHTILDDLKLFPNGLDYQVVQKYLFQIINGIGFCHSHNII  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenil+s+sgvvklcdfGfar+laapg+vytdyvatrwyrapellvgd+kyGk+v

Q: 124   HRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAV  183

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         d+waiGcl++e+l+G+plfpg+sd+dql++i+++lG+liprhq++f+kn+vfaGv+lpev

Q: 184   DIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQELFYKNPVFAGVRLPEV  243

         ************************************************************

S: 241   edl..eslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +d+  e+le++ypkl e++++l+kkcl++dp++r +c++ll+h++f

Q: 244   KDAeaEPLESRYPKLPEAVISLAKKCLHIDPDKRPFCADLLRHDFF  289

         9874479*************************************98

Domain Sequence
(FASTA)

YENLGLVGEG SYGMVMKCRN KDSGRIVAIK KFLESDDDKM VKKIAMREIK LLKQLRHENL 60

VNLLEVCKKK KRWYLVFEFV DHTILDDLKL FPNGLDYQVV QKYLFQIING IGFCHSHNII 120

HRDIKPENIL VSQSGVVKLC DFGFARTLAA PGEVYTDYVA TRWYRAPELL VGDVKYGKAV 180

DIWAIGCLVI EMLMGQPLFP GESDIDQLHH IMTCLGNLIP RHQELFYKNP VFAGVRLPEV 240

KDAEAEPLES RYPKLPEAVI SLAKKCLHID PDKRPFCADL LRHDFF 286

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0007049	; P:cell cycle

KEGG

mmu:53886

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013