EKS-MUM-00305

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00305

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	373.6	2.1E-111	11	347	337

Status

Reviewed

Ensembl Protein

ENSMUSP00000103990

UniProt Accession

Q3V016; A8R3X8; B9EJV5;

Protein Name

Homeodomain-interacting protein kinase 4

Protein Synonyms/Alias

Gene Name

Hipk4

Gene Synonyms/Alias

Hipk4; Gm162;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000040424	ENSMUSP00000043175	ENSMUST00000037134
ENSMUSG00000040424	ENSMUSP00000103990	ENSMUST00000108353

Organism

Mus musculus

Functional Description

Protein kinase that phosphorylates murine TP53 at Ser-9,and thus induces TP53 repression of BIRC5 promoter. May act as a corepressor of transcription factors (Potential).

Protein Length

616

Protein Sequence
(FASTA)

MATIQSETDC YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRSR IIKNELKLLR 60

CVRGLDPDEA HVIRFLEFFH DALKFYLVFE LLEQNLFEFQ KENNFAPLPA RHIRTVTLQV 120

LRALARLKEL AIIHADLKPE NIMLVDQTRC PFRVKVIDFG SASIFSEVRY VKEPYIQSRF 180

YRAPEILLGL PFCEKVDVWS LGCVMAELHL GWPLYPGNNE YDQVRYICET QGLPKPHLLH 240

AARKAHHFFK RNPHPDATNP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGGAV 300

SRLSFPDREA LAEHADLKSM VELIKRMLTW ESHERISPSA ALRHPFVSMQ QLRSAHEATR 360

YYQLSLRGCR LSLQVDGKPP PPVIASAEDG PPYYRLAEEE ETAGLGGVTG SGSFFREDKA 420

PGMQRAIDQL DDLSLQEARR GLWSDTRADM VSDMLVPLKV ASTSHRVPDS GPEPILAFYG 480

SRLTGRHKAR KAPAGSKSDS NFSNLIRLSQ ASPEDAGPCR GSGWEEGEGR TTSTEPSVIP 540

QREGDGPGIK DRPMDAERPG PELFDPSSCP GEWLSEPEWT LEGIRGSRAQ GLPAHHPHPH 600

GPPRTTSFLQ HVGGHH 616

Nucleotide Sequence
(FASTA)

ATGGCCACCA TCCAGTCAGA GACTGACTGC TACGACATCA TTGAAGTTCT GGGCAAGGGC 60

ACTTTTGGAG AGGTGGCCAA GGGCTGGCGT CGGAGTACAG GTGAAATGGT GGCCATCAAG 120

ATCCTGAAGA ACGATGCGTA CCGAAGCCGC ATCATCAAGA ATGAGCTGAA GCTGCTGCGC 180

TGCGTGCGAG GCCTGGACCC TGACGAGGCC CACGTTATCC GCTTCCTTGA GTTCTTCCAC 240

GATGCCCTCA AGTTCTACCT GGTCTTCGAG CTTTTGGAGC AAAACCTCTT TGAGTTCCAG 300

AAAGAGAACA ACTTCGCACC CCTTCCTGCC AGGCACATCC GCACGGTCAC ACTGCAGGTA 360

CTAAGAGCGC TGGCCCGGCT CAAGGAACTG GCCATCATCC ACGCTGACCT CAAGCCTGAA 420

AACATTATGT TGGTAGACCA GACGCGCTGC CCCTTCAGGG TCAAGGTGAT CGACTTTGGC 480

TCGGCCAGCA TATTCAGTGA GGTACGCTAT GTGAAGGAGC CTTACATCCA GTCCCGCTTC 540

TACAGGGCCC CAGAGATCCT GCTGGGGCTG CCCTTCTGTG AGAAGGTGGA CGTGTGGTCT 600

CTGGGCTGTG TCATGGCCGA GCTACATCTG GGCTGGCCTC TCTACCCAGG CAACAATGAG 660

TATGACCAGG TGCGCTACAT CTGTGAGACC CAGGGCTTAC CCAAGCCCCA TTTGCTGCAT 720

GCGGCTCGCA AGGCTCACCA CTTCTTCAAG CGTAACCCCC ACCCCGATGC CACCAACCCC 780

TGGCAGCTGA AGTCCTCTGC TGACTACCTA GCTGAGACCA AGGTACGTCC TCTGGAGCGC 840

CGCAAGTACA TGCTCAAATC CTTGGACCAG ATTGAGACAG TGAATGGTGG TGGAGCTGTG 900

AGCCGGCTGA GTTTTCCAGA CCGGGAGGCC CTGGCGGAAC ACGCAGACCT CAAGAGCATG 960

GTGGAGCTGA TCAAACGCAT GCTGACATGG GAGTCGCACG AACGCATCAG TCCCAGTGCG 1020

GCCCTGCGTC ACCCCTTCGT GTCCATGCAG CAGCTGCGGA GTGCCCACGA GGCCACCCGC 1080

TACTACCAGC TGTCGCTCAG AGGCTGTCGG CTGTCCCTGC AGGTGGATGG CAAGCCACCC 1140

CCACCTGTCA TAGCCAGCGC AGAGGACGGG CCTCCCTACT ACCGCCTGGC TGAGGAGGAG 1200

GAGACTGCAG GCCTGGGTGG TGTGACAGGC AGTGGGTCCT TCTTCAGGGA GGACAAGGCT 1260

CCGGGAATGC AGAGGGCCAT CGACCAGCTC GATGACCTGA GTCTGCAAGA GGCCAGACGG 1320

GGGCTGTGGA GCGACACACG GGCCGACATG GTCTCTGACA TGCTGGTTCC ACTCAAAGTG 1380

GCCAGTACCA GCCACCGAGT CCCTGACTCA GGCCCAGAGC CTATCCTGGC CTTCTACGGC 1440

AGCCGATTGA CCGGCCGCCA TAAGGCCCGC AAGGCCCCAG CAGGCTCCAA ATCTGACTCC 1500

AACTTCAGTA ACCTCATTCG GCTGAGCCAG GCCTCACCTG AGGATGCCGG GCCCTGTCGG 1560

GGCAGTGGCT GGGAGGAAGG AGAAGGCCGC ACGACCTCCA CAGAGCCGTC TGTCATCCCA 1620

CAACGGGAAG GAGATGGGCC TGGCATCAAA GACAGGCCCA TGGATGCCGA GAGGCCAGGC 1680

CCTGAGCTCT TTGATCCCAG CAGCTGTCCT GGAGAGTGGC TGAGTGAGCC AGAATGGACC 1740

CTAGAGGGCA TCCGGGGGTC TCGAGCTCAA GGGCTCCCAG CTCACCATCC CCACCCCCAC 1800

GGGCCACCCA GGACCACCAG CTTTCTGCAG CATGTTGGAG GGCACCACTG A 1851

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         y+++ev+gkG+fg+V+k+++++t e+vaiki+kn++   r +++E+++L++++  d++e+

Q: 11    YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCVRGLDPDEA  70

         99*******************************************************988

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

          +v+r+le+f+   +++lvfell+qnL+e+ k+n+f++l+ +++r+++ q+l+aL+ Lke

Q: 71    -HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLRALARLKE  129

         .9**********************************************************

S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqk..eiytyiqsrfYraPEiilg  176

         l+iiHaDlKPeNi+lv+++r++  vkviDFGs+s +s+   + ++yiqsrfYraPEi+lg

Q: 130   LAIIHADLKPENIMLVDQTRCPfrVKVIDFGSASIFSEVryVKEPYIQSRFYRAPEILLG  189

         *********************999**********99987447899***************

S: 177   lkydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff  236

         l+++e++D+WSlGcv+aEl++G+pL+pG+ne+dq+++i+e++glp+++ll++a+ka++ff

Q: 190   LPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAARKAHHFF  249

         ************************************************************

S: 237   tkkeapkyilktk.............ksdrkkklvlnvkkaakkrk.....aplskelge  278

         +++ +p  +  ++                +++k++l+  +++++++     + ls   +e

Q: 250   KRNPHPDATNPWQlkssadylaetkvRPLERRKYMLKSLDQIETVNgggavSRLSFPDRE  309

         888888777666667779999988885667777888888877777611111334445678

S: 279   alkekedkl.fkdllkrmleldpakRitpkealkhpfv  315

         al+e++d + +++l+krml++++++Ri+p++al+hpfv

Q: 310   ALAEHADLKsMVELIKRMLTWESHERISPSAALRHPFV  347

         8889999888***************************7

Domain Sequence
(FASTA)

YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRSR IIKNELKLLR CVRGLDPDEA 60

HVIRFLEFFH DALKFYLVFE LLEQNLFEFQ KENNFAPLPA RHIRTVTLQV LRALARLKEL 120

AIIHADLKPE NIMLVDQTRC PFRVKVIDFG SASIFSEVRY VKEPYIQSRF YRAPEILLGL 180

PFCEKVDVWS LGCVMAELHL GWPLYPGNNE YDQVRYICET QGLPKPHLLH AARKAHHFFK 240

RNPHPDATNP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGGAV SRLSFPDREA 300

LAEHADLKSM VELIKRMLTW ESHERISPSA ALRHPFV 337

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

mmu:233020

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013