EKS-MUM-00479
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00479
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/PDHK218.37.5E-65236361126
StatusReviewed
Ensembl ProteinENSMUSP00000036604
UniProt AccessionQ922H2; Q8BTX1;
Protein Name[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial
Protein Synonyms/Alias Pyruvate dehydrogenase kinase isoform 3;
Gene NamePdk3
Gene Synonyms/Alias Pdk3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000035232ENSMUSP00000036604ENSMUST00000045748
OrganismMus musculus
Functional DescriptionInhibits the mitochondrial pyruvate dehydrogenasecomplex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism (By similarity).
Protein Length415
Protein Sequence
(FASTA)
MRLFYRLLKQ PVPKQIERYS RFSPSPLSIK QFLDFGRDNA CEKTSYMFLR KELPVRLANT 60
MREVNLLPDN LLNRPSVGLV QSWYMQSFLE LLEYENKSPE DPRVLDNFLN VLINIRNRHN 120
DVVPTMAQGV IEYKEKFGFD PFISSNIQYF LDRFYTNRIS FRMLINQHTL LFGGDTNPAH 180
PKHIGSIDPT CNVADVVKDA YETAKMLCEQ YYLVAPELEV EEFNAKAPNK PIQVVYVPSH 240
LFHMLFELFK NSMRATVELH EDKKEGYPAV KTLVTLGKED LSIKISDLGG GVPLRKIDRL 300
FNYMYSTAPR PSLEPTRAAP LAGFGYGLPI SRLYARYFQG DLKLYSMEGV GTDAVIYLKA 360
LSSESFERLP VFNKSAWRHY KTTPEADDWS NPSSEPRDAS KYKAKQDKIK SNRTF 415
Nucleotide Sequence
(FASTA)
ATGCGGCTCT TCTACCGGCT GCTCAAGCAG CCGGTCCCCA AGCAGATCGA GCGCTACTCC 60
CGCTTCTCCC CGTCGCCACT GTCTATCAAA CAGTTCCTGG ACTTCGGAAG GGATAATGCA 120
TGTGAAAAAA CTTCCTATAT GTTTCTGCGC AAGGAACTTC CTGTGCGACT GGCTAACACC 180
ATGAGAGAGG TTAATCTCTT GCCGGATAAC TTGTTGAACC GCCCTTCCGT GGGATTAGTT 240
CAGAGCTGGT ACATGCAGAG CTTCCTTGAA CTTTTAGAAT ATGAAAACAA GAGCCCAGAA 300
GACCCACGAG TTTTGGATAA CTTTCTCAAC GTTCTGATAA ATATCAGAAA CAGACACAAT 360
GATGTTGTTC CTACAATGGC CCAAGGCGTG ATTGAGTACA AGGAAAAGTT CGGGTTTGAT 420
CCGTTCATTA GCAGTAACAT TCAATATTTC CTGGATCGGT TTTATACCAA CCGCATTTCT 480
TTCCGCATGC TTATTAACCA GCACACACTT CTGTTTGGTG GTGACACTAA CCCTGCACAT 540
CCGAAACATA TAGGGAGTAT CGACCCCACC TGTAATGTAG CTGATGTGGT TAAAGATGCA 600
TATGAAACAG CCAAGATGCT TTGTGAACAG TATTACCTGG TAGCTCCAGA GCTAGAAGTT 660
GAAGAATTCA ATGCCAAAGC GCCAAACAAA CCCATTCAGG TAGTTTATGT GCCGTCACAT 720
CTGTTTCACA TGCTATTTGA GCTGTTCAAG AACTCAATGA GGGCAACAGT TGAACTACAT 780
GAAGATAAAA AAGAAGGCTA CCCAGCTGTT AAAACTCTCG TTACTCTGGG TAAAGAAGAC 840
TTGTCCATTA AGATAAGTGA CCTAGGTGGT GGAGTCCCAC TTCGAAAAAT AGACCGTCTT 900
TTTAACTACA TGTACTCAAC TGCTCCTCGT CCCAGCCTGG AGCCTACAAG AGCGGCGCCC 960
TTGGCTGGAT TTGGTTATGG CTTGCCAATT TCTCGTCTGT ATGCCAGATA TTTTCAGGGA 1020
GATCTAAAAC TGTATTCCAT GGAAGGAGTG GGTACCGATG CAGTCATTTA TTTGAAGGCC 1080
CTTTCAAGTG AATCCTTTGA GAGGCTGCCA GTTTTCAATA AGTCTGCATG GCGCCATTAC 1140
AAGACCACTC CTGAAGCTGA TGACTGGAGC AATCCCAGCA GTGAACCAAG GGATGCATCA 1200
AAATACAAGG CTAAACAGGA CAAGATCAAG AGTAATAGAA CTTTCTAG 1248
Domain Profile
S: 1     yvpshlyyllfellknamratveshedkkv.lpdvkvlvalgkedliikisdrGGGvplr  59
         yvpshl+++lfel+kn+mratve hedkk+ +p+vk+lv+lgkedl+ikisd GGGvplr
Q: 236   YVPSHLFHMLFELFKNSMRATVELHEDKKEgYPAVKTLVTLGKEDLSIKISDLGGGVPLR  295
         9***************************999*****************************
S: 60    kidrlldymystapapskddaraaplaGfGyGlpisrlyakylqGdlkllsleGiGtdav  119
         kidrl++ymystap+ps +++raaplaGfGyGlpisrlya+y+qGdlkl+s+eG+Gtdav
Q: 296   KIDRLFNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAV  355
         ************************************************************
S: 120   iylkal  125
         iylkal
Q: 356   IYLKAL  361
         ****85
Domain Sequence
(FASTA)
YVPSHLFHML FELFKNSMRA TVELHEDKKE GYPAVKTLVT LGKEDLSIKI SDLGGGVPLR 60
KIDRLFNYMY STAPRPSLEP TRAAPLAGFG YGLPISRLYA RYFQGDLKLY SMEGVGTDAV 120
IYLKAL 126
KeywordATP-binding; Carbohydrate metabolism; Complete proteome; Glucose metabolism; Kinase; Mitochondrion; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00418
EKS-ANC-00434
EKS-BOT-00448
EKS-CAJ-00453
EKS-CAF-00447
EKS-CAP-00482
EKS-DAR-00852
EKS-DRM-00211
EKS-EQC-00438
EKS-ERE-00045
EKS-FEC-00427
EKS-GAM-00260
EKS-GAG-00377
EKS-GAA-00542
EKS-GOG-00440
EKS-HOS-00455
EKS-LAC-00462
EKS-LOA-00455
EKS-MAM-00446
EKS-MOD-00437
EKS-MUP-00441
EKS-MYL-00439
EKS-NOL-00407
EKS-ORN-00565
EKS-ORC-00419
EKS-ORL-00517
EKS-OTG-00451
EKS-PAT-00423
EKS-PES-00394
EKS-POA-00437
EKS-PTV-00156
EKS-RAN-00460
EKS-SAH-00414
EKS-SOA-00041
EKS-SUS-00395
EKS-TAG-00513
EKS-TAR-00559
EKS-TAS-00061
EKS-TEN-00562
EKS-TUB-00041
EKS-VIP-00082
EKS-XET-00600
EKS-XIM-00559
EKS-SAC-00132
EKS-SCP-00083
Gene Ontology
GO:0005759; C:mitochondrial matrix
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0006006; P:glucose metabolic process
GO:0006468; P:protein phosphorylation
KEGG
mmu:236900;
InterPros
IPR003594; ATPase-like_ATP-bd.
IPR018955; BCDHK/PDK_N.
IPR005467; Sig_transdc_His_kinase_core.
Pfam
PF10436; BCDHK_Adom3; 1.
PF02518; HATPase_c; 1.
SMARTs
SM00387; HATPase_c; 1.
Prosites
PS50109; HIS_KIN; 1.
Prints
Created Date20-Feb-2013