EKS-MUM-00536
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00536
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/TIF1N/AN/AN/AN/AN/A
StatusReviewed
Ensembl ProteinENSMUSP00000031859
UniProt AccessionQ64127; Q64126;
Protein NameTranscription intermediary factor 1-alpha
Protein Synonyms/Alias TIF1-alpha; E3 ubiquitin-protein ligase Trim24; Tripartite motif-containing protein 24;
Gene NameTrim24
Gene Synonyms/Alias Trim24; Tif1, Tif1a;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000029833ENSMUSP00000114001ENSMUST00000120238
ENSMUSG00000029833ENSMUSP00000113063ENSMUST00000120428
ENSMUSG00000029833ENSMUSP00000031859ENSMUST00000031859
OrganismMus musculus
Functional DescriptionTranscriptional coactivator that interacts with numerousnuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand- dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes.
Protein Length1051
Protein Sequence
(FASTA)
MEVAVEKAAA AAAPAGGPAA AAPSGENEAE SRQGPDSESG GEASRLNLLD TCAVCHQNIQ 60
SRVPKLLPCL HSFCQRCLPA PQRYLMLTAP ALGSAETPPP APAPAPAPGS PAGGPSPFAT 120
QVGVIRCPVC SQECAERHII DNFFVKDTTE VPSSTVEKSN QVCTSCEDNA EANGFCVECV 180
EWLCKTCIRA HQRVKFTKDH TVRQKEEVSP EAVGVTSQRP VFCPFHKKEQ LKLYCETCDK 240
LTCRDCQLLE HKEHRYQFIE EAFQNQKVII DTLITKLMEK TKYIKYTGNQ IQNRIIEINQ 300
NQKQVEQDIK VAIFTLMVEI NKKGKALLHQ LESLAKDHRM KLMQQQQEVA GLSKQLEHVM 360
HFSKWAVSSG SSTALLYSKR LITYRLRHLL RARCDASPVT NTTIQFHCDP SFWAQNIINL 420
GSLVIEDKES QPQMPKQNPV VEQSSQPPGG LPSNQLSKFP TQISLAQLRL QHIQQQVMAQ 480
RQQVQRRPAP VGLPNPRMQG PIQQPSISHQ HPPPRLINFQ NHSPKPNGPV LPPYPQQLRY 540
SPSQNVPRQT TIKPNPLQMA FLAQQAIKQW QISSVQAPPT TASSSSSTPS SPTITSAAGY 600
DGKAFSSPMI DLSAPVGGSY NLPSLPDIDC SSTIMLDNIA RKDTGVDHAQ PRPPSNRTVQ 660
SPNSSVPSPG LAGPVTMTSV HPPIRSPSAS SVGSRGSSGS SSKPAGADST HKVPVVMLEP 720
IRIKQENSGP PENYDFPVVI VKQESDEESR PQNTNYPRSI LTSLLLNSSQ SSASEETVLR 780
SDAPDSTGDQ PGLHQENSSN GKSEWSDASQ KSPVHVGETR KEDDPNEDWC AVCQNGGELL 840
CCEKCPKVFH LTCHVPTLTN FPSGEWICTF CRDLSKPEVD YDCDVPSHHS EKRKSEGLTK 900
LTPIDKRKCE RLLLFLYCHE MSLAFQDPVP LTVPDYYKII KNPMDLSTIK KRLQEDYCMY 960
TKPEDFVADF RLIFQNCAEF NEPDSEVANA GIKLESYFEE LLKNLYPEKR FPKVEFRHEA 1020
EDCKFSDDSD DDFVQPRKKR LKSTEDRQLL K 1051
Nucleotide Sequence
(FASTA)
ATGGAGGTGG CTGTGGAGAA GGCGGCGGCG GCAGCGGCTC CGGCCGGAGG CCCCGCAGCG 60
GCGGCGCCGA GCGGGGAGAA TGAGGCCGAG AGCCGGCAGG GCCCGGACTC GGAGAGCGGC 120
GGCGAGGCGT CCCGGCTCAA CCTGTTGGAC ACTTGCGCCG TGTGCCACCA GAACATCCAG 180
AGCCGGGTGC CCAAGCTGCT GCCCTGCCTG CACTCGTTCT GCCAGCGCTG TTTGCCCGCG 240
CCGCAGCGCT ATCTCATGCT GACGGCGCCC GCGCTGGGCT CGGCAGAGAC CCCTCCACCC 300
GCTCCCGCCC CCGCCCCCGC CCCGGGCTCC CCGGCCGGTG GTCCTTCGCC ATTCGCCACC 360
CAAGTTGGAG TCATTCGATG CCCAGTTTGC AGTCAAGAGT GTGCTGAGAG ACACATCATA 420
GACAACTTTT TTGTGAAGGA CACCACTGAA GTTCCTAGTA GTACAGTAGA AAAGTCTAAT 480
CAGGTATGTA CAAGCTGTGA AGACAATGCA GAAGCTAATG GGTTTTGTGT AGAGTGTGTT 540
GAATGGCTCT GCAAGACATG TATTAGAGCT CACCAGAGGG TGAAGTTCAC AAAAGACCAC 600
ACAGTCAGGC AGAAAGAAGA AGTATCTCCA GAGGCAGTTG GGGTGACCAG TCAGCGACCA 660
GTGTTTTGTC CCTTCCATAA AAAGGAGCAG TTGAAACTTT ACTGTGAAAC ATGTGATAAA 720
CTGACCTGTC GAGACTGCCA GCTGCTAGAA CACAAAGAAC ACAGGTATCA ATTTATAGAA 780
GAAGCTTTTC AGAATCAAAA AGTGATCATA GATACTCTAA TCACCAAACT GATGGAAAAA 840
ACAAAATATA TAAAGTATAC AGGAAATCAG ATCCAAAATA GGATAATTGA AATAAATCAA 900
AACCAAAAGC AGGTGGAACA GGATATTAAA GTTGCCATCT TCACATTGAT GGTGGAGATA 960
AACAAAAAAG GGAAAGCTCT GCTGCACCAG CTTGAGAGTC TTGCAAAGGA CCATCGAATG 1020
AAACTCATGC AACAACAGCA GGAAGTGGCT GGGCTTTCTA AGCAGTTAGA GCACGTCATG 1080
CATTTTTCTA AATGGGCTGT TTCCAGTGGC AGCAGCACAG CCTTGCTGTA CAGCAAGCGG 1140
CTGATTACAT ACAGGTTACG GCACCTTCTT CGTGCAAGGT GTGATGCTTC TCCTGTGACC 1200
AACACCACCA TCCAGTTTCA CTGTGATCCT AGTTTCTGGG CTCAAAATAT TATCAACTTG 1260
GGTTCTTTAG TAATCGAGGA TAAAGAGAGC CAGCCACAAA TGCCTAAGCA GAATCCTGTC 1320
GTGGAGCAGA GTTCACAGCC ACCAGGTGGT TTACCTTCCA ACCAGTTATC CAAGTTCCCA 1380
ACACAGATCA GCCTAGCTCA GTTACGACTC CAGCATATTC AGCAACAGGT AATGGCTCAG 1440
AGGCAACAGG TGCAACGGAG GCCAGCACCT GTGGGTTTAC CAAACCCTAG AATGCAGGGG 1500
CCCATCCAGC AGCCTTCCAT CTCTCATCAG CATCCGCCAC CACGCTTAAT AAACTTTCAG 1560
AATCACAGCC CTAAGCCCAA TGGACCAGTT CTTCCTCCTT ATCCTCAGCA GCTGAGATAT 1620
TCACCAAGCC AGAATGTACC TCGGCAGACA ACAATAAAGC CCAACCCCTT GCAAATGGCT 1680
TTTTTGGCTC AACAGGCCAT AAAACAGTGG CAGATCAGCA GTGTACAGGC TCCGCCCACA 1740
ACTGCCAGCA GCTCCTCCTC CACGCCGTCC AGCCCCACAA TCACAAGTGC AGCTGGGTAC 1800
GATGGAAAAG CTTTTAGTTC ACCCATGATT GATCTGAGTG CACCGGTGGG AGGGTCTTAC 1860
AATCTTCCTT CTCTTCCAGA TATTGATTGT TCAAGTACTA TAATGTTGGA CAACATTGCA 1920
AGGAAAGACA CAGGTGTAGA TCACGCCCAG CCGAGGCCTC CGTCAAACAG AACGGTGCAG 1980
TCACCAAATT CATCAGTGCC ATCTCCAGGC CTTGCAGGGC CTGTTACTAT GACTAGCGTC 2040
CATCCCCCAA TACGTTCACC TAGTGCCTCC AGTGTTGGAA GTCGAGGAAG CTCTGGCTCT 2100
TCCAGCAAAC CAGCAGGAGC TGATTCTACT CACAAGGTCC CAGTAGTCAT GCTGGAGCCA 2160
ATTCGAATAA AACAGGAAAA CAGTGGACCA CCTGAAAATT ATGATTTTCC TGTTGTTATA 2220
GTAAAACAAG AATCAGATGA AGAATCTAGA CCTCAAAATA CTAACTATCC AAGAAGCATA 2280
CTTACCTCCC TCCTCTTAAA CAGCAGTCAG AGCTCTGCTT CTGAGGAAAC CGTGTTACGA 2340
TCTGATGCCC CTGATAGTAC AGGAGATCAG CCTGGACTCC ATCAAGAAAA TTCCTCAAAT 2400
GGAAAGTCTG AGTGGTCGGA TGCCTCCCAG AAGTCCCCTG TGCATGTCGG AGAGACGAGG 2460
AAGGAGGATG ACCCCAATGA AGACTGGTGT GCTGTTTGTC AAAATGGTGG GGAACTCCTA 2520
TGCTGTGAGA AATGTCCTAA AGTATTCCAT CTTACTTGTC ATGTGCCCAC CTTGACAAAT 2580
TTTCCAAGTG GAGAATGGAT CTGTACTTTC TGCCGAGACT TATCTAAGCC AGAGGTTGAC 2640
TATGATTGTG ATGTTCCCAG TCACCACTCA GAGAAACGGA AAAGTGAAGG CCTTACTAAG 2700
TTAACGCCAA TAGACAAAAG GAAATGTGAA CGCCTACTTC TGTTTCTTTA CTGCCATGAA 2760
ATGAGCCTGG CTTTCCAAGA CCCTGTTCCT CTAACTGTGC CTGATTATTA TAAAATAATT 2820
AAAAACCCAA TGGACTTGTC AACCATCAAG AAAAGACTTC AGGAGGATTA TTGCATGTAT 2880
ACAAAGCCTG AAGACTTTGT AGCTGATTTT AGATTGATCT TTCAAAACTG TGCTGAATTC 2940
AATGAGCCTG ATTCTGAAGT AGCCAATGCT GGTATAAAAC TTGAAAGCTA TTTTGAAGAA 3000
CTTCTAAAGA ATCTTTATCC AGAAAAAAGG TTTCCTAAGG TAGAATTCAG GCATGAAGCA 3060
GAAGACTGTA AGTTCAGTGA CGACTCAGAC GATGACTTTG TACAGCCCCG GAAGAAGCGT 3120
CTCAAGAGCA CCGAGGATCG CCAGCTGCTT AAGTAA 3156
Domain Profile
N/A
Domain Sequence
(FASTA)
N/A
KeywordAlternative splicing; Bromodomain; Chromosomal rearrangement; Coiled coil; Complete proteome; Cytoplasm; DNA-binding; Isopeptide bond; Ligase; Metal-binding; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Tumor suppressor; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-BOT-00500
EKS-CAJ-00510
EKS-CAF-00498
EKS-CAP-00534
EKS-EQC-00488
EKS-FEC-00477
EKS-GAG-00418
EKS-GOG-00494
EKS-HOS-00506
EKS-ICT-00475
EKS-LOA-00507
EKS-MAM-00493
EKS-MEG-00405
EKS-MOD-00490
EKS-MUP-00485
EKS-MYL-00490
EKS-NOL-00457
EKS-ORA-00432
EKS-ORC-00468
EKS-OTG-00505
EKS-PAT-00469
EKS-PES-00433
EKS-POA-00486
EKS-RAN-00511
EKS-SAH-00466
EKS-SOA-00069
EKS-TAG-00563
EKS-TAS-00080
EKS-TEN-00623
EKS-XET-00651
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005719; C:nuclear euchromatin
GO:0005726; C:perichromatin fibrils
GO:0003682; F:chromatin binding
GO:0034056; F:estrogen response element binding
GO:0070577; F:histone acetyl-lysine binding
GO:0016922; F:ligand-dependent nuclear receptor binding
GO:0004672; F:protein kinase activity
GO:0043565; F:sequence-specific DNA binding
GO:0003713; F:transcription coactivator activity
GO:0004842; F:ubiquitin-protein ligase activity
GO:0008270; F:zinc ion binding
GO:0055074; P:calcium ion homeostasis
GO:0071391; P:cellular response to estrogen stimulus
GO:0008285; P:negative regulation of cell proliferation
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0046777; P:protein autophosphorylation
GO:0030163; P:protein catabolic process
GO:0042981; P:regulation of apoptotic process
GO:0031647; P:regulation of protein stability
GO:0070562; P:regulation of vitamin D receptor signaling pathway
GO:0006351; P:transcription, DNA-dependent
KEGG
mmu:21848;
InterPros
IPR003649; Bbox_C.
IPR001487; Bromodomain.
IPR018359; Bromodomain_CS.
IPR019786; Zinc_finger_PHD-type_CS.
IPR000315; Znf_B-box.
IPR011011; Znf_FYVE_PHD.
IPR001965; Znf_PHD.
IPR019787; Znf_PHD-finger.
IPR001841; Znf_RING.
IPR013083; Znf_RING/FYVE/PHD.
IPR017907; Znf_RING_CS.
Pfam
PF00439; Bromodomain; 1.
PF00628; PHD; 1.
PF00643; zf-B_box; 2.
SMARTs
SM00502; BBC; 1.
SM00336; BBOX; 2.
SM00297; BROMO; 1.
SM00249; PHD; 1.
SM00184; RING; 1.
Prosites
PS00633; BROMODOMAIN_1; 1.
PS50014; BROMODOMAIN_2; 1.
PS50119; ZF_BBOX; 2.
PS01359; ZF_PHD_1; 1.
PS50016; ZF_PHD_2; 1.
PS00518; ZF_RING_1; 1.
PS50089; ZF_RING_2; 1.
Prints
PR00503; BROMODOMAIN.
Created Date20-Feb-2013