EPS-MUM-00151

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUM-00151

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PSP-Other/RPAP2	N/A	N/A	N/A	N/A	N/A

Status

Reviewed

Ensembl Protein

ENSMUSP00000070209

UniProt Accession

Q8VC34; Q3TLC8; Q3TSP8; Q3UKX0; Q8C7M5; Q8CBW8;

Protein Name

Putative RNA polymerase II subunit B1 CTD phosphatase Rpap2

Protein Synonyms/Alias

RNA polymerase II-associated protein 2;

Gene Name

Rpap2

Gene Synonyms/Alias

Rpap2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000033773	ENSMUSP00000121306	ENSMUST00000150074
ENSMUSG00000033773	ENSMUSP00000108269	ENSMUST00000112650
ENSMUSG00000033773	ENSMUSP00000070209	ENSMUST00000065422
ENSMUSG00000033773	ENSMUSP00000108273	ENSMUST00000112654
ENSMUSG00000033773	ENSMUSP00000108274	ENSMUST00000112655
ENSMUSG00000033773	ENSMUSP00000108270	ENSMUST00000112651

Organism

Mus musculus

Functional Description

Protein phosphatase that displays CTD phosphataseactivity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity).

Protein Length

614

Protein Sequence
(FASTA)

MADSAVPCSL GPSTRASSTH RDATGTKQTR ALKRGDASKR QAELEAAIQR KVEFERKAVR 60

IVEQLLEENI TEEFLKECGM FITPAHYSDV VDERSIIKLC GYPLCQKKLG VIPKQKYRIS 120

TKTNKVYDIT ERKSFCSNFC YRASKFFETQ IPKTPVWVRE EERPPDFQLL KKGQSGSSGE 180

VVQFFRDAVT AADVDGSGAL EAQCDPASSS SWSERASDEE EQGFVSSLLP GNRPKAVDTR 240

PQPHTKSSIM RKKAAQNVDS KEGEQTVSEV TEQLDNCRLD SQEKVATCKR PLKKESTQIS 300

SPGPLCDRFN TSAISEHKHG VSQVTLVGIS KKSAEHFRSK FAKSNPGSGS ASGLVHVRPE 360

VAKANLLRVL SDTLTEWKTE ETLKFLYGQN HDSVCLKPSS ASEPDEELDE DDISCDPGSC 420

GPALSQAQNT LDATLPFRGS DTAIKPLPSY ESLKKETEML NLRVREFYRG RCVLNEDTTK 480

SQDSKESVLQ RDPSFPLIDS SSQNQIRRRI VLEKLSKVLP GLLGPLQITM GDIYTELKNL 540

IQTFRLSNRN IIHKPVEWTL IAVVLLLLLT PILGIQKHSP KNVVFTQFIA TLLTELHLKF 600

EDLEKLTMIF RTSC 614

Nucleotide Sequence
(FASTA)

ATGGCTGACT CTGCCGTACC TTGCTCTCTA GGCCCAAGTA CCCGGGCTTC CAGCACCCAC 60

CGAGATGCTA CCGGTACTAA ACAGACCCGA GCCCTGAAAC GAGGAGATGC ATCTAAAAGG 120

CAAGCAGAAC TGGAAGCTGC TATACAAAGG AAGGTGGAGT TTGAAAGGAA AGCTGTGCGC 180

ATCGTAGAGC AGCTCTTAGA GGAGAACATC ACAGAAGAAT TCCTGAAGGA GTGTGGCATG 240

TTCATCACAC CAGCTCACTA CAGCGACGTT GTGGATGAGC GGTCCATCAT CAAACTCTGT 300

GGCTATCCTT TGTGTCAGAA GAAGCTAGGG GTTATCCCGA AACAGAAATA TCGAATTTCT 360

ACTAAAACCA ATAAAGTCTA TGATATTACT GAAAGGAAGT CTTTCTGCAG CAATTTTTGT 420

TACAGAGCAT CTAAATTTTT TGAAACACAG ATTCCCAAAA CTCCAGTATG GGTTCGAGAG 480

GAAGAGAGGC CTCCTGACTT TCAGCTGCTG AAGAAAGGAC AAAGCGGCAG TTCTGGAGAA 540

GTAGTACAGT TCTTCCGAGA TGCCGTGACA GCAGCAGATG TTGACGGTTC CGGCGCCTTG 600

GAGGCGCAGT GTGACCCTGC TTCTTCCAGC TCTTGGAGTG AGCGAGCCAG TGATGAGGAG 660

GAGCAAGGCT TTGTTTCTTC TCTTCTACCA GGAAACAGAC CAAAGGCAGT GGATACAAGA 720

CCGCAGCCGC ACACAAAAAG CAGCATCATG AGAAAGAAGG CTGCTCAGAA CGTGGACTCC 780

AAGGAGGGAG AGCAGACCGT GTCAGAGGTT ACCGAGCAGC TGGATAATTG CAGATTAGAT 840

AGTCAGGAGA AAGTGGCCAC TTGTAAACGT CCTTTAAAGA AAGAAAGTAC TCAGATTTCT 900

TCACCTGGCC CTTTGTGTGA CAGATTTAAC ACTTCAGCCA TTTCTGAACA TAAACACGGT 960

GTATCACAAG TTACGCTTGT AGGCATAAGC AAGAAGAGTG CTGAGCATTT CAGGAGCAAA 1020

TTTGCCAAGT CAAATCCAGG TTCTGGGTCA GCCTCTGGTT TGGTACACGT GCGTCCTGAG 1080

GTTGCGAAGG CAAATTTACT CCGAGTTCTG TCGGACACTC TGACTGAATG GAAGACAGAA 1140

GAAACACTGA AGTTTTTATA TGGCCAGAAC CACGATTCTG TGTGTCTGAA ACCCTCTTCA 1200

GCCTCTGAGC CTGATGAAGA ACTTGATGAA GATGACATAA GTTGTGACCC AGGTAGTTGT 1260

GGTCCTGCCC TGAGTCAAGC TCAGAACACC CTAGATGCAA CACTGCCCTT TAGAGGCTCA 1320

GACACAGCCA TTAAGCCACT GCCAAGTTAT GAGAGCTTGA AAAAGGAAAC GGAGATGCTG 1380

AACCTGAGGG TCAGGGAGTT CTACAGAGGG CGCTGTGTTT TAAATGAAGA CACTACCAAG 1440

TCTCAGGACT CTAAAGAGAG TGTGCTTCAG CGTGACCCCA GCTTCCCGCT GATAGATTCA 1500

AGTTCCCAGA ACCAGATTAG AAGACGGATT GTTCTTGAAA AACTGAGCAA AGTATTGCCT 1560

GGACTTTTGG GTCCTCTTCA GATTACAATG GGAGATATTT ACACTGAACT TAAAAACCTC 1620

ATTCAGACTT TCAGATTATC AAATAGAAAC ATTATACACA AACCTGTGGA GTGGACTTTA 1680

ATTGCTGTGG TCTTGCTGTT ACTATTGACA CCGATTCTTG GCATTCAGAA GCATTCTCCG 1740

AAAAATGTGG TTTTTACACA GTTTATAGCC ACCCTGCTGA CAGAATTGCA TTTAAAATTC 1800

GAAGATCTTG AAAAATTAAC CATGATATTT AGAACCAGCT GCTAG 1845

Domain Profile

N/A

Domain Sequence
(FASTA)

N/A

Keyword

Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Nucleus; Protein phosphatase; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016591	; C:DNA-directed RNA polymerase II, holoenzyme
GO:0008420	; F:CTD phosphatase activity
GO:0046872	; F:metal ion binding
GO:0070940	; P:dephosphorylation of RNA polymerase II C-terminal domain
GO:0009301	; P:snRNA transcription

KEGG

mmu:231571

;

InterPros

IPR007308

; DUF408.

Pfam

PF04181

; RPAP2_Rtr1; 1.

SMARTs

Prosites

PS51479

; ZF_RTR1; 1.

Prints

Created Date

20-Feb-2013