EKS-MUM-00396

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00396

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Lmr	528.1	9.7E-159	136	409	274

Status

Reviewed

Ensembl Protein

ENSMUSP00000048238

UniProt Accession

Q3TYD6; A6BLY9; Q6PDK6; Q6ZPY9; Q8CA34;

Protein Name

Serine/threonine-protein kinase LMTK2

Protein Synonyms/Alias

Brain-enriched kinase; Lemur tyrosine kinase 2;

Gene Name

Lmtk2

Gene Synonyms/Alias

Lmtk2; Brek, Kiaa1079;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000038970	ENSMUSP00000048238	ENSMUST00000041804

Organism

Mus musculus

Functional Description

Phosphorylates PPP1C, phosphorylase b and CFTR (Bysimilarity).

Protein Length

1471

Protein Sequence
(FASTA)

MPGPPASPPP PMLLLLLLLT VGCARAAPLP QTGAGEVPVV EVPSLFVILS VCSLLILIVL 60

IANCVSCCKD PEIDFKEFED NFDDEIDFTP PAEDTPSIQS PAEVFTLSVP NISLPAPSQF 120

QASVEGLKSQ VARHSLNYIQ EIGSGWFGKV LLGETYTGTS VARVIVKELK VSASPKEQDT 180

FLKSGEPYYI LQHPNVLQCV GQCVEAIPYL LVFEFCDLGD LKAYLHNEQE HVRGDSQTML 240

LQRMACEIAA GLAAMHKLHF LHSDLALRNC YLTSDLNVKV GDYGIGFSRY KEDYIETDDK 300

KVFPLRWTAP ELVTSFQDRL LTADQTKYSN IWSLGVTLWE LFNNAAQPYA NLSDLDVLNQ 360

VIRERDMKLP KPQLEQPYSD RWYEVLQFCW LPPDKRPAAE DVHRLLTYLR MQSQRDSEVD 420

FEQQWTALKP DTNSRDASSS AAFPILDHFA RDRLGREMEE VLTVTETSQG LSFEYVWEAA 480

KHDHFDEQGR GHPDEALSYS SMFFPVEVFE NSLSDPGPGK QDDSGQEVPV RAPGVVPVFD 540

AHNLSVGSDY YIQLEEKSSS NLGLDPPALL TTEVDKLERA GAEEPRTEED FFQSSAHPKE 600

ASSTEDSRAT SIPGSPFNLF SDLDKADDLP SHQKIFDLME LNGVQADFKP AILSSSLDDP 660

KDTCQSDKEK PHKLLDQGPL CLSESLLHQD HFDPLSVQEL SENFLFLQEK NLLKGSLTTK 720

EQVSDLQTEL KNAGFTSALL ESPQRGSESS ELEFLENTLD FPLSQGDTRG QNEGAGVRRH 780

SGTSPQASPA LLTEEGSPTA PTDPILKPEE TKSFRDVRVP EDSICLELGP DPVTVGVEIP 840

ATDAKTLDGG NRPPDVTCQS KEALSLTNRH PILVNDITAQ GSVESCLPES RQDLQNEPFS 900

EDPLSVSSLE KHSEAAETLN QLNSKAAPED AALASALSSD STSQDSLLED SLSTPIPTSE 960

QSVETPDSLD SVDVREALLE SLGSHTPRKL LPPDKPADSG YETENLESPE WTLHPAPEGT 1020

ADSDAAAAGD SGHSSLPPNP VIVISDAGDG HRGAEGPPQS FTLGPQSSYR DSAYFSDNDS 1080

EPDKKPEEVP GTSANALVLV KGQSPPESVV PEESSDVREG CLEAPQDKPD QSRVSTLQNS 1140

CHSELQETLQ PTPADASRES CPVNDEASSP LSLLNSEPSS CDDLDTQEDR PCTLASTGTN 1200

TNELLAYMSS TLDKSLPSHL ESSKLKEPDI EGKYLGKLCV SGMLDLSEDG MDADEEDENS 1260

DDSDEDLRAF NLHSLSSESE DDTEHPVPII VSNDDGRHLR SLLKPSAAEA IEQLPEDWKK 1320

EKKAVTFFDD VTVYLFDQET PTKELGHCGG EAHGPGPSSP AASSSSPYLG RCMNSESSTD 1380

EEGGGFEWDD DFSPDPFMSK TTSLLGSKPS LQTSKYFSPP PPARSAEQSW PHVSPCSRFS 1440

ISPANIASFS LTHLTDSDIE QGGSSEDGDK D 1471

Nucleotide Sequence
(FASTA)

ATGCCGGGGC CGCCGGCGTC GCCGCCGCCG CCGATGCTCC TGCTGCTCCT GCTCCTGACG 60

GTCGGCTGTG CCCGGGCCGC GCCACTTCCG CAAACAGGTG CAGGGGAAGT ACCTGTTGTA 120

GAAGTTCCCT CCTTGTTTGT GATCCTGTCG GTGTGCAGTT TATTGATACT GATAGTGTTA 180

ATTGCAAACT GTGTTTCCTG CTGTAAGGAC CCAGAAATAG ACTTTAAGGA ATTTGAAGAC 240

AATTTTGATG ATGAGATAGA CTTCACCCCA CCAGCAGAAG ACACCCCGTC CATCCAGTCC 300

CCAGCAGAGG TCTTCACGCT CTCAGTGCCC AACATCTCAC TTCCAGCTCC ATCCCAGTTC 360

CAGGCTTCTG TGGAAGGTTT GAAGTCTCAA GTCGCCCGCC ACAGTCTCAA CTACATACAG 420

GAGATCGGGA GTGGCTGGTT TGGAAAGGTC CTCCTGGGAG AGACTTACAC AGGCACCAGC 480

GTCGCGAGAG TCATAGTGAA GGAGTTAAAA GTCAGTGCAA GCCCCAAGGA GCAGGACACT 540

TTCCTGAAGA GTGGAGAGCC TTACTACATC CTCCAGCATC CAAATGTCCT CCAGTGTGTG 600

GGGCAGTGTG TGGAAGCCAT CCCCTACCTT CTGGTGTTTG AGTTCTGCGA CCTGGGTGAC 660

CTGAAGGCTT ACCTGCACAA TGAGCAAGAA CACGTGCGGG GTGATTCACA GACCATGCTG 720

CTACAGAGGA TGGCGTGTGA GATTGCCGCA GGGCTGGCAG CCATGCACAA GCTGCACTTT 780

CTGCACAGTG ATCTGGCCCT GCGGAATTGT TATCTCACCT CCGACTTAAA TGTCAAAGTG 840

GGTGACTATG GAATAGGCTT CAGCAGATAC AAGGAGGATT ACATTGAGAC AGATGACAAG 900

AAAGTTTTCC CCCTGAGATG GACTGCTCCA GAATTAGTGA CCAGCTTTCA AGACAGACTC 960

TTGACTGCAG ATCAGACTAA ATACAGTAAT ATCTGGTCCT TAGGTGTAAC ACTTTGGGAA 1020

CTCTTCAACA ATGCTGCTCA GCCGTATGCA AACCTTTCTG ACCTGGATGT CCTCAATCAA 1080

GTCATTCGGG AGAGGGACAT GAAGCTCCCA AAGCCGCAGC TGGAGCAGCC GTACTCGGAT 1140

AGATGGTACG AAGTGCTGCA GTTCTGCTGG CTGCCTCCTG ACAAGAGGCC AGCCGCAGAA 1200

GACGTGCACC GTCTGCTAAC TTACCTGAGG ATGCAGAGCC AGCGGGACTC GGAGGTCGAC 1260

TTTGAACAGC AGTGGACTGC TCTCAAGCCC GACACCAACA GCAGGGACGC ATCCAGCAGC 1320

GCTGCCTTCC CCATCCTTGA CCACTTCGCC CGGGACCGGC TGGGTCGGGA GATGGAGGAG 1380

GTCCTCACGG TGACGGAGAC CAGCCAGGGC CTGAGCTTTG AGTATGTGTG GGAGGCTGCC 1440

AAGCACGACC ATTTTGATGA GCAGGGCCGG GGCCACCCAG ATGAAGCCCT GTCTTACTCC 1500

AGCATGTTCT TCCCAGTGGA GGTGTTTGAG AATTCGCTTT CAGATCCTGG CCCTGGCAAG 1560

CAAGATGACA GTGGCCAGGA GGTGCCCGTG AGGGCCCCTG GGGTGGTTCC TGTGTTTGAT 1620

GCACACAACC TCTCTGTTGG AAGTGACTAC TACATCCAGC TGGAGGAGAA AAGCAGCAGC 1680

AATCTGGGAC TGGACCCCCC TGCACTGCTC ACAACTGAAG TAGATAAGCT AGAGAGGGCT 1740

GGGGCTGAGG AACCCAGGAC AGAAGAGGAT TTCTTCCAGA GCAGTGCTCA CCCCAAAGAA 1800

GCCAGCTCTA CCGAGGACTC ACGTGCTACC AGCATCCCTG GGAGCCCTTT CAACCTATTT 1860

AGTGACCTTG ACAAAGCAGA TGACCTGCCC AGTCACCAAA AAATATTTGA TCTAATGGAA 1920

CTAAATGGAG TTCAAGCTGA CTTTAAGCCA GCCATCTTGA GTTCAAGCCT GGATGACCCC 1980

AAGGACACCT GCCAGTCTGA CAAAGAAAAG CCCCATAAGC TCTTGGACCA GGGCCCTCTG 2040

TGCTTATCAG AAAGCCTTTT GCACCAAGAT CACTTTGATC CACTGAGTGT CCAAGAATTG 2100

TCAGAAAACT TTTTATTTCT TCAGGAGAAA AATCTACTGA AAGGCTCTCT GACTACCAAG 2160

GAGCAAGTGA GCGACCTTCA AACAGAACTC AAGAATGCAG GTTTTACCTC AGCACTGTTG 2220

GAGTCACCCC AGAGAGGCTC TGAAAGTTCT GAACTTGAGT TCCTGGAAAA TACACTAGAC 2280

TTTCCTTTGT CACAGGGAGA CACGCGTGGA CAGAATGAAG GTGCAGGTGT CAGGCGTCAC 2340

AGTGGTACCT CACCACAGGC CTCCCCAGCC TTGCTCACAG AAGAAGGATC TCCTACTGCC 2400

CCCACAGACC CAATTCTGAA GCCAGAAGAA ACCAAATCCT TTAGAGATGT CAGAGTCCCC 2460

GAGGACTCCA TCTGCTTGGA GCTAGGCCCC GACCCCGTGA CTGTTGGAGT TGAAATTCCT 2520

GCTACTGATG CCAAAACCCT CGATGGGGGC AACAGACCCC CAGACGTCAC TTGCCAAAGC 2580

AAGGAGGCCT TGAGTCTAAC CAACAGACAC CCCATCCTTG TGAATGATAT TACTGCTCAG 2640

GGTAGCGTGG AGAGTTGTCT TCCAGAATCG AGACAGGATT TACAAAATGA GCCATTTTCA 2700

GAAGACCCTC TTAGTGTCAG CTCACTGGAG AAACACTCGG AAGCTGCGGA GACTTTAAAC 2760

CAGCTTAACT CTAAGGCTGC CCCGGAGGAT GCAGCCTTGG CGTCTGCCCT CTCCTCGGAT 2820

TCTACCAGCC AAGATAGCCT CTTAGAAGAC AGTTTGTCAA CACCCATCCC CACCTCAGAG 2880

CAGTCTGTGG AGACGCCAGA CTCCCTGGAT TCAGTGGATG TCCGTGAAGC ATTGCTAGAG 2940

TCCCTAGGCT CCCACACCCC TCGGAAACTC TTGCCTCCCG ATAAGCCTGC CGACAGCGGC 3000

TATGAGACGG AGAACCTGGA ATCTCCTGAG TGGACCCTGC ACCCTGCACC CGAAGGCACT 3060

GCTGACTCAG ACGCAGCTGC AGCAGGTGAC AGTGGCCACA GCAGTTTGCC TCCCAACCCG 3120

GTCATTGTCA TCTCGGATGC AGGCGATGGC CACAGAGGTG CTGAAGGTCC TCCTCAGAGC 3180

TTCACACTTG GCCCCCAGAG TTCATATCGA GACTCTGCAT ACTTCTCAGA CAATGACTCG 3240

GAGCCAGATA AAAAGCCCGA GGAGGTCCCA GGAACATCTG CCAATGCCCT GGTGTTGGTA 3300

AAGGGCCAGT CCCCACCTGA GTCAGTTGTC CCAGAAGAAA GCTCTGATGT CAGAGAAGGC 3360

TGCCTGGAAG CCCCACAGGA CAAGCCAGAT CAAAGTCGGG TGTCTACTTT GCAGAATTCT 3420

TGTCACTCAG AACTACAAGA AACATTGCAG CCCACACCAG CTGATGCTTC CAGAGAGTCC 3480

TGTCCTGTGA ACGACGAGGC CAGCAGCCCC TTGAGTTTGT TGAATTCAGA ACCTAGCAGC 3540

TGCGATGACC TGGACACACA GGAAGATCGC CCATGCACCC TGGCCTCCAC AGGTACAAAT 3600

ACCAATGAAC TCCTTGCATA CATGAGTTCC ACACTGGATA AATCTTTGCC CAGCCACTTG 3660

GAGAGCTCCA AGCTGAAGGA GCCAGACATT GAAGGGAAAT ACCTTGGCAA ACTTTGTGTG 3720

TCTGGGATGC TGGACCTCTC GGAGGATGGG ATGGATGCCG ATGAGGAGGA TGAGAACAGC 3780

GACGACTCGG ACGAGGACCT TCGAGCCTTC AACTTGCACA GCCTAAGCTC TGAGTCTGAA 3840

GACGACACGG AGCACCCTGT GCCCATCATT GTCAGTAACG ATGATGGTAG GCACCTGCGG 3900

AGTTTGCTGA AACCCTCAGC TGCCGAGGCC ATTGAGCAGC TGCCGGAAGA CTGGAAGAAG 3960

GAAAAGAAGG CAGTGACATT TTTCGATGAT GTCACCGTTT ATCTGTTTGA CCAGGAAACC 4020

CCCACCAAAG AGCTGGGGCA CTGCGGGGGA GAAGCACATG GCCCTGGGCC CAGCAGCCCA 4080

GCAGCGTCCT CAAGTTCCCC CTACCTAGGG AGGTGCATGA ATTCCGAAAG TTCCACGGAT 4140

GAAGAAGGCG GAGGCTTTGA ATGGGACGAT GACTTCTCCC CGGACCCTTT CATGTCAAAG 4200

ACAACAAGCC TTCTGGGTTC CAAGCCTTCT CTTCAAACCT CCAAATACTT CTCTCCTCCC 4260

CCACCGGCCA GGAGCGCAGA GCAGAGCTGG CCGCACGTGT CCCCCTGCTC CCGGTTCTCC 4320

ATCTCTCCTG CCAACATTGC CAGCTTCTCT CTCACACACC TCACGGACTC AGACATTGAA 4380

CAAGGAGGCA GCAGTGAAGA CGGAGACAAG GACTAG 4416

Domain Profile

S: 1     lsylkeigsgwfgkvllgevfsdvssaqvvvkelkasaspkeqrkfleeaqpyralqhpn  60

         l+y++eigsgwfgkvllge+++++s+a+v+vkelk+saspkeq++fl++++py++lqhpn

Q: 136   LNYIQEIGSGWFGKVLLGETYTGTSVARVIVKELKVSASPKEQDTFLKSGEPYYILQHPN  195

         79**********************************************************

S: 61    vlqclgqcvealpyllvlefcdlgdlkaylraereaeslspdlrtlqrmalevaaglahl  120

         vlqc+gqcvea+pyllv+efcdlgdlkayl++e+e+++ ++++++lqrma+e+aagla++

Q: 196   VLQCVGQCVEAIPYLLVFEFCDLGDLKAYLHNEQEHVRGDSQTMLLQRMACEIAAGLAAM  255

         ************************************************************

S: 121   hklnyvhsdlalrnclltsdltvkvgdyglahskykedylltadklvvplrwaapelvde  180

         hkl+++hsdlalrnc+ltsdl+vkvgdyg+++s+ykedy++t+dk+v+plrw+apelv++

Q: 256   HKLHFLHSDLALRNCYLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTS  315

         ************************************************************

S: 181   lhdrllvvdqtkesnvwslgvtlwelfelgaqpyrklsdeevlafvvreqdvklakprlk  240

         ++drll++dqtk+sn+wslgvtlwelf+++aqpy++lsd +vl++v+re+d+kl+kp+l+

Q: 316   FQDRLLTADQTKYSNIWSLGVTLWELFNNAAQPYANLSDLDVLNQVIRERDMKLPKPQLE  375

         ************************************************************

S: 241   lpysdrwyevlqfcwlppekrpaaedvhllltyl  274

         +pysdrwyevlqfcwlpp+krpaaedvh+lltyl

Q: 376   QPYSDRWYEVLQFCWLPPDKRPAAEDVHRLLTYL  409

         *********************************8

Domain Sequence
(FASTA)

LNYIQEIGSG WFGKVLLGET YTGTSVARVI VKELKVSASP KEQDTFLKSG EPYYILQHPN 60

VLQCVGQCVE AIPYLLVFEF CDLGDLKAYL HNEQEHVRGD SQTMLLQRMA CEIAAGLAAM 120

HKLHFLHSDL ALRNCYLTSD LNVKVGDYGI GFSRYKEDYI ETDDKKVFPL RWTAPELVTS 180

FQDRLLTADQ TKYSNIWSLG VTLWELFNNA AQPYANLSDL DVLNQVIRER DMKLPKPQLE 240

QPYSDRWYEV LQFCWLPPDK RPAAEDVHRL LTYL 274

Keyword

ATP-binding; Complete proteome; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005769	; C:early endosome
GO:0005794	; C:Golgi apparatus
GO:0016021	; C:integral to membrane
GO:0048471	; C:perinuclear region of cytoplasm
GO:0055037	; C:recycling endosome
GO:0005524	; F:ATP binding
GO:0004864	; F:protein phosphatase inhibitor activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0007411	; P:axon guidance
GO:0045022	; P:early endosome to late endosome transport
GO:0032456	; P:endocytic recycling
GO:0048011	; P:nerve growth factor receptor signaling pathway
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0046777	; P:protein autophosphorylation
GO:0001881	; P:receptor recycling
GO:0033572	; P:transferrin transport

KEGG

mmu:231876

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013