| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00449 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/DAPK | 475.9 | 7.2E-143 | 24 | 285 | 262 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000034944 |
| UniProt Accession | Q8VDF3; O88861; Q9QYM4; |
| Protein Name | Death-associated protein kinase 2 |
| Protein Synonyms/Alias | DAP kinase 2; DAP-kinase-related protein 1; DRP-1; |
| Gene Name | Dapk2 |
| Gene Synonyms/Alias | Dapk2; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Calcium/calmodulin-dependent serine/threonine kinaseinvolved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell deaths signal. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta- catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity). |
| Protein Length | 370 |
Protein Sequence
(FASTA) | | MVQASMRSPN METFKQQKVE DFYDIGEELG SGQFAIVKKC REKSTGLEYA AKFIKKRQSR 60 | | ASRRGVCREE IEREVSILRQ VLHPNIITLH DVYENRTDVV LILELVSGGE LFDFLAQKES 120 | | LSEEEATSFI KQILDGVNYL HTKKIAHFDL KPENIMLLDK NIPIPHIKLI DFGLAHEIED 180 | | GVEFKNIFGT PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGD TKQETLANIT 240 | | AVSYDFDEEF FSQTSELAKD FIRKLLVKET RKRLTIQEAL RHPWITPVDT QQAMVRRESV 300 | | VNLENFKKQY VRRRWKLSFS IVSLCNHLTR SLMKKVHLRT SEDLRNCESD TEENIARRKA 360 | | LHPRRRSSTS 370 |
|
Nucleotide Sequence
(FASTA) | | ATGGTCCAGG CCTCGATGAG GAGCCCAAAT ATGGAGACGT TCAAACAGCA GAAGGTGGAG 60 | | GACTTTTATG ATATTGGAGA GGAGCTGGGC AGTGGCCAGT TTGCCATCGT GAAGAAGTGC 120 | | CGGGAGAAGA GCACGGGGCT GGAGTATGCA GCCAAGTTCA TTAAGAAGAG GCAGAGCCGG 180 | | GCCAGCCGTC GGGGCGTGTG CCGGGAGGAA ATCGAGCGGG AGGTGAGCAT CCTGCGGCAG 240 | | GTGCTGCACC CCAACATCAT CACGCTGCAC GACGTCTATG AGAACCGCAC CGACGTGGTG 300 | | CTCATCCTTG AGCTAGTGTC CGGAGGAGAA CTGTTTGATT TCCTGGCCCA GAAGGAGTCG 360 | | TTAAGTGAGG AGGAAGCCAC CAGCTTCATT AAGCAGATCC TGGATGGGGT GAATTACCTT 420 | | CACACAAAGA AAATTGCTCA CTTTGATCTC AAGCCAGAAA ACATCATGTT GTTAGACAAG 480 | | AATATCCCAA TTCCACACAT CAAGCTGATT GACTTTGGCC TGGCTCACGA AATAGAAGAT 540 | | GGAGTTGAAT TTAAAAACAT TTTTGGGACA CCTGAATTTG TTGCTCCAGA AATCGTGAAC 600 | | TATGAGCCAC TGGGACTGGA GGCCGACATG TGGAGCATTG GAGTCATCAC CTATATCCTT 660 | | CTAAGTGGAG CGTCCCCCTT CCTGGGAGAC ACAAAACAAG AAACCCTGGC AAATATCACT 720 | | GCTGTGAGTT ACGACTTTGA TGAGGAATTC TTCAGCCAGA CAAGCGAGCT GGCCAAGGAC 780 | | TTCATTCGGA AGCTTCTTGT GAAAGAGACC CGGAAACGGC TTACCATCCA AGAGGCTCTC 840 | | AGACATCCCT GGATCACGCC GGTGGACACC CAGCAAGCTA TGGTACGCAG AGAGTCCGTG 900 | | GTCAACCTGG AGAATTTTAA GAAGCAGTAT GTCCGCAGGC GGTGGAAGCT GTCCTTCAGC 960 | | ATCGTCTCCT TGTGCAACCA CCTCACTCGC TCCCTGATGA AGAAGGTACA TCTGAGGACA 1020 | | AGCGAGGACC TGAGGAACTG CGAGAGTGAC ACAGAGGAGA ACATCGCCAG GAGGAAAGCC 1080 | | CTTCACCCCC GGAGGAGGAG CAGTACCTCC TAA 1113 |
|
| Domain Profile | S: 2 etgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirs 61 | ++g+elgsG+fa+v+kcrekstG eyaakf+kkr++++srrgv+reeierev++l+++ | Q: 24 DIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL- 82 | 689********************************************************. |
| S: 62 epnvinlhevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylhs 121 | +pn+i+lh+vyen++dv+lilelv+GGelfd+la+keslseeeat+++kqil+gv+ylh+ | Q: 83 HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 142 | ************************************************************ |
| S: 122 kkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivnye 181 | kki+h+dlkPeni+lldk++p ++iklidfGl+++ie+g+e+k+i+GtPefvaPeivnye | Q: 143 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE 202 | ************************************************************ |
| S: 182 plsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdfi 241 | pl+le+dmwsiGvityillsgasPflGdtkqetl+ni+av++df+ee+fs++selakdfi | Q: 203 PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFI 262 | ************************************************************ |
| S: 242 rrllvkdpekrltieeclehswl 264 | r+llvk+++krlti+e+l+h+w+ | Q: 263 RKLLVKETRKRLTIQEALRHPWI 285 | **********************8 |
|
Domain Sequence
(FASTA) | | DIGEELGSGQ FAIVKKCREK STGLEYAAKF IKKRQSRASR RGVCREEIER EVSILRQVLH 60 | | PNIITLHDVY ENRTDVVLIL ELVSGGELFD FLAQKESLSE EEATSFIKQI LDGVNYLHTK 120 | | KIAHFDLKPE NIMLLDKNIP IPHIKLIDFG LAHEIEDGVE FKNIFGTPEF VAPEIVNYEP 180 | | LGLEADMWSI GVITYILLSG ASPFLGDTKQ ETLANITAVS YDFDEEFFSQ TSELAKDFIR 240 | | KLLVKETRKR LTIQEALRHP WI 262 |
|
| Keyword | 3D-structure; Alternative splicing; Apoptosis; ATP-binding; Calmodulin-binding; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
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| Pfam | |
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| Prints | |
| Created Date | 20-Feb-2013 |