EKS-MUM-00411
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00411
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK344.11.2E-10299357259
StatusReviewed
Ensembl ProteinENSMUSP00000103978
UniProt AccessionQ66L42; Q80UW4;
Protein NameMitogen-activated protein kinase kinase kinase 10
Protein Synonyms/Alias
Gene NameMap3k10
Gene Synonyms/Alias Map3k10;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000040390ENSMUSP00000037725ENSMUST00000036453
ENSMUSG00000040390ENSMUSP00000103978ENSMUST00000108341
OrganismMus musculus
Functional DescriptionActivates the JUN N-terminal pathway (By similarity).
Protein Length942
Protein Sequence
(FASTA)
MEEEEGAAAR EWGATPAGPV WTAVFDYEAV GDEELTLRRG DRVQVLSQDC AVSGDEGWWT 60
GQLPSGRVGV FPSNYVAPAA PAAPSDLQLP QEIPFHELQL EEIIGVGGFG KVYRAVWRGE 120
EVAVKAARLD PERDPAVTAE QVRQEARLFG ALQHPNIIAL RGACLSPPNL CLVMEYARGG 180
ALSRVLAGRR VPPHVLVNWA VQVARGMNYL HNDAPVPIIH RDLKSINILI LEAIENHNLA 240
DTVLKITDFG LAREWHKTTK MSAAGTYAWM APEVIRLSLF SKSSDVWSFG VLLWELLTGE 300
VPYREIDALA VAYGVAMNKL TLPIPSTCPE PFARLLEECW DPDPHGRPDF GSILKQLEVI 360
EQSALFQMPL ESFHSLQEDW KLEIQHMFDD LRTKEKELRS REEELLRAAQ EQRFQEEQLR 420
RREQELAERE MDIVERELHL LMSQLSQEKP RVRKRKGNFK RSRLLKLREG SSHISLPSGF 480
EHKITVQASP TLDKRKGSDG ASPPASPSII PRLRAIRLTP MDCGGSSGSG TWSRSGPPKK 540
EELVGGKKKG RTWGPSSTLQ KERAGGEERL KALGEGSKQW SSSAPNLGKS PKHTPMAPGF 600
ASLNEMEEFA EADEGNNVPP SPYSTPSYLK VPLPAEPSPC VQAPWEPPAV TPSRPGHGAR 660
RRCDLALLSC ATLLSAVGLG ADVAEARAGD GEEQRRWLDS LFFPRPGRFP RGLSPTGRPG 720
GRREDTAPGL GLAPSATLVS LSSVSDCNST RSLLRSDSDE AAPAAPSPPP SPLAPSPSTN 780
PLVDVELESF KKDPRQSLTP THVTAAHAVS RGHRRTPSDG ALRQREPLEL TNHGQGPRDP 840
LDFPRLPDPQ ALFPTRRRPL EFPGRPTTLT FAPRPRPAAS RPRLDPWKLV SFGRTLSISP 900
PSRPDTPESP GPPSVQPTLL DMDMEGQSQD NTVPLCGVYG SH 942
Nucleotide Sequence
(FASTA)
ATGGAGGAGG AGGAGGGGGC GGCGGCCAGA GAGTGGGGCG CGACCCCCGC GGGGCCAGTG 60
TGGACCGCCG TGTTCGACTA CGAGGCGGTG GGCGACGAGG AGCTGACCCT GCGGAGAGGC 120
GACCGCGTCC AGGTGCTTTC CCAGGACTGT GCGGTGTCTG GAGATGAGGG CTGGTGGACA 180
GGGCAGCTGC CCAGCGGCCG TGTGGGCGTC TTCCCCAGCA ACTACGTGGC CCCCGCTGCA 240
CCCGCCGCAC CCTCAGACCT CCAGCTGCCA CAGGAGATCC CCTTCCACGA GCTGCAGCTG 300
GAGGAGATCA TCGGTGTCGG GGGCTTTGGC AAAGTCTATC GCGCCGTATG GCGTGGAGAG 360
GAAGTAGCGG TCAAGGCCGC TCGGCTGGAC CCTGAACGGG ACCCGGCAGT GACAGCGGAG 420
CAGGTCCGCC AGGAGGCCCG GCTCTTTGGA GCCCTGCAGC ACCCCAACAT CATTGCCCTG 480
AGGGGCGCCT GCCTCAGCCC CCCAAACCTC TGCCTGGTGA TGGAATATGC TCGGGGAGGT 540
GCATTGAGCA GGGTACTGGC AGGTCGCCGG GTCCCCCCTC ATGTGCTGGT CAACTGGGCT 600
GTGCAGGTGG CTCGGGGCAT GAACTATCTA CACAATGATG CCCCTGTGCC CATCATTCAC 660
CGGGACCTCA AGTCCATCAA CATCCTAATC CTGGAGGCCA TTGAGAACCA CAACCTCGCT 720
GACACGGTGC TCAAGATCAC AGACTTCGGC CTTGCCCGAG AGTGGCACAA GACGACCAAA 780
ATGAGTGCAG CGGGGACCTA CGCCTGGATG GCTCCTGAGG TTATCCGCCT GTCCCTCTTC 840
TCCAAAAGCA GCGACGTCTG GAGCTTCGGG GTTCTTCTTT GGGAGCTGCT GACCGGGGAG 900
GTCCCCTACC GAGAAATCGA CGCCTTGGCC GTGGCTTACG GTGTGGCTAT GAACAAGCTG 960
ACGCTACCCA TCCCCTCCAC GTGCCCCGAG CCCTTTGCCC GCCTACTGGA GGAATGCTGG 1020
GACCCAGACC CTCACGGGCG ACCAGATTTT GGCAGCATCC TGAAGCAGCT GGAGGTCATC 1080
GAGCAGTCAG CCCTGTTCCA GATGCCACTG GAGTCCTTCC ACTCCCTGCA GGAAGACTGG 1140
AAGCTGGAGA TTCAGCATAT GTTTGATGAC CTTCGGACCA AGGAGAAGGA GTTGCGCAGC 1200
CGGGAAGAGG AGCTATTGCG GGCTGCACAG GAGCAGCGTT TTCAGGAAGA GCAGCTACGG 1260
CGTCGGGAGC AGGAGCTGGC AGAGCGAGAG ATGGACATCG TAGAACGTGA GCTGCACCTG 1320
CTCATGAGCC AGCTGAGCCA GGAGAAGCCC AGGGTCCGAA AACGCAAGGG CAACTTCAAG 1380
CGCAGCCGCT TGCTCAAGCT ACGGGAAGGA AGCAGCCACA TCAGCCTGCC CTCTGGATTT 1440
GAACATAAGA TCACCGTCCA GGCCTCCCCA ACCCTGGACA AGAGGAAAGG ATCCGATGGG 1500
GCCAGCCCTC CTGCCAGCCC CAGCATCATT CCCCGGTTGA GGGCCATTCG ATTGACTCCC 1560
ATGGACTGTG GTGGCAGCAG TGGTAGTGGA ACATGGAGCC GCAGTGGGCC ACCAAAGAAG 1620
GAAGAACTGG TTGGGGGCAA GAAGAAAGGC AGGACATGGG GCCCCAGTTC CACTTTGCAG 1680
AAGGAGCGAG CTGGAGGAGA GGAGAGGCTC AAGGCCCTGG GGGAAGGAAG CAAGCAGTGG 1740
TCCTCGAGCG CCCCCAACCT GGGCAAATCC CCTAAGCACA CCCCCATGGC CCCAGGCTTC 1800
GCCAGCCTCA ACGAGATGGA AGAATTTGCG GAGGCAGATG AAGGCAACAA CGTGCCCCCT 1860
TCTCCCTACT CCACCCCGTC CTACCTCAAG GTGCCTCTGC CCGCCGAGCC TTCTCCTTGT 1920
GTTCAGGCGC CTTGGGAGCC GCCGGCTGTC ACCCCTTCCC GGCCAGGACA CGGAGCTCGT 1980
AGGCGCTGCG ACCTGGCGCT GCTAAGCTGT GCCACGCTGC TGAGTGCGGT GGGCCTGGGC 2040
GCCGACGTGG CCGAGGCACG GGCCGGGGAC GGTGAGGAGC AGCGGCGCTG GCTGGACAGT 2100
CTCTTCTTCC CGCGCCCCGG CCGCTTCCCT CGCGGTCTCA GCCCAACCGG GCGCCCCGGA 2160
GGTCGCCGCG AAGACACAGC CCCAGGCTTG GGTCTGGCAC CCTCGGCCAC CCTGGTGTCA 2220
TTATCCTCTG TATCGGATTG TAACTCTACG CGCTCATTGC TGCGCTCTGA CAGTGACGAG 2280
GCTGCCCCTG CCGCCCCCTC CCCGCCGCCT TCTCCGCTCG CGCCCTCACC CAGCACCAAT 2340
CCTCTCGTGG ACGTGGAGTT GGAGAGCTTC AAGAAGGACC CCCGGCAGTC ACTTACGCCC 2400
ACCCACGTCA CTGCCGCCCA CGCTGTGAGC CGTGGACACA GGCGGACGCC ATCAGATGGG 2460
GCTTTGAGAC AACGGGAGCC TCTGGAGCTC ACCAACCACG GACAGGGTCC TCGAGACCCC 2520
CTGGACTTCC CTCGACTGCC CGACCCCCAG GCCCTGTTCC CTACCCGACG CCGGCCCCTG 2580
GAGTTCCCTG GCCGCCCCAC CACCCTCACT TTTGCCCCAA GACCCCGGCC TGCTGCCAGC 2640
CGCCCCCGTC TGGATCCCTG GAAACTGGTC TCCTTTGGCC GGACACTCAG CATCTCGCCT 2700
CCAAGCAGGC CAGACACTCC AGAGAGCCCT GGGCCCCCCA GCGTGCAACC CACGTTGCTG 2760
GACATGGACA TGGAGGGCCA GAGCCAGGAC AATACAGTGC CCCTATGTGG GGTCTATGGC 2820
TCTCACTGA 2829
Domain Profile
S: 2     eleeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpnii  59
         +lee+ig g fgkvy+a wr++evavK++r + e+  + ++e++++ea+l+ +l+hpnii
Q: 99    QLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERdpAVTAEQVRQEARLFGALQHPNII  158
         789*******************************988999********************
S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119
         +l+G+cl++pnl+lvmey++gg+Ls+vl++   r+++++vlv+wa+q+ArGm+YLh++ap
Q: 159   ALRGACLSPPNLCLVMEYARGGALSRVLAG---RRVPPHVLVNWAVQVARGMNYLHNDAP  215
         ******************************...9**************************
S: 120   kkiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvl  172
         ++iihrdLks n+L+       + ++++lki+dFG are++k+tkmsaagt+awmaPEv+
Q: 216   VPIIHRDLKSINILIleaienhNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVI  275
         ********************99999***********************************
S: 173   keekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkL  232
         + + +s++sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++L
Q: 276   RLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARL  335
         ************************************************************
S: 233   mkecwnedpekRpsfseivksl  254
         ++ecw+ dp+ Rp+f +i+k+l
Q: 336   LEECWDPDPHGRPDFGSILKQL  357
         ******************9986
Domain Sequence
(FASTA)
QLEEIIGVGG FGKVYRAVWR GEEVAVKAAR LDPERDPAVT AEQVRQEARL FGALQHPNII 60
ALRGACLSPP NLCLVMEYAR GGALSRVLAG RRVPPHVLVN WAVQVARGMN YLHNDAPVPI 120
IHRDLKSINI LILEAIENHN LADTVLKITD FGLAREWHKT TKMSAAGTYA WMAPEVIRLS 180
LFSKSSDVWS FGVLLWELLT GEVPYREIDA LAVAYGVAMN KLTLPIPSTC PEPFARLLEE 240
CWDPDPHGRP DFGSILKQL 259
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; SH3 domain; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00351
EKS-ANC-00366
EKS-BOT-00379
EKS-CAJ-00382
EKS-CAP-00410
EKS-DAR-00758
EKS-FEC-00366
EKS-GAA-00461
EKS-GOG-00369
EKS-HOS-00385
EKS-ICT-00357
EKS-LOA-00388
EKS-MOD-00368
EKS-MUP-00371
EKS-MYL-00376
EKS-NOL-00352
EKS-ORN-00485
EKS-ORC-00355
EKS-OTG-00380
EKS-PAT-00359
EKS-POA-00368
EKS-RAN-00393
EKS-SUS-00331
EKS-TEN-00479
EKS-TUT-00103
EKS-XET-00491
Gene Ontology
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0004672; F:protein kinase activity
GO:0003714; F:transcription corepressor activity
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR016231; MAPKKK9/10/11.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR001452; SH3_domain.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00018; SH3_1; 1.
SMARTs
SM00326; SH3; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013