EKS-MUM-00481
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00481
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/PDHK215.17.2E-64240363124
StatusReviewed
Ensembl ProteinENSMUSP00000041447
UniProt AccessionQ9JK42; Q8VC63;
Protein Name[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial
Protein Synonyms/Alias Pyruvate dehydrogenase kinase isoform 2;
Gene NamePdk2
Gene Synonyms/Alias Pdk2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000038967ENSMUSP00000041447ENSMUST00000038431
OrganismMus musculus
Functional DescriptionInhibits the mitochondrial pyruvate dehydrogenasecomplex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
Protein Length407
Protein Sequence
(FASTA)
MRWVRALLKN ASLAGAPKYI EHFSKFSPSP LSMKQFLDFG SSNACEKTSF TFLRQELPVR 60
LANIMKEINL LPDRVLGTPS VQLVQSWYVQ SLLDIMEFLD KDPEDHRTLS QFTDALVTIR 120
NRHNDVVPTM AQGVLEYKDT YGDDPVSNQN IQYFLDRFYL SRISIRMLIN QHTLIFDGST 180
NPAHPKHIGS IDPNCSVSDV VKDAYDMAKL LCDKYYMASP DLEIQEVNAT NANQPIHMVY 240
VPSHLYHMLF ELFKNAMRAT VESHESSLTL PPIKIMVALG EEDLSIKMSD RGGGVPLRKI 300
ERLFSYMYST APTPQPGTGG TPLAGFGYGL PISRLYAKYF QGDLQLFSME GFGTDAVIYL 360
KALSTDSVER LPVYNKSAWR HYQTIQEAGD WCVPSTEPKN TSTYRVS 407
Nucleotide Sequence
(FASTA)
ATGCGCTGGG TCCGGGCGCT GTTGAAGAAT GCGTCCCTGG CAGGGGCACC CAAGTACATC 60
GAGCACTTCA GCAAGTTCTC CCCGTCCCCG TTGTCCATGA AGCAGTTTCT AGACTTCGGA 120
TCCAGCAATG CCTGCGAGAA GACGTCATTC ACTTTCCTCC GGCAGGAGCT GCCCGTTCGC 180
CTGGCCAACA TCATGAAAGA GATCAACCTG CTTCCTGACC GAGTGCTGGG CACCCCATCG 240
GTGCAGCTGG TGCAGAGCTG GTATGTCCAG AGTCTGCTGG ACATCATGGA ATTCCTGGAC 300
AAAGACCCCG AGGACCACCG GACTCTAAGC CAGTTCACAG ATGCCCTGGT CACCATCCGG 360
AACCGGCACA ATGACGTGGT GCCCACCATG GCACAGGGAG TGCTGGAGTA CAAGGACACC 420
TATGGAGATG ACCCCGTCTC CAACCAGAAC ATCCAGTACT TCCTGGACCG CTTCTACCTC 480
AGCCGCATCT CCATCCGAAT GCTAATCAAT CAACACACCC TCATCTTTGA TGGCAGCACC 540
AACCCAGCCC ACCCCAAACA CATTGGCAGC ATCGATCCCA ACTGCAGCGT GTCTGATGTG 600
GTGAAAGACG CCTATGACAT GGCTAAGCTC CTGTGTGACA AGTATTACAT GGCTTCCCCT 660
GACCTGGAGA TCCAGGAAGT CAATGCCACC AACGCCAACC AGCCCATTCA CATGGTCTAT 720
GTCCCTTCCC ACCTGTACCA CATGCTCTTT GAACTCTTTA AGAATGCCAT GCGGGCCACT 780
GTGGAAAGCC ACGAGTCCAG CCTCACACTC CCCCCCATCA AGATTATGGT GGCCCTCGGT 840
GAAGAAGATC TGTCCATCAA AATGAGTGAC CGAGGCGGGG GTGTCCCCTT GAGGAAGATC 900
GAGAGGCTCT TCAGCTACAT GTACTCCACA GCTCCCACAC CCCAGCCTGG CACTGGGGGT 960
ACCCCGCTGG CTGGCTTTGG GTACGGACTC CCCATTTCCC GCCTCTACGC CAAGTACTTC 1020
CAGGGGGACT TGCAGCTTTT CTCTATGGAG GGCTTTGGGA CAGATGCTGT CATCTATCTG 1080
AAGGCCCTGT CCACGGACTC AGTGGAGCGC CTGCCTGTCT ACAACAAGTC TGCCTGGCGC 1140
CACTACCAGA CCATCCAGGA GGCCGGCGAC TGGTGTGTGC CCAGCACAGA GCCCAAGAAC 1200
ACATCGACGT ATCGGGTCAG CTAG 1224
Domain Profile
S: 1     yvpshlyyllfellknamratveshedkkvlpdvkvlvalgkedliikisdrGGGvplrk  60
         yvpshly++lfel+knamratveshe++ +lp++k++valg+edl+ik+sdrGGGvplrk
Q: 240   YVPSHLYHMLFELFKNAMRATVESHESSLTLPPIKIMVALGEEDLSIKMSDRGGGVPLRK  299
         9***********************************************************
S: 61    idrlldymystapapskddaraaplaGfGyGlpisrlyakylqGdlkllsleGiGtdavi  120
         i+rl++ymystap+p+   + ++plaGfGyGlpisrlyaky+qGdl+l+s+eG+Gtdavi
Q: 300   IERLFSYMYSTAPTPQPG-TGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVI  358
         ***************998.899**************************************
S: 121   ylkal  125
         ylkal
Q: 359   YLKAL  363
         ***85
Domain Sequence
(FASTA)
YVPSHLYHML FELFKNAMRA TVESHESSLT LPPIKIMVAL GEEDLSIKMS DRGGGVPLRK 60
IERLFSYMYS TAPTPQPGTG GTPLAGFGYG LPISRLYAKY FQGDLQLFSM EGFGTDAVIY 120
LKAL 124
KeywordATP-binding; Carbohydrate metabolism; Complete proteome; Glucose metabolism; Kinase; Mitochondrion; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00419
EKS-ANC-00435
EKS-BOT-00447
EKS-CAE-00378
EKS-CAJ-00454
EKS-CAF-00448
EKS-CAP-00481
EKS-CII-00254
EKS-DAR-00853
EKS-EQC-00439
EKS-GAM-00258
EKS-GAA-00541
EKS-GOG-00441
EKS-HOS-00456
EKS-ICT-00430
EKS-LAC-00461
EKS-LOA-00457
EKS-MOD-00438
EKS-MYL-00441
EKS-NOL-00408
EKS-ORN-00566
EKS-ORC-00421
EKS-ORL-00518
EKS-OTG-00452
EKS-PAT-00424
EKS-PEM-00246
EKS-PTV-00157
EKS-RAN-00462
EKS-SAH-00415
EKS-SUS-00397
EKS-TAR-00556
EKS-TEN-00560
EKS-XET-00599
EKS-XIM-00557
Gene Ontology
GO:0005759; C:mitochondrial matrix
GO:0005739; C:mitochondrion
GO:0005634; C:nucleus
GO:0045254; C:pyruvate dehydrogenase complex
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0006006; P:glucose metabolic process
KEGG
mmu:18604;
InterPros
IPR003594; ATPase-like_ATP-bd.
IPR018955; BCDHK/PDK_N.
IPR005467; Sig_transdc_His_kinase_core.
Pfam
PF10436; BCDHK_Adom3; 1.
PF02518; HATPase_c; 1.
SMARTs
SM00387; HATPase_c; 1.
Prosites
PS50109; HIS_KIN; 1.
Prints
Created Date20-Feb-2013