EKS-MUM-00197
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00197
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/LISK412.32.0E-12361309249
StatusReviewed
Ensembl ProteinENSMUSP00000041009
UniProt AccessionQ8VCT9;
Protein NameDual specificity testis-specific protein kinase 2
Protein Synonyms/Alias Testicular protein kinase 2;
Gene NameTesk2
Gene Synonyms/Alias Tesk2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000033985ENSMUSP00000041009ENSMUST00000045542
ENSMUSG00000033985ENSMUSP00000102064ENSMUST00000106456
ENSMUSG00000033985ENSMUSP00000102067ENSMUST00000106459
OrganismMus musculus
Functional DescriptionDual specificity protein kinase activity catalyzingautophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis (By similarity).
Protein Length570
Protein Sequence
(FASTA)
MDRSKRNSIA GFPPRVERLE EFEGGGGGDG NTVQVGRVSS SSYRAIISAF SRLTSLDDFT 60
REKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANLLK EMQLMNRLSH PNILRFMGVC 120
VHQGQLHALT EYINSGNLEQ LLDSDLYLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 180
NCLIKRDENG YSAVVADFGL AEKIPDASIG REKLAVVGSP FWMAPEVLRD EPYNEKADVF 240
SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQNMVGDC PSDFLQLTFN CCNMDPKLRP 300
SFEEIGKTLK EIMSRLPEEE LERDRKLQPT AKGPLEKVPG GKRLSSLDDK IPHKSPRPRR 360
TIWLSRSQSD IFSHKPPRTV SVLDPYYQPR DGATHTPKVN PFSARQDLKG GKVKFFDLPS 420
KSVISLVFDL DAPGPGSTTL ADCQEPLAMS SRRWRSLPGS PEFLHQACPF MGCEESLSDG 480
PPPRLSSLKY GVREIPPFRT SALSAASGHE AMDCSNPQEE NGFGPRLKGT SLCTGAASEE 540
MEVEEERPRR ASVYFSISGI SLQTQAKQDG 570
Nucleotide Sequence
(FASTA)
ATGGATCGGA GCAAGCGGAA CTCAATTGCA GGGTTTCCCC CACGTGTGGA GCGTCTGGAA 60
GAATTTGAAG GAGGTGGTGG AGGGGATGGG AACACTGTGC AGGTGGGAAG AGTTTCATCA 120
TCTTCATATC GTGCGATTAT TAGTGCCTTT TCCAGACTGA CGAGTTTGGA TGACTTCACC 180
CGTGAAAAAA TAGGATCTGG GTTCTTCTCC GAAGTGTTCA AGGTGCGACA CAGAGCTTCT 240
GGTCAGGTGA TGGCTCTCAA GATGAACACG CTGAGCAGTA ACCGAGCAAA CCTGCTGAAA 300
GAGATGCAGC TCATGAATAG ACTCTCCCAC CCCAACATCC TCAGGTTCAT GGGTGTATGT 360
GTACATCAAG GACAGTTGCA TGCACTTACA GAGTATATCA ACTCTGGGAA CCTGGAGCAG 420
CTGCTGGACA GTGACTTGTA TTTACCGTGG ACTGTGAGAG TGAAACTGGC CTATGACATA 480
GCAGTGGGCC TCAGCTACCT TCACTTCAAA GGCATTTTCC ATCGGGACCT CACATCAAAG 540
AACTGCCTGA TAAAGAGAGA TGAAAACGGT TACTCTGCTG TGGTAGCTGA CTTCGGCCTG 600
GCTGAGAAGA TCCCTGACGC TAGTATAGGG AGGGAGAAGC TAGCTGTGGT GGGCTCGCCT 660
TTCTGGATGG CACCTGAGGT TCTCCGAGAT GAGCCTTATA ATGAGAAGGC AGATGTCTTC 720
TCTTATGGTA TCATCCTCTG CGAGATCATC GCCCGCATTC AGGCTGATCC GGACTATCTT 780
CCCCGCACAG AGAATTTCGG GCTGGATTAC GATGCTTTCC AGAACATGGT GGGAGACTGC 840
CCCTCAGACT TCCTGCAGCT CACCTTTAAC TGCTGTAATA TGGACCCCAA ACTGCGCCCA 900
TCCTTTGAGG AGATTGGGAA GACCCTAAAG GAAATTATGA GCCGCTTACC GGAAGAAGAG 960
TTGGAGAGAG ATAGGAAGCT ACAGCCCACA GCTAAAGGAC CACTGGAGAA AGTGCCTGGA 1020
GGGAAGCGAC TGAGTTCACT GGATGACAAG ATTCCCCACA AGTCTCCACG TCCAAGACGT 1080
ACTATCTGGC TGTCTCGAAG CCAGTCAGAT ATTTTTTCTC ATAAGCCCCC ACGTACAGTC 1140
AGTGTCTTGG ACCCCTATTA CCAGCCACGA GATGGTGCTA CACATACCCC AAAAGTCAAC 1200
CCTTTCAGTG CACGCCAAGA CCTCAAGGGC GGGAAGGTCA AATTCTTTGA CCTACCCAGC 1260
AAATCTGTCA TTTCCCTTGT ATTTGACCTG GATGCACCGG GGCCTGGAAG TACAACTCTG 1320
GCTGACTGTC AGGAGCCTTT GGCCATGTCT TCCAGACGGT GGCGGTCTTT GCCTGGTTCA 1380
CCTGAGTTCT TGCATCAGGC TTGTCCATTT ATGGGCTGTG AAGAATCACT CTCTGATGGG 1440
CCTCCACCAC GACTCAGTAG TCTCAAGTAC GGAGTAAGAG AGATCCCACC ATTCCGGACA 1500
TCTGCCCTAT CAGCTGCTTC AGGCCACGAG GCCATGGACT GCTCTAACCC CCAAGAAGAG 1560
AACGGTTTTG GACCCAGGCT TAAGGGGACC AGCCTATGCA CTGGGGCTGC CTCTGAGGAG 1620
ATGGAGGTGG AAGAGGAAAG GCCACGAAGA GCTTCTGTCT ACTTCTCTAT CTCTGGAATA 1680
AGCTTGCAAA CCCAGGCAAA GCAGGATGGG TGA 1713
Domain Profile
S: 4     geklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfiG  63
          ek+G+Gffsevfkv+hrasG+vm+lk  ++++++nr+nllke++l+++l+hpn+l+f+G
Q: 61    REKIGSGFFSEVFKVRHRASGQVMALK--MNTLSSNRANLLKEMQLMNRLSHPNILRFMG  118
         69*************************..*******************************
S: 64    vlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihrdln  123
         v+v++++lh+lteyi++G+l++ll+s+  lpwt+rv+la+dia+Glsylh+kgi+hrdl+
Q: 119   VCVHQGQLHALTEYINSGNLEQLLDSDLYLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLT  178
         ************************************************************
S: 124   sknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaPe  180
         skncl+++   ++s+vvadfGla          ek+++++ +  +++l+vvGsP+wmaPe
Q: 179   SKNCLIKRdenGYSAVVADFGLA----------EKIPDASIG--REKLAVVGSPFWMAPE  226
         *******9887899*********..........99***9888..99**************
S: 181   vlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPeaf  240
         vl+++ y+ek+dvfs+Gi+lceiiar++adPdylPrte+fgld++af++ +v+ dcP++f
Q: 227   VLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQN-MVG-DCPSDF  284
         *************************************************.999.******
S: 241   lklavvccdldpesrpsfeelekkl  265
         l+l+++cc++dp+ rpsfee+ k+l
Q: 285   LQLTFNCCNMDPKLRPSFEEIGKTL  309
         *********************9876
Domain Sequence
(FASTA)
REKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANLLK EMQLMNRLSH PNILRFMGVC 60
VHQGQLHALT EYINSGNLEQ LLDSDLYLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 120
NCLIKRDENG YSAVVADFGL AEKIPDASIG REKLAVVGSP FWMAPEVLRD EPYNEKADVF 180
SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQNMVGDC PSDFLQLTFN CCNMDPKLRP 240
SFEEIGKTL 249
KeywordATP-binding; Complete proteome; Kinase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00182
EKS-ANC-00186
EKS-BOT-00194
EKS-CAJ-00200
EKS-CAF-00199
EKS-CAP-00219
EKS-CIS-00230
EKS-DAR-00495
EKS-ECT-00070
EKS-EQC-00188
EKS-FEC-00181
EKS-GAG-00166
EKS-GOG-00188
EKS-HOS-00200
EKS-ICT-00185
EKS-LAC-00205
EKS-LOA-00191
EKS-MAM-00194
EKS-MEG-00149
EKS-MOD-00192
EKS-MUP-00194
EKS-MYL-00198
EKS-NOL-00181
EKS-OCP-00126
EKS-ORN-00247
EKS-ORA-00171
EKS-ORC-00177
EKS-ORL-00230
EKS-OTG-00199
EKS-PAT-00185
EKS-PES-00168
EKS-POA-00185
EKS-RAN-00188
EKS-SAH-00186
EKS-SUS-00168
EKS-TAG-00218
EKS-TAR-00250
EKS-TEN-00246
EKS-TUT-00180
EKS-XIM-00241
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004712; F:protein serine/threonine/tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0030036; P:actin cytoskeleton organization
GO:0048041; P:focal adhesion assembly
GO:0007283; P:spermatogenesis
KEGG
mmu:230661;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013