EKS-MUM-00488

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00488

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/CK1	464.0	3.0E-139	44	307	264

Status

Reviewed

Ensembl Protein

ENSMUSP00000113160

UniProt Accession

Q8BTH8; E9QPK6;

Protein Name

Casein kinase I isoform gamma-1

Protein Synonyms/Alias

CKI-gamma 1;

Gene Name

Csnk1g1

Gene Synonyms/Alias

Csnk1g1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000032384	ENSMUSP00000034949	ENSMUST00000034949
ENSMUSG00000032384	ENSMUSP00000113160	ENSMUST00000117849
ENSMUSG00000032384	ENSMUSP00000119407	ENSMUST00000154589

Organism

Mus musculus

Functional Description

Serine/threonine-protein kinase. Casein kinases areoperationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CLSPN (By similarity). Regulates fast synaptic transmission mediated by glutamate.

Protein Length

430

Protein Sequence
(FASTA)

MDHSNREKDD RQRTTKTMAQ RNTHCSRPSG TSTSSGVLMV GPNFRVGKKI GCGNFGELRL 60

GKNLYTNEYV AIKLEPIKSR APQLHLEYRF YKQLGSAGEG LPQVYYFGPC GKYNAMVLEL 120

LGPSLEDLFD LCDRTFTLKT VLMIAIQLLS RMEYVHSKNL IYRDVKPENF LIGRQGNKKE 180

HVIHIIDFGL AKEYVDPETK KHIPYREHKS LTGTARYMSI NTHLGKEQSR RDDLEALGHM 240

FMYFLRGSLP WQGLKADTLK ERYQKIGDTK RNTPIEALCE NFPEEMATYL RYVRRLDFFE 300

KPDYEYLRTL FTDLFERKGY TFDYAYDWVG RPIPTPVGSV HVDSGASAIT RESHTHRDRP 360

SQQQPLRNQV VSSTNGELNV DDPTGAHSNA PITAHAEVEV VEEANCLKML NLWCCCFFKR 420

KRKKTAQRHK 430

Nucleotide Sequence
(FASTA)

ATGGACCATT CTAATAGGGA AAAGGATGAT AGACAACGGA CAACTAAAAC CATGGCACAA 60

AGGAATACAC ACTGTTCGAG ACCATCTGGC ACTTCAACAT CCTCTGGGGT TCTCATGGTG 120

GGACCCAACT TCAGGGTTGG CAAGAAGATA GGGTGTGGGA ACTTCGGAGA GCTCAGATTA 180

GGTAAAAATC TCTACACCAA TGAATATGTA GCCATTAAAC TGGAACCAAT AAAATCACGT 240

GCTCCACAAC TTCATTTAGA GTACAGGTTT TATAAACAGC TTGGCAGTGC AGGTGAAGGC 300

CTCCCACAGG TTTATTACTT TGGACCATGT GGGAAGTACA ATGCCATGGT GCTGGAACTC 360

CTTGGCCCTA GCTTGGAAGA CTTGTTTGAC CTCTGTGACC GAACGTTTAC TTTGAAGACG 420

GTGTTAATGA TAGCCATCCA GTTGCTTTCT CGAATGGAGT ATGTACACTC AAAGAATCTT 480

ATTTACCGAG ATGTCAAACC AGAGAACTTC TTGATTGGCC GACAAGGCAA TAAGAAAGAG 540

CATGTAATAC ACATTATAGA TTTTGGACTG GCCAAGGAAT ATGTTGATCC TGAAACCAAA 600

AAACACATAC CTTACAGAGA GCACAAAAGT TTGACTGGAA CTGCGAGATA CATGTCTATC 660

AACACACATC TAGGCAAAGA GCAAAGCCGG CGAGATGATT TGGAAGCCTT AGGCCATATG 720

TTCATGTACT TCCTCCGAGG CAGCCTACCC TGGCAAGGAC TCAAGGCTGA TACATTAAAA 780

GAGAGATATC AAAAAATCGG TGATACCAAA AGGAATACTC CCATCGAAGC TCTCTGTGAG 840

AACTTTCCAG AGGAGATGGC AACCTACCTT CGATATGTCA GGCGATTAGA CTTCTTTGAA 900

AAACCTGATT ATGAGTATTT ACGGACCCTC TTCACAGATC TGTTTGAACG GAAAGGCTAT 960

ACCTTTGACT ATGCCTATGA TTGGGTTGGA AGGCCTATTC CTACTCCAGT AGGATCAGTT 1020

CATGTAGATT CTGGTGCATC TGCAATAACT CGAGAAAGCC ACACACACAG GGATCGGCCA 1080

TCACAACAAC AGCCTCTTAG AAATCAGGTG GTTAGCTCAA CCAATGGAGA GCTGAATGTC 1140

GATGACCCCA CTGGAGCTCA CTCCAATGCA CCAATCACAG CTCATGCCGA AGTGGAGGTA 1200

GTGGAGGAAG CTAACTGCCT GAAAATGCTC AACCTGTGGT GCTGCTGTTT CTTTAAGAGG 1260

AAAAGGAAGA AGACAGCCCA GCGACACAAG TGA 1293

Domain Profile

S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqg.gvgiPe  59

         +rv+kkiG+G+fG+++lgknl+++e+vaikle++ks+apql+le+r+yk+l + g+g+P+

Q: 44    FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSaGEGLPQ  103

         89*************************************************8779*****

S: 60    vryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyr  119

         v+yfg+++kyn++vl+llGpsledlfdlc+r+f+lktvl++a+ql+sr+eyvhsk+liyr

Q: 104   VYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYR  163

         ************************************************************

S: 120   dikPdnfllgigrkgkk....vylidfGlakkyrdaktkkhipyreeksltGtaryasin  175

         d+kP+nfl  igr+g+k    +++idfGlak+y+d++tkkhipyre+ksltGtary+sin

Q: 164   DVKPENFL--IGRQGNKkehvIHIIDFGLAKEYVDPETKKHIPYREHKSLTGTARYMSIN  221

         ********..67777666777***************************************

S: 176   thlgkeqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlceg  235

         thlgkeqsrrddle+lg++++yflrgslPWqglka+t k++y+ki+++k++t+ie+lce+

Q: 222   THLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCEN  281

         ************************************************************

S: 236   fPeefatylkyvrklkfeekPdyeyl  261

         fPee+atyl+yvr+l+f+ekPdyeyl

Q: 282   FPEEMATYLRYVRRLDFFEKPDYEYL  307

         ************************97

Domain Sequence
(FASTA)

FRVGKKIGCG NFGELRLGKN LYTNEYVAIK LEPIKSRAPQ LHLEYRFYKQ LGSAGEGLPQ 60

VYYFGPCGKY NAMVLELLGP SLEDLFDLCD RTFTLKTVLM IAIQLLSRME YVHSKNLIYR 120

DVKPENFLIG RQGNKKEHVI HIIDFGLAKE YVDPETKKHI PYREHKSLTG TARYMSINTH 180

LGKEQSRRDD LEALGHMFMY FLRGSLPWQG LKADTLKERY QKIGDTKRNT PIEALCENFP 240

EEMATYLRYV RRLDFFEKPD YEYL 264

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

mmu:214897

;

InterPros

IPR022247	; Casein_kinase-1_gamma_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12605	; CK1gamma_C; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013