EKS-MUM-00153

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00153

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	555.4	4.3E-167	389	665	277

Status

Reviewed

Ensembl Protein

ENSMUSP00000131343

UniProt Accession

P16092; E9Q2P4; Q01736; Q60830; Q61562; Q80T10; Q8CFK8; Q9QZM7;

Protein Name

Fibroblast growth factor receptor 1

Protein Synonyms/Alias

FGFR-1; bFGF-R-1; Basic fibroblast growth factor receptor 1; MFR; Proto-oncogene c-Fgr;

Gene Name

Fgfr1

Gene Synonyms/Alias

Fgfr1; Flg;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000031565	ENSMUSP00000116564	ENSMUST00000124228
ENSMUSG00000031565	ENSMUSP00000137515	ENSMUST00000178276
ENSMUSG00000031565	ENSMUSP00000136640	ENSMUST00000179592
ENSMUSG00000031565	ENSMUSP00000081041	ENSMUST00000084027
ENSMUSG00000031565	ENSMUSP00000113855	ENSMUST00000119398
ENSMUSG00000031565	ENSMUSP00000113909	ENSMUST00000117179
ENSMUSG00000031565	ENSMUSP00000131343	ENSMUST00000167764
ENSMUSG00000031565	ENSMUSP00000117884	ENSMUST00000155564

Organism

Mus musculus

Functional Description

Tyrosine-protein kinase that acts as cell-surfacereceptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).

Protein Length

733

Protein Sequence
(FASTA)

MWGWKCLLFW AVLVTATLCT ARPAPTLPEQ DALPSSEDDD DDDDSSSEEK ETDNTKPNPV 60

APYWTSPEKM EKKLHAVPAA KTVKFKCPSS GTPNPTLRWL KNGKEFKPDH RIGGYKVRYA 120

TWSIIMDSVV PSDKGNYTCI VENEYGSINH TYQLDVVERS PHRPILQAGL PANKTVALGS 180

NVEFMCKVYS DPQPHIQWLK HIEVNGSKIG PDNLPYVQIL KHSGINSSDA EVLTLFNVTE 240

AQSGEYVCKV SNYIGEANQS AWLTVTRPVA KALEERPAVM TSPLYLEIII YCTGAFLISC 300

MLGSVIIYKM KSGTKKSDFH SQMAVHKLAK SIPLRRQVTV SADSSASMNS GVLLVRPSRL 360

SSSGTPMLAG VSEYELPEDP RWELPRDRLV LGKPLGEGCF GQVVLAEAIG LDKDKPNRVT 420

KVAVKMLKSD ATEKDLSDLI SEMEMMKMIG KHKNIINLLG ACTQDGPLYV IVEYASKGNL 480

REYLQARRPP GLEYCYNPSH NPEEQLSSKD LVSCAYQVAR GMEYLASKKC IHRDLAARNV 540

LVTEDNVMKI ADFGLARDIH HIDYYKKTTN GRLPVKWMAP EALFDRIYTH QSDVWSFGVL 600

LWEIFTLGGS PYPGVPVEEL FKLLKEGHRM DKPSNCTNEL YMMMRDCWHA VPSQRPTFKQ 660

LVEDLDRIVA LTSNQEYLDL SIPLDQYSPS FPDTRSSTCS SGEDSVFSHE PLPEEPCLPR 720

HPTQLANSGL KRR 733

Nucleotide Sequence
(FASTA)

ATGTGGGGCT GGAAGTGCCT CCTCTTCTGG GCTGTGCTGG TCACAGCCAC TCTCTGCACT 60

GCCAGGCCAG CCCCAACCTT GCCTGAACAA GATGCACTCC CATCCTCGGA AGATGATGAC 120

GACGACGATG ACTCCTCCTC GGAGGAGAAA GAGACGGACA ACACCAAACC AAACCCTGTA 180

GCTCCCTACT GGACATCCCC AGAGAAAATG GAGAAGAAAC TGCATGCGGT GCCCGCTGCC 240

AAGACGGTGA AGTTCAAGTG CCCGTCGAGT GGGACACCCA ACCCCACTCT GCGCTGGTTG 300

AAAAATGGCA AAGAGTTTAA GCCTGACCAC CGAATTGGAG GCTACAAGGT TCGCTATGCC 360

ACCTGGAGCA TCATAATGGA TTCTGTGGTG CCTTCTGACA AGGGCAACTA CACCTGCATC 420

GTGGAGAATG AGTATGGGAG CATCAACCAC ACCTACCAGC TTGACGTCGT GGAACGATCT 480

CCGCACCGAC CCATCCTTCA GGCAGGGCTG CCTGCCAACA AGACAGTGGC CCTGGGCAGC 540

AATGTGGAGT TCATGTGTAA GGTGTACAGC GATCCGCAGC CTCACATTCA GTGGCTGAAG 600

CACATCGAGG TGAACGGGAG TAAGATCGGG CCAGACAACT TGCCGTATGT CCAGATCCTG 660

AAGCATTCGG GAATTAATAG CTCGGATGCG GAGGTGCTGA CCCTGTTCAA TGTGACAGAG 720

GCCCAGAGCG GGGAGTATGT GTGTAAGGTT TCCAATTATA TTGGTGAAGC TAACCAGTCT 780

GCGTGGCTCA CTGTCACCAG ACCTGTGGCA AAAGCCCTGG AAGAGAGACC AGCTGTGATG 840

ACCTCACCGC TCTACCTGGA GATCATTATC TACTGCACCG GGGCCTTCCT GATCTCCTGC 900

ATGTTGGGCT CTGTCATCAT CTATAAGATG AAGAGCGGCA CCAAGAAGAG CGACTTCCAT 960

AGCCAGATGG CTGTGCACAA GCTGGCCAAG AGCATCCCTC TGCGCAGACA GGTAACAGTG 1020

TCAGCTGACT CCAGTGCATC CATGAACTCT GGGGTTCTCC TGGTTCGGCC CTCACGGCTC 1080

TCCTCCAGCG GGACCCCCAT GCTGGCTGGA GTCTCCGAAT ATGAGCTCCC TGAGGATCCC 1140

CGCTGGGAGC TGCCACGAGA CAGACTGGTC TTAGGCAAAC CACTTGGCGA GGGCTGCTTC 1200

GGGCAGGTGG TGTTGGCTGA GGCCATCGGG CTGGATAAGG ACAAACCCAA CCGTGTGACC 1260

AAAGTGGCCG TGAAGATGTT GAAGTCCGAC GCAACGGAGA AGGACCTGTC GGATCTGATC 1320

TCGGAGATGG AGATGATGAA AATGATTGGG AAGCACAAGA ATATCATCAA CCTTCTGGGA 1380

GCGTGCACAC AGGATGGTCC TCTTTATGTC ATTGTGGAGT ACGCCTCCAA AGGCAATCTC 1440

CGGGAGTATC TACAGGCCCG GAGGCCTCCT GGGCTGGAGT ACTGCTATAA CCCCAGCCAC 1500

AACCCCGAGG AACAGCTGTC TTCCAAAGAT CTGGTATCCT GTGCCTATCA GGTGGCTCGG 1560

GGCATGGAGT ATCTTGCCTC TAAGAAGTGT ATACACCGAG ACCTGGCTGC TAGGAACGTC 1620

CTGGTGACCG AGGATAACGT AATGAAGATC GCAGACTTTG GCTTAGCTCG AGACATTCAT 1680

CATATCGACT ACTACAAGAA AACCACCAAC GGCCGGCTGC CTGTGAAGTG GATGGCCCCT 1740

GAGGCGTTGT TTGACCGGAT CTACACACAC CAGAGCGATG TGTGGTCTTT TGGAGTGCTC 1800

TTGTGGGAGA TCTTCACTCT GGGTGGCTCC CCATACCCCG GTGTGCCTGT GGAGGAACTT 1860

TTCAAGCTGC TGAAGGAGGG TCATCGAATG GACAAGCCCA GTAACTGTAC CAATGAGCTG 1920

TACATGATGA TGCGGGACTG CTGGCATGCA GTGCCCTCTC AGAGACCTAC GTTCAAGCAG 1980

TTGGTGGAAG ACCTGGACCG CATTGTGGCC TTGACCTCCA ACCAGGAGTA TCTGGACCTG 2040

TCCATACCGC TGGACCAGTA CTCACCCAGC TTTCCCGACA CACGGAGCTC CACCTGCTCC 2100

TCAGGGGAGG ACTCTGTCTT CTCTCATGAG CCGTTACCTG AGGAGCCCTG TCTGCCTCGA 2160

CACCCCACCC AGCTTGCCAA CAGTGGACTC AAACGGCGCT GA 2202

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 389   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  448

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++

Q: 449   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  508

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 509   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  568

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 569   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  628

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 629   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  665

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

3D-structure; Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Disulfide bond; Glycoprotein; Heparin-binding; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016023	; C:cytoplasmic membrane-bounded vesicle
GO:0005829	; C:cytosol
GO:0016021	; C:integral to membrane
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0017134	; F:fibroblast growth factor binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008201	; F:heparin binding
GO:0001525	; P:angiogenesis
GO:0060117	; P:auditory receptor cell development
GO:0060445	; P:branching involved in salivary gland morphogenesis
GO:0048469	; P:cell maturation
GO:0021954	; P:central nervous system neuron development
GO:0002062	; P:chondrocyte differentiation
GO:0030326	; P:embryonic limb morphogenesis
GO:0035607	; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0001701	; P:in utero embryonic development
GO:0042472	; P:inner ear morphogenesis
GO:0060484	; P:lung-associated mesenchyme development
GO:0048762	; P:mesenchymal cell differentiation
GO:0030901	; P:midbrain development
GO:0042474	; P:middle ear morphogenesis
GO:0021837	; P:motogenic signaling involved in postnatal olfactory bulb interneuron migration
GO:0043066	; P:negative regulation of apoptotic process
GO:0045668	; P:negative regulation of osteoblast differentiation
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0031175	; P:neuron projection development
GO:0001759	; P:organ induction
GO:0042473	; P:outer ear morphogenesis
GO:0048339	; P:paraxial mesoderm development
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0045787	; P:positive regulation of cell cycle
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0090080	; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045666	; P:positive regulation of neuron differentiation
GO:0010976	; P:positive regulation of neuron projection development
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0051930	; P:regulation of sensory perception of pain
GO:0072091	; P:regulation of stem cell proliferation
GO:0007605	; P:sensory perception of sound
GO:0019827	; P:stem cell maintenance
GO:0001657	; P:ureteric bud development
GO:0060979	; P:vasculogenesis involved in coronary vascular morphogenesis
GO:0021847	; P:ventricular zone neuroblast division

KEGG

mmu:14182

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013