Tag | Content |
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EKPD ID | EKS-MUM-00187 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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AGC/PKA | 445.9 | 9.4E-134 | 46 | 300 | 255 |
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Status | Reviewed |
Ensembl Protein | ENSMUSP00000045304 |
UniProt Accession | Q922R0; B1AVU0; Q3UCD1; Q8BHD6; Q9QZ12; |
Protein Name | cAMP-dependent protein kinase catalytic subunit PRKX |
Protein Synonyms/Alias | PrKX; Protein kinase X; Protein kinase X-linked; Serine/threonine-protein kinase PRKX; PKA-related protein kinase; |
Gene Name | Prkx |
Gene Synonyms/Alias | Prkx; Pkare; |
Ensembl Information | |
Organism | Mus musculus |
Functional Description | Serine/threonine protein kinase regulated by andmediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. |
Protein Length | 355 |
Protein Sequence (FASTA) | MEPPAGAAAT VKDPDHDPVK TKVSAPAADP KPRTSSQKAG HSLQDWDTIA TVGTGTFGRV 60 | NLVKEKTGRQ YCALKIMSIP DVIRLKQEQH VQNEKAVLKE INHPFLIKLL WTGHDNRFLY 120 | MLMEFVPGGE LFTYLRNRGR FSSVASVFYA TEIVCAIEYL HSKEIVYRDL KPENILLDRE 180 | GHIKLTDFGF AKKLVDRTWT LCGTPEYLAP EVIQSKGHGR AVDWWALGIL IFEMLSGFPP 240 | FFDDNPFGIY QKILACKIDF PRQLDFTSKD LIKKLLVVDR TRRLGNMKNG AEDIKRHRWF 300 | RGVEWESVPQ RKLKPPIVPK LSGDGDISNF ETYPESELDK TPSVSDKDLE TFKNF 355 |
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Nucleotide Sequence (FASTA) | ATGGAGCCGC CCGCTGGTGC CGCGGCGACC GTAAAAGATC CAGACCATGA CCCCGTGAAG 60 | ACCAAGGTCT CGGCGCCCGC CGCGGACCCC AAACCCAGGA CATCGTCACA GAAGGCGGGG 120 | CACTCGTTAC AAGATTGGGA CACCATAGCC ACCGTGGGCA CTGGGACCTT TGGCCGTGTA 180 | AACCTGGTGA AGGAGAAGAC AGGCAGGCAA TACTGTGCCT TGAAGATTAT GAGTATCCCA 240 | GATGTCATCC GCCTGAAACA GGAACAGCAT GTGCAGAATG AGAAAGCAGT CCTGAAGGAA 300 | ATAAACCATC CCTTCCTCAT TAAACTGCTT TGGACAGGCC ATGACAACCG CTTCCTATAC 360 | ATGTTGATGG AGTTCGTGCC TGGTGGTGAG CTCTTCACCT ACCTGCGTAA TCGTGGCCGA 420 | TTCTCCTCAG TTGCTTCAGT CTTCTACGCC ACAGAGATTG TGTGTGCCAT AGAATATCTA 480 | CACTCAAAGG AAATCGTATA CAGGGACCTG AAGCCTGAAA ACATCCTTCT AGACAGGGAA 540 | GGACATATTA AACTGACAGA CTTCGGCTTC GCCAAGAAAC TGGTGGATAG GACATGGACT 600 | CTCTGTGGGA CACCAGAATA TCTCGCCCCA GAAGTCATTC AGAGCAAAGG TCATGGAAGG 660 | GCTGTGGACT GGTGGGCACT GGGCATTCTT ATATTCGAGA TGCTGTCTGG GTTTCCCCCA 720 | TTTTTCGATG ACAACCCGTT TGGGATTTAC CAGAAAATCC TTGCATGCAA AATAGATTTC 780 | CCCAGACAAT TGGATTTCAC CTCTAAGGAC CTCATCAAGA AGCTGCTGGT GGTGGACAGG 840 | ACCCGACGCC TAGGCAACAT GAAGAATGGG GCAGAAGACA TCAAGCGGCA CCGGTGGTTC 900 | CGAGGTGTGG AGTGGGAATC TGTGCCACAA AGAAAACTGA AGCCACCCAT TGTGCCCAAG 960 | TTATCGGGTG ATGGTGACAT CTCCAACTTT GAGACTTATC CAGAGAGTGA ATTGGACAAG 1020 | ACACCTTCTG TATCTGACAA AGACCTGGAA ACATTCAAAA ATTTCTGA 1068 |
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Domain Profile | S: 1 ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf 60 | +++++t+GtG+fGrv+lv+ek++++y+alk++s+ +v++lkq +hv+nek vlk++++pf | Q: 46 WDTIATVGTGTFGRVNLVKEKTGRQYCALKIMSIPDVIRLKQEQHVQNEKAVLKEINHPF 105 | 5789******************************************************** |
| S: 61 lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl 120 | l+kll++ +d+++ly+++e+v+GGelf+ylr+++rfs+ a+ fya+eiv+a+eylhs+++ | Q: 106 LIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVASVFYATEIVCAIEYLHSKEI 165 | ************************************************************ |
| S: 121 iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww 180 | +yrdlkpen+lld+eG+ik+tdfGfakk+ drtwtlcGtpeylape+iqskg+++avdww | Q: 166 VYRDLKPENILLDREGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWW 225 | ************************************************************ |
| S: 181 alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg 240 | alG+li+e+l+G+ppffdd+p+ iy+ki+++k++fp++l+ + kdl+kkll+vd+t+rlg | Q: 226 ALGILIFEMLSGFPPFFDDNPFGIYQKILACKIDFPRQLDFTSKDLIKKLLVVDRTRRLG 285 | ************************************************************ |
| S: 241 nlkngvedikehkwf 255 | n+kng+edik+h+wf | Q: 286 NMKNGAEDIKRHRWF 300 | **************9 |
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Domain Sequence (FASTA) | WDTIATVGTG TFGRVNLVKE KTGRQYCALK IMSIPDVIRL KQEQHVQNEK AVLKEINHPF 60 | LIKLLWTGHD NRFLYMLMEF VPGGELFTYL RNRGRFSSVA SVFYATEIVC AIEYLHSKEI 120 | VYRDLKPENI LLDREGHIKL TDFGFAKKLV DRTWTLCGTP EYLAPEVIQS KGHGRAVDWW 180 | ALGILIFEML SGFPPFFDDN PFGIYQKILA CKIDFPRQLD FTSKDLIKKL LVVDRTRRLG 240 | NMKNGAEDIK RHRWF 255 |
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Keyword | Angiogenesis; ATP-binding; cAMP; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |