EKS-MUM-00151
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00151
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR559.13.3E-168269545277
StatusUnreviewed
Ensembl ProteinENSMUSP00000113452
UniProt AccessionE9QK53;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFgfr2
Gene Synonyms/Alias Fgfr2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000030849ENSMUSP00000113415ENSMUST00000120141
ENSMUSG00000030849ENSMUSP00000112471ENSMUST00000118296
ENSMUSG00000030849ENSMUSP00000112992ENSMUST00000117089
ENSMUSG00000030849ENSMUSP00000112672ENSMUST00000117073
ENSMUSG00000030849ENSMUSP00000113248ENSMUST00000120187
ENSMUSG00000030849ENSMUSP00000113474ENSMUST00000120715
ENSMUSG00000030849ENSMUSP00000112580ENSMUST00000117357
ENSMUSG00000030849ENSMUSP00000120100ENSMUST00000153166
ENSMUSG00000030849ENSMUSP00000122856ENSMUST00000127091
ENSMUSG00000030849ENSMUSP00000113010ENSMUST00000119260
ENSMUSG00000030849ENSMUSP00000112430ENSMUST00000122054
ENSMUSG00000030849ENSMUSP00000113452ENSMUST00000121064
ENSMUSG00000030849ENSMUSP00000112585ENSMUST00000121080
ENSMUSG00000030849ENSMUSP00000130971ENSMUST00000124096
ENSMUSG00000030849ENSMUSP00000113180ENSMUST00000117691
ENSMUSG00000030849ENSMUSP00000112623ENSMUST00000117858
ENSMUSG00000030849ENSMUSP00000113993ENSMUST00000122448
ENSMUSG00000030849ENSMUSP00000113994ENSMUST00000117872
ENSMUSG00000030849ENSMUSP00000113187ENSMUST00000117754
OrganismMus musculus
Functional Description
Protein Length609
Protein Sequence
(FASTA)
MVSWGRFICL VLVTMATLSL ARPSFSLVED TTLEPEERSP HRPILQAGLP ANASTVVGGD 60
VEFVCKVYSD AQPHIQWIKH VEKNGSKYGP DGLPYLKVLK HSGINSSNAE VLALFNVTEM 120
DAGEYICKVS NYIGQANQSA WLTVLPKQQA PVREKEITAS PDYLEIAIYC IGVFLIACMV 180
VTVIFCRMKT TTKKPDFSSQ PAVHKLTKRI PLRRQVTVSA ESSSSMNSNT PLVRITTRLS 240
STADTPMLAG VSEYELPEDP KWEFPRDKLT LGKPLGEGCF GQVVMAEAVG IDKDKPKEAV 300
TVAVKMLKDD ATEKDLSDLV SEMEMMKMIG KHKNIINLLG ACTQDGPLYV IVEYASKGNL 360
REYLRARRPP GMEYSYDINR VPEEQMTFKD LVSCTYQLAR GMEYLASQKC IHRDLAARNV 420
LVTENNVMKI ADFGLARDIN NIDYYKKTTN GRLPVKWMAP EALFDRVYTH QSDVWSFGVL 480
MWEIFTLGGS PYPGIPVEEL FKLLKEGHRM DKPTNCTNEL YMMMRDCWHA VPSQRPTFKQ 540
LVEDLDRILT LTTNEEYLDL TQPLEQYSPS YPDTRSSCSS GDDSVFSPDP MPYEPCLPQY 600
PHINGSVKT 609
Nucleotide Sequence
(FASTA)
ATGGTCAGCT GGGGGCGCTT CATCTGCCTG GTCTTGGTCA CCATGGCAAC CTTGTCCCTG 60
GCCCGGCCCT CCTTCAGTTT AGTTGAGGAT ACCACTTTAG AACCAGAAGA ACGGTCACCA 120
CACCGGCCCA TCCTCCAAGC TGGACTGCCT GCAAATGCCT CCACGGTGGT CGGAGGGGAT 180
GTGGAGTTTG TCTGCAAGGT TTACAGCGAT GCCCAGCCCC ACATCCAGTG GATCAAGCAC 240
GTGGAAAAGA ACGGCAGTAA ATACGGGCCT GATGGGCTGC CCTACCTCAA GGTCCTGAAG 300
CACTCGGGGA TAAATAGCTC CAATGCAGAA GTGCTGGCTC TGTTCAATGT GACGGAGATG 360
GATGCTGGGG AATATATATG TAAGGTCTCC AATTATATAG GGCAGGCCAA CCAGTCTGCC 420
TGGCTCACTG TCCTGCCCAA ACAGCAAGCG CCTGTGAGAG AGAAGGAGAT CACGGCTTCC 480
CCAGATTATC TGGAGATAGC TATTTACTGC ATAGGGGTCT TCTTAATCGC CTGCATGGTG 540
GTGACAGTCA TCTTTTGCCG AATGAAGACC ACGACCAAGA AGCCAGACTT CAGCAGCCAG 600
CCAGCTGTGC ACAAGCTGAC CAAGCGCATC CCCCTGCGGA GACAGGTAAC AGTTTCGGCC 660
GAGTCCAGCT CCTCCATGAA CTCCAACACC CCGCTGGTGA GGATAACAAC GCGTCTGTCC 720
TCAACAGCGG ACACCCCGAT GCTAGCAGGG GTCTCCGAGT ATGAGTTGCC AGAGGATCCA 780
AAGTGGGAAT TCCCCAGAGA TAAGCTGACG CTGGGCAAAC CCCTGGGGGA AGGTTGCTTC 840
GGGCAAGTAG TCATGGCTGA AGCAGTGGGA ATCGATAAAG ACAAACCCAA GGAGGCGGTC 900
ACCGTGGCAG TGAAGATGTT GAAAGATGAT GCCACAGAGA AGGACCTGTC TGATCTGGTA 960
TCAGAGATGG AGATGATGAA GATGATTGGG AAACATAAGA ACATTATCAA CCTCCTGGGG 1020
GCCTGCACGC AGGATGGACC TCTCTACGTC ATAGTTGAAT ATGCATCGAA AGGCAACCTC 1080
CGGGAATACC TCCGAGCCCG GAGGCCACCT GGCATGGAGT ACTCCTATGA CATTAACCGT 1140
GTCCCCGAGG AGCAGATGAC CTTCAAGGAC TTGGTGTCCT GCACCTACCA GCTGGCTAGA 1200
GGCATGGAGT ACTTGGCTTC CCAAAAATGT ATCCATCGAG ATTTGGCTGC CAGAAACGTG 1260
TTGGTAACAG AAAACAATGT GATGAAGATA GCAGACTTTG GCCTGGCCAG GGATATCAAC 1320
AACATAGACT ACTATAAAAA GACCACAAAT GGGCGACTTC CAGTCAAGTG GATGGCTCCT 1380
GAAGCCCTTT TTGATAGAGT TTACACTCAT CAGAGCGATG TCTGGTCCTT CGGGGTGTTA 1440
ATGTGGGAGA TCTTTACTTT AGGGGGCTCA CCCTACCCAG GGATTCCCGT GGAGGAACTT 1500
TTTAAGCTGC TCAAAGAGGG ACACAGGATG GACAAGCCCA CCAACTGCAC CAATGAACTG 1560
TACATGATGA TGAGGGATTG CTGGCATGCT GTACCCTCAC AGAGACCCAC ATTCAAGCAG 1620
TTGGTCGAAG ACTTGGATCG AATTCTGACT CTCACAACCA ATGAGGAATA CTTGGATCTC 1680
ACCCAGCCTC TCGAACAGTA TTCTCCTAGT TACCCCGACA CAAGGAGCTC TTGTTCTTCA 1740
GGGGACGATT CTGTGTTTTC TCCAGACCCC ATGCCTTATG AACCCTGTCT GCCTCAGTAT 1800
CCACACATAA ACGGCAGTGT TAAAACATGA 1830
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+
Q: 269   LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  328
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d ++++eeq+t+
Q: 329   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF  388
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt
Q: 389   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  448
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh
Q: 449   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  508
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl
Q: 509   RMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  545
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 120
KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPTNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00139
EKS-ANC-00140
EKS-BOT-00148
EKS-CAJ-00155
EKS-CAF-00154
EKS-CAP-00147
EKS-EQC-00145
EKS-FEC-00140
EKS-GAG-00125
EKS-GOG-00147
EKS-ICT-00144
EKS-LOA-00149
EKS-MAM-00147
EKS-MEG-00115
EKS-MOD-00147
EKS-MUP-00151
EKS-OTG-00152
EKS-PAT-00137
EKS-PES-00132
EKS-POA-00143
EKS-PTV-00139
EKS-RAN-00145
EKS-SAH-00142
EKS-TAG-00176
Gene Ontology
GO:0005938; C:cell cortex
GO:0009986; C:cell surface
GO:0031012; C:extracellular matrix
GO:0005576; C:extracellular region
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0017134; F:fibroblast growth factor binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0001525; P:angiogenesis
GO:0007409; P:axonogenesis
GO:0030282; P:bone mineralization
GO:0060667; P:branch elongation involved in salivary gland morphogenesis
GO:0060670; P:branching involved in labyrinthine layer morphogenesis
GO:0048755; P:branching morphogenesis of a nerve
GO:0060449; P:bud elongation involved in lung branching
GO:0045165; P:cell fate commitment
GO:0060365; P:coronal suture morphogenesis
GO:0048557; P:embryonic digestive tract morphogenesis
GO:0009880; P:embryonic pattern specification
GO:0061031; P:endodermal digestive tract morphogenesis
GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060595; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0031069; P:hair follicle morphogenesis
GO:0032808; P:lacrimal gland development
GO:0060601; P:lateral sprouting from an epithelium
GO:0070307; P:lens fiber cell development
GO:0060174; P:limb bud formation
GO:0048286; P:lung alveolus development
GO:0060463; P:lung lobe morphogenesis
GO:0060484; P:lung-associated mesenchyme development
GO:0060615; P:mammary gland bud formation
GO:0003149; P:membranous septum morphogenesis
GO:0060915; P:mesenchymal cell differentiation involved in lung development
GO:0060916; P:mesenchymal cell proliferation involved in lung development
GO:0030901; P:midbrain development
GO:0035264; P:multicellular organism growth
GO:0008285; P:negative regulation of cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0007528; P:neuromuscular junction development
GO:0042476; P:odontogenesis
GO:0035265; P:organ growth
GO:0030916; P:otic vesicle formation
GO:0003148; P:outflow tract septum morphogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0051781; P:positive regulation of cell division
GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0010518; P:positive regulation of phospholipase activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009791; P:post-embryonic development
GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523; P:prostate epithelial cord elongation
GO:0046777; P:protein autophosphorylation
GO:0060687; P:regulation of branching involved in prostate gland morphogenesis
GO:0010453; P:regulation of cell fate commitment
GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0040014; P:regulation of multicellular organism growth
GO:0051150; P:regulation of smooth muscle cell differentiation
GO:0008589; P:regulation of smoothened signaling pathway
GO:0060529; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0048489; P:synaptic vesicle transport
GO:0001657; P:ureteric bud development
GO:0055010; P:ventricular cardiac muscle tissue morphogenesis
KEGG
mmu:14183;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013