EKS-MUM-00250

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00250

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	358.8	3.4E-107	20	271	252

Status

Unreviewed

Ensembl Protein

ENSMUSP00000038761

UniProt Accession

F8VPT7;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase SIK2;

Gene Name

Sik2

Gene Synonyms/Alias

Sik2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000037112	ENSMUSP00000134936	ENSMUST00000176824
ENSMUSG00000037112	ENSMUSP00000038761	ENSMUST00000041375
ENSMUSG00000037112	ENSMUSP00000134954	ENSMUST00000176491
ENSMUSG00000037112	ENSMUSP00000135376	ENSMUST00000176663

Organism

Mus musculus

Functional Description

Protein Length

931

Protein Sequence
(FASTA)

MVMADGPRHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI IDKSQLDAVN 60

LEKIYREVQI MKMLDHPHII KLYQVMETKS MLYLVTEYAK NGEIFDYLAN HGRLNESEAR 120

RKFWQILSAV DYCHGRKVVH RDLKAENLLL DNNMNIKIAD FGFGNFFKTG ELLATWCGSP 180

PYAAPEVFEG QQYEGPQLDI WSMGVVLYVL VCGALPFDGP TLPILRQRVL EGRFRIPYFM 240

SEDCEHLIRR MLVLDPSKRL SIAQIKEHKW MLIEVPVQRP ILYPQEQENE PSIGEFNEQV 300

LRLMHSLGID QQKTVESLQN KSYNHFAAIY FLLVERLKSH RSSFPVEQRL DGRQRRPSTI 360

AEQTVAKAQT VGLPVTLHPP NVRLMRSTLL PQASNVEAFS FPTSSCQAEA AFMEEECVDT 420

PKVNGCLLDP VPPVLVRKGC QSLPSSMMET SIDEGLETEG EAEEDPSQAF EAFQATRSGQ 480

RRHTLSEVTN QLVVMPGAGK MFSMSDNPSL ESVDSEYDMG SAQRDLNFLE DSPSLKDIML 540

ANQPSPRMTS PFISLRPANP AMQALSSQKR EAHNRSPVSF REGRRASDTS LTQGIVAFRQ 600

HLQNLARTKG ILELNKVQLL YEQMGSNADP TLTSTAPQLQ DLSSSCPQEE ISQQQESVSS 660

LSASMHPQLS PQQSLETQYL QHRLQKPNLL PKAQSPCPVY CKEPPRSLEQ QLQEHRLQQK 720

RLFLQKQSQL QAYFNQMQIA ESSYPGPSQQ LALPHQETPL TSQQPPSFSL TQALSPVLEP 780

SSEQMQFSSF LSQYPEMQLQ PLPSTPGPQA PPPLPSQLQQ HQQPPPPPPP PPPQQPGAAP 840

TSLQFSYQTC ELPSTTSSVP NYPASCHYPV DGAQQSNLTG ADCPRSSGLQ DTASSYDPLA 900

LSELPGLFDC EMVEAVDPQH NGVVSCLARE T 931

Nucleotide Sequence
(FASTA)

ATGGTCATGG CGGATGGCCC GAGGCACTTG CAGCGCGGGC CAGTCCGGGT GGGGTTCTAC 60

GACATCGAGG GCACGCTGGG CAAGGGCAAC TTTGCCGTGG TGAAGCTGGG GCGGCACCGG 120

ATCACCAAGA CGGAGGTGGC TATAAAAATA ATAGACAAGT CACAGCTGGA TGCAGTAAAC 180

CTTGAGAAAA TCTACCGAGA AGTACAGATA ATGAAAATGC TCGACCATCC TCACATCATT 240

AAACTGTATC AGGTAATGGA GACCAAAAGT ATGTTGTACC TTGTGACAGA ATATGCCAAA 300

AATGGAGAAA TTTTTGATTA TCTTGCTAAT CATGGCCGAT TAAATGAATC TGAAGCCAGG 360

AGAAAATTCT GGCAAATTCT GTCTGCTGTT GATTATTGCC ATGGCCGGAA GGTAGTGCAC 420

AGAGACCTGA AGGCTGAAAA TCTCCTGCTG GATAACAACA TGAATATCAA AATAGCAGAT 480

TTCGGCTTTG GAAATTTCTT TAAAACTGGT GAACTGCTGG CAACATGGTG TGGCAGCCCC 540

CCTTATGCAG CCCCAGAAGT CTTTGAAGGG CAGCAGTATG AAGGACCACA GCTGGATATA 600

TGGAGCATGG GAGTTGTTCT TTATGTCCTT GTCTGTGGAG CTCTACCTTT TGATGGACCA 660

ACTCTCCCTA TTTTGAGGCA GAGGGTTTTA GAAGGAAGAT TCCGGATTCC TTATTTCATG 720

TCAGAAGATT GTGAACACCT CATTAGAAGG ATGTTGGTCC TAGATCCTTC CAAACGGCTA 780

AGCATAGCTC AAATCAAGGA GCACAAGTGG ATGCTCATAG AGGTTCCTGT ACAGAGGCCT 840

ATTCTCTACC CACAAGAACA GGAAAACGAG CCGTCCATTG GAGAATTTAA TGAGCAGGTT 900

CTTCGACTGA TGCACAGCCT TGGGATTGAT CAGCAGAAGA CTGTTGAGTC TTTGCAAAAC 960

AAGAGCTATA ATCACTTTGC TGCCATTTAT TTCTTGTTGG TGGAACGTCT AAAATCACAT 1020

AGGAGCAGTT TTCCTGTGGA GCAGAGACTT GATGGCCGCC AGCGTCGGCC TAGCACCATT 1080

GCTGAACAAA CAGTTGCCAA GGCACAAACT GTGGGGCTGC CAGTGACCTT GCATCCACCG 1140

AACGTGAGAC TGATGCGATC TACCCTCCTC CCACAGGCAT CCAATGTGGA GGCCTTTTCA 1200

TTTCCAACAT CCAGCTGTCA AGCAGAAGCT GCCTTTATGG AGGAAGAGTG TGTCGACACT 1260

CCAAAGGTGA ATGGCTGCCT GCTTGACCCT GTGCCCCCTG TCCTGGTGAG GAAGGGATGC 1320

CAGTCACTGC CCAGCAGTAT GATGGAGACC TCCATTGATG AAGGCTTGGA GACAGAAGGA 1380

GAGGCTGAGG AAGACCCCAG TCAGGCCTTT GAAGCTTTCC AGGCCACACG CAGTGGGCAG 1440

CGACGGCACA CTCTGTCAGA AGTGACTAAC CAATTGGTTG TGATGCCCGG GGCAGGGAAA 1500

ATGTTCTCCA TGAGTGATAA CCCCTCCCTT GAGAGTGTGG ACTCTGAGTA TGATATGGGG 1560

TCTGCCCAGA GGGACCTGAA CTTTCTGGAA GACAGCCCTT CCTTGAAGGA CATCATGTTA 1620

GCCAATCAGC CGTCACCCCG CATGACATCT CCTTTCATAA GCCTCAGACC TGCCAACCCA 1680

GCCATGCAGG CTCTGAGCTC ACAGAAGCGT GAGGCCCACA ACCGGTCCCC CGTGAGCTTC 1740

CGAGAAGGCC GCAGAGCATC AGATACGTCC CTTACACAAG GAATTGTAGC ATTTAGACAA 1800

CATCTTCAGA ATCTTGCTAG AACCAAAGGA ATTCTGGAGT TGAACAAAGT ACAATTGCTG 1860

TATGAACAAA TGGGATCAAA CGCAGACCCT ACCTTAACAT CAACTGCTCC TCAGCTCCAA 1920

GACCTTTCGA GCAGTTGCCC TCAGGAGGAA ATCTCCCAGC AGCAGGAAAG TGTCTCCAGC 1980

CTGTCTGCCA GCATGCACCC TCAGCTCTCA CCACAGCAAA GCTTGGAAAC CCAGTACCTA 2040

CAGCATCGAC TCCAGAAGCC CAATCTTCTG CCAAAGGCCC AGAGTCCTTG TCCAGTGTAT 2100

TGTAAAGAGC CACCTCGGAG CCTGGAACAG CAGCTACAGG AGCATAGGCT CCAACAGAAG 2160

CGACTCTTCC TCCAGAAGCA GTCTCAGCTG CAAGCATATT TTAATCAGAT GCAGATAGCA 2220

GAGAGCTCCT ACCCTGGACC AAGTCAGCAG CTGGCTCTTC CCCACCAGGA GACTCCACTG 2280

ACATCCCAGC AGCCCCCATC ATTCAGCCTG ACCCAGGCCC TGAGTCCTGT CCTCGAGCCC 2340

TCTTCTGAGC AGATGCAATT TAGCTCTTTC CTCAGCCAAT ACCCAGAGAT GCAGTTGCAG 2400

CCACTGCCCT CTACTCCCGG CCCCCAGGCT CCACCTCCCT TACCCTCACA ATTGCAGCAA 2460

CATCAGCAGC CACCACCCCC ACCACCACCC CCTCCACCAC AGCAGCCAGG AGCTGCTCCA 2520

ACCTCCTTAC AGTTCTCCTA TCAGACTTGT GAGCTGCCAA GCACCACTTC TTCTGTACCA 2580

AACTATCCTG CTTCCTGTCA CTATCCTGTG GATGGAGCCC AGCAGAGCAA CCTCACAGGG 2640

GCGGACTGTC CCAGGAGCTC AGGACTTCAG GACACCGCAT CTAGCTATGA CCCACTGGCC 2700

CTCTCTGAGC TCCCTGGACT CTTTGATTGT GAAATGGTAG AAGCTGTGGA TCCACAACAC 2760

AATGGGGTTG TGAGCTGCTT AGCCCGGGAG ACCTAG 2796

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++  tlG+g+f+ Vkl +h+ tk++va+Kii+k++l++ +leki+rE++i+k+l+hp+i

Q: 20    YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHI  79

         89999*******************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++lylv+eya++ge+fdy+ ++grl+e+ear+ f q++sav+Y+h +++v

Q: 80    IKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKVV  139

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+fk+g+ll t+cGsppYaaPe+++g++Yegp++D

Q: 140   HRDLKAENLLLDNNMNIKIADFGFGNFFKTGELLATWCGSPPYAAPEVFEGQQYEGPQLD  199

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +Ws+GvvLy+lv+g+lPfd+++l  l++++l+g+++ip+ +s+++e+L+r++Lv dp+kR

Q: 200   IWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKR  259

         ************************************************************

S: 241   atieeilkhewl  252

         ++i +i++h+w+

Q: 260   LSIAQIKEHKWM  271

         ***********8

Domain Sequence
(FASTA)

YDIEGTLGKG NFAVVKLGRH RITKTEVAIK IIDKSQLDAV NLEKIYREVQ IMKMLDHPHI 60

IKLYQVMETK SMLYLVTEYA KNGEIFDYLA NHGRLNESEA RRKFWQILSA VDYCHGRKVV 120

HRDLKAENLL LDNNMNIKIA DFGFGNFFKT GELLATWCGS PPYAAPEVFE GQQYEGPQLD 180

IWSMGVVLYV LVCGALPFDG PTLPILRQRV LEGRFRIPYF MSEDCEHLIR RMLVLDPSKR 240

LSIAQIKEHK WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008286	; P:insulin receptor signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0046777	; P:protein autophosphorylation

KEGG

mmu:235344

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR017090	; Ser/Thr_kinase_SIK1/2.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013