EKS-MUM-00119

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00119

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	384.8	5.3E-115	48	310	263

Status

Reviewed

Ensembl Protein

ENSMUSP00000108598

UniProt Accession

Q91Z96; Q8C8L7;

Protein Name

BMP-2-inducible protein kinase

Protein Synonyms/Alias

BIKe;

Gene Name

Bmp2k

Gene Synonyms/Alias

Bmp2k; Bike;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000034663	ENSMUSP00000108598	ENSMUST00000112974
ENSMUSG00000034663	ENSMUSP00000037970	ENSMUST00000035635

Organism

Mus musculus

Functional Description

May be involved in osteoblast differentiation.

Protein Length

649

Protein Sequence
(FASTA)

MKKFSRMPKS EGSGGGAAAG GAAGGGLGGG FASSSMGVRV FAVGRYQVTL EESLAEGGFS 60

TVFLVRTHSG IRCALKRMYV NNTPDLNICK REITIMKELS GHKNIVGYLD CAVNSISDNV 120

WEVLILMEYC RAGQVVNQMN KKLQTGFTES EVLQIFCDTC EAVARLHQCK TPIIHRDLKV 180

ENILLNDAGN YVLCDFGSAT NKFLNPQKDG VNVVEEEIKK YTTLSYRAPE MINLYGGKPI 240

TTKADIWALG CLLYKLCFFT LPFGESQVAI CDGSFTIPDN SRYSHNVHCL IRFMLEPDPE 300

CRPDIFQVSY FAFKFAKKDC PVSNINNSFL PSTLPEPMTA TEAAARKSQM KARITDTIGP 360

TETSIAPRQR PKANSTAATS SVLTIQSSAT PVKVPAPGEF SNHKPKGALR PGNGSEVLMV 420

QGPPQQPPQQ HRVLQQLQQG DWRLQQLHLH RHPHHHHQQQ QQQQQQQQQQ QLQQQQQQQQ 480

QLLQNAYLQQ YQHAMHQQHI LQQQFLMHSV YQPQPPASQY PAMMQQYQQA FLQQQMLARH 540

QQPAQQVSPE YLTSPQEFSP ALVSYASSLP AQVGTIVDSS YGANRSVAEK EAVANFTNQK 600

TISHPPDMSG WNPFGEDNFS KLTEEELLDR EFDLLRSSKG HLKAYFASQ 649

Nucleotide Sequence
(FASTA)

ATGAAGAAGT TCTCTCGGAT GCCCAAGTCG GAGGGCAGCG GCGGCGGGGC GGCGGCTGGC 60

GGGGCCGCGG GCGGCGGGCT CGGCGGCGGC TTCGCAAGCT CGTCCATGGG GGTCCGGGTG 120

TTCGCCGTCG GCCGCTACCA GGTCACCCTG GAGGAGTCGC TGGCCGAAGG TGGATTCTCC 180

ACTGTTTTCC TGGTGCGGAC TCACAGTGGG ATCCGATGTG CACTGAAGCG AATGTATGTC 240

AATAACACAC CCGACCTCAA CATTTGTAAA AGGGAAATCA CGATTATGAA AGAGTTATCT 300

GGCCACAAAA ATATTGTCGG TTATTTGGAC TGTGCTGTCA ATTCAATTAG TGACAATGTG 360

TGGGAAGTGC TTATCTTAAT GGAATATTGT CGAGCTGGGC AGGTTGTGAA CCAGATGAAT 420

AAGAAGCTGC AGACAGGCTT TACCGAGTCA GAAGTCCTAC AAATCTTCTG TGATACCTGC 480

GAAGCTGTCG CACGATTGCA TCAATGTAAG ACTCCCATAA TCCACCGGGA TCTGAAGGTA 540

GAAAATATTT TGCTAAATGA TGCTGGAAAT TATGTGCTTT GTGACTTTGG CAGTGCCACT 600

AATAAATTTC TCAATCCTCA AAAAGATGGA GTTAATGTAG TAGAAGAAGA AATTAAAAAA 660

TACACGACTC TGTCGTATAG AGCACCAGAA ATGATCAACC TTTATGGAGG GAAACCGATC 720

ACCACCAAGG CTGATATCTG GGCCTTGGGA TGTTTACTGT ATAAACTTTG TTTCTTCACT 780

CTTCCTTTTG GTGAGAGTCA GGTTGCTATC TGTGATGGCA GCTTCACCAT CCCAGACAAT 840

TCTCGCTACT CCCACAACGT GCATTGCTTG ATTAGGTTCA TGCTTGAACC AGACCCCGAG 900

TGCAGACCTG ACATATTTCA AGTATCCTAC TTTGCGTTTA AATTCGCCAA AAAGGATTGT 960

CCGGTCTCCA ACATCAATAA TTCTTTTCTT CCATCAACTC TTCCCGAGCC GATGACTGCT 1020

ACTGAAGCTG CTGCTAGGAA AAGCCAGATG AAAGCCAGAA TAACAGATAC CATTGGACCA 1080

ACAGAAACCT CAATTGCACC AAGACAAAGA CCAAAGGCCA ATTCCACTGC TGCCACTTCC 1140

AGTGTGCTGA CCATTCAGAG TTCAGCAACG CCTGTCAAAG TCCCTGCTCC TGGGGAGTTC 1200

AGCAACCACA AACCCAAAGG AGCATTGAGA CCTGGAAATG GGTCTGAAGT CTTAATGGTT 1260

CAGGGACCCC CTCAGCAACC CCCACAGCAG CATAGAGTCC TCCAGCAGTT GCAGCAGGGA 1320

GACTGGAGAT TACAGCAACT TCATTTGCAT CGTCATCCCC ACCACCACCA TCAGCAACAG 1380

CAACAACAGC AACAACAACA GCAGCAACAA CAGCTGCAGC AACAACAGCA ACAGCAACAG 1440

CAACTACTTC AAAATGCTTA CTTGCAGCAG TATCAGCATG CAATGCACCA GCAGCATATA 1500

CTTCAGCAAC AGTTTCTAAT GCACTCAGTG TATCAGCCAC AACCGCCTGC ATCCCAGTAT 1560

CCTGCCATGA TGCAGCAGTA TCAGCAGGCT TTCTTGCAGC AGCAGATGCT AGCTCGCCAT 1620

CAGCAGCCAG CACAGCAGGT ATCACCCGAG TATCTTACCT CCCCGCAAGA GTTCTCACCA 1680

GCCTTAGTTT CCTACGCCTC GTCACTTCCA GCTCAGGTTG GAACCATAGT GGACTCTTCT 1740

TACGGTGCCA ACAGGTCAGT TGCTGAGAAA GAGGCAGTTG CAAATTTTAC AAATCAGAAG 1800

ACCATTAGTC ACCCTCCTGA CATGTCAGGC TGGAATCCTT TTGGAGAAGA CAATTTTTCC 1860

AAGTTAACAG AAGAGGAACT GTTGGACAGA GAATTTGACC TTCTAAGATC AAGTAAGGGA 1920

CACTTGAAGG CTTATTTTGC TTCACAGTAA 1950

Domain Profile

S: 1     vriekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghkniv  60

         v++e++laeGGf++v+l++ +++g ++alKr++vn++ dl+ +krEi+imk+lsghkniv

Q: 48    VTLEESLAEGGFSTVFLVR-THSGIRCALKRMYVNNTPDLNICKREITIMKELSGHKNIV  106

         6899***************.999*************************************

S: 61    klvdssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrava  120

          ++d++v++ +d +++evl+l+eyc++g++v+++nk+l++g ++e+e+l+i++d+++ava

Q: 107   GYLDCAVNSISD-NVWEVLILMEYCRAGQVVNQMNKKLQTG-FTESEVLQIFCDTCEAVA  164

         ************.7**************************9.******************

S: 121   alHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeiekntt  180

         +lH++++p+iHRDlkveNill+d+g++vlcD+GSat+++l+++ k+++++++eei+k+tt

Q: 165   RLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGSATNKFLNPQ-KDGVNVVEEEIKKYTT  223

         *******************************************.****************

S: 181   lsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPensr  240

         lsyr+PE+i+ly +++i++k+DiWaLGcllYklcff+ Pf+es ++ai++g+++iP+nsr

Q: 224   LSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGES-QVAICDGSFTIPDNSR  282

         *******************************************.****************

S: 241   yseklkslikkmlevdpeeRptiaqvle  268

         ys+++++li+ mle+dpe Rp+i+qv++

Q: 283   YSHNVHCLIRFMLEPDPECRPDIFQVSY  310

         **************************87

Domain Sequence
(FASTA)

VTLEESLAEG GFSTVFLVRT HSGIRCALKR MYVNNTPDLN ICKREITIMK ELSGHKNIVG 60

YLDCAVNSIS DNVWEVLILM EYCRAGQVVN QMNKKLQTGF TESEVLQIFC DTCEAVARLH 120

QCKTPIIHRD LKVENILLND AGNYVLCDFG SATNKFLNPQ KDGVNVVEEE IKKYTTLSYR 180

APEMINLYGG KPITTKADIW ALGCLLYKLC FFTLPFGESQ VAICDGSFTI PDNSRYSHNV 240

HCLIRFMLEP DPECRPDIFQ VSY 263

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0019208	; F:phosphatase regulator activity
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030500	; P:regulation of bone mineralization

KEGG

mmu:140780

;

InterPros

IPR026105	; BMP-2-ind_kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013