EKS-MUM-00013
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00013
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph383.58.8E-115663907245
StatusReviewed
Ensembl ProteinENSMUSP00000110380
UniProt AccessionO08644; Q3TQ77; Q8BN76; Q8K0A9;
Protein NameEphrin type-B receptor 6
Protein Synonyms/Alias MEP; Tyrosine-protein kinase-defective receptor EPH-6;
Gene NameEphb6
Gene Synonyms/Alias Ephb6; Cekl;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000029869ENSMUSP00000110380ENSMUST00000114732
ENSMUSG00000029869ENSMUSP00000133131ENSMUST00000167082
ENSMUSG00000029869ENSMUSP00000132773ENSMUST00000167497
OrganismMus musculus
Functional DescriptionKinase-defective receptor for members of the ephrin-Bfamily. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity).
Protein Length1014
Protein Sequence
(FASTA)
MATEGTTGSG SRVVAGMVCS LWLLVLGSSV LALEEVLLDT TGETSEIGWL TYPPGGWDEV 60
SVLDDQRRLT RTFEACHVAG LPPGSGQDNW LQTHFVERRG AQRAHIRLHF SVRACSSLGV 120
SGGTCRETFT LYYRQADEPD GPDSIAAWHL KRWTKVDTIA ADESFPASSS SSSWAVGPHR 180
TGQRVGLQLN VKERSFGPLT QRGFYVAFQD TGACLALVAV KLFSYTCPSV LRAFASFPET 240
QASGAGGASL VAAVGTCVAH AEPEEDGVGG QAGGSPPRLH CNGEGRWMVA VGGCRCQPGH 300
QPARGDKLCQ ACPEGSYKAL AGNVPCSPCP ARSHSPDPAA PVCPCLQGFY RASSDPPEAP 360
CTGPPSAPRE LWFEVQGSAL MLHWRLPQEL GGRGDLLFNV VCKECGGHGE PSSGGMCRRC 420
RDEVHFDPRQ RGLTESRVLV GGLRAHVPYI LEVQAVNGVS ELSPDPPQAA AINVSTSHEV 480
PSAVPVMHQV SRAANSITVS WPQPEQTNGN ILDYQLRYYD QAEDESHSFT MTSETNTATV 540
TRLSPGHIYG FQVRARTAAG HGPYGGKVYF QTLPQGELSS QLPEKLSLVI GSILGALAFL 600
LLAAITVLAV IFQRKRRGTG YTEQLQQYSS PGLGVKYYID PSTYDDPCQA IRELAREVDP 660
TYIKIEEVIG AGSFGEVRRG RLQPRGRREQ AVAIQALWAG GAESLKMTFL GRAALLGQFQ 720
HPNILRLEGV VTKSRPVMVL TELMELGPLD SFLRQREGQF SSLQLVAMQR GVAAAMQYLS 780
SFAFVHRALS ARSVLVNSHL VCKVARLGHS PQGSSSLLRW AAPEVITHGK YTTSSDVWSF 840
GILMWEVMSY GERPYWDMNE QEVLNAIEQE FRLPPPPGCP PGLHLLMLDT WQKDRARRPH 900
FDQLVAAFDK MIRKPDTLQA EGGSGDRPSQ ALLNPVALDF PCLDSPQAWL SAIGLECYQD 960
NFSKFGLSTF SDVAQLSLED LPGLGITLAG HQKKLLHNIQ LLQQHLRQPG SVEV 1014
Nucleotide Sequence
(FASTA)
ATGGCTACTG AGGGCACGAC TGGCTCAGGG AGCAGAGTGG TGGCGGGCAT GGTGTGCAGT 60
CTGTGGCTCC TGGTTCTAGG GTCATCAGTT CTAGCTCTGG AAGAGGTGCT GCTGGATACC 120
ACAGGAGAGA CCTCTGAGAT TGGCTGGCTC ACCTACCCGC CAGGTGGGTG GGATGAGGTG 180
AGTGTTCTAG ATGACCAGCG CCGTCTGACT CGGACCTTCG AAGCATGCCA CGTTGCAGGG 240
CTCCCTCCTG GTTCTGGCCA GGACAATTGG CTGCAGACAC ACTTTGTGGA ACGGCGAGGG 300
GCCCAGAGGG CACACATCCG CCTTCACTTC TCTGTACGAG CCTGTTCCAG CCTGGGTGTG 360
AGTGGGGGTA CCTGCCGAGA GACCTTCACC CTTTACTACC GGCAGGCTGA TGAGCCAGAC 420
GGCCCCGACA GTATTGCGGC CTGGCACCTC AAACGCTGGA CCAAAGTGGA CACAATTGCC 480
GCAGATGAGA GCTTCCCTGC CTCCTCTTCC TCTTCCTCAT GGGCTGTGGG ACCCCACAGG 540
ACCGGTCAGC GGGTGGGACT GCAGCTGAAT GTCAAAGAGC GCAGCTTTGG TCCTCTCACT 600
CAGCGTGGCT TCTATGTGGC CTTCCAGGAC ACAGGGGCCT GCCTGGCCCT TGTGGCAGTC 660
AAGCTCTTCT CCTACACCTG TCCCTCCGTC CTGCGTGCCT TTGCCTCTTT TCCTGAGACA 720
CAGGCCAGTG GAGCTGGAGG GGCTTCCTTA GTGGCAGCTG TGGGCACCTG TGTAGCTCAT 780
GCAGAACCAG AGGAGGATGG AGTAGGAGGC CAGGCAGGGG GCAGCCCCCC AAGGTTACAC 840
TGTAATGGCG AAGGCAGGTG GATGGTAGCT GTGGGAGGCT GCCGCTGCCA GCCTGGACAC 900
CAGCCTGCTC GTGGAGACAA GCTCTGCCAA GCCTGCCCTG AGGGATCCTA TAAGGCCCTG 960
GCTGGGAATG TTCCCTGTTC ACCGTGTCCA GCCCGCAGCC ACTCCCCTGA CCCTGCAGCC 1020
CCAGTTTGCC CATGTCTCCA AGGCTTCTAC AGGGCCAGTT CGGACCCACC AGAGGCTCCC 1080
TGCACTGGTC CTCCATCGGC TCCCCGGGAG CTATGGTTTG AGGTGCAAGG CTCGGCACTC 1140
ATGCTGCACT GGCGTCTGCC TCAGGAGCTG GGTGGACGAG GGGATCTGCT CTTCAATGTT 1200
GTGTGCAAGG AGTGTGGAGG TCACGGAGAG CCCAGCAGTG GGGGGATGTG TCGCCGCTGC 1260
AGGGACGAGG TGCATTTCGA CCCCCGCCAG AGGGGACTGA CTGAGAGTCG AGTGTTAGTT 1320
GGGGGGCTCC GAGCACACGT GCCATACATC TTGGAAGTGC AGGCTGTCAA TGGGGTGTCT 1380
GAGCTCAGCC CTGACCCTCC CCAGGCAGCA GCCATCAATG TCAGCACCAG CCACGAAGTC 1440
CCTTCTGCAG TCCCTGTGAT GCACCAGGTG AGCCGGGCAG CCAACAGCAT CACAGTATCC 1500
TGGCCACAGC CTGAGCAAAC AAATGGGAAC ATCCTCGACT ACCAGCTGCG CTACTATGAC 1560
CAGGCAGAAG ATGAATCCCA CTCCTTCACC ATGACCAGTG AGACCAACAC TGCCACTGTG 1620
ACACGGTTGA GCCCTGGCCA CATCTATGGC TTCCAGGTGC GGGCACGGAC TGCAGCTGGC 1680
CACGGCCCCT ATGGGGGCAA AGTCTATTTT CAGACATTGC CTCAAGGTGA GCTGTCCTCC 1740
CAGCTTCCAG AGAAGCTGTC CTTGGTGATT GGTTCCATCC TGGGGGCCTT GGCCTTCCTT 1800
CTACTGGCAG CCATCACTGT ACTGGCTGTC ATCTTCCAGC GGAAGCGCCG TGGGACCGGC 1860
TACACAGAAC AACTGCAACA ATACAGCAGC CCAGGACTTG GAGTGAAGTA TTACATTGAC 1920
CCTTCTACAT ACGATGACCC CTGCCAGGCC ATCAGAGAGC TTGCTCGAGA GGTTGACCCT 1980
ACATATATCA AGATTGAAGA AGTCATTGGG GCAGGTTCCT TTGGAGAAGT GCGTCGGGGC 2040
CGACTGCAAC CCCGGGGAAG GAGGGAACAA GCTGTGGCTA TCCAGGCCTT GTGGGCAGGG 2100
GGTGCTGAGA GCCTGAAGAT GACCTTTCTG GGTCGGGCAG CACTGCTGGG CCAGTTCCAG 2160
CACCCCAATA TCCTGCGGCT GGAAGGTGTA GTCACTAAGA GTCGGCCTGT CATGGTGCTG 2220
ACAGAACTCA TGGAACTTGG TCCCCTGGAC AGCTTTCTTA GGCAGCGAGA GGGCCAGTTC 2280
AGTAGCCTGC AGCTGGTGGC CATGCAGCGG GGTGTGGCTG CTGCCATGCA GTACTTGTCC 2340
AGCTTTGCCT TTGTTCACCG AGCACTCTCG GCCCGAAGTG TGCTAGTGAA TAGCCACCTG 2400
GTGTGTAAGG TGGCACGTCT CGGCCACAGT CCTCAGGGTT CAAGTTCCTT GCTTCGCTGG 2460
GCAGCCCCAG AGGTCATTAC ACATGGAAAG TATACAACAT CTAGCGATGT CTGGAGCTTT 2520
GGCATACTCA TGTGGGAAGT GATGAGCTAT GGAGAACGGC CCTACTGGGA CATGAACGAG 2580
CAGGAGGTAC TAAATGCAAT AGAGCAAGAG TTCCGGCTGC CCCCACCTCC AGGGTGCCCC 2640
CCTGGACTAC ATCTACTGAT GCTAGACACT TGGCAGAAGG ACCGTGCCCG TCGGCCTCAT 2700
TTTGACCAGC TGGTAGCTGC ATTTGACAAG ATGATTCGCA AGCCTGATAC TCTCCAGGCT 2760
GAAGGGGGCT CCGGGGACAG GCCTTCCCAG GCTCTTCTGA ACCCTGTGGC CTTGGACTTC 2820
CCTTGCCTGG ACTCTCCCCA GGCCTGGCTT TCAGCCATTG GACTAGAGTG CTACCAGGAC 2880
AACTTCTCCA AGTTTGGTCT TTCCACCTTC AGTGATGTGG CTCAGCTCAG CCTGGAAGAC 2940
CTGCCAGGCC TGGGCATCAC CCTAGCTGGC CACCAGAAGA AACTTCTGCA CAACATTCAG 3000
CTCCTCCAGC AGCACCTGAG GCAGCCAGGC TCAGTGGAAG TGTAA 3045
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kie+viGaG+fGev++Grl+ +g+re+avai++l+ag +e+ +++fl +a++lGqf+hp
Q: 663   IKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQFQHP  722
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         ni+rleGvvtks+pvm++te me g ldsflr+++gqf+++qlv+m+rG+a++m+yls++
Q: 723   NILRLEGVVTKSRPVMVLTELMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSF  782
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         ++vhr l+ar++lvns+lvckv+++G+s++            g+++ +rw+ape+i+++k
Q: 783   AFVHRALSARSVLVNSHLVCKVARLGHSPQ------------GSSSLLRWAAPEVITHGK  830
         ****************************98............8999**************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         +t++sdvws+Gi++wev+syGerpywdm++q+v++aie+++rlppp +cp +l+ lmld+
Q: 831   YTTSSDVWSFGILMWEVMSYGERPYWDMNEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDT  890
         ************************************************************
S: 241   wqkdraerpkfeqivsi  257
         wqkdra+rp+f+q+v++
Q: 891   WQKDRARRPHFDQLVAA  907
         **************986
Domain Sequence
(FASTA)
IKIEEVIGAG SFGEVRRGRL QPRGRREQAV AIQALWAGGA ESLKMTFLGR AALLGQFQHP 60
NILRLEGVVT KSRPVMVLTE LMELGPLDSF LRQREGQFSS LQLVAMQRGV AAAMQYLSSF 120
AFVHRALSAR SVLVNSHLVC KVARLGHSPQ GSSSLLRWAA PEVITHGKYT TSSDVWSFGI 180
LMWEVMSYGE RPYWDMNEQE VLNAIEQEFR LPPPPGCPPG LHLLMLDTWQ KDRARRPHFD 240
QLVAA 245
KeywordAlternative splicing; ATP-binding; Cell membrane; Complete proteome; Glycoprotein; Membrane; Nucleotide-binding; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00013
EKS-CAJ-00013
EKS-CAF-00013
EKS-CAP-00012
EKS-EQC-00013
EKS-FEC-00010
EKS-GOG-00014
EKS-HOS-00014
EKS-ICT-00014
EKS-MAM-00012
EKS-MOD-00012
EKS-MUP-00014
EKS-NOL-00013
EKS-ORC-00013
EKS-OTG-00014
EKS-PAT-00011
EKS-POA-00012
EKS-RAN-00013
EKS-SAH-00012
EKS-SUS-00012
Gene Ontology
GO:0005576; C:extracellular region
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
GO:0055074; P:calcium ion homeostasis
GO:0035898; P:parathyroid hormone secretion
KEGG
mmu:13848;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR011510; SAM_2.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013