EKS-MUM-00351

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00351

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	345.3	5.4E-103	20	277	258

Status

Reviewed

Ensembl Protein

ENSMUSP00000106196

UniProt Accession

Q8BPM2; Q6PEQ2; Q8C3U5; Q8CGF3; Q99LM7; Q9CX73;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase 5

Protein Synonyms/Alias

MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5;

Gene Name

Map4k5

Gene Synonyms/Alias

Map4k5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000034761	ENSMUSP00000047812	ENSMUST00000049239
ENSMUSG00000034761	ENSMUSP00000106196	ENSMUST00000110567
ENSMUSG00000034761	ENSMUSP00000106199	ENSMUST00000110570
ENSMUSG00000034761	ENSMUSP00000126006	ENSMUST00000171211

Organism

Mus musculus

Functional Description

May play a role in the response to environmental stress.Appears to act upstream of the JUN N-terminal pathway (By similarity).

Protein Length

828

Protein Sequence
(FASTA)

MEAPLRPAAD ILRRNPQHDY ELVQRVGSGT YGDVYKARNV HTGELAAVKI IKLEPGDDFS 60

LIQQEIFMVK ECKHCNIVAY FGSYLSREKL WICMEYCGGG SLQDIYHVTG PLSEMQIAYV 120

CRETLQGLAY LHTKGKMHRD IKGANILLTD HGDVKLADFG VAAKITATIA KRKSFIGTPY 180

WMAPEVAAVE KNGGYNQLCD IWAVGITAIE LGELQPPMFD LHPMRALFLM SKSNFQPPKL 240

KDKTKWSSTF HNFVKIALTK NPKKRPTAER LLTHTFVGQP GLSRALAVEL LDKPHAIIRH 300

TIRSTNRNSR AERTASEINF DKLQFEPPLR KETEARDEMG LSSEPNFILH WNPFVDGANT 360

GRSTSKRAIP PPLPPKPRVN TYPEDSLPDE EKSSTIKRCP DLEARAPQVL RRQSSPSCVP 420

VAETSSSIGN GDGISKLISE NTEGSAQAPQ LPRKKDKRDF PKPTINGLPP TPKVLMGACF 480

SKVFDGCPLK INCATSWIHP DTKDQYIIFG TEDGIYTLNL NELHEATMEQ LFPRKCTWLY 540

VINNTLMSLS EGKTFQLYSH NLIALFEQAK KPGLAAHIQT HRFPDRILPR KFALTTKIPD 600

TKGCHKCCIV RNPYTGHKYL CGALQSGIVL LQWYEPMQKF MLIKHFDFPL PSPLNVFEML 660

VIPEQEYPMV CVAISKGSDS SQVVQFETIN LNSASSWFTE IGAGSQQLDS IHVTQLERDT 720

VLVCLDKFVK IVNLQGKLKS SKKLASELSF DFRIESVVCL QDSVLAFWKH GMQGKSFKSD 780

EVTQEISDET RVFRLLGSDR VVVLESRPTE NPAAHSNLYI LAGHENSY 828

Nucleotide Sequence
(FASTA)

ATGGAGGCCC CGCTGAGGCC TGCCGCCGAC ATCCTGAGAC GGAACCCGCA GCACGACTAC 60

GAGCTGGTGC AGAGGGTCGG CAGCGGCACC TACGGGGACG TGTACAAGGC CAGAAATGTA 120

CATACAGGAG AATTAGCTGC AGTAAAGATC ATCAAGTTGG AGCCTGGTGA TGATTTTTCT 180

TTGATTCAGC AAGAGATATT TATGGTTAAA GAATGTAAGC ATTGCAACAT CGTAGCCTAC 240

TTTGGGAGCT ATCTCAGTAG GGAGAAGCTG TGGATTTGCA TGGAGTACTG CGGTGGCGGA 300

TCACTTCAAG ATATCTATCA CGTGACTGGG CCATTATCTG AAATGCAAAT AGCCTACGTC 360

TGCAGAGAGA CCTTACAGGG TCTTGCCTAC TTGCATACTA AAGGCAAAAT GCATAGAGAT 420

ATCAAAGGTG CAAATATCTT ATTAACAGAC CATGGTGATG TAAAATTAGC TGATTTTGGT 480

GTGGCTGCAA AAATTACAGC TACCATTGCA AAGAGGAAGT CCTTCATCGG CACCCCTTAC 540

TGGATGGCTC CAGAAGTTGC AGCAGTGGAA AAGAATGGTG GCTACAACCA ACTCTGTGAT 600

ATCTGGGCCG TCGGAATAAC AGCAATCGAG CTGGGAGAAC TGCAGCCGCC TATGTTTGAC 660

CTGCATCCAA TGAGGGCTCT CTTCTTAATG TCAAAAAGTA ATTTCCAGCC TCCAAAGCTA 720

AAGGACAAAA CTAAATGGTC ATCGACATTC CATAATTTTG TCAAAATAGC ACTAACTAAA 780

AACCCCAAGA AAAGACCAAC TGCTGAAAGG CTTCTGACTC ACACTTTTGT TGGGCAGCCA 840

GGCCTGTCTC GGGCGCTCGC GGTTGAGCTG TTGGACAAGC CCCACGCAAT CATTCGTCAT 900

ACCATTAGAT CAACAAACAG GAATTCCAGA GCGGAGCGGA CAGCTTCAGA AATAAACTTT 960

GACAAATTAC AATTTGAACC TCCTCTGAGA AAAGAAACAG AAGCCCGGGA TGAAATGGGA 1020

TTATCATCAG AGCCAAACTT TATATTACAT TGGAATCCTT TTGTGGATGG AGCAAATACA 1080

GGCAGATCAA CCTCTAAGCG TGCAATACCA CCTCCGCTAC CTCCTAAGCC GAGGGTCAAC 1140

ACTTACCCTG AAGACAGCCT CCCAGATGAA GAAAAATCAT CAACCATCAA ACGTTGCCCT 1200

GATCTGGAGG CGAGAGCACC TCAGGTCCTC AGAAGACAGA GTAGCCCAAG TTGTGTTCCT 1260

GTGGCGGAGA CATCCTCCTC TATAGGAAAT GGTGATGGTA TTTCAAAACT GATCAGTGAA 1320

AATACAGAGG GATCCGCACA AGCTCCGCAG TTACCTCGGA AAAAGGACAA GCGGGACTTC 1380

CCCAAACCAA CCATCAATGG CCTTCCACCC ACCCCAAAAG TACTGATGGG AGCATGTTTT 1440

TCAAAAGTAT TTGATGGCTG CCCTTTGAAA ATTAATTGTG CAACATCCTG GATACACCCT 1500

GATACAAAAG ATCAGTATAT TATTTTTGGA ACTGAAGATG GTATTTACAC ATTGAATCTC 1560

AATGAGCTAC ATGAAGCAAC TATGGAACAG TTATTTCCAC GGAAATGTAC GTGGCTCTAC 1620

GTCATCAATA ATACACTGAT GTCATTATCA GAAGGAAAAA CCTTTCAGCT CTACTCTCAC 1680

AACCTTATTG CTTTGTTTGA ACAAGCCAAA AAACCAGGGT TAGCCGCCCA CATCCAAACT 1740

CACAGGTTTC CTGACCGCAT TCTGCCAAGA AAATTTGCCT TAACAACTAA GATTCCCGAT 1800

ACAAAAGGCT GCCACAAATG CTGCATAGTT AGAAACCCTT ACACGGGACA TAAGTACCTC 1860

TGTGGAGCTT TGCAGTCTGG CATCGTTCTG CTTCAGTGGT ATGAGCCGAT GCAGAAATTC 1920

ATGCTGATAA AGCATTTCGA TTTTCCTTTA CCAAGTCCAC TGAATGTTTT TGAAATGCTG 1980

GTGATCCCAG AGCAGGAGTA CCCCATGGTT TGTGTGGCTA TCAGCAAAGG CTCGGACTCC 2040

AGCCAAGTAG TTCAGTTTGA GACAATCAAC TTGAATTCTG CATCTTCCTG GTTTACAGAA 2100

ATTGGTGCAG GCAGCCAACA GCTGGATTCC ATTCATGTGA CACAGTTGGA GAGAGATACT 2160

GTTTTGGTGT GTTTAGACAA ATTTGTAAAA ATTGTAAATC TACAAGGAAA GCTGAAGTCC 2220

AGTAAGAAGC TGGCATCTGA GCTCAGTTTT GACTTCCGCA TTGAGTCTGT GGTGTGCCTT 2280

CAAGACAGCG TGTTGGCTTT CTGGAAACAC GGGATGCAGG GTAAAAGCTT CAAATCAGAT 2340

GAGGTTACCC AGGAAATTTC AGATGAGACC AGGGTTTTCC GCCTGCTGGG ATCAGACAGG 2400

GTGGTGGTTT TGGAAAGCCG GCCAACAGAA AACCCTGCAG CACACAGCAA TCTCTACATC 2460

CTGGCTGGAC ATGAAAACAG TTACTAA 2487

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         yel++++g+G++g+vy+ar+++tgel+a+k+i+le  ++ +++q+ei ++k++kh niv+

Q: 20    YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVA  79

         99**********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+l +e+lw++mey+ gGsl+d+++  ++ +l+E qiay++re+l++L+ylH+k+++

Q: 80    YFGSYLSREKLWICMEYCGGGSLQDIYH--VTGPLSEMQIAYVCRETLQGLAYLHTKGKM  137

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlt++g+VkL+dfgvaa++++t +krk+++gtpywmAPEv a+e + gY++

Q: 138   HRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEkNGGYNQ  197

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +Diw++GItaiel e +pP++dl+p++al++++k++  ppklk+k+k+s++f++fv+ +

Q: 198   LCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKDKTKWSSTFHNFVKIA  257

         ********************************9999988*********************

S: 238   lqknpekRpsasellkhkFl  257

         l+knp+kRp+a++ll+h+F+

Q: 258   LTKNPKKRPTAERLLTHTFV  277

         *******************7

Domain Sequence
(FASTA)

YELVQRVGSG TYGDVYKARN VHTGELAAVK IIKLEPGDDF SLIQQEIFMV KECKHCNIVA 60

YFGSYLSREK LWICMEYCGG GSLQDIYHVT GPLSEMQIAY VCRETLQGLA YLHTKGKMHR 120

DIKGANILLT DHGDVKLADF GVAAKITATI AKRKSFIGTP YWMAPEVAAV EKNGGYNQLC 180

DIWAVGITAI ELGELQPPMF DLHPMRALFL MSKSNFQPPK LKDKTKWSST FHNFVKIALT 240

KNPKKRPTAE RLLTHTFV 258

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006950	; P:response to stress

KEGG

mmu:399510

;

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

Created Date

20-Feb-2013