EKS-MUM-00416

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00416

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	295.2	1.0E-87	462	718	257

Status

Reviewed

Ensembl Protein

ENSMUSP00000070561

UniProt Accession

Q5GIG6; B2RTJ7; Q5GIG5;

Protein Name

Serine/threonine-protein kinase TNNI3K

Protein Synonyms/Alias

Cardiac ankyrin repeat kinase; TNNI3-interacting kinase;

Gene Name

Tnni3k

Gene Synonyms/Alias

Tnni3k; Cark;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000040086	ENSMUSP00000070561	ENSMUST00000064076
ENSMUSG00000040086	ENSMUSP00000122478	ENSMUST00000143410

Organism

Mus musculus

Functional Description

May play a role in cardiac physiology (By similarity).

Protein Length

834

Protein Sequence
(FASTA)

MGNYKSRPTQ TCSDEWKKKV SESYAIIIER LEDDLQIKEN EFQELRHIFG SDEAFSEVSL 60

NYRTERGLSL LHLCCACGGN KSHIRALMLK GLRPSRLTRN GFPALHLAVY KDSLELITSL 120

LHSGADVQQA GYGGLTALHI AAIAGHPEAV EVLLQHGANV NVQDAVFFTP LHIAAYYGHE 180

QVTSVLLKFG ADVNVSGEVG DRPLHLASAK GFFNIVKLLV EGNKADVNAQ DNEDHVPLHF 240

CSRFGHHNIV SYLLQSDLEV QPHVINIYGD TPLHLACYNG NFEVAKEIVH VTGTESLTKE 300

NIFSETAFHS ACTYGKNIDL VKFLLDQNAV NINHRGRDGH TGLHSACYHG HIRLVQFLLD 360

NGADMNLVAC DPSRSSGEKD EQTCLMWAYE KGHDAIVTLL KHYKRPQDEL PCNEYSQPGG 420

DGSYVSVPSP LGKIKSMTKE KADVLLLRAE LPSRFHLQLS EIEFHEIIGS GSFGKVYKGR 480

CRNKIVAIKR YRANTYCSKS DVDMFCREVS ILCQLNHPCV VQFVGACLDD PSQFAIVTQY 540

ISGGSLFSLL HEQKRILDLQ SKLIIAVDVA KGMEYLHSLT QPIIHRDLNS HNILLYEDGH 600

AVVADFGESR FLQSLDEDNM TKQPGNLRWM APEVFTQCTR YTIKADVFSY ALCLWELLTG 660

EIPFAHLKPA AAAADMAYHH IRPPIGYSIP KPISSLLMRG WNACPEGRPE FSEVVRKLEE 720

CLCNVELMSP ASSNSSGSLS PSSSSDCLLS RGGPGRSHVA ALRSRFELEY ALNARSYTGW 780

PQSVGTHTNP GLSLEEMNRG AQYSAVDKYG YVSDPMSPMH LHSRRNSGSF EDGN 834

Nucleotide Sequence
(FASTA)

ATGGGGAATT ACAAATCCAG ACCGACACAG ACTTGTTCTG ATGAATGGAA GAAGAAAGTT 60

AGTGAATCTT ATGCTATTAT AATAGAAAGG CTGGAAGATG ACCTGCAGAT CAAAGAAAAT 120

GAATTTCAAG AACTAAGACA CATCTTTGGC TCTGACGAAG CCTTCAGTGA AGTCAGTTTA 180

AATTACCGCA CAGAGCGTGG CCTGTCCCTA CTGCACCTCT GCTGTGCCTG CGGTGGCAAC 240

AAGTCGCATA TCCGTGCCCT TATGTTAAAA GGGCTCCGTC CATCCAGACT GACAAGAAAT 300

GGGTTTCCAG CTCTGCACTT GGCTGTTTAC AAGGATAGCC TGGAACTTAT CACTTCACTG 360

TTGCATAGCG GAGCAGATGT TCAGCAAGCG GGATATGGCG GCCTCACAGC CCTCCACATC 420

GCTGCAATAG CTGGGCACCC AGAGGCCGTG GAAGTGCTGC TGCAGCATGG AGCCAATGTG 480

AACGTTCAAG ATGCAGTCTT CTTCACCCCA CTGCACATCG CAGCCTATTA CGGGCACGAG 540

CAGGTAACCA GTGTCCTTTT GAAGTTTGGA GCTGATGTCA ATGTAAGCGG TGAAGTTGGA 600

GACAGGCCTC TGCACCTGGC CTCTGCAAAA GGGTTCTTCA ACATTGTGAA ACTCCTGGTA 660

GAAGGGAACA AAGCCGACGT GAACGCTCAG GACAATGAAG ACCATGTCCC TCTGCACTTC 720

TGTTCTCGAT TTGGACACCA CAATATAGTG AGCTACTTGC TCCAGAGTGA CTTGGAGGTT 780

CAGCCTCACG TCATTAACAT CTATGGTGAC ACTCCTTTGC ACCTGGCGTG CTACAATGGA 840

AATTTTGAAG TTGCCAAGGA AATTGTCCAC GTAACAGGAA CTGAAAGTCT GACTAAGGAA 900

AACATCTTCA GTGAGACAGC TTTTCACAGT GCTTGTACCT ATGGCAAGAA CATTGACCTG 960

GTCAAATTCC TTCTTGATCA GAATGCTGTG AACATTAACC ATCGAGGAAG AGATGGGCAC 1020

ACAGGATTAC ACTCTGCTTG CTACCATGGC CACATACGCC TGGTTCAGTT CCTACTGGAT 1080

AATGGTGCAG ATATGAATCT AGTTGCTTGT GATCCCAGCA GGTCTAGTGG TGAAAAAGAT 1140

GAGCAGACAT GTTTGATGTG GGCTTATGAG AAAGGACATG ATGCCATTGT TACACTCCTG 1200

AAGCACTATA AGAGACCCCA GGATGAGCTG CCATGTAACG AATATTCTCA GCCTGGAGGA 1260

GATGGCTCCT ATGTGTCTGT CCCATCCCCC TTGGGGAAGA TTAAAAGCAT GACAAAAGAG 1320

AAGGCAGATG TTCTCCTCCT GAGGGCTGAA TTACCCTCCC GTTTCCATCT GCAGCTCTCG 1380

GAAATTGAAT TCCATGAGAT TATCGGCTCA GGTTCTTTTG GGAAAGTCTA TAAAGGGCGA 1440

TGCAGAAATA AAATAGTGGC AATCAAACGA TACCGAGCCA ACACCTACTG CTCCAAGTCA 1500

GACGTGGATA TGTTTTGCCG AGAAGTGTCC ATCCTCTGCC AGCTCAATCA CCCCTGCGTG 1560

GTTCAGTTTG TGGGTGCCTG CCTGGATGAC CCCAGCCAGT TTGCCATTGT CACACAATAC 1620

ATTTCAGGAG GCTCTCTGTT CTCCCTGCTT CATGAACAGA AGAGAATTCT TGACTTGCAG 1680

TCTAAATTAA TCATTGCAGT AGACGTTGCC AAGGGCATGG AGTACCTGCA CAGCTTGACC 1740

CAGCCAATCA TACACCGCGA CCTGAACAGT CACAATATTC TTCTCTATGA GGACGGCCAT 1800

GCTGTGGTGG CAGATTTTGG AGAATCAAGA TTTCTGCAGT CCCTGGATGA AGACAACATG 1860

ACAAAGCAGC CAGGGAACCT GCGCTGGATG GCCCCCGAGG TGTTCACACA GTGCACGCGC 1920

TACACCATCA AGGCTGATGT CTTCAGTTAC GCCCTGTGTC TGTGGGAGCT CCTCACTGGA 1980

GAAATTCCAT TCGCTCATCT GAAGCCAGCC GCTGCAGCAG CAGATATGGC GTACCACCAC 2040

ATCAGACCTC CCATCGGCTA CTCCATCCCC AAGCCAATCT CATCTCTGCT GATGCGGGGC 2100

TGGAATGCAT GTCCCGAAGG AAGACCCGAG TTCTCTGAAG TCGTTAGGAA GCTGGAGGAG 2160

TGCCTGTGTA ACGTGGAGCT CATGTCTCCT GCATCAAGTA ACAGCAGTGG CTCTCTGTCA 2220

CCTTCCTCTT CTTCTGATTG CCTACTGAGC CGAGGAGGGC CTGGCCGGAG CCATGTGGCA 2280

GCTTTACGGA GTCGTTTTGA GTTGGAATAC GCCCTAAATG CAAGGTCCTA CACTGGGTGG 2340

CCTCAAAGTG TCGGGACACA CACTAATCCA GGCCTGTCTT TGGAGGAAAT GAACAGAGGT 2400

GCCCAGTATT CAGCTGTTGA CAAATATGGC TACGTGTCTG ATCCCATGAG CCCGATGCAC 2460

CTCCACTCCC GCCGGAACAG TGGCAGCTTT GAGGACGGCA ACTGA 2505

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaee.kekleklereakllsklshpnii  59

         ie++e+igsg+fgkvyk+++r+k va+K++r+++++ k+++++++re+++l++l+hp+++

Q: 462   IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCsKSDVDMFCREVSILCQLNHPCVV  521

         5899****************************99998999********************

S: 60    ellGvcleepn.lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhsea  118

         +++G+cl++p+ +++v++y++ggsL+++lhe +kr +dl+  + +a+++A+Gm+YLhs +

Q: 522   QFVGACLDDPSqFAIVTQYISGGSLFSLLHE-QKRILDLQSKLIIAVDVAKGMEYLHSLT  580

         ***********99******************.99*************************6

S: 119   pkkiihrdLksknvLlseekktlkicdFGtarelsk..stkmsaa.gtlawmaPEvl.ke  174

         + +iihrdL+s+n+Ll  e+ ++ ++dFG++r+l++  +++m+++ g+l+wmaPEv+ ++

Q: 581   Q-PIIHRDLNSHNILL-YEDGHAVVADFGESRFLQSldEDNMTKQpGNLRWMAPEVFtQC  638

         6.9*************.9*****************99877777777**************

S: 175   ekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmk  234

         ++++ k+Dv+Sy+++LWellt+e+P+++l+++a+a+++a++++r+pi+ s+p+++++L+

Q: 639   TRYTIKADVFSYALCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLM  698

         ************************************************************

S: 235   ecwnedpekRpsfseivksl  254

         + wn++pe Rp+fse+v++l

Q: 699   RGWNACPEGRPEFSEVVRKL  718

         ****************9875

Domain Sequence
(FASTA)

IEFHEIIGSG SFGKVYKGRC RNKIVAIKRY RANTYCSKSD VDMFCREVSI LCQLNHPCVV 60

QFVGACLDDP SQFAIVTQYI SGGSLFSLLH EQKRILDLQS KLIIAVDVAK GMEYLHSLTQ 120

PIIHRDLNSH NILLYEDGHA VVADFGESRF LQSLDEDNMT KQPGNLRWMA PEVFTQCTRY 180

TIKADVFSYA LCLWELLTGE IPFAHLKPAA AAADMAYHHI RPPIGYSIPK PISSLLMRGW 240

NACPEGRPEF SEVVRKL 257

Keyword

Alternative splicing; ANK repeat; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Kinase; Lipoprotein; Magnesium; Metal-binding; Myristate; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

mmu:435766

;

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00023	; Ank; 1.
PF12796	; Ank_2; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 10.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 6.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013