EKS-MUM-00373
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00373
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK409.02.7E-1225891075487
StatusReviewed
Ensembl ProteinENSMUSP00000034093
UniProt AccessionQ9Z2B5; Q9CTK8; Q9CWT5;
Protein NameEukaryotic translation initiation factor 2-alpha kinase 3
Protein Synonyms/Alias PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase;
Gene NameEif2ak3
Gene Synonyms/Alias Eif2ak3; Pek, Perk;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000031668ENSMUSP00000034093ENSMUST00000034093
ENSMUSG00000031668ENSMUSP00000123759ENSMUST00000162950
OrganismMus musculus
Functional DescriptionPhosphorylates the alpha subunit of eukaryotictranslation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1).
Protein Length1114
Protein Sequence
(FASTA)
MERATRPGPR ALLLLLFLLL GCAAGISAVA PARSLLAPAS ETVFGLGAAA APTSAARVPA 60
VATAEVTVED AEALPAAAGE PESRATEPDD DVELRPRGRS LVIISTLDGR IAALDAENDG 120
KKQWDLDVGS GSLVSSSLSK PEVFGNKMII PSLDGDLFQW DRDRESMEAV PFTVESLLES 180
SYKFGDDVVL VGGKSLTTYG LSAYSGKLRY ICSALGCRRW DSDEMEEEED ILLLQRTQKT 240
VRAVGPRSGS EKWNFSVGHF ELRYIPDMET RAGFIESTFK PGGNKEDSKI ISDVEEQEAT 300
MLDTVIKVSV ADWKVMAFSR KGGRLEWEYQ FCTPIASAWL VRDGKVIPIS LFDDTSYTAS 360
EEALGDEEDI VEAARGATEN SVYLGMYRGQ LYLQSSVRVS EKFPTSPKAL ESVNGENAII 420
PLPTIKWKPL IHSPSRTPVL VGSDEFDKCL SNDKYSHEEY SNGALSILQY PYDNGYYLPY 480
YKRERNKRST QITVRFLDSP HYSKNIRKKD PILLLHWWKE IFGTILLCIV ATTFIVRRLF 540
HPQPHRQRKE SETQCQTESK YDSVSADVSD NSWNDMKYSG YVSRYLTDFE PIQCMGRGGF 600
GVVFEAKNKV DDCNYAIKRI RLPNRELARE KVMREVKALA KLEHPGIVRY FNAWLETPPE 660
KWQEEMDEIW LKDESTDWPL SSPSPMDAPS VKIRRMDPFS TKEQIEVIAP SPERSRSFSV 720
GISCGQTSSS ESQFSPLEFS GTDCGDNSDS ADAAYNLQDS CLTDCEDVED GTVDGNDEGH 780
SFELCPSEAS PYTRSREGTS SSIVFEDSGC GNASSKEEPR GNRLHDGNHY VNKLTDLKCS 840
SSRSSSEATT LSTSPTRPTT LSLDFTKNTV GQLQPSSPKV YLYIQMQLCR KENLKDWMNR 900
RCSLEDREHG VCLHIFLQIA EAVEFLHSKG LMHRDLKPSN IFFTMDDVVK VGDFGLVTAM 960
DQDEEEQTVL TPMPAYATHT GQVGTKLYMS PEQIHGNNYS HKVDIFSLGL ILFELLYPFS 1020
TQMERVRILT DVRNLKFPLL FTQKYPQEHM MVQDMLSPSP TERPEATDII ENAIFENLEF 1080
PGKTVLRQRS RSMSSSGTKH SRQPSCSYSP LPGN 1114
Nucleotide Sequence
(FASTA)
ATGGAGCGCG CCACCCGGCC CGGGCCGCGC GCGCTGCTGC TGCTTCTGTT CCTGCTGCTG 60
GGCTGCGCGG CGGGGATCTC GGCGGTCGCG CCCGCCCGCA GTTTGCTTGC TCCCGCGTCG 120
GAGACAGTGT TTGGCTTAGG GGCAGCGGCC GCCCCGACTT CGGCCGCGCG GGTGCCTGCG 180
GTGGCAACGG CCGAAGTGAC CGTGGAGGAC GCCGAGGCAT TGCCGGCTGC CGCTGGCGAA 240
CCGGAGTCAC GCGCGACGGA GCCCGATGAC GACGTGGAAC TGCGGCCTCG CGGCAGGTCC 300
TTGGTAATCA TCAGCACTTT AGATGGACGA ATCGCTGCAC TGGATGCCGA GAATGATGGG 360
AAAAAGCAGT GGGATTTGGA CGTGGGGTCT GGTTCCTTGG TTTCATCTAG CCTCAGCAAG 420
CCAGAGGTGT TTGGGAACAA GATGATCATC CCCTCCCTGG ATGGAGACCT CTTCCAGTGG 480
GACCGGGACC GAGAGAGCAT GGAGGCCGTC CCCTTCACGG TGGAGTCCCT GCTCGAATCT 540
TCCTACAAGT TTGGAGATGA TGTTGTTCTG GTTGGAGGGA AATCTCTGAC TACATACGGA 600
CTCAGTGCTT ACAGTGGAAA GCTGAGGTAT ATCTGTTCTG CCTTGGGATG TCGCCGATGG 660
GATAGTGATG AAATGGAAGA AGAGGAAGAC ATCTTGCTTC TGCAGCGTAC GCAGAAGACT 720
GTGCGAGCTG TCGGGCCTCG AAGCGGCAGT GAGAAGTGGA ATTTCAGTGT TGGCCACTTT 780
GAACTTCGGT ATATTCCAGA CATGGAAACT AGAGCCGGAT TCATTGAAAG CACCTTTAAA 840
CCGGGTGGAA ACAAAGAAGA CTCTAAAATT ATTTCAGATG TGGAAGAACA AGAAGCCACC 900
ATGCTGGACA CAGTGATAAA AGTTTCCGTT GCTGATTGGA AGGTCATGGC GTTTAGTAGG 960
AAGGGAGGCC GCCTGGAATG GGAGTACCAG TTTTGTACTC CCATCGCGTC CGCCTGGCTG 1020
GTGAGGGATG GCAAGGTCAT CCCCATCAGC CTGTTTGATG ATACAAGTTA CACAGCCAGC 1080
GAAGAAGCCT TGGGAGACGA AGAAGACATT GTAGAGGCTG CTCGGGGAGC CACAGAGAAC 1140
AGCGTGTACT TAGGGATGTA CAGAGGCCAG CTGTACCTGC AGTCGTCCGT CAGGGTCTCA 1200
GAAAAGTTCC CTACAAGCCC AAAGGCCTTG GAGTCTGTAA ATGGCGAAAA TGCAATTATT 1260
CCTCTGCCGA CGATCAAATG GAAGCCCTTA ATCCATTCTC CTTCTAGGAC TCCTGTCTTG 1320
GTTGGGTCTG ATGAATTTGA CAAATGTCTA AGTAATGATA AGTATTCCCA CGAAGAATAC 1380
AGTAATGGTG CACTTTCAAT CCTCCAGTAT CCATACGATA ACGGTTACTA TCTGCCATAC 1440
TACAAGAGAG AAAGGAATAA GCGGAGCACG CAGATCACAG TCAGGTTCCT GGACAGCCCC 1500
CACTACAGCA AGAACATCCG CAAGAAGGAC CCTATCCTCC TGCTGCACTG GTGGAAGGAG 1560
ATATTCGGGA CGATCCTGCT TTGCATCGTA GCCACGACCT TCATCGTGCG CAGGCTTTTC 1620
CATCCTCAGC CCCACAGGCA GCGGAAGGAG TCTGAAACTC AGTGCCAGAC TGAAAGTAAA 1680
TACGACTCCG TGAGTGCCGA TGTCAGTGAC AACAGCTGGA ATGACATGAA GTACTCAGGA 1740
TACGTATCCC GATATCTAAC AGATTTTGAG CCAATTCAGT GCATGGGTCG TGGTGGCTTT 1800
GGCGTTGTCT TTGAAGCTAA AAACAAAGTA GATGACTGCA ATTACGCTAT CAAGAGGATC 1860
CGGCTCCCCA ACAGGGAGTT GGCACGGGAG AAGGTAATGC GGGAAGTTAA AGCCTTGGCT 1920
AAGCTGGAAC ACCCAGGCAT TGTGAGGTAT TTCAACGCCT GGCTGGAAAC CCCACCAGAG 1980
AAGTGGCAAG AAGAGATGGA TGAGATCTGG CTCAAAGACG AAAGCACAGA CTGGCCGCTC 2040
AGCTCCCCTA GCCCGATGGA TGCCCCATCT GTTAAGATCC GAAGGATGGA TCCTTTCTCT 2100
ACAAAAGAGC AGATCGAAGT CATAGCTCCT TCTCCTGAAA GAAGTCGGTC TTTCTCGGTG 2160
GGCATTTCCT GTGGCCAGAC AAGCTCATCG GAGAGCCAGT TCTCTCCCCT GGAGTTCTCA 2220
GGGACAGACT GCGGAGACAA CAGTGACTCA GCGGACGCAG CCTACAACCT CCAGGACAGT 2280
TGCCTGACGG ACTGCGAGGA CGTGGAAGAT GGCACCGTGG ACGGCAATGA CGAGGGACAC 2340
TCCTTTGAAC TTTGTCCGTC CGAAGCTTCT CCCTATACCC GGTCAAGGGA AGGAACGTCC 2400
TCCTCCATAG TGTTTGAGGA CTCTGGCTGC GGCAACGCGT CCAGTAAGGA GGAGCCCAGA 2460
GGGAACCGGC TGCATGATGG CAACCATTAT GTTAATAAGC TAACTGATCT CAAGTGCTCC 2520
AGCAGCAGGT CTTCTTCAGA AGCCACCACC TTGTCTACCT CCCCTACCAG GCCAACCACT 2580
CTAAGCTTGG ATTTCACCAA GAACACTGTG GGCCAGCTCC AGCCCAGCTC CCCCAAGGTG 2640
TATCTGTACA TTCAGATGCA GCTGTGCAGG AAGGAGAACC TCAAAGACTG GATGAACCGG 2700
CGCTGCAGCT TGGAGGACCG GGAGCACGGC GTGTGCCTGC ACATCTTCCT GCAGATCGCA 2760
GAGGCAGTGG AGTTCCTGCA CAGCAAGGGA CTCATGCACA GGGACCTCAA GCCTTCCAAC 2820
ATATTCTTCA CAATGGATGA TGTGGTCAAG GTTGGGGACT TTGGACTGGT GACTGCTATG 2880
GACCAAGATG AAGAAGAGCA GACTGTACTG ACTCCAATGC CAGCCTATGC TACGCACACG 2940
GGACAAGTAG GGACCAAGCT ATACATGAGC CCAGAGCAGA TTCATGGAAA CAACTACTCC 3000
CATAAAGTGG ACATCTTCTC TTTAGGCTTG ATTCTGTTTG AACTCCTCTA CCCATTCAGC 3060
ACCCAGATGG AACGAGTCCG GATTTTAACT GATGTCAGAA ATCTCAAGTT TCCTCTACTG 3120
TTCACTCAGA AATATCCCCA AGAGCATATG ATGGTTCAAG ACATGCTCTC TCCATCCCCC 3180
ACGGAGCGGC CTGAAGCCAC AGACATCATT GAAAATGCCA TATTTGAGAA CTTGGAGTTT 3240
CCCGGGAAAA CGGTTCTGAG ACAGCGGTCC CGCTCCATGA GTTCATCTGG AACAAAACAT 3300
TCCAGACAGC CCAGCTGCTC GTACAGCCCA CTGCCTGGCA ACTAG 3345
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60
         fe i+++G+GgfgvV++aknk+d+++yaikri+l++++ ++ekv+revkaLaklehp+iv
Q: 589   FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV  648
         799*********************************************************
S: 61    rYfaawleekeesl..............................................  74
         rYf+awle+++e++                                              
Q: 649   RYFNAWLETPPEKWqeemdeiwlkdestdwplsspspmdapsvkirrmdpfstkeqievi  708
         ************************************************************
S: 75    ............................................................  74
                                                                     
Q: 709   apspersrsfsvgiscgqtsssesqfsplefsgtdcgdnsdsadaaynlqdscltdcedv  768
         ************************************************************
S: 75    ...td.sseveaeaeleesesseesdtk................................  98
            t  ++++ +++el++se+s++++++                                
Q: 769   edgTVdGNDEGHSFELCPSEASPYTRSRegtsssivfedsgcgnasskeeprgnrlhdgn  828
         **96669*****************************************************
S: 99    ....................................................llyiqmel  106
                                                             +lyiqm+l
Q: 829   hyvnkltdlkcsssrssseattlstsptrpttlsldftkntvgqlqpsspkvYLYIQMQL  888
         ************************************************************
S: 107   ceketLkdwiderkllesrselvm.rlfkqllegleylHskgliHrdLkpsniFldsddq  165
         c+ke+Lkdw+++r++le+r++ v+ ++f q++e++e+lHskgl+HrdLkpsniF+++dd 
Q: 889   CRKENLKDWMNRRCSLEDREHGVClHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDV  948
         ************************************************************
S: 166   vKigDFgLatalaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsL  225
         vK+gDFgL+ta++++++e+++ ++++++a+htgqvgtklymsPeq+++++Y++kvDifsL
Q: 949   VKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSL  1008
         ************************************************************
S: 226   GlilfeLlypfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsase  285
         GlilfeLlypfst+merv++lt++r++k+p  f++k+p+e++++q++ls +p+eRp+a++
Q: 1009  GLILFELLYPFSTQMERVRILTDVRNLKFPLLFTQKYPQEHMMVQDMLSPSPTERPEATD  1068
         ************************************************************
S: 286   llksell  292
         +++++++
Q: 1069  IIENAIF  1075
         ***9875
Domain Sequence
(FASTA)
FEPIQCMGRG GFGVVFEAKN KVDDCNYAIK RIRLPNRELA REKVMREVKA LAKLEHPGIV 60
RYFNAWLETP PEKWQEEMDE IWLKDESTDW PLSSPSPMDA PSVKIRRMDP FSTKEQIEVI 120
APSPERSRSF SVGISCGQTS SSESQFSPLE FSGTDCGDNS DSADAAYNLQ DSCLTDCEDV 180
EDGTVDGNDE GHSFELCPSE ASPYTRSREG TSSSIVFEDS GCGNASSKEE PRGNRLHDGN 240
HYVNKLTDLK CSSSRSSSEA TTLSTSPTRP TTLSLDFTKN TVGQLQPSSP KVYLYIQMQL 300
CRKENLKDWM NRRCSLEDRE HGVCLHIFLQ IAEAVEFLHS KGLMHRDLKP SNIFFTMDDV 360
VKVGDFGLVT AMDQDEEEQT VLTPMPAYAT HTGQVGTKLY MSPEQIHGNN YSHKVDIFSL 420
GLILFELLYP FSTQMERVRI LTDVRNLKFP LLFTQKYPQE HMMVQDMLSP SPTERPEATD 480
IIENAIF 487
Keyword3D-structure; ADP-ribosylation; ATP-binding; Complete proteome; Endoplasmic reticulum; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Signal; Stress response; Transferase; Translation regulation; Transmembrane; Transmembrane helix; Unfolded protein response.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00317
EKS-ANC-00330
EKS-BOT-00338
EKS-CAE-00275
EKS-CAJ-00347
EKS-CAF-00346
EKS-CAP-00372
EKS-CII-00189
EKS-CIS-00091
EKS-DAR-00702
EKS-DRM-00166
EKS-EQC-00330
EKS-FEC-00329
EKS-GAG-00285
EKS-GAA-00421
EKS-GOG-00335
EKS-HOS-00345
EKS-ICT-00322
EKS-LAC-00353
EKS-LOA-00350
EKS-MAM-00344
EKS-MEG-00279
EKS-MOD-00334
EKS-MUP-00333
EKS-MYL-00337
EKS-NOL-00309
EKS-ORN-00442
EKS-ORA-00297
EKS-ORC-00317
EKS-ORL-00409
EKS-OTG-00343
EKS-PAT-00321
EKS-PES-00298
EKS-PEM-00179
EKS-POA-00331
EKS-PTV-00079
EKS-RAN-00353
EKS-SAH-00317
EKS-SUS-00302
EKS-TAG-00414
EKS-TAR-00445
EKS-TEN-00441
EKS-VIP-00041
EKS-XET-00434
EKS-XIM-00430
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0030282; P:bone mineralization
GO:0019722; P:calcium-mediated signaling
GO:0002063; P:chondrocyte development
GO:0031018; P:endocrine pancreas development
GO:0007029; P:endoplasmic reticulum organization
GO:0030968; P:endoplasmic reticulum unfolded protein response
GO:0006983; P:ER overload response
GO:0045444; P:fat cell differentiation
GO:0030073; P:insulin secretion
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0007595; P:lactation
GO:0031642; P:negative regulation of myelination
GO:0017148; P:negative regulation of translation
GO:0032092; P:positive regulation of protein binding
GO:0009967; P:positive regulation of signal transduction
GO:0046777; P:protein autophosphorylation
GO:0051260; P:protein homooligomerization
GO:0019217; P:regulation of fatty acid metabolic process
GO:0032933; P:SREBP signaling pathway
GO:0006412; P:translation
GO:0006926; P:virus-infected cell apoptotic process
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR011047; Quinonprotein_ADH-like.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013