EKS-MUM-00419
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00419
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11366.52.3E-109658912255
StatusReviewed
Ensembl ProteinENSMUSP00000033665
UniProt AccessionA2AQW0;
Protein NameMitogen-activated protein kinase kinase kinase 15
Protein Synonyms/Alias MAPK/ERK kinase kinase 15; MEK kinase 15; MEKK 15;
Gene NameMap3k15
Gene Synonyms/Alias Map3k15;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000031303ENSMUSP00000033665ENSMUST00000033665
OrganismMus musculus
Functional DescriptionMay function in a signal transduction pathway that isactivated by various cell stresses and leads to apoptosis (By similarity).
Protein Length1331
Protein Sequence
(FASTA)
MEGGGGSGGG GGPVPAEAPE EAGEPPQGRL PPGPEGAAGL AEPESTGDAA GGEAEGGRGP 60
RRALRAVYVR SESSQGAAAG GGPEAGALKC LLRACEAEGA HLTSVPFGEL DFGETAVLDA 120
FYDADVAIVD MSDISRQPSL FYHLGVRESF DMANNVILYY DTDADTALSL KDMVTQKNTA 180
SSGNYYFIPY TVTPCADYFC CESDAQRRAS EYMQPNWDTI LGPLCMPLVD RFTSLLKDIR 240
VTSCAYYKET LLNDIRKARE KYQGDELAKE LTRIKFRMDN IEVLTSDIII NLLLSYRDIQ 300
DYDAMVKLVE TLKMLPTCDL ADQHNIKFHY AFALNRRNST GDREKALQVM LQVLQSCDHP 360
APDMFCLCGR IYKDIFLDSG CEEDASRDSA IEWYRKGFEL QSSLYSGINL AVLLIVSGQQ 420
FETSMELRKI GVRLNSLLGR KGSLEKMNNY WDVGQFFTVS MLASDIGKAV QAAERLFKLK 480
PPVWYLRSLV QNLLLIQRFK KPITEHSPRQ ERLNFWLDII FEATNEVTNG LRFPVLVIEP 540
TKVYQPSYVS INNEAEERTV SLWHVSPTEM KQIHEWNFTA SSIKGISLSK FDERCCFLYV 600
HDNSDDFQIY FSTEDQCNRF CSLVKEMLNN GVGSTVELEG EADGDTLEYE YDHDANGERV 660
VLGKGSYGIV YAGRDLSNQV RIAIKEIPER DIRYSQPLHE EIALHKYLKH RNIVQYLGSV 720
SENGYIKIFM EQVPGGSLSA LLRSKWGPMK EPTIKFYTKQ ILEGLKYLHE NQIVHRDIKG 780
DNVLVNTYSG VVKISDFGTS KRLAGINPCT ETFTGTLQYM APEIIDQGPR GYGAPADIWS 840
LGCTIIEMAT SRPPFHELGE PQAAMFKVGM FKIHPEIPEA LSAEARAFIL SCFEPDPQKR 900
VTAADLLQEG FLRQVNKGKK NRIAFKPSEG VRSGTGTLAL PSSGELVGSS SSEHGSISPD 960
SDAQPDAFFE KVQVPKHQLS HLLSVPDESP ALDDRSTALP PEERDPGLFL LRKDSERRAI 1020
LYRILWEEQN QVASNLQECV VQSSEELLLS VSHIKQIIGI LRDFIRSPEH RVMAATISKL 1080
KVDLDFDSSS INQIHLILFG FQDAVNRILR NHLIRPHWMF AMDNIIRRAV QAAVTILIPE 1140
LQAHFEPASE TEGVDKDTEV EGDYPLVDLL SQEVHVTPRG TRPGSVAIQE GQPHQQDPSL 1200
QLSKLRQETN RLWEHLVQKE REYQNLLRLI LDQKTQELYH LQLQYKSNGG TENPPPPDGL 1260
GTDRELIDWL QLQGVDANTI EKIVEEDYTL SDILNDITKE DLRCLRLRGG VLCRLWHAVS 1320
QHRRQMQESS Q 1331
Nucleotide Sequence
(FASTA)
ATGGAGGGCG GCGGCGGCAG CGGCGGCGGC GGCGGGCCAG TCCCTGCCGA GGCTCCGGAG 60
GAAGCCGGCG AGCCGCCCCA GGGCAGGCTG CCCCCGGGGC CCGAGGGCGC GGCGGGGCTG 120
GCGGAGCCCG AGAGCACGGG GGACGCGGCG GGCGGCGAGG CCGAGGGCGG GCGCGGGCCA 180
CGCCGGGCTC TGCGGGCTGT CTACGTGCGC AGCGAAAGTT CGCAGGGGGC AGCCGCCGGC 240
GGCGGCCCCG AGGCCGGGGC GCTCAAGTGC CTGCTTCGGG CTTGCGAAGC CGAGGGCGCC 300
CACCTCACCT CCGTCCCCTT CGGGGAGCTC GACTTCGGGG AGACGGCCGT GCTCGATGCC 360
TTCTACGATG CAGATGTTGC CATTGTGGAC ATGAGTGATA TCTCCAGACA GCCTTCCCTT 420
TTCTACCATC TTGGAGTCCG AGAGAGTTTT GACATGGCTA ACAATGTAAT TCTCTACTAT 480
GATACTGATG CTGACACTGC TCTGTCATTG AAGGATATGG TCACTCAAAA AAACACAGCA 540
TCCAGTGGAA ATTATTATTT TATCCCCTAC ACTGTGACAC CATGTGCTGA CTATTTTTGC 600
TGTGAGAGTG ATGCCCAAAG GAGAGCCTCA GAGTACATGC AGCCTAACTG GGACACCATA 660
CTGGGCCCGC TGTGTATGCC CCTGGTCGAC AGGTTCACTA GCCTCCTTAA GGACATCCGT 720
GTGACTTCAT GTGCTTATTA TAAAGAAACA TTGTTAAATG ACATCCGGAA AGCCAGAGAG 780
AAATACCAAG GTGATGAACT GGCGAAAGAG TTGACTCGGA TCAAATTCCG TATGGATAAC 840
ATTGAGGTTC TGACATCGGA CATCATCATT AACTTACTTC TGTCCTACCG TGATATCCAG 900
GACTACGATG CAATGGTCAA GCTGGTAGAG ACACTGAAGA TGCTGCCAAC GTGTGATTTG 960
GCTGATCAGC ACAACATTAA ATTTCACTAT GCATTTGCAC TGAATAGGAG AAACAGCACA 1020
GGTGACCGTG AAAAGGCTCT TCAGGTTATG CTCCAAGTTC TGCAAAGCTG TGACCACCCA 1080
GCTCCTGACA TGTTTTGCCT GTGTGGGCGG ATATACAAGG ACATCTTCCT GGATTCAGGT 1140
TGTGAAGAGG ATGCAAGCAG AGACAGTGCC ATTGAGTGGT ATCGCAAAGG GTTTGAACTC 1200
CAGTCATCCC TTTATTCAGG AATTAACCTT GCAGTTTTGC TGATAGTTTC TGGACAACAG 1260
TTTGAAACTT CGATGGAACT AAGGAAAATA GGTGTCCGGC TGAACAGTTT ATTGGGAAGA 1320
AAAGGGAGCC TGGAGAAAAT GAACAATTAC TGGGATGTAG GTCAGTTCTT CACCGTCAGC 1380
ATGCTGGCAA GTGATATTGG GAAAGCTGTC CAGGCAGCAG AGAGGTTGTT CAAACTGAAA 1440
CCCCCAGTCT GGTACCTGCG GTCATTAGTT CAGAACTTGC TGTTAATTCA ACGCTTCAAG 1500
AAACCCATTA CAGAACATTC ACCCAGGCAG GAACGGCTTA ACTTCTGGTT AGATATCATT 1560
TTTGAAGCAA CGAATGAAGT TACTAATGGA CTCAGATTTC CAGTTCTGGT AATAGAGCCA 1620
ACCAAAGTCT ACCAGCCTTC TTATGTTTCT ATCAACAATG AAGCTGAAGA AAGAACTGTT 1680
TCTTTATGGC ATGTCTCACC CACAGAAATG AAACAAATCC ATGAGTGGAA TTTTACAGCC 1740
TCTTCTATTA AAGGAATAAG CCTATCCAAG TTTGATGAAC GGTGCTGTTT TCTTTATGTC 1800
CATGATAATT CTGATGACTT TCAAATCTAC TTTTCCACCG AAGACCAGTG TAATAGATTT 1860
TGTTCTTTGG TCAAAGAGAT GCTAAACAAT GGAGTGGGCA GTACAGTGGA GTTGGAGGGA 1920
GAGGCTGATG GAGACACCTT AGAGTATGAG TATGACCATG ATGCGAATGG GGAGAGAGTT 1980
GTCTTGGGGA AAGGCTCCTA TGGGATTGTG TATGCCGGCC GTGATCTCAG TAATCAAGTA 2040
CGGATAGCCA TCAAGGAAAT CCCAGAGAGA GATATCAGGT ACTCTCAGCC TCTGCATGAA 2100
GAAATAGCTC TGCACAAGTA TCTCAAACAT CGCAACATCG TCCAGTACCT AGGCTCTGTT 2160
TCAGAGAATG GCTACATTAA GATATTTATG GAGCAGGTGC CTGGAGGAAG CCTTTCTGCT 2220
CTCTTACGAT CTAAATGGGG ACCTATGAAG GAACCCACTA TCAAGTTTTA TACCAAACAG 2280
ATCCTGGAAG GCCTGAAGTA TCTCCATGAA AACCAGATAG TGCACAGAGA CATAAAGGGA 2340
GATAATGTTC TGGTGAACAC CTATAGTGGA GTGGTAAAAA TCTCTGATTT TGGAACCTCT 2400
AAACGCCTCG CAGGAATTAA CCCATGCACC GAGACCTTTA CAGGAACTCT GCAGTACATG 2460
GCACCTGAGA TTATTGATCA AGGACCTCGG GGATATGGTG CTCCAGCTGA TATCTGGTCC 2520
TTGGGCTGCA CCATCATTGA GATGGCAACC AGCAGGCCTC CATTCCATGA GCTTGGTGAG 2580
CCCCAAGCAG CCATGTTTAA GGTAGGGATG TTTAAGATCC ACCCTGAAAT TCCAGAGGCC 2640
CTTTCAGCTG AAGCCAGAGC CTTCATCTTG TCTTGTTTTG AGCCTGACCC TCAGAAACGT 2700
GTCACTGCTG CTGACCTTCT CCAAGAAGGG TTCTTAAGGC AGGTGAACAA AGGCAAAAAG 2760
AACCGAATTG CTTTCAAGCC TTCAGAGGGT GTTCGGAGTG GCACTGGTAC TCTGGCTCTG 2820
CCTTCATCAG GAGAGCTTGT GGGCAGCAGC AGCAGCGAGC ATGGCTCAAT CTCCCCAGAC 2880
TCGGATGCCC AGCCTGATGC ATTCTTTGAG AAAGTCCAGG TGCCCAAACA TCAGCTCAGC 2940
CACCTTCTCA GTGTCCCAGA TGAAAGCCCA GCCTTAGATG ACCGAAGCAC AGCCTTACCC 3000
CCAGAGGAGA GGGACCCTGG TCTCTTTCTG CTGCGCAAGG ACAGTGAGCG CAGAGCCATC 3060
CTTTACAGAA TCCTTTGGGA GGAACAGAAC CAAGTGGCTT CCAACTTGCA AGAGTGTGTG 3120
GTCCAGAGTT CAGAAGAGTT GCTTCTCTCA GTTAGCCACA TCAAACAGAT AATTGGAATC 3180
CTGAGGGACT TCATCCGCTC CCCAGAGCAC AGGGTGATGG CAGCCACAAT ATCAAAACTA 3240
AAGGTGGACC TGGACTTTGA CAGCTCATCC ATCAACCAGA TTCACCTGAT TCTGTTTGGG 3300
TTCCAAGATG CTGTCAATAG AATTTTGAGA AACCACTTAA TTAGGCCCCA CTGGATGTTT 3360
GCAATGGACA ACATCATTCG CAGAGCTGTG CAGGCTGCAG TCACCATTCT CATTCCAGAG 3420
CTCCAAGCCC ACTTTGAGCC TGCTTCTGAG ACTGAAGGGG TAGACAAGGA CACAGAAGTA 3480
GAAGGGGACT ATCCCCTAGT AGACCTCCTC AGCCAAGAAG TGCATGTGAC ACCTAGAGGC 3540
ACCAGACCTG GCTCAGTGGC TATCCAGGAG GGCCAGCCCC ACCAGCAAGA CCCAAGTCTC 3600
CAACTGAGCA AGCTCAGGCA AGAGACCAAC AGACTTTGGG AACACCTAGT TCAAAAAGAG 3660
AGGGAGTACC AGAATCTTCT TCGCCTAATT CTAGACCAGA AAACTCAAGA ATTGTATCAC 3720
CTTCAGTTAC AGTACAAATC CAATGGTGGT ACAGAGAACC CTCCACCCCC TGATGGACTG 3780
GGAACCGACA GAGAGCTTAT AGACTGGTTG CAACTACAAG GAGTGGATGC CAATACAATA 3840
GAAAAGATTG TTGAAGAGGA CTATACACTT TCTGATATTC TCAATGATAT CACTAAGGAA 3900
GACCTAAGGT GCCTCCGACT ACGGGGTGGT GTCCTCTGTA GGCTCTGGCA TGCAGTCTCC 3960
CAGCACAGAA GACAAATGCA GGAGTCTTCA CAGTGA 3996
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkGs+g vya++d++++ ++a+Ke+   pe++   +++++l+eEi+l+k lkH+n
Q: 658   ERVVLGKGSYGIVYAGRDLSNQVRIAIKEI---PERDI--RYSQPLHEEIALHKYLKHRN  712
         6899**************************...77665..59******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkleesvikkytkqileglayLHekk  121
         iv+y+G+ +e++++kif+E+v+gGsls+ll+ k+g+++e +ik+ytkqilegl+yLHe++
Q: 713   IVQYLGSVSENGYIKIFMEQVPGGSLSALLRsKWGPMKEPTIKFYTKQILEGLKYLHENQ  772
         *******************************9****************************
S: 122   ivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkke  180
         ivHRDiKg+N+l+++ sgvvk+sDFG+skrla +n++   +e++tGtl+ymaPE+i+++ 
Q: 773   IVHRDIKGDNVLVNTySGVVKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDQGP  829
         *************************************...8*******************
S: 181   kgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdfl  240
         +gyg+ aDiWslgc++iem+t+++Pf+el+e++a+mfkvg+ k++Peipe+ls+e+++f+
Q: 830   RGYGAPADIWSLGCTIIEMATSRPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFI  889
         ************************************************************
S: 241   ekcleldpkkrpsaeeLLkhefl  263
          +c+e dp+kr++a++LL++ fl
Q: 890   LSCFEPDPQKRVTAADLLQEGFL  912
         *******************9985
Domain Sequence
(FASTA)
ERVVLGKGSY GIVYAGRDLS NQVRIAIKEI PERDIRYSQP LHEEIALHKY LKHRNIVQYL 60
GSVSENGYIK IFMEQVPGGS LSALLRSKWG PMKEPTIKFY TKQILEGLKY LHENQIVHRD 120
IKGDNVLVNT YSGVVKISDF GTSKRLAGIN PCTETFTGTL QYMAPEIIDQ GPRGYGAPAD 180
IWSLGCTIIE MATSRPPFHE LGEPQAAMFK VGMFKIHPEI PEALSAEARA FILSCFEPDP 240
QKRVTAADLL QEGFL 255
KeywordATP-binding; Coiled coil; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00362
EKS-BOT-00389
EKS-CAE-00316
EKS-CAJ-00395
EKS-CAF-00389
EKS-DAR-00771
EKS-DRM-00182
EKS-EQC-00381
EKS-FEC-00377
EKS-GAG-00326
EKS-GAA-00474
EKS-GOG-00379
EKS-ICT-00367
EKS-LAC-00400
EKS-LOA-00398
EKS-MEG-00319
EKS-MUP-00383
EKS-MYL-00390
EKS-NOL-00359
EKS-ORN-00498
EKS-ORA-00337
EKS-ORC-00366
EKS-OTG-00391
EKS-PES-00344
EKS-POA-00378
EKS-RAN-00409
EKS-SAH-00357
EKS-SUS-00340
EKS-TAG-00458
EKS-TAR-00495
EKS-TEN-00491
EKS-XET-00501
EKS-XIM-00488
Gene Ontology
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0046872; F:metal ion binding
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
KEGG
mmu:270672;
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013