EPS-MUM-00128

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUM-00128

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	277.6	2.8E-82	131	324	194

Status

Reviewed

Ensembl Protein

ENSMUSP00000031359

UniProt Accession

O35385;

Protein Name

Serine/threonine-protein phosphatase with EF-hands 2

Protein Synonyms/Alias

PPEF-2;

Gene Name

Ppef2

Gene Synonyms/Alias

Ppef2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000029410	ENSMUSP00000031359	ENSMUST00000031359

Organism

Mus musculus

Functional Description

May play a role in phototransduction. Maydephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission.

Protein Length

757

Protein Sequence
(FASTA)

MGSSSSTQHH FAFQNAEKAF KAAALIQRWY RRYMARLEMR RRCTWNIFQS IEYAGQQDQV 60

KLHEFFSYLV DHFTPSSHHE RDFLNRMFTE ERFAQDVETE EGGDFESIEV PDSYTGPRLS 120

FPLLPDHATA LVEAFRLRQQ LHARYVLNLL YETRKHLAQL PNINRVSTCY SEEVTVCGDL 180

HGQLDDLIFI FYKNGLPSPE RAYVFNGDFV DRGKDSVEVL MVLFAFMLVY PKEFHLNRGN 240

HEDHLVNLRY GFTKEVMHKY KIHGKKILRT LQDVFCWLPL ATLVDEKVLV LHGGVSDKTD 300

LELLAKLDRH KIVSTMRCKT RKESENREEQ KRKDNQTSSG QKPTPWFLPQ SRSLPSSPFH 360

LGSGFKAYKA GRSCSIPCGS PNSKELSRRG QVRRSVDLEL EQCRQQAGFL GIREKGESLP 420

LAPDADCVAD GGGVLEPTPE EWKQVVDILW SDPAAQEGCK ANAVRGGGCY FGPDVTERLM 480

EKYKLQLLIR SHECKPEGYE FCHNRKVLTI FSASNYYEVG SNRGAYVKLG PALTPHIVQY 540

QANKATHRLT MRQRISRVEE SALRALRQKL FAHSSDLLVE FRKRDPDESG VITLSDWATA 600

VESVLHLGLP WRMLRPQLVN SSADNVLEYR SWLDSLAKEQ LSRENIQSSL LEKLYRNRSN 660

LETIFRIIDS DHSGFISLDE FRQTWKLFSS HMSIDITDDG ICDLARSIDF NKDGHIDINE 720

FLEAFRLVEQ SCLEGHASAC LQSTDTAESG HSSPGPC 757

Nucleotide Sequence
(FASTA)

ATGGGAAGCA GCTCATCCAC CCAGCACCAC TTTGCGTTTC AGAACGCTGA GAAAGCCTTC 60

AAGGCAGCGG CCCTGATCCA GAGATGGTAC CGGCGCTACA TGGCCCGCCT AGAGATGAGG 120

AGGCGATGTA CCTGGAACAT CTTCCAGTCT ATAGAGTATG CTGGACAGCA AGACCAGGTC 180

AAGCTCCATG AATTCTTCAG CTACCTTGTG GACCATTTCA CTCCCAGCAG CCACCATGAG 240

AGAGATTTCC TGAACCGCAT GTTCACCGAA GAGAGATTCG CCCAGGACGT GGAGACAGAG 300

GAGGGTGGAG ATTTTGAATC CATAGAGGTG CCAGACAGCT ACACGGGGCC ACGCCTCTCC 360

TTCCCCCTTC TTCCTGACCA TGCCACTGCC CTGGTGGAAG CTTTCAGGCT GCGACAACAG 420

CTCCATGCTC GATACGTCTT GAATCTTCTG TACGAGACCA GAAAACACCT GGCCCAGCTG 480

CCCAACATCA ACCGAGTCTC CACCTGCTAC AGCGAGGAGG TCACAGTGTG TGGAGATCTA 540

CATGGCCAGT TGGATGATTT AATATTTATA TTTTATAAGA ACGGTCTACC ATCACCAGAG 600

AGAGCATACG TGTTCAATGG TGACTTTGTG GATCGAGGCA AGGACTCTGT AGAGGTCCTG 660

ATGGTTCTCT TTGCCTTCAT GTTGGTATAC CCCAAGGAGT TCCATCTTAA CAGAGGAAAC 720

CATGAGGACC ATCTAGTGAA CCTACGATAT GGCTTCACCA AGGAAGTGAT GCATAAATAC 780

AAGATACATG GGAAGAAAAT CCTAAGGACA CTTCAGGATG TCTTCTGCTG GCTTCCGTTG 840

GCCACTCTGG TTGATGAGAA AGTCCTTGTT CTTCATGGTG GAGTCTCAGA CAAGACAGAC 900

CTGGAACTTC TGGCTAAACT AGACAGGCAC AAGATTGTTT CTACCATGAG GTGCAAAACA 960

AGAAAGGAAA GTGAGAATCG AGAGGAGCAG AAGAGAAAAG ATAACCAGAC AAGCTCTGGA 1020

CAGAAACCTA CTCCGTGGTT TCTTCCTCAA AGCCGCTCTC TGCCCTCTTC GCCTTTTCAC 1080

CTGGGCTCTG GCTTTAAGGC CTACAAAGCC GGCAGGTCCT GCAGCATCCC CTGTGGCTCC 1140

CCTAACAGCA AGGAGCTATC CCGGCGGGGG CAGGTGCGGC GCTCAGTGGA CCTGGAACTG 1200

GAACAGTGCC GGCAGCAAGC CGGCTTCCTG GGGATCAGAG AGAAGGGGGA GTCCTTGCCT 1260

TTGGCCCCAG ATGCTGACTG TGTTGCTGAT GGGGGAGGGG TGCTGGAACC CACCCCCGAG 1320

GAGTGGAAGC AGGTTGTAGA TATTCTGTGG AGTGATCCCG CGGCTCAGGA GGGCTGCAAG 1380

GCCAACGCTG TCCGAGGAGG AGGCTGTTAC TTTGGGCCTG ACGTGACAGA ACGGTTGATG 1440

GAAAAATACA AGCTGCAACT CCTGATCCGT TCGCATGAGT GCAAACCCGA GGGCTATGAG 1500

TTCTGTCACA ACCGCAAGGT GTTAACCATC TTTTCTGCCT CCAACTACTA TGAAGTTGGC 1560

AGCAACAGAG GAGCCTACGT CAAGCTGGGG CCAGCCCTGA CTCCACATAT CGTGCAGTAT 1620

CAAGCTAACA AGGCGACCCA CAGGCTAACC ATGAGGCAAA GGATCAGCAG GGTGGAGGAG 1680

TCGGCCCTCA GAGCCCTTCG ACAGAAATTA TTTGCTCATT CGTCGGACCT GCTTGTTGAG 1740

TTTAGGAAGC GCGACCCGGA TGAGAGCGGT GTCATCACCC TGAGTGATTG GGCGACTGCC 1800

GTGGAGTCTG TGCTGCACCT GGGACTGCCC TGGCGGATGC TGCGGCCACA ACTGGTGAAT 1860

AGTTCAGCGG ATAACGTGTT GGAATACAGG TCCTGGTTGG ACAGTTTGGC CAAAGAACAG 1920

CTGAGCCGAG AGAATATTCA GTCGAGTTTG CTGGAAAAGC TCTATCGAAA CCGATCCAAC 1980

TTGGAGACCA TTTTTAGGAT CATAGACAGC GATCATTCAG GATTCATCTC CCTGGATGAG 2040

TTCAGGCAGA CTTGGAAGCT CTTCAGCTCA CATATGAGCA TCGACATCAC AGATGACGGC 2100

ATCTGTGACC TCGCCAGAAG CATCGACTTC AACAAGGATG GCCACATCGA CATCAATGAG 2160

TTCCTGGAGG CCTTCCGCCT CGTGGAGCAG TCCTGCTTAG AGGGCCACGC CTCTGCTTGC 2220

CTGCAGTCCA CAGACACTGC TGAGAGTGGC CATAGCAGTC CAGGCCCATG CTGA 2274

Domain Profile

S: 4     llevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddlllv  63

         l+e+f+ +++lha+yvl++l+e++k l qlpni++vst+ s+evtv+GdlhG+lddl+++

Q: 131   LVEAFRLRQQLHARYVLNLLYETRKHLAQLPNINRVSTCYSEEVTVCGDLHGQLDDLIFI  190

         89**********************************************************

S: 64    lkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmnary  123

         ++knGlPs +++yvfnGdfvdrGk ++evl+vl +++lv+P++ +lnrGnhed+++n+ry

Q: 191   FYKNGLPSPERAYVFNGDFVDRGKDSVEVLMVLFAFMLVYPKEFHLNRGNHEDHLVNLRY  250

         ************************************************************

S: 124   GfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksverk  183

         Gf+kev++kyk +gk+ilr+l++v+ wlPl+++vd++vlv+hGG+s+ t+l+ll +++r+

Q: 251   GFTKEVMHKYKIHGKKILRTLQDVFCWLPLATLVDEKVLVLHGGVSDKTDLELLAKLDRH  310

         ************************************************************

S: 184   krksvllpPeessr  197

         k +s ++  +  +

Q: 311   KIVSTMRCKTRKES  324

         ****9987664333

Domain Sequence
(FASTA)

LVEAFRLRQQ LHARYVLNLL YETRKHLAQL PNINRVSTCY SEEVTVCGDL HGQLDDLIFI 60

FYKNGLPSPE RAYVFNGDFV DRGKDSVEVL MVLFAFMLVY PKEFHLNRGN HEDHLVNLRY 120

GFTKEVMHKY KIHGKKILRT LQDVFCWLPL ATLVDEKVLV LHGGVSDKTD LELLAKLDRH 180

KIVSTMRCKT RKES 194

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Manganese; Metal-binding; Protein phosphatase; Reference proteome; Repeat; Sensory transduction; Vision.

Sequence Source

Ensembl

Orthology

Ortholog group

Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception
GO:0043409	; P:negative regulation of MAPK cascade
GO:0010801	; P:negative regulation of peptidyl-threonine phosphorylation
GO:0007601	; P:visual perception

KEGG

mmu:19023

;

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 3.
PS50222	; EF_HAND_2; 3.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013