EKS-MUM-00295
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00295
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK382.13.1E-11427279253
StatusReviewed
Ensembl ProteinENSMUSP00000100988
UniProt AccessionQ4FZD7; Q0VGS4; Q8C096;
Protein NameInactive serine/threonine-protein kinase PLK5
Protein Synonyms/Alias Polo-like kinase 5; PLK-5;
Gene NamePlk5
Gene Synonyms/Alias Plk5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000035486ENSMUSP00000044400ENSMUST00000039836
ENSMUSG00000035486ENSMUSP00000100988ENSMUST00000105351
OrganismMus musculus
Functional DescriptionInactive serine/threonine-protein kinase that plays arole in cell cycle progression and neuronal differentiation.
Protein Length595
Protein Sequence
(FASTA)
MEPRSRRRRS RQLVATFLRD PGSGRVYRRG KLIGKGAFSR CYKLTDMSTS AVFALKVVPR 60
GGAGRLRLRG KVEREIALHS RLRHRNIVAF HAHFADRDHV YMVLEYCSRQ SLAHVLKVRR 120
TLTEPEVRYY LRGLVSGLRY LHQQRIVHRD LKPSNFFLNK NMEVKIGDLG LAARVGPAGR 180
CHRVLCGTPN FQAPEVVSRN GHSCKSDIWA LGCIMYTVLT GTPPFAAAPL SEMYQNIRDG 240
HYLEPTHLSP SARSLIARLL APDPAERPSL DHLLQDDFFS QGFTPERLPP HSCHSPPVFA 300
FPPPLGRLFR KVGQLLLTQC RPPCPFTSKE ASGPGEEGTE PDHMEAGNEE RDPLCTEGRI 360
HLLTLGTPRT GLAGPKGSLA LQLEVATRKL FLCLDAGPMA GQDPPGEQRP VLWAPKWVDY 420
SLKYGFGYQL SDGGSGVLFR DGSHMALRPQ GGHVSYQPDQ GTLWTFTLRD VPSPLRAKLA 480
VLRLFACYMQ RRLREEGTVP MPATPASPDI SLLSFIADSQ AMVMLFSNGT VQVSLKTSQT 540
QLVLSGEDED LLLTLQEPGG PAVGVSYTLD VLRSHGFTLA VHHHLRHGLH LLQSV 595
Nucleotide Sequence
(FASTA)
ATGGAGCCCC GGTCCCGGCG GCGGCGGAGC CGCCAGCTTG TGGCCACCTT CCTGCGCGAC 60
CCAGGCTCGG GGCGCGTGTA CCGGCGCGGG AAGCTGATCG GCAAGGGAGC CTTCAGCCGC 120
TGCTACAAGC TCACGGACAT GTCCACCAGC GCTGTGTTCG CTCTTAAGGT GGTGCCAAGG 180
GGCGGAGCGG GGCGGCTGCG CCTGCGCGGG AAGGTGGAGC GTGAGATCGC CCTGCACAGC 240
CGCCTGCGCC ACCGCAACAT CGTGGCCTTC CACGCACACT TTGCTGACCG CGATCACGTG 300
TACATGGTGC TGGAGTATTG TAGCCGCCAG TCCTTGGCTC ATGTGCTGAA AGTGCGGCGG 360
ACTCTGACAG AGCCTGAAGT GCGCTATTAC CTTCGGGGCC TGGTCAGCGG CCTGCGCTAC 420
TTGCACCAAC AACGCATCGT GCACAGGGAC CTGAAACCCA GTAATTTCTT CCTTAACAAG 480
AACATGGAGG TTAAGATAGG TGACCTGGGG CTGGCTGCCC GTGTGGGGCC TGCTGGTCGC 540
TGCCACAGGG TGCTCTGCGG GACTCCAAAC TTCCAGGCAC CTGAAGTGGT GTCCCGAAAT 600
GGACACTCGT GCAAATCTGA CATCTGGGCT CTGGGATGCA TCATGTACAC GGTGCTGACA 660
GGCACGCCAC CCTTTGCCGC GGCACCCTTG TCAGAGATGT ACCAAAACAT CCGTGACGGC 720
CACTACCTCG AGCCTACTCA CCTGTCGCCC AGCGCCCGCA GCCTCATTGC ACGGCTCCTG 780
GCACCGGACC CCGCCGAGCG GCCCAGCCTG GACCACTTAC TGCAAGATGA CTTCTTCAGT 840
CAGGGCTTCA CCCCGGAGCG GCTGCCTCCA CATTCCTGCC ACAGCCCACC TGTGTTTGCC 900
TTTCCCCCAC CTCTGGGCAG GTTGTTCCGG AAGGTGGGCC AGCTCCTGCT GACCCAGTGC 960
CGGCCACCTT GTCCCTTTAC CTCAAAAGAG GCCTCAGGCC CTGGAGAAGA GGGCACAGAA 1020
CCAGACCACA TGGAAGCCGG CAACGAGGAA AGGGATCCTC TCTGCACCGA GGGCCGAATC 1080
CACCTCCTCA CCCTTGGGAC CCCGCGGACT GGCCTGGCGG GCCCAAAAGG GAGCTTGGCT 1140
CTGCAGCTGG AAGTGGCAAC CAGAAAACTG TTCCTCTGCT TGGACGCAGG ACCTATGGCT 1200
GGACAGGACC CCCCAGGGGA GCAGCGGCCT GTTCTCTGGG CTCCTAAGTG GGTGGATTAC 1260
TCCCTCAAGT ATGGCTTCGG CTACCAGCTG TCGGATGGGG GCAGTGGGGT GCTGTTTCGG 1320
GATGGCTCCC ACATGGCCCT GCGCCCCCAA GGCGGCCATG TCTCCTACCA ACCTGACCAA 1380
GGGACTCTCT GGACCTTCAC CCTGAGGGAC GTCCCCAGCC CACTTCGTGC CAAGCTGGCT 1440
GTCCTGCGGC TCTTTGCCTG CTATATGCAG CGGCGTCTGC GGGAGGAGGG GACTGTGCCC 1500
ATGCCTGCCA CACCTGCCTC TCCTGACATC TCTCTGCTGA GCTTCATTGC TGACTCCCAG 1560
GCTATGGTCA TGCTGTTTAG CAATGGGACA GTGCAGGTCA GCCTCAAAAC CTCCCAAACC 1620
CAGCTGGTGC TAAGTGGGGA GGACGAGGAC CTCCTGCTCA CCCTCCAGGA GCCAGGGGGA 1680
CCCGCTGTGG GCGTCTCCTA CACACTCGAT GTCCTGCGGA GCCATGGCTT CACCCTTGCA 1740
GTCCACCATC ACCTGCGCCA TGGCCTGCAT CTGCTACAGA GTGTCTGA 1788
Domain Profile
S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60
         y+rgkl+GkG+f++cy+l+d++t++vfa+kvvp+    + ++r kve+ei++h++l+h+n
Q: 27    YRRGKLIGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLRHRN  86
         99**********************************************************
S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120
         iv+++++f+d+++vy+vle+csr+sla++lk r++ltepevryylr +vsgl+ylh++ri
Q: 87    IVAFHAHFADRDHVYMVLEYCSRQSLAHVLKVRRTLTEPEVRYYLRGLVSGLRYLHQQRI  146
         ************************************************************
S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180
         +hrdlk +n+fln+++evkigd+Gla+r+ ++++++++lcGtPn++aPev+s++ghs+++
Q: 147   VHRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSCKS  206
         ************************************************************
S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240
         diW+lGci+yt+l+G+PPf+++ l+e+y++i++ +y  P++ls++a+slia+ll+++P+e
Q: 207   DIWALGCIMYTVLTGTPPFAAAPLSEMYQNIRDGHYLEPTHLSPSARSLIARLLAPDPAE  266
         ************************************************************
S: 241   rpsleevlkdefl  253
         rpsl+++l+d+f+
Q: 267   RPSLDHLLQDDFF  279
         ************8
Domain Sequence
(FASTA)
YRRGKLIGKG AFSRCYKLTD MSTSAVFALK VVPRGGAGRL RLRGKVEREI ALHSRLRHRN 60
IVAFHAHFAD RDHVYMVLEY CSRQSLAHVL KVRRTLTEPE VRYYLRGLVS GLRYLHQQRI 120
VHRDLKPSNF FLNKNMEVKI GDLGLAARVG PAGRCHRVLC GTPNFQAPEV VSRNGHSCKS 180
DIWALGCIMY TVLTGTPPFA AAPLSEMYQN IRDGHYLEPT HLSPSARSLI ARLLAPDPAE 240
RPSLDHLLQD DFF 253
KeywordATP-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Differentiation; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00247
EKS-BOT-00264
EKS-CAJ-00270
EKS-CAF-00271
EKS-CAP-00298
EKS-EQC-00255
EKS-FEC-00250
EKS-GOG-00262
EKS-ICT-00249
EKS-LOA-00274
EKS-MOD-00262
EKS-MUP-00261
EKS-MYL-00265
EKS-ORA-00229
EKS-OTG-00270
EKS-POA-00256
EKS-RAN-00279
EKS-SAH-00248
EKS-SUS-00229
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005730; C:nucleolus
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0016772; F:transferase activity, transferring phosphorus-containing groups
GO:0007049; P:cell cycle
GO:0051301; P:cell division
GO:0002357; P:defense response to tumor cell
GO:0008285; P:negative regulation of cell proliferation
GO:0010976; P:positive regulation of neuron projection development
GO:0006468; P:protein phosphorylation
GO:2000045; P:regulation of G1/S transition of mitotic cell cycle
GO:0006974; P:response to DNA damage stimulus
GO:0006927; P:transformed cell apoptotic process
KEGG
mmu:216166;
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50078; POLO_BOX; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013