| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00450 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/DAPK | 475.5 | 9.2E-143 | 13 | 275 | 263 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000035962 |
| UniProt Accession | O54784; |
| Protein Name | Death-associated protein kinase 3 |
| Protein Synonyms/Alias | DAP kinase 3; DAP-like kinase; Dlk; MYPT1 kinase; ZIP-kinase; |
| Gene Name | Dapk3 |
| Gene Synonyms/Alias | Dapk3; Zipk; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Serine/threonine kinase which is involved in theregulation of apoptosis, autophagy, transcription, actin cytoskeleton reorganization, cell motility, smooth muscle contraction, and mitosis, particularly cytokinesis. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase- dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Regulates myosin phosphorylation in both smooth muscle and non- muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A, and the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates STAT3 and enhances its transcriptional activity. Positively regulates the canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Can disrupt the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection (By similarity). |
| Protein Length | 448 |
Protein Sequence
(FASTA) | | MSTFRQEDVE DHYEMGEELG SGQFAIVRKC QQKGTGMEYA AKFIKKRRLP SSRRGVSREE 60 | | IEREVSILRE IRHPNIITLH DVFENKTDVV LILELVSGGE LFDFLAEKES LTEDEATQFL 120 | | KQILDGVHYL HSKRIAHFDL KPENIMLLDK HAASPRIKLI DFGIAHRIEA GSEFKNIFGT 180 | | PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGE TKQETLTNIS AVNYDFDEEY 240 | | FSSTSELAKD FIRRLLVKDP KRRMTIAQSL EHSWIKVRRR EDGARKPERR RLRAARLREY 300 | | SLKSHSSMPR NTSYASFERF SRVLEDVAAA EQGLRELQRG RRQCRERVCA LRAAAEQREA 360 | | RCRDGSAGLG RDLRRLRTEL GRTEALRTRA QEEARAALLG AGGLKRRLCR LENRYDALAA 420 | | QVAAEVQFVR DLVRALEQER LQAECGVR 448 |
|
Nucleotide Sequence
(FASTA) | | ATGTCCACAT TCAGGCAAGA GGATGTTGAG GACCATTATG AGATGGGAGA GGAGCTTGGC 60 | | AGTGGCCAAT TTGCCATCGT GCGCAAGTGC CAGCAGAAGG GCACGGGCAT GGAGTATGCA 120 | | GCCAAGTTCA TCAAGAAGCG GCGCCTGCCA TCCAGCCGGC GCGGTGTGAG CCGGGAGGAG 180 | | ATCGAACGCG AGGTGAGCAT CCTGCGCGAG ATCCGCCACC CCAACATCAT AACACTGCAT 240 | | GACGTGTTCG AGAACAAGAC AGATGTGGTG CTGATCCTGG AGCTGGTGTC CGGTGGCGAG 300 | | CTTTTCGACT TCCTGGCCGA GAAGGAGTCA TTGACGGAGG ATGAGGCCAC GCAGTTCCTC 360 | | AAACAAATCC TAGACGGTGT CCACTACCTG CACTCCAAGC GCATCGCACA CTTTGACCTG 420 | | AAGCCCGAGA ACATCATGTT GCTGGACAAG CACGCAGCCA GCCCCCGCAT TAAGCTCATC 480 | | GACTTTGGCA TCGCGCACAG GATCGAGGCT GGCAGCGAGT TCAAGAACAT CTTTGGCACA 540 | | CCCGAGTTTG TCGCCCCCGA GATCGTGAAC TATGAGCCAC TTGGCTTGGA GGCTGACATG 600 | | TGGAGCATTG GCGTCATCAC CTACATCCTC CTGAGCGGAG CGTCCCCATT CCTGGGCGAG 660 | | ACCAAGCAGG AGACGCTGAC GAACATCTCA GCAGTGAACT ATGACTTTGA TGAGGAATAC 720 | | TTCAGCAGCA CCAGCGAGCT GGCCAAGGAC TTCATCCGCA GGCTGCTGGT CAAAGACCCC 780 | | AAGAGGAGGA TGACCATCGC ACAGAGCCTG GAGCATTCCT GGATCAAGGT GCGCAGGCGC 840 | | GAGGACGGCG CCCGGAAGCC AGAGCGACGG CGGCTGCGCG CCGCGCGCCT GCGCGAGTAC 900 | | AGCCTCAAGT CCCACTCGAG CATGCCGCGC AACACGAGCT ACGCCAGCTT CGAGCGCTTC 960 | | TCACGCGTGC TGGAGGACGT GGCGGCGGCA GAGCAGGGGC TGCGCGAGCT GCAGCGAGGC 1020 | | AGGCGCCAGT GCCGGGAGCG CGTGTGTGCG CTGCGCGCGG CCGCCGAGCA GCGGGAGGCG 1080 | | CGCTGCCGCG ACGGGAGCGC AGGGCTAGGG CGCGACCTGC GACGCCTGCG CACGGAGCTG 1140 | | GGGCGCACCG AGGCTCTGCG CACGCGCGCG CAGGAGGAGG CGCGGGCGGC GCTGTTGGGT 1200 | | GCCGGGGGCC TGAAGCGTCG CCTGTGTCGC CTGGAGAACC GTTACGACGC GCTAGCCGCT 1260 | | CAGGTGGCCG CTGAGGTGCA ATTCGTGCGC GACCTGGTGC GTGCGCTGGA GCAGGAACGG 1320 | | CTGCAGGCTG AGTGCGGCGT GCGCTAG 1347 |
|
| Domain Profile | S: 1 letgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeir 60 | +e+g+elgsG+fa+vrkc++k tG+eyaakf+kkrrl ssrrgvsreeierev++l+eir | Q: 13 YEMGEELGSGQFAIVRKCQQKGTGMEYAAKFIKKRRLPSSRRGVSREEIEREVSILREIR 72 | 5789******************************************************** |
| S: 61 sepnvinlhevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylh 120 | +pn+i+lh+v+enk+dv+lilelv+GGelfd+laekesl+e+eat++lkqil+gv+ylh | Q: 73 -HPNIITLHDVFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLH 131 | .*********************************************************** |
| S: 121 skkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivny 180 | sk+i+h+dlkPeni+lldk+ ++++iklidfG++++ie+g+e+k+i+GtPefvaPeivny | Q: 132 SKRIAHFDLKPENIMLLDKHAASPRIKLIDFGIAHRIEAGSEFKNIFGTPEFVAPEIVNY 191 | ************************************************************ |
| S: 181 eplsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdf 240 | epl+le+dmwsiGvityillsgasPflG+tkqetl+nisavn+df+ee+fss+selakdf | Q: 192 EPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSSTSELAKDF 251 | ************************************************************ |
| S: 241 irrllvkdpekrltieeclehswl 264 | irrllvkdp++r+ti+++lehsw+ | Q: 252 IRRLLVKDPKRRMTIAQSLEHSWI 275 | ***********************8 |
|
Domain Sequence
(FASTA) | | YEMGEELGSG QFAIVRKCQQ KGTGMEYAAK FIKKRRLPSS RRGVSREEIE REVSILREIR 60 | | HPNIITLHDV FENKTDVVLI LELVSGGELF DFLAEKESLT EDEATQFLKQ ILDGVHYLHS 120 | | KRIAHFDLKP ENIMLLDKHA ASPRIKLIDF GIAHRIEAGS EFKNIFGTPE FVAPEIVNYE 180 | | PLGLEADMWS IGVITYILLS GASPFLGETK QETLTNISAV NYDFDEEYFS STSELAKDFI 240 | | RRLLVKDPKR RMTIAQSLEH SWI 263 |
|
| Keyword | Activator; Apoptosis; ATP-binding; Centromere; Chromatin regulator; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transcription; Transcription regulation; Transferase; Ubl conjugation. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
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| Pfam | |
| SMARTs | |
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| Prints | |
| Created Date | 20-Feb-2013 |