EKS-MUM-00213

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00213

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	464.1	3.2E-139	13	297	285

Status

Reviewed

Ensembl Protein

ENSMUSP00000084342

UniProt Accession

Q3UTQ8; Q05BK3; Q8BWI8;

Protein Name

Cyclin-dependent kinase-like 5

Protein Synonyms/Alias

Gene Name

Cdkl5

Gene Synonyms/Alias

Cdkl5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000031292	ENSMUSP00000084342	ENSMUST00000087104
ENSMUSG00000031292	ENSMUSP00000107974	ENSMUST00000112355

Organism

Mus musculus

Functional Description

Mediates phosphorylation of MECP2 (By similarity).

Protein Length

938

Protein Sequence
(FASTA)

MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI 120

KAIHWCHKND IVHRDIKPEN LLISHNDVLK LCDFGFARNL SEGNNANYTE YVATRWYRSP 180

ELLLGAPYGK SVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS 240

NPRFHGLRFP AVNHPQSLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ 300

RLLDRSPSRS TKRKPYHVES STLSNRNQST KGAALQTHHR SNSKDIQNLS VGLPRAEEGL 360

PANESFLNGN LAGATLSPMH TKTYQASTQP GSSSKDLTNN NIPHLLSPKE AKSKTEFDFN 420

IDTKPSEGPG TKYLKSSTRS QQNRHSFMES SQSKAGTLQP SEKQSRHSYI DTIPQSSRSP 480

SYRTKAKSHG ALSDSKSVSN LSEARAQITE TNTSRYFPSS CLDLNSPTSP TPTRHTDTRT 540

LLSPSGRNNR NEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS 600

PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS IGQGMAARAN SLQLLSPQPG EQLPPEMTVA 660

RPSVKESSRE GASSFHTRQK SEGGVYHDPH SDDGTAPKEN RHLYNDPVPR RVGSFYRVPS 720

PRPDNSFHEN NVSTRVSSLP SDSSSGTNHS KRQPGFDPWK SPENISHADQ LKEKEKQGFF 780

RSMKKKKKKT QTVPNTDGPD LLTLQKAIHS SSTASSRPKE WRPEKLSDLQ TQSQPLKSLR 840

KLLHLSSSTN HPASSDPRFQ PLTAQQAKNS FSEIRIHPLS QATGGSSNIR QEPTPKGRPA 900

LQLPGSSLLR YNGWKHSRSR SSQPDEVIFL ASHEKWKQ 938

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTCGGT 60

GAAGGAGCCT ATGGAGTTGT ACTTAAATGC AGACACAAGG AAACACATGA AATTGTGGCA 120

ATCAAGAAAT TCAAGGACAG CGAAGAAAAT GAAGAAGTCA AGGAGACGAC CTTACGAGAG 180

CTTAAAATGC TTCGCACTCT CAAGCAGGAA AACATTGTGG AGCTGAAGGA AGCTTTTCGT 240

CGGAGAGGAA AATTATACCT GGTGTTTGAA TATGTTGAGA AGAATATGCT TGAATTGCTG 300

GAAGAAATGC CAAATGGAGT TCCACCTGAA AAAGTCAAGA GCTATATCTA CCAACTAATC 360

AAAGCTATCC ACTGGTGCCA CAAGAACGAC ATCGTCCACA GAGATATAAA GCCTGAAAAT 420

CTCTTAATCA GCCACAATGA TGTCCTGAAA CTATGTGACT TTGGTTTTGC TCGCAATCTC 480

TCAGAGGGCA ATAATGCTAA TTATACAGAG TATGTGGCTA CAAGGTGGTA CCGATCCCCA 540

GAACTGCTAC TTGGAGCCCC CTATGGAAAG TCAGTGGACA TGTGGTCAGT GGGCTGTATT 600

CTTGGAGAGC TTAGTGATGG CCAGCCCTTA TTTCCTGGAG AAAGTGAAAT TGACCAACTC 660

TTTACTATTC AGAAGGTGCT AGGACCACTT CCATCTGAGC AAATGAAGCT CTTCTACAGT 720

AACCCTCGTT TCCATGGGCT CCGGTTCCCA GCTGTTAACC ATCCTCAGTC ATTAGAGAGA 780

AGATACCTTG GAATTTTAAA TAGTGTTTTA CTTGACCTAA TGAAGAATTT ACTGAAGTTG 840

GACCCAGCTG ACAGATACTT GACAGAGCAG TGTTTAAATC ATCCTACATT TCAGACTCAG 900

AGACTTTTGG ACCGGTCTCC TTCAAGATCA ACAAAAAGGA AACCTTATCA TGTGGAAAGC 960

AGCACCCTGT CTAATAGAAA CCAATCCACC AAGGGTGCTG CCTTACAGAC TCACCACAGA 1020

TCCAACAGCA AGGACATTCA GAACTTAAGT GTGGGTCTGC CCAGGGCTGA GGAAGGCCTG 1080

CCTGCAAACG AAAGCTTCCT CAATGGAAAC CTTGCTGGAG CAACTCTCAG CCCAATGCAC 1140

ACCAAAACCT ACCAAGCAAG CACCCAGCCT GGCTCTTCCA GCAAAGATCT CACAAACAAC 1200

AACATACCAC ACCTTCTCAG TCCAAAAGAA GCCAAGTCCA AAACAGAGTT TGACTTCAAT 1260

ATTGACACAA AGCCTTCAGA AGGTCCAGGC ACAAAGTACC TCAAGTCCAG CACCAGATCT 1320

CAGCAGAACA GGCACTCATT CATGGAAAGC TCCCAGAGCA AAGCTGGGAC CCTGCAGCCC 1380

AGTGAGAAGC AGAGTCGGCA CAGCTATATT GACACCATTC CCCAGTCCTC CCGGAGTCCA 1440

TCCTACAGGA CAAAGGCCAA AAGCCATGGG GCGTTGAGTG ACTCCAAGTC TGTGAGCAAC 1500

CTTTCCGAAG CCAGAGCCCA AATCACAGAG ACTAATACCA GTAGATACTT CCCATCCAGT 1560

TGTTTGGACT TGAACTCTCC CACCAGCCCA ACCCCCACCA GGCACACTGA TACGAGAACT 1620

TTGCTCAGCC CTTCCGGTCG AAATAATAGA AATGAAGGCA CTCTGGACTC ACGGCGAACC 1680

ACCACTAGAC ACTCAAAAAC CATGGAGGAG TTGAAGCTGC CTGAACACAT GGACAGCAGC 1740

CATTCGCATT CACTGTCTGC ACCTCATGAA TCATTTTCTT ATGGGCTAGG CTACACCAGC 1800

CCCTTCTCCT CTCAGCAGCG TCCTCACAGG CATTCCATGT ACGTGACCCG GGACAAAGTG 1860

AGAGCGAAAG GCCTTGATGG AAGCTTGAGC ATAGGACAAG GGATGGCAGC CAGAGCCAAC 1920

AGTTTGCAGC TCTTATCACC CCAGCCTGGA GAACAGCTCC CTCCAGAGAT GACTGTGGCA 1980

AGACCTTCTG TTAAAGAGTC CTCCCGAGAA GGCGCCTCTT CATTCCACAC CCGTCAGAAG 2040

TCTGAGGGTG GAGTATACCA TGACCCACAC TCTGACGACG GCACAGCTCC CAAAGAAAAT 2100

CGGCATCTGT ACAATGACCC TGTCCCAAGG AGAGTTGGTA GCTTTTATAG AGTGCCATCT 2160

CCACGACCAG ACAATTCTTT CCATGAAAAT AATGTGTCCA CTCGAGTTTC TTCTCTGCCA 2220

TCTGATAGCA GTTCTGGTAC AAATCATTCA AAAAGACAAC CAGGATTTGA TCCATGGAAA 2280

AGTCCTGAAA ACATTAGTCA TGCCGATCAA CTCAAAGAAA AGGAGAAGCA AGGTTTTTTC 2340

AGGTCAATGA AAAAGAAAAA GAAGAAAACT CAAACAGTGC CCAACACTGA CGGTCCTGAT 2400

CTATTGACCT TACAGAAAGC CATTCATTCT TCTAGCACTG CAAGCAGCAG ACCAAAGGAG 2460

TGGCGACCTG AGAAGCTCTC AGATCTACAG ACCCAGAGCC AACCACTAAA ATCTCTTCGA 2520

AAGCTGTTGC ATCTGTCTTC ATCAACCAAT CATCCAGCTT CTTCAGATCC TCGGTTCCAG 2580

CCCTTAACAG CTCAACAAGC CAAAAATTCC TTCTCAGAAA TTCGGATTCA CCCTCTGAGT 2640

CAGGCCACTG GTGGGAGCAG CAACATCCGG CAGGAGCCTA CACCAAAAGG CAGACCAGCC 2700

CTTCAGTTGC CAGGATCTTC CCTCTTAAGG TACAACGGAT GGAAACACTC AAGATCAAGA 2760

TCCAGCCAGC CAGACGAAGT GATCTTCTTG GCATCCCATG AGAAATGGAA ACAGTGA 2817

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg+vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+++v+klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGks

Q: 133   HRDIKPENLLISHNDVLKLCDFGFARNLSeGNNANYTEYVATRWYRSPELLLG-APYGKS  191

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v++++sle++y   ln+vlldl+k++lkldpa+r+++e++l+h++f

Q: 252   VNHPQSLERRYLgILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF  297

         ***********9899****************************998

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHNDVLKLC DFGFARNLSE GNNANYTEYV ATRWYRSPEL LLGAPYGKSV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPS EQMKLFYSNP RFHGLRFPAV 240

NHPQSLERRY LGILNSVLLD LMKNLLKLDP ADRYLTEQCL NHPTF 285

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0016301	; F:kinase activity
GO:0007049	; P:cell cycle
GO:0046777	; P:protein autophosphorylation

KEGG

mmu:382253

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013