EKS-MUM-00034

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00034

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	332.4	5.3E-99	917	1186	270

Status

Unreviewed

Ensembl Protein

ENSMUSP00000001036

UniProt Accession

E9QJS1;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

Tyk2

Gene Synonyms/Alias

Tyk2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000032175	ENSMUSP00000001036	ENSMUST00000001036

Organism

Mus musculus

Functional Description

Protein Length

1207

Protein Sequence
(FASTA)

MVGTMPLCGR RAILEDSKAD GTEAQPLVPT GCLMVLLHWP GPEGGEPWVT FSQTSLTAEE 60

VCIHIAHKVG ITPPCLNLFA LYNAQAKVWL PPNHILDTSQ DMNLYFRMRF YFRNWHGMNP 120

QEPAVYRCGF PGAETSSDRA EQGVQLLDSA SFEYLFEQGW YVGNRAKSSH TSFSIHRSTP 180

QGKHEFMNDV VSLRDLSSEE EIHHFKNESL GMAFLHLCHL ALSRGVPLEE MAREISFKNC 240

IPHSFRQHIR QHNVLTRLRL HRVFRRFLRA FRPGHLSQQV VMVKYLATLE RLAPRFGSER 300

IPVCHLEVLA QPERDPCYIQ NSGQTAGDPG PELPSGPPTH EVLVTGTGGI QWHPLQTQES 360

ERGNSRGNPH GSRSGKKPKA PKAGEHLTES PQEPPWTYFC DFQDISHVVL KERRVHIHLQ 420

DNKCLLLCLC SQAEALSFVA LVDGYFRLTA DSSHYLCHEV APPRLVTSIQ NGIHGPLMDP 480

FVQAKLWPED GLYLIQWSTS HLHRLILTVA HRNPAFSNGP RGLRLRKFPI TQQPGAFVLD 540

GWGRSFASLG DLRLALQGCS LRAGDDCFPL HHCCLPRPRE ISNLVIMRGS RAHTRPLNLS 600

QLSFHRVHQD EITQLSHLGQ GTRTNVYEGL LRVGGPDEGK VDNGCPPEPG GTSGQQLRVV 660

LKVLDPSHHD IALAFYETAS LMSQVSHMHL AFLHGVCVRG SENIIVTEFV EHGPLDVWLR 720

RQRGQVPMTW KMVVAQQLAS ALSYLEDKNL VHGNVCGRNI LLARLGLEEG TNPFIKLSDP 780

GVGQGALSRE ERVERIPWTA PECLSGGTSS LGTATDMWGF GATLLEICFD GEAPLQGRGP 840

SEKERFYTKK HQLPEPSSPE LATLTRQCLT YEPAQRPSFR TILRDLTRLQ PQNLVGTSAV 900

NSDSPASDPT VFHKRYLKKI RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK ALKEGCGPQL 960

RSGWQREIEI LRTLYHEHIV KYKGCCEDQG EKSVQLVMEY VPLGSLRDYL PRHCVGLAQL 1020

LLFAQQICEG MAYLHAQHYI HRDLAARNVL LDNDRLVKIG DFGLAKAVPE GHEYYRVRED 1080

GDSPVFWYAP ECLKECKFYY ASDVWSFGVT LYELLTYCDS NQSPHMKFTE LIGHTQGQMT 1140

VLRLTELLER GERLPRPDRC PCEIYHLMKN CWETEASFRP TFQNLVPILQ TAQEKYQGQV 1200

PSVFSVC 1207

Nucleotide Sequence
(FASTA)

ATGGTGGGGA CCATGCCTCT GTGTGGGCGG AGAGCCATCT TGGAAGACAG CAAGGCAGAT 60

GGCACAGAAG CTCAGCCCCT GGTGCCCACA GGATGCTTGA TGGTGCTACT GCATTGGCCT 120

GGGCCTGAGG GCGGGGAGCC CTGGGTCACC TTCAGCCAGA CATCTCTGAC TGCAGAGGAG 180

GTCTGCATCC ACATCGCACA CAAAGTCGGC ATCACTCCAC CCTGCTTGAA TCTCTTCGCA 240

CTCTACAATG CACAGGCTAA GGTCTGGCTG CCCCCAAACC ATATTCTGGA TACATCCCAA 300

GACATGAACC TCTATTTTCG AATGAGGTTT TACTTCCGGA ACTGGCATGG CATGAATCCC 360

CAGGAGCCAG CTGTATACCG GTGTGGTTTC CCAGGGGCAG AGACTTCCTC AGACCGGGCA 420

GAGCAAGGTG TACAGCTCTT GGACTCTGCC TCGTTTGAAT ACCTTTTTGA GCAGGGATGG 480

TATGTTGGCA ATAGAGCAAA AAGCTCCCAC ACCTCTTTTT CTATCCATCG CTCTACCCCT 540

CAGGGAAAGC ATGAGTTCAT GAACGATGTG GTGTCTCTGC GGGACCTGTC TAGCGAGGAG 600

GAGATCCACC ACTTTAAGAA TGAGAGCTTA GGCATGGCCT TCCTGCACCT GTGTCACCTT 660

GCTCTCAGCC GAGGCGTCCC CCTGGAGGAG ATGGCCAGAG AGATCAGCTT CAAGAACTGC 720

ATCCCTCATT CCTTCCGACA GCACATCCGG CAGCACAATG TGCTCACACG CCTGCGGCTC 780

CACAGAGTCT TCCGCCGCTT CCTGCGGGCC TTCCGGCCTG GCCACCTCTC CCAGCAGGTT 840

GTGATGGTGA AGTACTTGGC TACCCTGGAG CGGCTGGCTC CGCGCTTTGG CTCAGAGCGC 900

ATACCTGTGT GTCATCTGGA GGTCCTGGCA CAGCCCGAGA GGGACCCCTG CTACATCCAG 960

AACAGTGGGC AGACCGCTGG GGATCCAGGC CCAGAGCTGC CTTCCGGGCC TCCCACCCAC 1020

GAGGTACTGG TGACAGGCAC CGGAGGTATC CAGTGGCATC CGCTGCAGAC CCAGGAATCT 1080

GAGAGAGGTA ACAGCAGAGG GAATCCCCAC GGCAGCCGGT CGGGGAAGAA GCCCAAAGCC 1140

CCCAAGGCTG GAGAGCACCT GACAGAGAGC CCTCAGGAAC CACCTTGGAC CTACTTCTGT 1200

GACTTCCAGG ACATTTCCCA CGTGGTGCTA AAGGAGCGTC GCGTGCACAT CCACCTCCAA 1260

GACAACAAGT GCTTGTTGCT GTGCCTCTGT TCCCAGGCTG AGGCCCTGTC CTTTGTGGCC 1320

CTGGTCGATG GCTATTTCCG CTTGACTGCT GACTCCAGCC ACTATCTGTG CCATGAGGTG 1380

GCACCCCCGA GGCTGGTGAC TAGCATCCAG AACGGCATCC ATGGGCCCCT GATGGATCCG 1440

TTTGTACAGG CCAAGCTGTG GCCAGAGGAC GGCCTCTACC TGATTCAGTG GAGCACCAGC 1500

CACCTGCACC GCCTGATCCT TACCGTGGCC CATCGAAACC CGGCTTTCAG TAATGGCCCT 1560

CGGGGCCTGC GCCTGCGAAA GTTCCCCATC ACACAGCAGC CTGGAGCCTT TGTGCTGGAT 1620

GGCTGGGGCC GCTCCTTTGC CAGCTTGGGG GACCTTCGGC TCGCCTTGCA GGGCTGCTCG 1680

TTGCGGGCCG GTGATGACTG TTTCCCCCTG CACCACTGCT GCCTGCCCCG GCCAAGAGAA 1740

ATCTCCAACC TCGTCATCAT GCGGGGGTCT AGGGCCCACA CCCGGCCTCT CAACCTCAGT 1800

CAGCTCAGCT TCCACAGGGT TCACCAGGAT GAAATCACCC AGCTGTCCCA CTTGGGCCAA 1860

GGCACAAGGA CCAATGTGTA TGAGGGCCTT CTAAGAGTGG GAGGCCCCGA TGAGGGCAAA 1920

GTGGACAATG GATGTCCCCC TGAGCCTGGT GGGACTAGTG GGCAGCAGCT TCGAGTGGTG 1980

CTCAAAGTTC TCGACCCCAG TCACCATGAT ATCGCCTTGG CCTTCTATGA GACTGCTAGC 2040

CTCATGAGCC AGGTGTCACA CATGCACCTG GCTTTCCTGC ATGGTGTTTG CGTGCGTGGC 2100

TCAGAGAATA TCATTGTGAC AGAATTCGTA GAACATGGTC CCTTGGATGT GTGGTTACGG 2160

CGACAGAGGG GCCAAGTGCC CATGACCTGG AAGATGGTCG TGGCTCAGCA GCTGGCCAGC 2220

GCCCTCAGCT ACCTGGAGGA CAAGAATCTG GTTCACGGGA ATGTATGTGG CCGGAACATC 2280

CTGCTGGCTC GCCTGGGGTT GGAGGAGGGT ACCAACCCCT TCATCAAGCT AAGTGATCCT 2340

GGTGTGGGCC AGGGTGCCCT CTCCAGGGAA GAGCGGGTGG AGCGCATCCC CTGGACAGCT 2400

CCCGAGTGCC TGTCTGGAGG GACCAGTAGC TTGGGTACTG CCACGGACAT GTGGGGCTTT 2460

GGTGCCACCC TTCTTGAGAT CTGCTTTGAT GGGGAGGCAC CCCTGCAGGG TCGTGGTCCC 2520

TCTGAGAAAG AACGGTTCTA CACAAAGAAA CATCAGCTGC CTGAACCCTC ATCCCCAGAG 2580

CTGGCCACAC TCACCCGCCA GTGCCTGACC TATGAACCAG CACAGCGGCC ATCCTTCCGC 2640

ACCATTTTGC GGGACCTCAC AAGGCTGCAG CCACAGAATC TAGTCGGCAC TTCGGCTGTG 2700

AACTCAGACT CACCAGCATC AGACCCCACT GTTTTCCACA AGCGCTATTT GAAAAAGATC 2760

CGGGATTTGG GTGAGGGTCA CTTTGGCAAG GTCAGCCTGT ACTGCTACGA CCCAACCAAT 2820

GACGGCACTG GCGAGATGGT GGCCGTGAAG GCCCTGAAGG AAGGGTGCGG TCCCCAGCTC 2880

CGCTCAGGCT GGCAGCGGGA GATCGAGATC CTGCGGACGC TGTACCACGA ACATATTGTC 2940

AAGTATAAAG GCTGCTGTGA GGACCAAGGA GAGAAGTCTG TACAGCTGGT CATGGAGTAC 3000

GTCCCTCTGG GCAGCCTCCG AGACTACCTG CCAAGGCACT GCGTAGGGCT GGCGCAGCTC 3060

CTGCTGTTTG CCCAGCAGAT CTGCGAGGGC ATGGCCTACC TGCACGCTCA GCACTACATT 3120

CACCGAGACC TCGCCGCGCG CAACGTGCTG CTGGACAACG ACAGGCTGGT CAAGATTGGA 3180

GACTTTGGCC TAGCCAAGGC TGTACCTGAA GGCCACGAGT ACTACCGAGT GCGCGAGGAC 3240

GGGGACAGCC CAGTGTTCTG GTATGCCCCA GAATGCCTGA AGGAGTGCAA ATTTTACTAT 3300

GCATCTGATG TCTGGTCCTT CGGGGTAACT CTGTATGAGT TGTTGACATA CTGTGACTCT 3360

AACCAGAGTC CCCATATGAA ATTCACCGAG CTCATCGGCC ATACCCAGGG CCAGATGACC 3420

GTGCTGAGGC TCACAGAGCT GCTGGAACGA GGAGAGAGGC TGCCTCGGCC TGACAGGTGT 3480

CCCTGTGAGA TCTATCACCT CATGAAGAAC TGCTGGGAGA CAGAGGCCTC CTTCCGGCCC 3540

ACCTTCCAGA ATCTTGTGCC CATCCTCCAG ACAGCACAGG AGAAGTACCA AGGTCAGGTG 3600

CCTTCCGTGT TCAGCGTGTG CTGA 3624

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k+Lk  +g++ +++++re+eil++l+h

Q: 917   LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKeGCGPQLRSGWQREIEILRTLYH  976

         6899*********************************99*********************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         ehivk+kg+c ++ge+  +lVmeyv+ GsL++yL+++  ++ l++ll +a+q++++m+YL

Q: 977   EHIVKYKGCCEDQGEKsvQLVMEYVPLGSLRDYLPRH--CVGLAQLLLFAQQICEGMAYL  1034

         ****************9********************..*********************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         ++++++hrd+aarnvL+++++       vk++d+glakav+++ eYy vre++ds+++w+

Q: 1035  HAQHYIHRDLAARNVLLDNDRL------VKIGDFGLAKAVPEGhEYYRVREDGDSPVFWY  1088

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp.lrsesle..........rklel  224

         apecl+e+k +++asdvWsFgvtlyellt c++++sp ++  +l+          r++el

Q: 1089  APECLKECK-FYYASDVWSFGVTLYELLTyCDSNQSPhMKFTELIghtqgqmtvlRLTEL  1147

         *********.***************************955555555557778889*****

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         le++erlp+p+ cp+e+++lm+nc+++e+s+rp+F++++

Q: 1148  LERGERLPRPDrCPCEIYHLMKNCWETEASFRPTFQNLV  1186

         ************************************986

Domain Sequence
(FASTA)

LKKIRDLGEG HFGKVSLYCY DPTNDGTGEM VAVKALKEGC GPQLRSGWQR EIEILRTLYH 60

EHIVKYKGCC EDQGEKSVQL VMEYVPLGSL RDYLPRHCVG LAQLLLFAQQ ICEGMAYLHA 120

QHYIHRDLAA RNVLLDNDRL VKIGDFGLAK AVPEGHEYYR VREDGDSPVF WYAPECLKEC 180

KFYYASDVWS FGVTLYELLT YCDSNQSPHM KFTELIGHTQ GQMTVLRLTE LLERGERLPR 240

PDRCPCEIYH LMKNCWETEA SFRPTFQNLV 270

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

mmu:54721

;

InterPros

IPR019749	; Band_41_domain.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045	; Tyr_kinase_non-rcpt_TYK2_N.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.
PR01827	; YKINASETYK2.

Created Date

20-Feb-2013