| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00149 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| TK/Csk | 472.4 | 5.9E-142 | 195 | 440 | 246 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000034863 |
| UniProt Accession | P41241; Q03143; Q80WU4; Q8VCW1; |
| Protein Name | Tyrosine-protein kinase CSK |
| Protein Synonyms/Alias | C-Src kinase; Protein-tyrosine kinase MPK-2; p50CSK; |
| Gene Name | Csk |
| Gene Synonyms/Alias | Csk; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Non-receptor tyrosine-protein kinase that plays animportant role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity). |
| Protein Length | 450 |
Protein Sequence
(FASTA) | | MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 60 | | PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120 | | SCEGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTTDA DGLCTRLIKP KVMEGTVAAQ 180 | | DEFYRSGWAL NMKELKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 240 | | TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 300 | | AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 360 | | KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 420 | | NCWHLDAATR PTFLQLREQL EHIKTHELHL 450 |
|
Nucleotide Sequence
(FASTA) | | ATGTCGGCAA TACAGGCCGC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTC 60 | | CATGGCACTG CTGAGCAAGA CCTTCCCTTC TGCAAAGGAG ATGTGCTCAC CATCGTGGCT 120 | | GTCACCAAGG ACCCCAACTG GTACAAAGCC AAAAACAAAG TGGGCCGTGA GGGCATCATC 180 | | CCAGCCAACT ATGTCCAGAA GCGTGAGGGT GTGAAGGCAG GCACCAAACT CAGCCTTATG 240 | | CCCTGGTTCC ACGGCAAGAT CACACGGGAG CAGGCCGAGC GGCTTCTTTA CCCACCAGAG 300 | | ACAGGCCTGT TCCTCGTGCG GGAAAGCACC AACTACCCTG GAGACTACAC ACTGTGTGTG 360 | | AGCTGTGAGG GCAAGGTGGA GCACTACCGC ATCATGTATC ATGCGAGCAA GCTGAGCATT 420 | | GATGAGGAGG TGTACTTTGA GAACCTCATG CAGCTGGTGG AGCACTACAC CACAGATGCC 480 | | GATGGACTCT GCACTCGCCT CATCAAACCA AAGGTCATGG AGGGCACCGT GGCGGCCCAG 540 | | GATGAGTTCT ACCGCAGTGG CTGGGCACTG AACATGAAGG AACTGAAGCT GCTACAGACA 600 | | ATAGGGAAGG GGGAGTTTGG AGATGTGATG CTGGGGGATT ACCGGGGCAA CAAAGTTGCA 660 | | GTCAAGTGCA TCAAGAATGA CGCAACTGCC CAGGCCTTCC TGGCTGAAGC CTCCGTCATG 720 | | ACGCAACTTC GGCACAGCAA CCTCGTCCAG CTGCTGGGTG TGATTGTGGA GGAGAAGGGT 780 | | GGGCTCTACA TCGTCACAGA GTACATGGCC AAGGGGAGTT TGGTGGACTA TCTTCGATCA 840 | | CGTGGTCGTT CGGTGCTAGG TGGAGACTGT CTCCTCAAAT TCTCATTAGA CGTCTGTGAA 900 | | GCCATGGAGT ACCTGGAGGG TAACAATTTT GTGCACCGGG ACTTGGCTGC CCGGAATGTG 960 | | CTGGTGTCTG AAGACAACGT GGCCAAAGTC AGTGACTTTG GCCTCACTAA GGAAGCCTCC 1020 | | AGCACTCAGG ACACAGGCAA GCTGCCAGTC AAATGGACAG CGCCTGAAGC CTTGAGAGAG 1080 | | AAGAAATTTT CCACCAAGTC TGATGTGTGG AGTTTCGGAA TCCTTCTCTG GGAAATCTAT 1140 | | TCCTTCGGGC GAGTGCCTTA CCCAAGAATT CCCCTGAAGG ACGTCGTCCC TCGGGTGGAA 1200 | | AAGGGCTATA AGATGGACGC TCCGGATGGC TGCCCGCCCG CAGTCTACGA GGTGATGAAG 1260 | | AACTGCTGGC ACCTGGATGC TGCCACACGG CCCACGTTTT TGCAGCTTCG GGAACAGCTC 1320 | | GAGCACATCA AGACCCATGA GCTGCACCTG TGA 1353 |
|
| Domain Profile | S: 1 lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv 60 | lkl +tigkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+h+nlv+llgv | Q: 195 LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV 254 | 6899******************************************************** |
| S: 61 ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd 119 | i+eek gly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd | Q: 255 IVEEKgGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 | *****99***************************************************** |
| S: 120 laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi 179 | laarnvlvsed+vakvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvwsfgi | Q: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI 374 | ************************************************************ |
| S: 180 llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa 239 | llwei+sfgrvpypriplkdvv++vekgykm+ap+gcpp+vye+mk++w+l+aa+rp+f | Q: 375 LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPTFL 434 | ************************************************************ |
| S: 240 klkekl 245 | +l+e+l | Q: 435 QLREQL 440 | ***997 |
|
Domain Sequence
(FASTA) | | LKLLQTIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTQLR HSNLVQLLGV 60 | | IVEEKGGLYI VTEYMAKGSL VDYLRSRGRS VLGGDCLLKF SLDVCEAMEY LEGNNFVHRD 120 | | LAARNVLVSE DNVAKVSDFG LTKEASSTQD TGKLPVKWTA PEALREKKFS TKSDVWSFGI 180 | | LLWEIYSFGR VPYPRIPLKD VVPRVEKGYK MDAPDGCPPA VYEVMKNCWH LDAATRPTFL 240 | | QLREQL 246 |
|
| Keyword | 3D-structure; Adaptive immunity; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Immunity; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |