| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00018 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/PHK | 527.5 | 1.6E-158 | 24 | 291 | 268 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000033086 |
| UniProt Accession | Q9DB30; A6H632; |
| Protein Name | Phosphorylase b kinase gamma catalytic chain, testis/liver isoform |
| Protein Synonyms/Alias | PHK-gamma-T; Phosphorylase kinase subunit gamma-2; Serine/threonine-protein kinase PHKG2; |
| Gene Name | Phkg2 |
| Gene Synonyms/Alias | Phkg2; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Catalytic subunit of the phosphorylase b kinase (PHK),which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase (PYGB, PYGL or PYGM). May regulate glycogeneolysis in the testis. In vitro, phosphorylates TNNI3, TNNT2, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). |
| Protein Length | 406 |
Protein Sequence
(FASTA) | | MTLDVGPEDE LPDWAAAKEF YQKYDPKDII GRGVSSVVRR CVHRATGDEF AVKIMEVSAE 60 | | RLSLEQLEEV RDATRREMHI LRQVAGHPHI ITLIDSYESS SFMFLVFDLM RKGELFDYLT 120 | | EKVALSEKET RSIMRSLLEA VSFLHANNIV HRDLKPENIL LDDNMQIRLS DFGFSCHLEA 180 | | GEKLRELCGT PGYLAPEILK CSMDETHPGY GKEVDLWACG VILFTLLAGS PPFWHRRQIL 240 | | MLRMIMEGQY QFTSPEWDDR SNTVKDLISK LLQVDPEARL TAEQALQHPF FERCEGSQPW 300 | | NLTPRQRFRV AVWTILAAGR VALSSHRLRP LTKNALLRDP YALRPVRRLI DNCAFRLYGH 360 | | WVKKGEQQNR AALFQHQPPR LFPIAATELE GDSGAITEDE ATLVRS 406 |
|
Nucleotide Sequence
(FASTA) | | ATGACGTTGG ACGTGGGGCC GGAGGATGAA CTCCCTGACT GGGCTGCGGC CAAAGAGTTT 60 | | TACCAGAAGT ACGACCCTAA GGACATCATT GGCAGAGGAG TGAGCTCTGT GGTCCGCCGC 120 | | TGTGTCCATC GAGCTACCGG TGATGAGTTC GCAGTGAAGA TCATGGAGGT GTCAGCTGAG 180 | | CGGCTGAGTC TTGAGCAGCT GGAGGAGGTG CGGGATGCCA CACGGCGAGA GATGCACATT 240 | | CTTCGCCAGG TCGCTGGCCA CCCCCATATC ATCACCCTCA TCGATTCCTA CGAGTCTTCT 300 | | AGCTTCATGT TCCTGGTGTT TGACCTGATG CGGAAAGGAG AGCTGTTTGA CTATCTCACC 360 | | GAGAAAGTGG CCCTCTCAGA AAAGGAAACC AGGTCCATCA TGAGGTCTCT ACTGGAAGCA 420 | | GTGAGCTTTC TCCATGCCAA CAACATTGTA CATCGAGACC TGAAGCCTGA GAATATTCTC 480 | | CTAGATGACA ATATGCAGAT ACGCCTTTCA GATTTTGGGT TCTCCTGCCA TTTGGAAGCT 540 | | GGCGAGAAGC TTCGAGAACT GTGCGGGACT CCAGGGTATC TAGCACCAGA GATCCTTAAA 600 | | TGCTCCATGG ATGAAACCCA CCCAGGCTAT GGCAAGGAAG TTGATCTCTG GGCTTGTGGG 660 | | GTGATCCTGT TCACACTTCT GGCTGGCTCA CCACCATTCT GGCACCGGCG CCAAATCCTG 720 | | ATGCTACGCA TGATCATGGA AGGCCAATAT CAGTTTACTT CACCTGAGTG GGATGATCGT 780 | | TCAAACACCG TCAAAGACCT GATCTCCAAG CTGCTGCAGG TGGATCCTGA AGCGCGCCTG 840 | | ACAGCTGAGC AAGCCCTGCA GCACCCCTTC TTTGAGCGCT GTGAAGGCAG CCAACCTTGG 900 | | AACCTCACGC CTCGCCAGCG GTTCCGGGTG GCAGTGTGGA CAATACTGGC TGCCGGACGA 960 | | GTGGCCTTAA GCAGTCACCG TTTACGGCCA CTAACTAAGA ATGCACTATT GAGAGACCCC 1020 | | TATGCACTGC GGCCAGTACG GCGCCTCATC GACAACTGTG CCTTCCGGCT CTATGGGCAC 1080 | | TGGGTAAAGA AGGGTGAGCA GCAGAACCGG GCAGCCCTCT TCCAGCACCA GCCTCCTAGG 1140 | | CTGTTCCCCA TTGCTGCCAC TGAACTCGAA GGAGACTCCG GTGCCATCAC AGAGGATGAG 1200 | | GCTACACTGG TACGGAGCTA G 1221 |
|
| Domain Profile | S: 1 yepkeilGrGvssvvrrciekatgqefavkiidvsaeklseeevkelreatlkeveilrq 60 | y+pk+i+GrGvssvvrrc+++atg+efavki++vsae+ls e+++e+r+at++e++ilrq | Q: 24 YDPKDIIGRGVSSVVRRCVHRATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQ 83 | 9*********************************************************** |
| S: 61 vsGhpsiiklkdvyesssflflvfdlmkkGelfdyltekvtlseketrkimralleavey 120 | v+Ghp+ii+l+d+yesssf+flvfdlm+kGelfdyltekv+lseketr+imr+lleav++ | Q: 84 VAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSF 143 | ************************************************************ |
| S: 121 lhaknivhrdlkpenillddneniklsdfGfstqleeGeklrelcGtpgylapeilkcsm 180 | lha+nivhrdlkpenillddn++i+lsdfGfs++le+GeklrelcGtpgylapeilkcsm | Q: 144 LHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEAGEKLRELCGTPGYLAPEILKCSM 203 | ************************************************************ |
| S: 181 deeapGyskevdlwalGvilytllaGsppfwhrkqllmlrlimeGkyqftspewddisee 240 | de++pGy+kevdlwa+Gvil+tllaGsppfwhr+q+lmlr+imeG+yqftspewdd+s++ | Q: 204 DETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFTSPEWDDRSNT 263 | ************************************************************ |
| S: 241 vkdliskllvvdpekrltaeealahpff 268 | vkdliskll+vdpe+rltae+al+hpff | Q: 264 VKDLISKLLQVDPEARLTAEQALQHPFF 291 | ***************************8 |
|
Domain Sequence
(FASTA) | | YDPKDIIGRG VSSVVRRCVH RATGDEFAVK IMEVSAERLS LEQLEEVRDA TRREMHILRQ 60 | | VAGHPHIITL IDSYESSSFM FLVFDLMRKG ELFDYLTEKV ALSEKETRSI MRSLLEAVSF 120 | | LHANNIVHRD LKPENILLDD NMQIRLSDFG FSCHLEAGEK LRELCGTPGY LAPEILKCSM 180 | | DETHPGYGKE VDLWACGVIL FTLLAGSPPF WHRRQILMLR MIMEGQYQFT SPEWDDRSNT 240 | | VKDLISKLLQ VDPEARLTAE QALQHPFF 268 |
|
| Keyword | ATP-binding; Calmodulin-binding; Carbohydrate metabolism; Complete proteome; Glycogen metabolism; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |