EPS-MUM-00141
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-MUM-00141
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
DSP/Myotubularins532.61.4E-159164538375
StatusReviewed
Ensembl ProteinENSMUSP00000033700
UniProt AccessionQ9Z2C5; Q5BKQ5;
Protein NameMyotubularin
Protein Synonyms/Alias
Gene NameMtm1
Gene Synonyms/Alias Mtm1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000031337ENSMUSP00000025391ENSMUST00000025391
ENSMUSG00000031337ENSMUSP00000057182ENSMUST00000061970
ENSMUSG00000031337ENSMUSP00000125798ENSMUST00000171933
ENSMUSG00000031337ENSMUSP00000110264ENSMUST00000114617
ENSMUSG00000031337ENSMUSP00000033700ENSMUST00000033700
ENSMUSG00000031337ENSMUSP00000110268ENSMUST00000114621
ENSMUSG00000031337ENSMUSP00000099040ENSMUST00000101501
OrganismMus musculus
Functional DescriptionLipid phosphatase which dephosphorylatesphosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine- containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology (By similarity). Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis.
Protein Length603
Protein Sequence
(FASTA)
MASASASKYN SHSLENESIK KVSQDGVSQD VSETVPRLPG ELLITEKEVI YICPFNGPIK 60
GRVYITNYRL YLRSLETDSA LILDVPLGVI SRIEKMGGAT SRGENSYGLD ITCKDLRNLR 120
FALKQEGHSR RDMFEILVKH AFPLAHNLPL FAFVNEEKFN VDGWTVYNPV EEYRRQGLPN 180
HHWRISFINK CYELCETYPA LLVVPYRTSD DDLRRIATFR SRNRLPVLSW IHPENKMVIM 240
RCSQPLVGMS GKRNKDDEKY LDVIRETNKQ TSKLMIYDAR PSVNAVANKA TGGGYESDDA 300
YQNSELSFLD IHNIHVMRES LKKVKDIVYP NIEESHWLSS LESTHWLEHI KLVLTGAIQV 360
ADQVSSGKSS VLVHCSDGWD RTAQLTSLAM LMLDSFYRTI EGFEILVQKE WISFGHKFAS 420
RIGHGDKNHA DADRSPIFLQ FIDCVWQMSK QFPTAFEFNE GFLITVLDHL YSCRFGTFLF 480
NCDSARERQK LTERTVSLWS LINSNKDKFK NPFYTKEINR VLYPVASMRH LELWVNYYIR 540
WNPRVKQQQP NPVEQRYMEL LALRDDYIKR LEELQLANSA KLADAPASTS SSSQMVPHVQ 600
THF 603
Nucleotide Sequence
(FASTA)
ATGGCTTCTG CATCAGCATC TAAGTATAAT TCACACTCCT TGGAGAATGA ATCCATTAAG 60
AAAGTGTCTC AAGATGGAGT CAGTCAGGAT GTGAGTGAGA CTGTCCCTCG GCTCCCAGGG 120
GAGTTACTAA TTACTGAAAA AGAAGTTATT TACATATGTC CTTTCAATGG CCCCATTAAG 180
GGAAGAGTTT ACATCACAAA TTATCGTCTT TATTTAAGAA GTTTGGAAAC GGATTCTGCT 240
CTAATACTTG ATGTTCCTCT GGGTGTGATA TCAAGAATTG AAAAAATGGG AGGCGCGACA 300
AGTAGAGGAG AAAATTCCTA TGGTCTAGAT ATTACTTGTA AAGATTTGAG AAACCTGAGG 360
TTTGCATTGA AGCAAGAAGG CCACAGCAGA AGAGATATGT TTGAGATCCT TGTAAAACAT 420
GCCTTTCCTC TGGCACACAA TCTGCCATTA TTTGCATTTG TAAATGAAGA GAAGTTTAAC 480
GTGGATGGGT GGACTGTTTA TAATCCAGTT GAAGAATATA GAAGGCAGGG CCTGCCCAAT 540
CACCATTGGA GGATAAGTTT TATTAACAAG TGCTATGAGC TCTGTGAGAC ATACCCTGCT 600
CTTTTGGTGG TTCCCTATCG GACCTCAGAT GATGATCTTA GGAGGATCGC AACGTTTAGA 660
TCCCGAAATC GGCTTCCTGT ACTGTCGTGG ATTCACCCAG AAAACAAAAT GGTCATTATG 720
CGCTGCAGTC AGCCTCTTGT CGGTATGAGT GGTAAAAGAA ATAAAGATGA CGAGAAATAC 780
CTGGATGTGA TCAGGGAAAC TAACAAACAA ACTTCTAAGC TCATGATTTA TGATGCACGA 840
CCCAGTGTAA ATGCAGTCGC CAACAAGGCA ACAGGAGGAG GATATGAAAG TGATGACGCA 900
TATCAAAACT CAGAACTTTC CTTCTTAGAC ATTCATAATA TTCATGTTAT GCGAGAATCT 960
TTAAAAAAAG TGAAAGATAT TGTTTATCCC AACATAGAAG AATCTCATTG GTTGTCCAGT 1020
TTGGAGTCTA CTCATTGGTT AGAACATATC AAGCTTGTTC TGACCGGTGC CATTCAAGTG 1080
GCAGACCAAG TGTCTTCAGG AAAGAGCTCG GTACTTGTGC ACTGCAGTGA CGGATGGGAC 1140
AGGACCGCTC AGCTGACATC CTTGGCCATG CTGATGTTGG ACAGCTTCTA CAGAACTATT 1200
GAAGGCTTTG AGATATTGGT ACAGAAAGAG TGGATAAGTT TTGGCCATAA ATTTGCATCT 1260
AGAATAGGTC ATGGTGATAA AAACCATGCT GATGCTGATC GATCTCCTAT TTTTCTTCAG 1320
TTTATTGACT GTGTGTGGCA GATGTCGAAA CAGTTCCCCA CAGCTTTTGA GTTCAATGAA 1380
GGCTTTTTGA TTACCGTTTT GGATCATCTG TATAGCTGTC GATTTGGTAC TTTCTTATTC 1440
AACTGTGACT CGGCTCGAGA AAGACAGAAA CTTACAGAAA GAACAGTTTC TCTATGGTCG 1500
CTAATTAACA GCAATAAAGA CAAATTCAAA AACCCCTTCT ATACAAAAGA AATCAATCGG 1560
GTTTTGTATC CAGTTGCCAG CATGCGTCAC TTGGAACTGT GGGTGAATTA TTACATCCGA 1620
TGGAATCCCA GGGTCAAGCA GCAACAGCCC AACCCAGTGG AGCAGCGTTA CATGGAGCTT 1680
TTGGCCTTGC GTGACGATTA TATAAAGAGG CTCGAGGAAT TGCAGCTGGC CAACTCCGCC 1740
AAGCTTGCTG ATGCCCCCGC TTCGACTTCC AGTTCGTCAC AGATGGTGCC CCATGTGCAG 1800
ACGCACTTCT GA 1812
Domain Profile
S: 2     etlkdleeelkrlglanekwrissvNeeykvcesyPallvVPksvqdeelkrvskffskk  61
         +t+++++ee++r+gl+n++wris +N+ y++ce+yPallvVP + +d++l+r+++f+s++
Q: 164   WTVYNPVEEYRRQGLPNHHWRISFINKCYELCETYPALLVVPYRTSDDDLRRIATFRSRN  223
         8999********************************************************
S: 62    riPvlswshkengaallrssqplssledrrskedekllqailkavagrskllivdtrkal  121
         r+Pvlsw h+en+++++r+sqpl++++++r+k+dek+l+ i ++++++skl+i+d+r+++
Q: 224   RLPVLSWIHPENKMVIMRCSQPLVGMSGKRNKDDEKYLDVIRETNKQTSKLMIYDARPSV  283
         ************************************************************
S: 122   aavankakgkgvese.aysnielvfvelenihevrasfkklkelclpdsvseekwlsaLe  180
         +avanka+g+g+es+ ay+n el f++++nih++r+s+kk+k++++p +++e++wls+Le
Q: 284   NAVANKATGGGYESDdAYQNSELSFLDIHNIHVMRESLKKVKDIVYP-NIEESHWLSSLE  342
         **********************************************9.9***********
S: 181   sseWLehikallkkavevaelvesekasvlvheedgwDltaqvtsLvqllldpyyRtleG  240
         s++WLehik +l+ a++va+ v+s+k+svlvh++dgwD+taq+tsL++l+ld++yRt+eG
Q: 343   STHWLEHIKLVLTGAIQVADQVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRTIEG  402
         ************************************************************
S: 241   fqvLvekeWlsfGhkFsdRlghleasekea.esPvflqFldcvwqlleQfPaaFEFneaf  299
         f++Lv+keW+sfGhkF++R+gh ++++++a +sP+flqF+dcvwq+ +QfP+aFEFne f
Q: 403   FEILVQKEWISFGHKFASRIGHGDKNHADAdRSPIFLQFIDCVWQMSKQFPTAFEFNEGF  462
         ***************************9999*****************************
S: 300   LlvlldhlysslfgtFLlnsekervkqsgekklkektlsvWdllqreskrkklfkNplYs  359
         L+++ldhlys++fgtFL+n+++ r    +++kl+e+t+s+W+l++  s+++k fkNp+Y+
Q: 463   LITVLDHLYSCRFGTFLFNCDSAR----ERQKLTERTVSLWSLIN--SNKDK-FKNPFYT  515
         ************************....9****************..66666.*******
S: 360   eeskevllPvvsvselklWkavy  382
         +e ++vl+Pv+s+++l+lW ++y
Q: 516   KEINRVLYPVASMRHLELWVNYY  538
         ********************998
Domain Sequence
(FASTA)
WTVYNPVEEY RRQGLPNHHW RISFINKCYE LCETYPALLV VPYRTSDDDL RRIATFRSRN 60
RLPVLSWIHP ENKMVIMRCS QPLVGMSGKR NKDDEKYLDV IRETNKQTSK LMIYDARPSV 120
NAVANKATGG GYESDDAYQN SELSFLDIHN IHVMRESLKK VKDIVYPNIE ESHWLSSLES 180
THWLEHIKLV LTGAIQVADQ VSSGKSSVLV HCSDGWDRTA QLTSLAMLML DSFYRTIEGF 240
EILVQKEWIS FGHKFASRIG HGDKNHADAD RSPIFLQFID CVWQMSKQFP TAFEFNEGFL 300
ITVLDHLYSC RFGTFLFNCD SARERQKLTE RTVSLWSLIN SNKDKFKNPF YTKEINRVLY 360
PVASMRHLEL WVNYY 375
KeywordCell membrane; Cell projection; Complete proteome; Cytoplasm; Endosome; Hydrolase; Membrane; Phosphoprotein; Protein phosphatase; Protein transport; Reference proteome; Transport.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EPS-AIM-00128
EPS-ANC-00137
EPS-BOT-00141
EPS-CAE-00161
EPS-CAJ-00142
EPS-CAF-00133
EPS-CAP-00134
EPS-EQC-00134
EPS-FEC-00131
EPS-GAG-00116
EPS-GOG-00131
EPS-HOS-00141
EPS-LAC-00137
EPS-LOA-00141
EPS-MAM-00149
EPS-MEG-00122
EPS-MOD-00149
EPS-MUP-00132
EPS-MYL-00138
EPS-NOL-00122
EPS-ORN-00186
EPS-ORA-00125
EPS-ORC-00142
EPS-ORL-00161
EPS-OTG-00147
EPS-PES-00123
EPS-POA-00130
EPS-PTV-00059
EPS-RAN-00150
EPS-SAH-00129
EPS-SUS-00136
EPS-XET-00125
EPS-XIM-00187
Gene Ontology
GO:0030175; C:filopodium
GO:0031674; C:I band
GO:0005770; C:late endosome
GO:0005886; C:plasma membrane
GO:0001726; C:ruffle
GO:0019215; F:intermediate filament binding
GO:0035091; F:phosphatidylinositol binding
GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
GO:0004438; F:phosphatidylinositol-3-phosphatase activity
GO:0004721; F:phosphoprotein phosphatase activity
GO:0004725; F:protein tyrosine phosphatase activity
GO:0008333; P:endosome to lysosome transport
GO:0045109; P:intermediate filament organization
GO:0048311; P:mitochondrion distribution
GO:0070584; P:mitochondrion morphogenesis
GO:0046716; P:muscle cell homeostasis
GO:0035335; P:peptidyl-tyrosine dephosphorylation
GO:0046856; P:phosphatidylinositol dephosphorylation
GO:0015031; P:protein transport
GO:0044088; P:regulation of vacuole organization
KEGG
mmu:17772;
InterPros
IPR004182; GRAM.
IPR010569; Myotub-related.
IPR017906; Myotubularin_phosphatase_dom.
IPR000387; Tyr/Dual-specificity_Pase.
IPR016130; Tyr_Pase_AS.
Pfam
PF02893; GRAM; 1.
PF06602; Myotub-related; 1.
SMARTs
SM00568; GRAM; 1.
Prosites
PS51339; PPASE_MYOTUBULARIN; 1.
PS00383; TYR_PHOSPHATASE_1; 1.
PS50056; TYR_PHOSPHATASE_2; 1.
Prints
Created Date20-Feb-2013