EKS-MUM-00172

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00172

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TTK	493.0	5.5E-148	498	764	267

Status

Reviewed

Ensembl Protein

ENSMUSP00000064839

UniProt Accession

P35761;

Protein Name

Dual specificity protein kinase TTK

Protein Synonyms/Alias

ESK; PYT;

Gene Name

Ttk

Gene Synonyms/Alias

Ttk; Esk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000038379	ENSMUSP00000064839	ENSMUST00000070326

Organism

Mus musculus

Functional Description

Essential for chromosome alignment by enhancing AURKBactivity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (By similarity). Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. May play some role in the control of cell proliferation or differentiation and could be involved in modulating different levels of signal transduction pathways.

Protein Length

830

Protein Sequence
(FASTA)

MEAEELIGSS VTIDSIMSKM RDIKNKINED CTDELSLSKI CADHTETVNQ IMRVGNTPEN 60

WLNFLLKLEK NSSPLNDDLL NKLIGRYSQA IEVLPPDKYG QNESFARIQV RLAELKAIQE 120

PDDARDYFQM ARENCKKFAF VHVSFAQFEL SQGNLKKSEQ LLHKAVETGA VPLQMLETAM 180

RNLHLQKKQL LPEEDKKSVS ASTVLSAQEP FSSSLGNVQN RSISCESRGQ AGAARVLYGE 240

NLPPQDAEVR HQNPFKQTHA AKRSCPFGRV PVNLLNSPDF YVKTDSSAVT QLTTRKGSGP 300

DRDAILPGSR PRGSDSYELR GLKPIQTIYL KDSLVSNEKS SELMSDLIAL KSKTDSSLTK 360

LEETKPEIAE RRPMQWQSTR KPECVFQNPA AFAPLRHVPD VTPKADKESP PISVPKWLDP 420

KSACETPSSS SLDDYMKCFK TPVVKNDFPP ACPSSTPYSQ LARLQQQQQQ GLSTPLQSLQ 480

ISGSSSINEC ISVNGRIYSI LKQIGSGGSS KVFQVLNEKK QINAIKYVNL EDADSQTIES 540

YRNEIAFLNK LQQHSDKIIR LYDYEITEQY IYMVMECGNI DLNSWLKKKK SINPWERKSY 600

WKNMLEAVHI IHQHGIVHSD LKPANFVIVD GMLKLIDFGI ANQMQPDTTS IVKDSQVGTV 660

NYMAPEAIRD MSSSRENSKI RTKVSPRSDV WSLGCILYYM TYGRTPFQHI INQVSKLHAI 720

INPAHEIEFP EISEKDLRDV LKCCLVRNPK ERISIPELLT HPYVQIQPHP GSQMARGATD 780

EMKYVLGQLV GLNSPNSILK TAKTLYERYN CGEGQDSSSS KTFDKKRERK 830

Nucleotide Sequence
(FASTA)

ATGGAGGCTG AAGAGTTAAT TGGCAGCAGT GTGACGATTG ATTCCATCAT GAGCAAAATG 60

AGAGATATTA AAAATAAGAT AAATGAAGAC TGTACTGATG AGCTAAGCTT GTCTAAAATC 120

TGTGCCGATC ACACGGAAAC TGTTAACCAA ATTATGAGGG TTGGGAACAC CCCAGAGAAC 180

TGGTTGAATT TCTTGCTGAA ACTAGAGAAA AACAGCTCAC CTCTAAATGA CGATCTTTTA 240

AATAAGCTGA TTGGTCGGTA TAGTCAAGCG ATTGAAGTAC TTCCTCCAGA TAAATACGGC 300

CAGAATGAGA GCTTTGCTCG AATACAAGTG AGACTTGCTG AACTAAAAGC TATTCAAGAG 360

CCTGATGATG CCCGTGACTA CTTCCAGATG GCCAGGGAAA ACTGCAAGAA GTTTGCTTTT 420

GTGCACGTAT CTTTTGCACA GTTTGAACTG TCTCAAGGCA ATCTTAAAAA AAGTGAGCAG 480

CTTCTTCATA AAGCTGTAGA GACTGGGGCG GTGCCGCTGC AGATGCTGGA GACGGCCATG 540

CGTAACTTAC ACCTCCAGAA AAAGCAGCTG CTTCCGGAGG AGGACAAGAA GAGTGTGTCA 600

GCATCGACAG TACTAAGTGC CCAAGAGCCG TTCTCCAGCT CACTTGGAAA TGTACAGAAT 660

CGGAGCATCA GCTGTGAGTC CAGAGGACAG GCTGGGGCAG CCAGGGTTTT ATATGGAGAG 720

AACTTGCCTC CACAAGATGC CGAAGTGAGG CATCAAAACC CCTTCAAGCA GACTCACGCA 780

GCTAAACGGT CATGCCCCTT TGGAAGAGTC CCAGTCAATC TTCTAAACAG CCCAGATTTC 840

TATGTGAAGA CAGATAGCTC AGCTGTGACA CAGTTAACAA CAAGAAAGGG GTCAGGACCA 900

GACCGAGACG CGATTCTGCC CGGCTCCAGA CCACGTGGCA GTGATTCCTA TGAACTGAGA 960

GGTTTAAAGC CCATTCAAAC TATCTATTTG AAAGACTCTT TGGTGTCCAA TGAAAAGAGT 1020

TCTGAACTTA TGTCTGATTT AATAGCCTTG AAGAGTAAAA CAGATTCAAG TCTAACAAAA 1080

TTGGAAGAAA CTAAGCCAGA GATTGCAGAA AGAAGGCCCA TGCAGTGGCA GTCTACCAGA 1140

AAGCCCGAGT GTGTGTTCCA GAACCCTGCT GCCTTTGCAC CCCTGCGGCA CGTTCCAGAT 1200

GTCACCCCGA AGGCTGACAA AGAGTCACCA CCAATATCAG TTCCTAAATG GCTTGATCCA 1260

AAGTCTGCTT GTGAGACACC TAGTAGCAGC TCCTTGGATG ATTACATGAA ATGTTTTAAG 1320

ACTCCAGTTG TAAAGAATGA CTTTCCACCT GCCTGTCCAT CATCAACACC TTACAGCCAG 1380

CTTGCCCGCC TCCAGCAGCA ACAGCAGCAG GGACTCAGCA CTCCTCTTCA AAGCTTGCAG 1440

ATTTCAGGTT CTTCATCAAT AAATGAATGC ATTTCAGTTA ACGGAAGAAT TTATTCCATA 1500

TTAAAGCAGA TAGGCAGTGG AGGTTCCAGT AAGGTGTTTC AGGTATTGAA TGAGAAAAAA 1560

CAGATAAACG CTATCAAATA TGTGAACCTA GAAGACGCCG ATAGCCAAAC TATTGAGAGC 1620

TACCGCAACG AGATAGCGTT TTTGAACAAA CTACAGCAAC ACAGTGATAA GATCATCCGC 1680

CTCTATGATT ATGAAATCAC CGAGCAGTAC ATCTACATGG TAATGGAATG TGGAAACATT 1740

GACCTAAATA GTTGGCTTAA AAAGAAAAAA TCCATCAATC CATGGGAACG CAAGAGCTAC 1800

TGGAAAAACA TGTTGGAGGC AGTACACATA ATCCATCAGC ATGGTATTGT TCATAGTGAT 1860

CTGAAGCCTG CTAACTTTGT GATAGTGGAT GGAATGCTAA AGCTAATTGA TTTTGGGATT 1920

GCAAACCAAA TGCAGCCAGA CACAACAAGC ATTGTTAAAG ATTCTCAGGT TGGCACAGTT 1980

AACTATATGG CCCCAGAAGC AATCAGAGAC ATGTCTTCTT CAAGAGAAAA TTCGAAAATC 2040

AGGACCAAGG TAAGTCCCAG AAGTGATGTC TGGTCCTTGG GGTGCATTTT GTACTACATG 2100

ACTTATGGGA GGACGCCATT TCAGCACATC ATCAATCAGG TCTCTAAACT GCACGCCATA 2160

ATCAACCCTG CTCATGAGAT TGAATTTCCC GAGATTTCGG AAAAAGATCT TCGAGACGTG 2220

TTAAAGTGCT GTTTAGTGAG GAACCCTAAA GAGAGGATAT CTATCCCTGA GCTTCTCACA 2280

CATCCGTATG TTCAAATTCA GCCCCATCCA GGCAGCCAAA TGGCTAGGGG AGCCACTGAT 2340

GAAATGAAAT ATGTGTTGGG TCAACTTGTT GGTCTGAATT CTCCTAACTC CATCTTGAAA 2400

ACTGCAAAAA CTTTGTATGA ACGTTATAAT TGTGGTGAAG GTCAAGATTC TTCGTCATCC 2460

AAGACTTTTG ACAAAAAGAG AGAAAGAAAG TGA 2493

Domain Profile

S: 1     yeilkklGsGGsskvfkvksekkrvyalkvvdleaaddqtidgykneielleklqdqs.k  59

         y+ilk++GsGGsskvf+v++ekk+++a+k+v+le+ad+qti++y+nei++l+klq++s k

Q: 498   YSILKQIGSGGSSKVFQVLNEKKQINAIKYVNLEDADSQTIESYRNEIAFLNKLQQHSdK  557

         99********************************************************9*

S: 60    virlydyeledsllylvmecGdidlnkilkkkksiepdyelvsyykemleavkvihqhGi  119

         +irlydye++++++y+vmecG+idln++lkkkksi+p +e++sy+k+mleav++ihqhGi

Q: 558   IIRLYDYEITEQYIYMVMECGNIDLNSWLKKKKSINP-WERKSYWKNMLEAVHIIHQHGI  616

         *************************************.**********************

S: 120   vhsdlkPanfllvdGilklidfGianavaedttsivkesqvGtvnylaPealkdmsssqs  179

         vhsdlkPanf++vdG+lklidfGian++++dttsivk+sqvGtvny+aPea++dmsss

Q: 617   VHSDLKPANFVIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTVNYMAPEAIRDMSSS--  674

         **********************************************************..

S: 180   sereaekskikvsrksdvwslGcilylllygktPfgsirnqvskllaiinPdveiefPei  239

           re++k+++kvs++sdvwslGcily+++yg+tPf++i+nqvskl+aiinP++eiefPei

Q: 675   --RENSKIRTKVSPRSDVWSLGCILYYMTYGRTPFQHIINQVSKLHAIINPAHEIEFPEI  732

         ..**********************************************************

S: 240   tsniekslvellkaclkrnPkkrisvdellsspfv  274

         +   ek+l+++lk+cl+rnPk+ris++ell++p+v

Q: 733   S---EKDLRDVLKCCLVRNPKERISIPELLTHPYV  764

         *...*****************************96

Domain Sequence
(FASTA)

YSILKQIGSG GSSKVFQVLN EKKQINAIKY VNLEDADSQT IESYRNEIAF LNKLQQHSDK 60

IIRLYDYEIT EQYIYMVMEC GNIDLNSWLK KKKSINPWER KSYWKNMLEA VHIIHQHGIV 120

HSDLKPANFV IVDGMLKLID FGIANQMQPD TTSIVKDSQV GTVNYMAPEA IRDMSSSREN 180

SKIRTKVSPR SDVWSLGCIL YYMTYGRTPF QHIINQVSKL HAIINPAHEI EFPEISEKDL 240

RDVLKCCLVR NPKERISIPE LLTHPYV 267

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR011990	; TPR-like_helical.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013