EKS-MUM-00125

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00125

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	461.5	1.9E-138	1059	1317	259

Status

Reviewed

Ensembl Protein

ENSMUSP00000035203

UniProt Accession

Q62190; E9QMZ4; Q62555;

Protein Name

Macrophage-stimulating protein receptor beta chain

Protein Synonyms/Alias

MSP receptor; Stem cell-derived tyrosine kinase; p185-Ron;

Gene Name

Mst1r

Gene Synonyms/Alias

Mst1r; Ron, Stk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000032584	ENSMUSP00000035203	ENSMUST00000035203

Organism

Mus musculus

Functional Description

Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Protein Length

1378

Protein Sequence
(FASTA)

MGLPLPLLQS SLLLMLLLRL SAASTNLNWQ CPRIPYAASR DFSVKYVVPS FSAGGRVQAT 60

AAYEDSTNSA VFVATRNHLH VLGPDLQFIE NLTTGPIGNP GCQTCASCGP GPHGPPKDTD 120

TLVLVMEPGL PALVSCGSTL QGRCFLHELE PRGKALHLAA PACLFSANNN KPEACTDCVA 180

SPLGTRVTVV EQGHASYFYV ASSLDPELAA SFSPRSVSIR RLKSDTSGFQ PGFPSLSVLP 240

KYLASYLIKY VYSFHSGDFV YFLTVQPISV TSPPSALHTR LVRLNAVEPE IGDYRELVLD 300

CHFAPKRRRR GAPEGTQPYP VLQAAHSAPV DAKLAVELSI SEGQEVLFGV FVTVKDGGSG 360

MGPNSVVCAF PIYHLNILIE EGVEYCCHSS NSSSLLSRGL DFFQTPSFCP NPPGGEASGP 420

SSRCHYFPLM VHASFTRVDL FNGLLGSVKV TALHVTRLGN VTVAHMGTVD GRVLQVEIAR 480

SLNYLLYVSN FSLGSSGQPV HRDVSRLGND LLFASGDQVF KVPIQGPGCR HFLTCWRCLR 540

AQRFMGCGWC GDRCDRQKEC PGSWQQDHCP PEISEFYPHS GPLRGTTRLT LCGSNFYLRP 600

DDVVPEGTHQ ITVGQSPCRL LPKDSSSPRP GSLKEFIQEL ECELEPLVTQ AVGTTNISLV 660

ITNMPAGKHF RVEGISVQEG FSFVEPVLTS IKPDFGPRAG GTYLTLEGQS LSVGTSRAVL 720

VNGTQCRLEQ VNEEQILCVT PPGAGTARVP LHLQIGGAEV PGSWTFHYKE DPIVLDISPK 780

CGYSGSHIMI HGQHLTSAWH FTLSFHDGQS TVESRCAGQF VEQQQRRCRL PEYVVRNPQG 840

WATGNLSVWG DGAAGFTLPG FRFLPPPSPL RAGLVELKPE EHSVKVEYVG LGAVADCVTV 900

NMTVGGEVCQ HELRGDVVIC PLPPSLQLGK DGVPLQVCVD GGCHILSQVV RSSPGRASQR 960

ILLIALLVLI LLVAVLAVAL IFNSRRRKKQ LGAHSLSPTT LSDINDTASG APNHEESSES 1020

RDGTSVPLLR TESIRLQDLD RMLLAEVKDV LIPHEQVVIH TDQVIGKGHF GVVYHGEYTD 1080

GAQNQTHCAI KSLSRITEVQ EVEAFLREGL LMRGLHHPNI LALIGIMLPP EGLPRVLLPY 1140

MRHGDLLHFI RSPQRNPTVK DLVSFGLQVA CGMEYLAEQK FVHRDLAARN CMLDESFTVK 1200

VADFGLARGV LDKEYYSVRQ HRHARLPVKW MALESLQTYR FTTKSDVWSF GVLLWELLTR 1260

GAPPYPHIDP FDLSHFLAQG RRLPQPEYCP DSLYHVMLRC WEADPAARPT FRALVLEVKQ 1320

VVASLLGDHY VQLTAAYVNV GPRAVDDGSV PPEQVQPSPQ HCRSTSKPRP LSEPPLPT 1378

Nucleotide Sequence
(FASTA)

ATGGGGCTGC CTCTGCCGCT GCTTCAATCC TCTCTTCTGC TAATGCTTCT TTTGCGGCTG 60

TCGGCGGCGT CCACCAACCT GAACTGGCAG TGCCCACGAA TACCCTACGC AGCCTCCCGA 120

GACTTCAGTG TCAAGTACGT GGTCCCCAGC TTCTCCGCGG GGGGCCGGGT ACAGGCCACC 180

GCAGCCTACG AGGACAGTAC AAATAGTGCG GTGTTTGTGG CCACACGCAA TCACCTGCAC 240

GTGCTTGGGC CTGACCTGCA GTTCATAGAG AACCTGACCA CTGGCCCTAT CGGGAACCCT 300

GGCTGCCAGA CTTGTGCGAG CTGTGGTCCA GGCCCTCATG GACCACCAAA GGACACAGAC 360

ACACTGGTGC TAGTGATGGA GCCAGGTTTG CCAGCCCTGG TCAGCTGTGG CTCAACCCTA 420

CAGGGCCGCT GCTTCCTGCA TGAGCTGGAG CCTCGGGGGA AAGCCCTGCA CTTAGCAGCT 480

CCAGCCTGCC TATTCTCAGC AAACAATAAC AAGCCTGAGG CCTGCACGGA CTGTGTGGCT 540

AGCCCCCTGG GCACTCGTGT GACTGTGGTG GAGCAGGGGC ATGCTTCCTA CTTCTATGTG 600

GCATCTTCGC TAGACCCAGA GTTGGCCGCT AGCTTTAGCC CCCGCTCGGT GTCCATCCGT 660

CGTCTAAAGT CTGATACTTC TGGATTCCAA CCAGGTTTTC CGTCGCTGTC GGTGCTGCCC 720

AAATATTTGG CCTCCTACCT CATCAAATAT GTGTACAGCT TCCACTCGGG GGATTTTGTC 780

TACTTTCTGA CTGTCCAGCC CATCAGTGTC ACAAGCCCTC CCAGTGCCTT GCATACACGT 840

CTGGTCCGGC TCAATGCTGT AGAGCCAGAG ATTGGTGACT ACCGGGAGCT GGTCTTGGAC 900

TGTCATTTTG CACCTAAACG CCGGCGCCGT GGAGCCCCGG AGGGCACACA GCCCTACCCA 960

GTGCTTCAGG CAGCCCACTC TGCTCCAGTG GATGCCAAAC TGGCTGTGGA ACTGAGCATT 1020

TCAGAGGGCC AGGAAGTGCT TTTTGGGGTC TTTGTGACCG TCAAGGATGG TGGCTCTGGC 1080

ATGGGTCCCA ACTCTGTTGT ATGTGCCTTC CCCATTTACC ACCTGAACAT CCTGATTGAA 1140

GAGGGTGTCG AATATTGCTG TCACTCTTCA AATTCTTCTT CCCTGTTGTC GAGAGGCCTT 1200

GACTTCTTCC AGACGCCCAG TTTTTGTCCT AATCCGCCTG GTGGAGAGGC CTCCGGCCCC 1260

AGCTCCCGTT GCCACTACTT CCCTTTGATG GTCCACGCTA GCTTCACCCG TGTGGACCTC 1320

TTCAATGGAC TGTTAGGATC AGTGAAGGTC ACCGCACTGC ATGTGACACG TCTTGGCAAT 1380

GTTACAGTGG CCCACATGGG CACTGTGGAT GGGCGTGTCC TACAGGTGGA GATAGCCAGG 1440

TCACTCAACT ACCTGCTGTA TGTGTCCAAC TTCTCCCTGG GCAGCAGTGG ACAGCCTGTT 1500

CATCGGGATG TCAGCCGCCT CGGGAATGAC CTACTCTTTG CCTCTGGGGA CCAGGTCTTC 1560

AAGGTGCCCA TCCAGGGCCC TGGCTGTCGT CATTTTCTCA CCTGTTGGCG TTGCCTGAGA 1620

GCACAGCGCT TCATGGGATG TGGCTGGTGT GGGGACCGGT GTGACCGGCA GAAGGAGTGT 1680

CCTGGCTCCT GGCAACAGGA CCACTGTCCG CCTGAGATCA GTGAGTTCTA TCCTCACAGC 1740

GGGCCTCTAA GGGGCACTAC GAGGCTCACC CTTTGTGGCT CCAACTTCTA CCTGCGACCT 1800

GATGATGTCG TACCTGAGGG AACACACCAG ATCACCGTGG GCCAAAGTCC CTGCCGACTG 1860

CTGCCTAAGG ACTCTTCAAG CCCTAGGCCA GGGTCCCTCA AGGAATTCAT ACAGGAACTT 1920

GAATGTGAGC TGGAGCCCCT GGTCACCCAG GCAGTGGGGA CTACAAACAT CAGCCTTGTC 1980

ATCACCAACA TGCCAGCAGG CAAGCACTTC CGAGTGGAAG GCATCTCTGT ACAGGAAGGC 2040

TTCTCTTTCG TGGAGCCAGT GCTGACATCA ATAAAACCTG ACTTTGGCCC GCGGGCTGGG 2100

GGTACTTATC TCACCCTTGA AGGCCAGAGC CTGTCTGTCG GCACCAGCCG GGCTGTGCTG 2160

GTCAATGGAA CCCAGTGCCG GCTGGAACAG GTCAATGAGG AGCAGATCTT ATGTGTCACG 2220

CCTCCTGGAG CTGGCACGGC CAGGGTCCCC CTTCATCTGC AGATAGGGGG TGCTGAGGTG 2280

CCTGGCTCCT GGACCTTTCA CTACAAGGAA GACCCTATTG TGTTGGACAT CAGTCCCAAG 2340

TGTGGCTACA GTGGCTCCCA CATCATGATC CATGGCCAGC ATCTGACTTC AGCATGGCAC 2400

TTCACGCTAT CATTCCATGA TGGACAAAGT ACAGTGGAGA GCAGGTGTGC GGGGCAGTTT 2460

GTGGAACAAC AGCAGCGTCG ATGTCGCCTG CCTGAATATG TGGTCCGAAA CCCTCAGGGG 2520

TGGGCAACAG GGAATCTGAG CGTCTGGGGT GATGGAGCAG CTGGCTTCAC GCTGCCTGGT 2580

TTTCGCTTCC TGCCCCCACC CAGTCCACTC AGAGCTGGCC TGGTTGAGTT GAAACCTGAA 2640

GAACATTCAG TTAAAGTTGA GTATGTCGGG CTGGGCGCTG TGGCAGACTG TGTGACTGTG 2700

AACATGACCG TGGGTGGTGA GGTCTGCCAA CATGAGCTCC GGGGGGATGT GGTGATCTGC 2760

CCCCTGCCCC CTTCCCTGCA ACTTGGCAAG GATGGTGTCC CATTGCAGGT CTGTGTAGAC 2820

GGTGGGTGTC ACATCCTGAG CCAAGTGGTT CGCTCAAGCC CAGGCAGGGC CTCACAGAGG 2880

ATACTCCTTA TTGCTCTTCT GGTCTTGATC CTGCTTGTGG CTGTGCTGGC CGTTGCCCTG 2940

ATCTTTAACT CCCGAAGACG GAAAAAGCAG CTAGGTGCTC ACTCCCTCTC CCCAACAACA 3000

CTCTCTGACA TCAACGATAC AGCTTCCGGG GCTCCGAACC ATGAAGAATC GTCAGAGAGT 3060

AGGGATGGGA CAAGTGTCCC ACTGCTGCGG ACAGAGTCTA TCCGGCTCCA GGATCTGGAC 3120

AGGATGCTCC TAGCTGAGGT CAAGGATGTA CTGATTCCCC ATGAACAAGT GGTCATCCAT 3180

ACTGACCAAG TCATTGGCAA AGGCCACTTT GGTGTTGTCT ACCACGGAGA ATATACAGAC 3240

GGAGCACAGA ATCAGACCCA CTGTGCCATC AAGTCTCTGA GTCGCATTAC AGAGGTGCAG 3300

GAGGTGGAGG CTTTCCTGCG GGAGGGGCTG CTCATGCGTG GCCTACATCA CCCAAACATC 3360

CTGGCTCTCA TCGGTATCAT GCTGCCCCCG GAGGGGCTTC CCCGGGTGCT GTTGCCCTAT 3420

ATGCGCCACG GAGACCTGCT TCATTTCATT CGCTCCCCTC AGAGGAACCC CACTGTGAAG 3480

GATCTTGTCA GCTTTGGCCT GCAGGTAGCC TGTGGTATGG AGTACCTGGC AGAGCAGAAG 3540

TTCGTGCACA GAGACCTGGC TGCTAGGAAC TGCATGCTGG ACGAGTCATT CACAGTCAAG 3600

GTGGCTGACT TTGGTCTGGC ACGGGGCGTC CTAGACAAGG AATACTACAG TGTTCGCCAG 3660

CATCGCCATG CTCGCCTGCC AGTCAAATGG ATGGCACTGG AGAGCCTGCA GACCTACAGG 3720

TTCACCACCA AGTCCGATGT GTGGTCATTC GGGGTGCTGC TCTGGGAGCT ACTAACACGG 3780

GGTGCTCCAC CCTACCCCCA TATCGATCCC TTCGACCTCT CTCACTTCCT GGCTCAGGGC 3840

CGTCGCCTGC CTCAGCCTGA GTACTGTCCT GATTCACTGT ATCACGTGAT GCTTCGATGC 3900

TGGGAGGCTG ACCCAGCGGC ACGACCCACC TTCAGAGCCC TAGTGCTGGA AGTAAAGCAG 3960

GTAGTGGCCT CACTGCTTGG GGACCACTAT GTGCAGCTGA CAGCAGCTTA TGTGAACGTA 4020

GGCCCCAGAG CGGTGGATGA TGGGAGTGTG CCTCCGGAGC AGGTACAGCC CTCGCCTCAG 4080

CATTGCAGGA GCACGTCAAA GCCCCGGCCT CTCTCAGAGC CACCCCTGCC CACTTGA 4137

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         +++++viGkGhfGvvy+ge++d a++++++a+ksl+rit++++ve+flregl+m++l+hp

Q: 1059  IHTDQVIGKGHFGVVYHGEYTDGAQNQTHCAIKSLSRITEVQEVEAFLREGLLMRGLHHP  1118

         5899********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         n+l+l+Gi+l++eglp v+lpym++Gdl +fir+++rn+tvkdl++f+lqva+gmeyla+

Q: 1119  NILALIGIMLPPEGLPRVLLPYMRHGDLLHFIRSPQRNPTVKDLVSFGLQVACGMEYLAE  1178

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         +kfvhrdlaarnc+lde++tvkvadfGlar vldke+y+v+++r+arlpvkw+aleslqt

Q: 1179  QKFVHRDLAARNCMLDESFTVKVADFGLARGVLDKEYYSVRQHRHARLPVKWMALESLQT  1238

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         ++ fttksdvwsfGvllwelltrga+py+++++fdl+++l++grrl++peycpd+ly+vm

Q: 1239  YR-FTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLSHFLAQGRRLPQPEYCPDSLYHVM  1297

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsi  260

         l+cw+a+pa+rp+f  lv

Q: 1298  LRCWEADPAARPTFRALVLE  1317

         **************999865

Domain Sequence
(FASTA)

IHTDQVIGKG HFGVVYHGEY TDGAQNQTHC AIKSLSRITE VQEVEAFLRE GLLMRGLHHP 60

NILALIGIML PPEGLPRVLL PYMRHGDLLH FIRSPQRNPT VKDLVSFGLQ VACGMEYLAE 120

QKFVHRDLAA RNCMLDESFT VKVADFGLAR GVLDKEYYSV RQHRHARLPV KWMALESLQT 180

YRFTTKSDVW SFGVLLWELL TRGAPPYPHI DPFDLSHFLA QGRRLPQPEY CPDSLYHVML 240

RCWEADPAAR PTFRALVLE 259

Keyword

Alternative splicing; ATP-binding; Cleavage on pair of basic residues; Complete proteome; Disulfide bond; Glycoprotein; Host-virus interaction; Immunity; Innate immunity; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0001725	; C:stress fiber
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0045087	; P:innate immune response
GO:0007275	; P:multicellular organismal development
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0009615	; P:response to virus
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0019048	; P:virus-host interaction

KEGG

mmu:19882

;

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013