EKS-MUM-00319
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00319
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/IRE450.06.4E-135508768261
StatusReviewed
Ensembl ProteinENSMUSP00000033153
UniProt AccessionQ9Z2E3; Q3U5E3;
Protein NameEndoribonuclease
Protein Synonyms/Alias Endoplasmic reticulum-to-nucleus signaling 2; Inositol-requiring protein 2; Ire1-beta; IRE1b; mIre1;
Gene NameErn2
Gene Synonyms/Alias Ern2; Ire2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000030866ENSMUSP00000033153ENSMUST00000033153
OrganismMus musculus
Functional DescriptionRole in expression of the DDIT3 transcription factor,required for the unfolded-protein response, growth arrest and apoptosis. Has no effect on 28S ribosomal RNA cleavage, unlike the corresponding human protein.
Protein Length911
Protein Sequence
(FASTA)
MARPVQRFQL WSPLGFLLQL VTLLGKLGPQ VQSVRPESLL FVSTLDGSLH ALNKQTGDLK 60
WTVKDDPIIQ GPMYVTEMAF LSDPADGSLY VLGTQKQQGL MKLPFTIPEL VHASPCRSSD 120
GVFYTGRKQD AWFVVDPESG ETQMTLTTEG LSTPQLFIGR TQYTVSMHDL RTPALRWNTT 180
YRRYSAPLLN GSPGKYMSHL TSCGMGLLLT VDPGSGIVLW TQDLGVPVTG IYTWHQDGLH 240
QLPHLTLARD TLHFLVLRWG HIRLPASSYQ DTATQFSSLD TQLLMTLYVG KEEAGFYVSK 300
ALVHAGVALV PRGLTLAPMD GPTTDEVTLQ VSGEREGSPS TAVRYPSGSV ALPSQWLLIG 360
YHEPPPVLHT TMLRVHPIPG KVSAETRASE DLHAPPVFFE LLNLRREDPE LHPEEKASDS 420
YPGLGSQDLL AATFTAILLG AWVLYLMRQQ QQSPSAPAGP PDLSQDAQGQ LSRDILQDQR 480
RFQSPSEPAQ PPHDPEAGQP TVVGKISFNP KDVLGRGAGG TFVFRGQFEG RAVAVKRLLR 540
ECFGLVRREV QLLQESDRHP NVLRYFCTEH GPQFHYIALE LCQASLQEYV ESPDLDRWGL 600
EPTTVLQQMM SGLAHLHSLH IVHRDLKPAN ILMAGPDSQG QGRVVISDFG LCKKLPVGRC 660
SFSLHSGIPG TEGWMAPELL QLPPDSPTSA VDIFSAGCVF YYVLSGGSHP FGESLYRQAN 720
ILSGDPCLAQ LQEETHDKVV ALDLVRAMLS LLPQDRPSAG WVLAHPLFWS RAKELQFFQD 780
VSDWLEKEPD QGPLVSALEA GSYKVVREDW HKHISAPLQA DLKRFRSYKG TSVRDLLRAM 840
RNKKHHYREL PAEVRQTLGQ LPAGFIQYFT QRFPRLLLHT HRAMRTCASE SLFLPYYPPA 900
LEARRPDATK S 911
Nucleotide Sequence
(FASTA)
ATGGCGAGAC CAGTCCAGAG ATTTCAACTG TGGTCTCCTC TCGGGTTCCT GCTGCAGCTT 60
GTGACGTTGC TGGGGAAACT CGGTCCACAG GTCCAGTCTG TCAGGCCAGA GAGCCTTCTG 120
TTTGTGTCTA CCTTGGACGG AAGTCTCCAT GCACTGAACA AGCAGACAGG GGACTTGAAG 180
TGGACAGTGA AGGATGACCC CATCATCCAG GGCCCAATGT ATGTCACAGA AATGGCCTTT 240
CTCTCTGACC CAGCTGACGG CAGCCTGTAT GTCTTGGGAA CCCAGAAACA ACAGGGGCTG 300
ATGAAACTGC CATTCACCAT CCCAGAGCTG GTTCATGCCT CTCCCTGTCG CAGCTCTGAT 360
GGTGTCTTCT ACACAGGCCG GAAGCAGGAT GCCTGGTTTG TAGTGGACCC TGAGTCAGGG 420
GAGACTCAGA TGACACTGAC CACAGAAGGC CTCTCTACTC CTCAACTTTT CATTGGCCGA 480
ACACAGTACA CAGTCTCCAT GCATGACCTA CGGACCCCAG CCCTGCGGTG GAACACAACC 540
TATCGCCGCT ACTCAGCACC CCTCCTGAAT GGCTCACCCG GGAAATACAT GAGCCACCTG 600
ACATCCTGTG GGATGGGCCT GCTTCTCACT GTGGATCCAG GAAGTGGAAT TGTGCTGTGG 660
ACACAGGACC TGGGAGTGCC TGTGACAGGG ATTTACACAT GGCACCAGGA TGGTCTGCAC 720
CAGCTGCCCC ATCTCACACT GGCTCGGGAC ACCCTACATT TCCTTGTCCT CCGCTGGGGC 780
CACATCCGTC TTCCTGCCTC CAGCTACCAA GACACAGCCA CCCAGTTCTC TTCCTTAGAC 840
ACCCAGCTTT TGATGACACT GTATGTGGGG AAAGAAGAAG CTGGGTTCTA TGTCTCTAAA 900
GCACTGGTCC ACGCTGGGGT GGCCCTCGTG CCCCGTGGAC TGACCCTGGC ACCCATGGAC 960
GGTCCCACAA CAGATGAGGT GACACTTCAA GTCTCGGGGG AGCGAGAGGG CTCACCCAGC 1020
ACTGCTGTCA GATACCCCTC AGGCAGCGTG GCCCTCCCCA GCCAGTGGCT ACTCATTGGA 1080
TACCACGAAC CTCCCCCCGT TCTACACACA ACCATGCTGC GGGTTCATCC CATCCCAGGG 1140
AAAGTGTCTG CTGAGACACG AGCCTCAGAG GACCTCCATG CTCCACCTGT CTTTTTTGAG 1200
CTCCTAAACC TGAGGAGGGA GGATCCAGAA CTACATCCTG AAGAGAAAGC TTCAGACTCT 1260
TATCCAGGGC TGGGATCCCA AGACCTGCTA GCAGCTACCT TCACTGCCAT CCTCCTGGGA 1320
GCCTGGGTCC TCTACCTGAT GAGGCAGCAG CAGCAGAGCC CTTCAGCACC TGCTGGCCCT 1380
CCTGACCTCT CACAGGATGC TCAGGGACAG CTCTCAAGGG ACATCTTACA GGACCAGAGG 1440
AGATTTCAAA GCCCCTCAGA GCCAGCCCAG CCACCTCATG ACCCTGAAGC AGGGCAGCCC 1500
ACCGTGGTGG GGAAGATTTC CTTCAACCCC AAGGATGTGC TGGGCCGTGG GGCAGGAGGG 1560
ACTTTTGTTT TCCGAGGACA GTTTGAGGGG CGGGCAGTAG CTGTGAAGAG GCTCCTCCGA 1620
GAGTGCTTTG GCTTGGTTCG GCGAGAGGTG CAGCTGCTGC AAGAGTCTGA CCGGCACCCC 1680
AACGTGCTTC GCTACTTCTG CACTGAGCAT GGTCCCCAGT TCCACTACAT TGCCTTGGAG 1740
CTCTGCCAGG CCTCCTTGCA AGAGTACGTG GAGAGCCCAG ACCTAGATCG CTGGGGCCTG 1800
GAGCCCACCA CAGTGCTGCA GCAGATGATG TCCGGCCTGG CCCATCTACA TTCCTTACAC 1860
ATAGTACACC GTGACCTAAA GCCAGCCAAC ATTCTCATGG CTGGGCCTGA CAGCCAGGGC 1920
CAAGGCAGAG TGGTCATCTC TGACTTCGGC CTCTGCAAGA AGCTACCTGT TGGCCGTTGT 1980
AGCTTCAGTC TCCATTCTGG TATTCCCGGC ACAGAAGGCT GGATGGCACC AGAGCTCCTG 2040
CAGCTCCCCC CAGACAGCCC GACCAGCGCT GTGGATATCT TCTCCGCAGG CTGCGTATTT 2100
TATTACGTGC TTTCCGGTGG CAGCCACCCC TTTGGAGAGA GTCTCTACCG ACAGGCCAAC 2160
ATCCTCTCAG GGGATCCCTG TCTGGCTCAG CTGCAGGAAG AGACCCATGA CAAGGTTGTG 2220
GCATTGGACT TAGTGAGAGC CATGCTGAGC TTGCTGCCCC AGGATCGCCC CTCGGCAGGA 2280
TGGGTACTGG CTCACCCCCT CTTTTGGAGC AGAGCTAAGG AGCTCCAGTT CTTCCAGGAT 2340
GTCAGTGACT GGTTGGAGAA GGAACCAGAT CAGGGGCCTC TCGTGTCGGC GCTGGAGGCA 2400
GGAAGCTACA AGGTGGTCCG GGAAGACTGG CACAAGCACA TCTCAGCCCC TCTGCAGGCA 2460
GATCTGAAAA GGTTCCGCTC ATACAAAGGG ACATCAGTTC GAGACCTGCT CCGGGCCATG 2520
AGGAACAAGA AGCACCACTA CAGGGAGCTC CCAGCTGAGG TGCGCCAGAC ACTAGGCCAA 2580
CTTCCTGCTG GCTTCATTCA GTACTTCACA CAGCGATTCC CCAGGCTGTT GCTGCACACT 2640
CACCGTGCCA TGAGGACCTG CGCCTCTGAG AGCCTCTTCC TGCCCTACTA CCCACCAGCT 2700
CTGGAAGCCA GGAGGCCAGA TGCCACAAAG AGCTGA 2736
Domain Profile
S: 1     fspkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfc  60
         f+pkdvlG+Ga+Gt+vfrG+fegr+vavkrll+e++ l++rev+ll+esd+hpnv+ryfc
Q: 508   FNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFC  567
         799*********************************************************
S: 61    tekdrqfryialelcaaslqdyvedkdlelqkelepisllkqiasGlahlhslkivhrdl  120
         te+++qf+yialelc+aslq+yve++dl+ +++lep+++l+q++sGlahlhsl+ivhrdl
Q: 568   TEHGPQFHYIALELCQASLQEYVESPDLD-RWGLEPTTVLQQMMSGLAHLHSLHIVHRDL  626
         *****************************.******************************
S: 121   kpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleeltke  180
         kp+nil++ pd++g+ rv+isdfGlckkl+vG++sfs +sg++GteGw+apell+ l+++
Q: 627   KPANILMAGPDSQGQGRVVISDFGLCKKLPVGRCSFSLHSGIPGTEGWMAPELLQ-LPPD  685
         *******************************************************.9***
S: 181   rltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdeeviaedli  240
         ++tsavdifs+Gcvfyyvls+G+hpfG+sl+rqanilsg+ +l++l+ee++++v+a dl+
Q: 686   SPTSAVDIFSAGCVFYYVLSGGSHPFGESLYRQANILSGDPCLAQLQEETHDKVVALDLV  745
         ************************************************************
S: 241   skmidkdplkrpsakkvlkhplf  263
         ++m++  p++rpsa +vl+hplf
Q: 746   RAMLSLLPQDRPSAGWVLAHPLF  768
         **********************9
Domain Sequence
(FASTA)
FNPKDVLGRG AGGTFVFRGQ FEGRAVAVKR LLRECFGLVR REVQLLQESD RHPNVLRYFC 60
TEHGPQFHYI ALELCQASLQ EYVESPDLDR WGLEPTTVLQ QMMSGLAHLH SLHIVHRDLK 120
PANILMAGPD SQGQGRVVIS DFGLCKKLPV GRCSFSLHSG IPGTEGWMAP ELLQLPPDSP 180
TSAVDIFSAG CVFYYVLSGG SHPFGESLYR QANILSGDPC LAQLQEETHD KVVALDLVRA 240
MLSLLPQDRP SAGWVLAHPL F 261
KeywordApoptosis; ATP-binding; Complete proteome; Endoplasmic reticulum; Glycoprotein; Hydrolase; Kinase; Magnesium; Membrane; Metal-binding; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Signal; Transcription; Transcription regulation; Transferase; Transmembrane; Transmembrane helix; Unfolded protein response.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>
EKS-AIM-00270
EKS-ANC-00278
EKS-BOT-00288
EKS-CAJ-00293
EKS-CAF-00294
EKS-CAP-00323
EKS-DAR-00633
EKS-ECT-00032
EKS-FEC-00274
EKS-GOG-00287
EKS-HOS-00294
EKS-ICT-00273
EKS-LOA-00298
EKS-MAM-00291
EKS-MEG-00230
EKS-MIM-00023
EKS-MOD-00283
EKS-MUP-00284
EKS-MYL-00290
EKS-OCP-00029
EKS-ORA-00254
EKS-ORC-00270
EKS-OTG-00294
EKS-PAT-00273
EKS-POA-00280
EKS-RAN-00304
EKS-SAH-00270
EKS-TAR-00377
EKS-TEN-00371
EKS-TUB-00026
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0016891; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006987; P:activation of signaling protein activity involved in unfolded protein response
GO:0006915; P:apoptotic process
GO:0007050; P:cell cycle arrest
GO:0006917; P:induction of apoptosis
GO:0006397; P:mRNA processing
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0006355; P:regulation of transcription, DNA-dependent
GO:0016075; P:rRNA catabolic process
GO:0006351; P:transcription, DNA-dependent
KEGG
mmu:26918;
InterPros
IPR010513; KEN_RNase_activator.
IPR011009; Kinase-like_dom.
IPR018391; PQQ_beta_propeller_repeat.
IPR002372; PQQ_repeat.
IPR000719; Prot_kinase_cat_dom.
IPR006567; PUG-dom.
IPR011047; Quinonprotein_ADH-like.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF01011; PQQ; 1.
PF06479; Ribonuc_2-5A; 1.
SMARTs
SM00564; PQQ; 4.
SM00580; PUG; 1.
Prosites
PS51392; KEN; 1.
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013