EPS-MUM-00070

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUM-00070

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Asp-Based PTP/FCP	77.3	3.4E-21	184	321	138

Status

Reviewed

Ensembl Protein

ENSMUSP00000038938

UniProt Accession

Q7TSG2; Q7TSS7; Q9D4S8;

Protein Name

RNA polymerase II subunit A C-terminal domain phosphatase

Protein Synonyms/Alias

TFIIF-associating CTD phosphatase;

Gene Name

Ctdp1

Gene Synonyms/Alias

Ctdp1; Fcp1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000033323	ENSMUSP00000123705	ENSMUST00000161003
ENSMUSG00000033323	ENSMUSP00000038938	ENSMUST00000036229

Organism

Mus musculus

Functional Description

Processively dephosphorylates 'Ser-2' and 'Ser-5' of theheptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation (By similarity).

Protein Length

960

Protein Sequence
(FASTA)

MEAPPAAGVP TECTPAVAGA EVRCPGPTPL RLLEWKVAAG ATVRIGSVLA VCETAASAQP 60

AGPAPARAAS GGCVRAARTE RRLRSERAGV VRELCAQPGQ VVAPGALLVR LEGCSHPVVM 120

KGLCAECGQD LTQLQSKNGR QQVPLSTATV SMVHSVPELM VSSEQAEKLG REDQQRLHRN 180

RKLVLMVDLD QTLIHTTEQH CPQMSNKGIF HFQLGRGEPM LHTRLRPHCK DFLEKIAKLY 240

ELHVFTFGSR LYAHTIAGFL DPEKKLFSHR ILSRDECIDP FSKTGNLRNL FPCGDSMVCI 300

IDDREDVWKF APNLITVKKY VYFPGTGDVN APPAARETQA RRKVNHSSKG GDALEQALSV 360

RDPEDGRPAP GVEHSNGLGK ASRELNGGEA VPGVFPSKAD EKEAWPLTRA SPASSSSGHE 420

PTEAPELPVS CEWDGRTTPG VQPTQGDAAT QDLDFDLSSD SESSESSSRS EGQRAPAPQE 480

RTKAAPEHSG PQDTSGGRAA ASPLGESGPS IHPHDKGSDL DTQEEGERDS LCGLGNGSVD 540

RKEAETESQN SEQSGVTAGE SLDQSVGEEE EEDTDDDDHL IHLEEILVRV HTDYYTKYDR 600

YLNKELEEAP DIRKIVPELK SKVLADVAVI FSGLHPTNFP VEKTREHYHA TALGAKVLTQ 660

LVLSPDAPDR ATHLIAARAG TEKVRQAQEC KHLHVVSPDW LWSCLERWDK VEEQLFPLID 720

DDTRTHRDNS PAVFPDRHSV LPTALFHPTP IHSKAHPGPE VRIYDSNTGK LIRMGPQGSA 780

PAPSSAPLNH GEPSSFRAVQ PHQQQMFGEE LPESQDGEQP GPARRKRQPS MSEAMPLYTL 840

CKEDLESMDK EVDDILGEGS DDSDIEKKKP EDQDNEQERA PKPRKPRAPG IRREQPVGLP 900

SSGERSTPGM RGPRGHKRKL NEEDAASESS GESSNDDEEG SSSEADEMAA ALEAELNDLM 960

Nucleotide Sequence
(FASTA)

ATGGAAGCGC CGCCCGCGGC CGGCGTCCCC ACCGAGTGCA CTCCGGCGGT GGCCGGGGCA 60

GAGGTGCGCT GCCCCGGCCC CACGCCGCTG CGTCTGCTGG AGTGGAAGGT GGCGGCGGGC 120

GCGACCGTGC GCATCGGCTC GGTGCTGGCA GTGTGCGAAA CCGCAGCCTC CGCGCAGCCC 180

GCAGGGCCGG CACCGGCTCG CGCGGCCTCT GGGGGCTGCG TGCGCGCCGC GCGGACCGAG 240

CGCAGGCTCA GGTCGGAGCG CGCCGGCGTG GTCCGTGAAC TGTGTGCGCA GCCAGGCCAG 300

GTGGTGGCCC CTGGAGCACT TCTGGTGAGA TTGGAAGGAT GCAGCCATCC TGTTGTCATG 360

AAGGGCCTGT GTGCCGAGTG TGGCCAGGAC CTGACCCAGC TGCAGAGTAA AAATGGAAGG 420

CAGCAGGTCC CCCTTTCCAC AGCGACGGTT TCCATGGTGC ACAGTGTGCC GGAGTTGATG 480

GTGAGCTCTG AGCAAGCTGA GAAACTAGGA AGAGAGGATC AGCAGCGACT ACATCGAAAC 540

AGAAAACTGG TTCTCATGGT TGACTTGGAC CAGACCCTGA TTCATACGAC TGAGCAGCAC 600

TGTCCCCAGA TGTCCAACAA AGGCATCTTC CACTTCCAGC TGGGCCGGGG GGAGCCCATG 660

CTGCACACGC GCCTGAGGCC TCACTGCAAG GATTTCCTGG AGAAAATCGC CAAGCTGTAT 720

GAGCTGCACG TTTTCACCTT CGGCAGCCGT CTGTATGCCC ACACCATCGC AGGCTTTCTG 780

GACCCCGAGA AGAAGCTTTT TTCTCATCGA ATATTGTCTA GAGATGAATG TATTGACCCG 840

TTTTCTAAAA CAGGAAACCT TAGAAATCTT TTCCCCTGTG GAGACTCAAT GGTTTGCATC 900

ATCGATGACC GAGAAGATGT GTGGAAGTTC GCCCCTAACC TCATAACTGT GAAGAAGTAC 960

GTCTACTTCC CAGGCACAGG TGATGTGAAT GCACCCCCTG CAGCCCGGGA AACTCAGGCA 1020

AGGAGAAAAG TAAATCATTC TTCTAAGGGA GGGGACGCCT TGGAACAAGC TCTCTCCGTG 1080

AGGGACCCTG AGGACGGCAG GCCTGCTCCC GGGGTGGAGC ACAGCAATGG CCTTGGGAAG 1140

GCCTCCCGAG AGCTCAATGG TGGTGAGGCT GTGCCAGGAG TTTTTCCCAG TAAAGCAGAT 1200

GAGAAGGAAG CCTGGCCCCT CACTCGGGCC TCTCCTGCCA GCAGCTCTAG TGGCCACGAG 1260

CCAACTGAAG CTCCAGAGCT CCCTGTGTCT TGTGAGTGGG ATGGTCGGAC AACGCCAGGG 1320

GTGCAGCCCA CTCAGGGTGA TGCCGCCACC CAGGATTTGG ACTTTGACCT GTCCAGCGAC 1380

AGCGAGAGCA GCGAGAGCAG CAGCAGGTCA GAAGGTCAGA GGGCTCCAGC CCCCCAGGAG 1440

AGAACAAAAG CAGCTCCAGA GCACAGTGGG CCCCAGGACA CGAGTGGGGG CAGAGCTGCA 1500

GCAAGCCCCC TGGGAGAGTC TGGGCCTAGC ATCCACCCCC ATGACAAAGG GTCAGACCTG 1560

GACACTCAGG AGGAGGGTGA ACGGGACAGC CTCTGTGGCC TGGGCAATGG CAGTGTGGAC 1620

CGGAAAGAGG CTGAAACGGA ATCCCAGAAC AGTGAGCAGT CAGGTGTCAC TGCAGGCGAG 1680

TCCCTAGATC AGAGTGTCGG GGAGGAAGAG GAAGAGGACA CAGACGACGA TGACCACTTG 1740

ATACACCTCG AGGAGATCCT GGTCCGAGTA CACACTGACT ATTACACAAA GTATGACAGA 1800

TACCTCAACA AGGAGCTTGA GGAAGCTCCA GATATACGGA AAATTGTGCC AGAGCTCAAG 1860

AGCAAGGTGC TCGCAGATGT GGCTGTGATA TTCAGTGGGC TGCACCCAAC AAACTTTCCT 1920

GTGGAAAAGA CTCGCGAGCA CTATCACGCC ACGGCCCTGG GAGCCAAGGT CCTTACCCAG 1980

CTGGTGCTGA GCCCTGATGC TCCAGACAGG GCCACTCACC TCATTGCAGC ACGGGCTGGT 2040

ACAGAGAAGG TGCGCCAGGC ACAGGAGTGC AAACACCTAC ATGTGGTCAG CCCTGATTGG 2100

CTGTGGAGCT GCCTGGAGCG CTGGGACAAG GTGGAGGAGC AGCTCTTCCC ACTCATAGAT 2160

GACGATACCC GCACACATAG GGATAACAGC CCTGCAGTCT TTCCAGACAG ACACAGTGTG 2220

CTTCCAACAG CCTTGTTCCA TCCAACACCC ATCCATTCCA AGGCCCATCC TGGTCCCGAG 2280

GTTCGGATCT ATGACTCTAA CACAGGCAAG CTGATCCGGA TGGGCCCCCA GGGTTCTGCA 2340

CCAGCTCCCT CCAGTGCCCC ACTTAACCAT GGAGAGCCTT CCTCCTTCAG AGCTGTTCAG 2400

CCACATCAGC AGCAAATGTT TGGTGAAGAG TTGCCAGAAT CTCAAGATGG AGAGCAGCCT 2460

GGCCCTGCTA GAAGAAAGCG ACAACCCAGT ATGTCCGAGG CAATGCCGCT GTACACTCTC 2520

TGTAAGGAGG ACTTAGAGAG TATGGACAAA GAGGTCGACG ACATCCTTGG AGAGGGCAGT 2580

GATGACAGTG ACATCGAGAA GAAGAAGCCA GAAGACCAAG ACAATGAGCA GGAGAGAGCC 2640

CCGAAGCCCA GGAAGCCCCG GGCTCCAGGG ATCCGAAGAG AGCAGCCTGT AGGCTTGCCC 2700

TCATCTGGCG AGAGGAGCAC CCCTGGCATG CGTGGGCCCA GAGGCCACAA GAGGAAACTA 2760

AATGAGGAAG ACGCTGCCAG CGAGTCCAGC GGGGAGTCCA GCAACGATGA TGAGGAGGGC 2820

AGCAGTTCAG AAGCAGATGA GATGGCCGCT GCTCTGGAGG CGGAGCTTAA TGACCTCATG 2880

TGA 2883

Domain Profile

S: 2     tLVLDLDetLvhsksekdee.........e...ektkasvkkRPgldeFLkelskayevv  49

         +L +DLD+tL+h+++++  +         +    +   ++ +RP++++FL++++k ye+

Q: 184   VLMVDLDQTLIHTTEQHCPQmsnkgifhfQlgrGEPMLHTRLRPHCKDFLEKIAKLYELH  243

         6899**********7777633467877662556777888889******************

S: 50    iftasskeyadavldkldpkkklf.kkrlyresctlengkyvKdLsll...grdlskvvi  105

         +ft +s+ ya+ +   ldp+kklf +++l+r++c+   + ++ +L+ l   g+  s v i

Q: 244   VFTFGSRLYAHTIAGFLDPEKKLFsHRILSRDECIDPFS-KTGNLRNLfpcGD--SMVCI  300

         ************************66666*****83222.2346666655477..9****

S: 106   vDdsprsfelqpdnlipiepfy  127

         +Dd+++++++   nli +++++

Q: 301   IDDREDVWKF-APNLITVKKYV  321

         *******988.56899999864

Domain Sequence
(FASTA)

VLMVDLDQTL IHTTEQHCPQ MSNKGIFHFQ LGRGEPMLHT RLRPHCKDFL EKIAKLYELH 60

VFTFGSRLYA HTIAGFLDPE KKLFSHRILS RDECIDPFSK TGNLRNLFPC GDSMVCIIDD 120

REDVWKFAPN LITVKKYV 138

Keyword

Acetylation; Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Hydrolase; Mitosis; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0015629	; C:actin cytoskeleton
GO:0005813	; C:centrosome
GO:0030496	; C:midbody
GO:0005634	; C:nucleus
GO:0051233	; C:spindle midzone
GO:0000922	; C:spindle pole
GO:0008420	; F:CTD phosphatase activity
GO:0051301	; P:cell division
GO:0010458	; P:exit from mitosis
GO:0007067	; P:mitosis
GO:0006470	; P:protein dephosphorylation

KEGG

mmu:67655

;

InterPros

IPR001357	; BRCT_dom.
IPR015388	; FCP1_C.
IPR011947	; FCP1_euk.
IPR023214	; HAD-like_dom.
IPR004274	; NIF.

Pfam

PF09309	; FCP1_C; 1.
PF03031	; NIF; 1.

SMARTs

SM00292	; BRCT; 1.
SM00577	; CPDc; 1.

Prosites

PS50172	; BRCT; 1.
PS50969	; FCP1; 1.

Prints

Created Date

20-Feb-2013